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High Expression of Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) is Highly Correlated with Eclampsia Lukas, Efendi
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Objectives: To understand the expression of placental vascular endothelial growth factor receptor (VEGFR-1) in severe preeclampsia with complication (eclampsia and HELLP syndrome). Methods: The study was an observational study with cross sectional design, performed at several hospitals of Department of Obstetrics and Gynecology Medical Faculty of University of Hasanuddin, Makassar. Subjects met to inclusion criteria were taken as samples. Placental tissue samples were taken from cord insertion site and fixated with formalin buffer solution. Immunohistochemical examination was performed at Center of Research University of Hasanuddin. Antibody used were primary antibody of Mouse monoclonal anti VEGFR-1 antibody (Santa Cruz) dissolved to 1:100 and link antibody (secondary antibody labeled with biotin) (Dakopatt). Placental tissues were examined in Streptavidin biotin peroxides and interpreted according to the intensity of trophoblast cytoplasmic dye. Results: High VEGFR-1 expression was found in 100% of the placenta from patients with eclampsia , 42.9&% in patients with HELLP syndrome and 37.8% in patients with severe preeclampsia. High VEGFR-1 expression was correlated to incidence of eclampsia (p=.000) and not correlated to severe preeclampsia and HELLP syndrome (p=0.734). Conclusion: High VEGFR-1 expression was correlated to eclampsia and not correlate to severe preeclampsia and HELLP syndrome. [Indones J Obstet Gynecol 2012; 36-3:116-20] Keywords: eclampsia, HELLP syndrome, severe preeclampsia, VEGFR-1 expression

Primipara Undergoing Episiotomy had Lower Postpartum Sexual Function Lukas, Efendi
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 2, April 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Objective: To compare postpartum sexual functions between primipara with episiotomy and without episiotomy. Method: The research was conducted in public service section of Dr. Wahidin Sudiro Husodo hospital and a number of educational hospitals obstetrics and gynecology of Faculty of Medicine of Hasanuddin University, started from February to May 2012. The research evaluated the sexual function of postpartum with episiotomy in 171 primipara, and 150 primipara postpartum without episiotomy. Sexual function was measured by Female Sexual Function Index (FSFI) questionnaire which had been validated in various countries. The research was conducted with cross sectional approach. Samples were withdrawn with consecutive sampling method. The data was processed with SPSS version 17, with chi-square test, and significant level of 0.05. Result: Indicated that either the episiotomy or non-episiotomy group has undisturbed sexual function score (>28.5), however, higher score was indicated in non- episiotomy group (65.477) compared to the episiotomy group (59.70), (p0.05). [Indones J Obstet Gynecol 2014; 2: 91-95] Keywords: episiotomy, FSFI, primipara, sexual functions

Hypertriglyceridemia is associated with the incidence of preeclampsia Dahlan, Intje S; Tahir, Mardiah; Lukas, Efendi; T Chalid, St. Maisuri
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 4 October 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Abstract Objective: to find out  the correlation between lipid profille at trimester II of pregnancy and the incidence.of preeclampsia Method : The research  was conducted in the Polyclinic of Hasanuddin University Teaching Hospital, Department of Obstetrics and Gynecology of the Faculty of Medicine, and it network in Makassar city from March, 2015 through March, 2016. The research used was the prospective cohort design. Results : The examination of the lipid levels of 115 pregnant mothers, aged 24-28 weeks. The mothers were then observed whether they experienced preeclampsia up to the time they gave birth or not. In the end, 8 subjects (6.9%) experienced preeclampsia and 107 subjects (93.1%) have no preeclampsia. The statistical analyses used Fisher’s Exact test and Mann Whitney test. The research results indicated that the mean value of the total cholesterol and Low Density Lipoprotein (LDL) was higher in the preeclampsia group compared to the non-preeclampsia group: 267.37 ± 64.12 : 238 ± 37.98; 177.38 ± 55.38 : 157.24 ± 35.08 (p>0.05). The mean value of High Density Lipoprotein (HDL) was lower in the preeclampsia group compared to the non-preeclampsia group: 64.75 ± 14.64 : 67.86 ± 16.72 (p>0,05). The mean value of trigliserida in preeclampsia group was significantly higher (19,5%) compared thanin the non-preeclampsia group: 260.12 ± 58.86 vs 209.14 ± 65.10 (p=0,027). Conclusion : The hypertrigliseridemia was correlated with the preeclampsia incidence. Keywords:preeclampsia, lipid profile, trimester II of pregnancy   Abstrak Tujuan: mengetahui hubungan antara profil lipid kehamilan trimester II dengan kejadian preeklamsia. Metode : Penelitian dilaksanakan di Poliklinik RS jejaring pendidikan Departemen Obstetri dan Ginekologi Fakulltas Kedokteran Universitas Hasanuddin dan Poliklinik Kesehatan Ibu dan Anak di beberapa Puskesmas Kota Makassar selama Maret 2015 sampai dengan Maret 2016. Rancangan penelitian yang digunakan adalah prospektif  kohort. Hasil: dari 115 ibu hamil dilakukan pemeriksaan  kadar lipid, 115 ibu hamil pada usia kehamilan 24 – 28 minggu, kemudian diamati apakah subyek mengalami preeklamsia hingga proses persalinan. Terdapat delapan subyek (6,9%) berkembang menjadi preeklampsia dan 107 subyek tidak preeklamsia. Data dianalisis secara statistik dengan menggunakan uji Fisher’s Exact dan uji Mann Whitney. Hasil penelitian menunjukkan bahwa nilai mean kolesterol total dan Low Density Lipoprotein (LDL) lebih tinggi pada kelompok preeklampsia dibandingkan kelompok tidak preeklamsia, yaitu 267,37 ± 64,12 : 238,01 ± 37,98; 177,38 ± 55,38 : 157,24 ± 35,08 (p>0,05). Nilai mean High Density Lipoprotein (HDL) lebih rendah pada kelompok preeklamsia dibandingkan tidak preeklamsia yaitu 64,75 ± 14,64 : 67,86 ± 16,72 (p>0,05). Nilai mean trigli seri daripada kelompok preeklamsia secara signifikan lebih tinggi 19,5 % dibandingkan kelompok tidak preeklamsia, yaitu 260,12 ± 58,86 : 209,14 ± 65,10 (p=0,027). Kesimpulan : Hiper trigli seridemia berhubungan dengan kejadian preeklamsia. Kata kunci : preeklamsia, profil lipid, kehamilan trimester II    

