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PENETAPAN KADAR ALKALI BEBAS PADA SABUN CUCI KRIM YANG DIJUAL DI MINI MARKET SECARA ASIDIMETRI Puput Kusuma Dipaningrum; Ade Maria Ulfa; Sudewi Mukaromah Khoirunnisa
Jurnal Analis Farmasi Vol 6, No 2 (2021)
Publisher : Program Studi Analisis Farmasi dan Makanan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v6i2.5956

Laundry soap cream is one PKRT (Household Health) which is used to clean equipment and to wash clothes. The main constituent component of fat and soap is alkaline, where if there is excess base does not react with the excess fat there will be alkali-free. If in the soap containing alkali-free high, it can cause skin irritations such as rough skin, flushed, sometimes there are small spots of water and cause itching. Limit allowed in the free alkali soap cream by the Indonesian National Standard 06-2048-1990 ie a maximum of 0.1%. This study aims to determine the levels of free alkaline detergent contained in the cream is sold in the mini market of Bandar Lampung. The method used is acidimetry, where the principle is the determination of free alkaline by neutralizing acids and bases. In this study HCl titrant used is a strong base that is titrated by using a strong acid, an indicator used is phenolpthalien with stretch pH 8.2 to 9.6 and endpoint occurring from pink to white. From the results obtained with the sample five different brands the average level of alkali-free for sample A: 3.06% B: 2.86%, C: 1.08%, D: 0.40%, E: 1.11 %. Based on the research results obtained showed that the alkali-free in all samples of soap cream does not meet the requirements of the maximum levels of Indonesian National Standard 06-2048-1990 ie 0.1%.

Optimasi Formula Mikroemulsi Berbahan Dasar Crude Palm Oil (CPO) Sebagai Antioksidan Potensial Pada Kulit Erga Syafitri; Nur Adliani; Sudewi Mukaromah Khoirunnisa; Fina Khaerunnisa Frima
Jurnal Industri Hasil Perkebunan Vol 15, No 1 (2020): Jurnal Industri Hasil Perkebunan
Publisher : Balai Besar Industri Hasil Perkebunan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33104/jihp.v15i1.6129

Minyak Kelapa Sawit (Crude Palm Oil/CPO) merupakan salah satu tanaman khas Sumatera yang berpotensi sebagai sediaan antioksidan. Bentuk sediaan mikroemulsi dipilih karena dapat meningkatkan penetrasi CPO ke dalam kulit. Oleh karena itu, pada penelitian ini akan dibentuk sediaan mikroemulsi mengandung CPO dan diuji aktivitas antioksidannya. Mikroemulsi CPO diformulasikan menggunakan metode Phase Titration Method dengan CPO sebagai fase minyak, tween 80 sebagai surfaktan, PEG 400 sebagai kosurfaktan dan aquadest sebagai fase air. Formula optimum dari penelitian ini mengandung 5% (b/b) CPO, 20% (b/b) tween 80, 10% (b/b) PEG 400, dan 65% (b/b) air. Hasil evaluasi formula menunjukkan bahwa formula ini memiliki ukuran globul sebesar 288,87 ± 20,94 nm, zeta potensial sebesar -0,36 mV, bobot jenis 1,024 ± 6,15x10-5 g/mL dan pH berada pada rentang 4,5-6,5. Dari evaluasi stabilitas didapat bahwa sediaan stabil dalam penyimpanan selama 28 hari di suhu ruang (25ºC), stabil terhadap perubahan suhu ekstrim dan terhadap agitasi. Sediaan mikroemulsi CPO ini memiliki nilai IC50 sebesar 10,5 µg/mL yang menunjukkan aktivitas antioksidan yang kuat. Dari hasil tersebut dapat disimpulkan bahwa sediaan mikroemulsi CPO memiliki karakterisasi fisik dan kestabilan yang baik dan dapat dikembangkan lebih lanjut sebagai sediaan antioksidan pada kulit.

THE EFFECTIVENESS AND COST ANALYSIS OF ZINC TREATMENT ON THE CHILDREN WITH ACUTE DIARRHEA IN PKU MUHAMMADIYAH YOGYAKARTA HOSPITAL IN 2011 Sudewi Mukaromah Khoirunnisa; Tri Murti Andayani; Inayati Inayati
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 2, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.93

Diarrhea is the second leading cause of death among children in the world and medical cost to deal with diarrhea is significantly high. WHO and UNICEF recommend the use of zinc to treat diarrhea on children. This research was aimed to assess of diarrhea the influence of giving zinc supplement on the duration, length of stay and frequency, and to identify the amount of direct medical cost borne by the patient who used utilizing zinc in order to treat diarrhea. This research was conducted with non-experimental descriptive design. Data were taken retrospectively from medical record and financial office of PKU Muhammadiyah Yogyakarta Hospital. The research subjects were child patients aged 1 - < 15 years old suffering from acute diarrhea, used antibiotic, had no other diseases, and treated as inpatient during the period of January 1 until December 31st 2011. The number of samples that met the inclusion criteria were 67 patients for each zinc and control group. The data were analyzed based on the characteristics of patients, diarrhea duration in the hospital, length of stay, diarrhea frequency and amount of medical cost. Data were analyzed descriptive quantitatively and statistically to compare the means of variables between both groups. The research result indicated that the group receiving zinc had shorter diarrhea duration of ±0.45 day (p<0.05), shorter length of stay of ±0.09 day (p>0.05), and lower diarrhea frequency from the second to the fourth day of the treatment (p<0.05). In regard to cost analysis, the total medical cost of zinc group was lower than that of control group (p<0.05) accounts for IDR. 1,155,407. However, it could not be concluded that the use of Zinc was effective. The use of zinc was effective in treating acute diarrhea on inpatients children.Keywords: zinc, acute diarrhea, effectiveness, direct medical cost

Formulasi Sediaan Masker Gel Peel-off Limbah Kulit Pisang Ambon (Musa paradisiaca var.sapientum) sebagai Antioksidan Sudewi Mukaromah Khoirunnisa; Dirga Dirga; Irfanianta Arif Setyawan; Atika Dalili Akhmad
Jurnal Farmasi Malahayati Vol 5, No 1 (2022)
Publisher : Jurnal Farmasi Malahayati (JFM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jfm.v5i1.6350

Provinsi Lampung merupakan penghasil pisang terbesar dengan jumlah sebanyak 1,48 juta ton atau 21,59 % dari total produksi pisang nasional. Jenis pisang yang banyak dikonsumsi masyarakat adalah pisang ambon (Musa paradisiaca var.sapientum.), namun pemanfaatan pisang sebagai bahan obat, kosmetik maupun pangan masih terbatas pada buahnya dan pengolahan bagian lainnya yang berupa limbah seperti kulit buah masih sedikit. Kulit pisang dilaporkan memiliki khasiat sebagai antioksidan, antikolesterol, antinyeri, antidiare, anti hipertensi, dan antihiperglikemi. Melihat besarnya potensi dari kulit pisang, maka diperlukan studi untuk memanfaatkan kulit pisang ambon sebagai sediaan masker gel peel-off yang stabil, berefek, dan aman. Pengujian aktivitas antioksidan dilakukan dengan metode Diphenylhydrazylpicryl (DPPH). Formulasi masker gel dibuat dengan basis Polyvinyl Alcohol (PVA) dengan konsentrasi 10%. Evaluasi sediaan masker gel meliputi pengamatan perubahan konsistensi, warna, bau, pH, dan viskositas selama 28 hari pada suhu penyimpanan yang berbeda, yaitu pada suhu 4◦C dan 27◦C. Hasil dari penelitian ini menunjukkan bahwa ekstrak etanol kulit pisang ambon memiliki IC50 sebesar 13,542 ppm. Dari hasil uji fisik menunjukkan bahwa formula 2 memiliki syarat yang paling baik sebagai sediaan masker. Hasil evaluasi aktivitas antioksidan, ketiga formula masker memiliki aktivitas antioksidan yang baik (IC50<50), namun formula yang disimpan dalam suhu 4◦C memiliki aktivitas antioksidan yang lebih baik.

PENETAPAN KADAR ALKALI BEBAS PADA SABUN CUCI KRIM YANG DIJUAL DI MINI MARKET SECARA ASIDIMETRI Puput Kusuma Dipaningrum; Ade Maria Ulfa; Sudewi Mukaromah Khoirunnisa
Jurnal Analis Farmasi Vol 6, No 2 (2021)
Publisher : Program Studi Analisis Farmasi dan Makanan Universitas Malahayati

Laundry soap cream is one PKRT (Household Health) which is used to clean equipment and to wash clothes. The main constituent component of fat and soap is alkaline, where if there is excess base does not react with the excess fat there will be alkali-free. If in the soap containing alkali-free high, it can cause skin irritations such as rough skin, flushed, sometimes there are small spots of water and cause itching. Limit allowed in the free alkali soap cream by the Indonesian National Standard 06-2048-1990 ie a maximum of 0.1%. This study aims to determine the levels of free alkaline detergent contained in the cream is sold in the mini market of Bandar Lampung. The method used is acidimetry, where the principle is the determination of free alkaline by neutralizing acids and bases. In this study HCl titrant used is a strong base that is titrated by using a strong acid, an indicator used is phenolpthalien with stretch pH 8.2 to 9.6 and endpoint occurring from pink to white. From the results obtained with the sample five different brands the average level of alkali-free for sample A: 3.06% B: 2.86%, C: 1.08%, D: 0.40%, E: 1.11 %. Based on the research results obtained showed that the alkali-free in all samples of soap cream does not meet the requirements of the maximum levels of Indonesian National Standard 06-2048-1990 ie 0.1%.

Quality of Life of Patient with Hypertension in Primary Health Care in Bandar Lampung Sudewi Mukaromah Khoirunnisa; Atika Dalili Akhmad
Indonesian Journal of Pharmacy Vol 30 No 4, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm30iss4pp309

The high prevalence of hypertension in Indonesia, encourages studies related to how the quality of life of patients with hypertension. The purpose of this study was to measure quality of life, identify and explain factors related to the quality of life of patients with hypertension.The study design was descriptive correlation using a cross sectional study approach. The study subjects were all outpatient hypertensive patients several health centers in Bandar Lampung. The instrument used in this study was the Indonesian SF-36. The data collected included the patient's demographic characteristics including gender, age, education, occupation, and marital status, and the fields related to the health history of the study subjects included the duration of hypertension, complications, and the number of antihypertensive drugs consumed. Data were analyzed using bivariate analysis to see the relationship between two variables with the level of significance used was 5% (α = 0.05) with the value of the confidence interval set was 95%. Multivariate analysis was conducted to study the relationship of several independent variables with one or several dependent variables.The results of univariate analysis showed that age, marital status, duration of illness, complications, and the number of drugs consumed had an effect on the quality of life of hypertensive patients (p <0.05). The results of multivariate analysis showed that the factors of age, marital status, and duration of hypertension are factors that influence the physical domain, while the factors of gender, marital status, duration of hypertension, complications, and the number of drugs are influential factors in the mental domain mental.

IDENTIFIKASI DEKSAMETASON DALAM JAMU PEGAL LINU SEDIAAN SERBUK YANG BEREDAR DI PASAR-PASAR KOTA BANDAR LAMPUNG SECARA KROMATOGRAFI LAPIS TIPIS Sudewi Mukaromah Khoirunnisa
Journal of Science and Applicative Technology Vol 1 No 2 (2017): Journal of Science and Applicative Technology December Chapter
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

A total of 26.6% of the population in Lampung Province consume traditional medicine, one of which is Jamu Pegal Linu. However, a large public interest in herbal products is often misused by herbal manufacturers that it is possible to add BKO (Medicinal Chemicals), such as dexamethasone.The purpose of this study is to identify the presence or absence of dexamethasone in the preparation of Jamu Pegal Linu. The samples are taken from the store and depot herbs contained in the Markets of Bandar Lampung, acquired three different brands. The method used is Thin Layer Chromatography using dikloretan motion: diethyl ether: methanol: water (77:15: 8: 1,2) as a mobile phase which are non-polar, and silica gel GF 254nm as a stationary phase. The result showed that the detection of three samples of Jamu Pegal Linu contained staining purple and the difference of Rf sample with reference standard on the first repetition is 0.46, 0.44, 0.47, and on the second repetition is 0.45, 0.45 and 0.48, which are â‰¥ 0.05. It can be concluded that the sample of Jamu Pegal Linu in Bandar Lampung 0% containing dexamethasone.

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