Effect of Pyridoxine on Prostaglandin Plasma Level for Primary Dysmenorrheal Treatment Randabunga, Ervan J; Lukas, Efendi; Tumedia, Josephine L; T. Chalid, St. Maisuri
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 4 October 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective : To determine the effect of vitamin B6 (pyridoxine) the levels of prostaglandins and intensity of pain in primary dysmenorrheal. Methods : The levels of prostaglandin (PGF2α) in plasma measured by ELISA and pain intensity by verbal rating scales conducted on 35 women with primary dysmenorrheal (n=35) supplemented with vitamin B6 100mg for 4 days and controls with placebo (n=35). Results : Prostaglandin levels decreased significantly after vitamin B6 supplementation (2212.9+1374.2 vs 1490.3+1119.0; p<0.05) followed by a significant reduction in pain intensity (4.29+0.7 vs 1.71+0.5; p<0.05) in the test group compared to control. Conclusion : Due to vitamin B6 effects on decreasing prostaglandin levels and pain of primary dysmenorrheal, so that B6 vitamin can become the treatment for the primary dysmenorrheal. Keywords : Primary dysmenorrheal, pyridoxine, prostaglandin   Tujuan: Untuk mengetahui pengaruh pemberian vitamin B6 (piridoksin) terhadap kadar prostaglandin dan intensitas nyeri pada dismenore primer. Metode: Pemeriksaan kadar prostaglandin (PGF2α) dengan ELISA dan pengukuran intensitas nyeri dengan verbal rating scales dilakukan pada 35 orang (n=35) wanita dengan dismenore primer yang mendapatkan vitamin B6 100mg selama 4 hari dan kontrol yang mendapatkan plasebo (n=35). Hasil: Kadar prostaglandin menurun bermakna setelah pemberian vitamin B6 (2212,9+1374,2 vs 1490,3+1119,0; p<0,05) disertai dengan penurunan intensitas nyeri yang bermakna (4,29+0,7 vs 1,71+0,5; p<0,05) pada kelompok uji dibandingkan kontrol. Kesimpulan: Vitamin B6 menurunkan kadar prostaglandin dan nyeri sehingga vitamin B6 dapat dipertimbangkan menjadi salah satu pengobatan dismenore primer. Kata kunci : Dismenore primer, piridoksin, prostaglandin

Vascular Endothelial Growth FactorC Serum and Endostatin Serum as Predictors of Lympho Vascular Invasion in Early Stage Cervical Cancer Rusmardiani, Andhinna; Rauf, Syahrul; Lukas, Efendi
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the relationship of Vascular Endothelial Growth Factors-C (VEGF-C), endostatin and the ratio of VEGF-C/ endostatin with limfo vascular invasion in patient with early stage cervical cancer. Methods: This study used a cross sectional method. Samples were all patients with early stage cervical cancer who came to the several teaching hospitals of Obstetrics and Gynecology Department Universitas Hasanuddin Medical Faculty that meet the criteria, then we measured the levels of VEGF-C and endostatin. Results: We get 30 women with cervical carcinoma. The results showed that the serum levels of VEGF-C was higher in limfo vascular invasion positive (p = 0.017); the ratio of VEGF-C/ endostatin higher in limfo vascular invasion positive (p = 0.004); whereas serum levels of endostatin did not differ significantly in limfo vascular invasion positive or negative (p = 0.522). Conclusion: The level of VEGF-C and VEGF-C/ endostatin ratio was higher in patients with early stage cervical cancer with positive LVSI than negative LVSI. [Indones J Obstet Gynecol 2017; 5-2: 105-109] Keywords: cervix uteri cancer, endostatin, limfo vascular invasion, VEGF-C

The Association of Creactive Protein Levels in Second Trimester of Pregnancy with Preeclampsia Nasruddin, Zulfaekasari; Lukas, Efendi; Malinta, Umar; Chalid, Maisuri T
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 1. January 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine C-reactive protein in second trimesterof pregnancy women who preeclamptic and non-preeclampticwomen, and to determine the relationship between the level ofC-Reactive protein of trimester two pregnancy and preeclampsiaoccurrence.Methods: This was a prospective study conducted at the policlinicsof network of academic hospitals of the Department of Obstetricsand Gynecology of Faculty of Medicine, Universitas Hasanuddin andpoliclinic of child and mother, and some Public Health Centers inMakassar city from September 2015 - April 2016. The C-reactiveprotein 115 level of pregnant women in pregnancy age of 24-28weeks was checked, whether the subjects underwent preeclampsiauntil the childbirth process. Statistics analysis used Fisher’s exacttest and Mann Whitney test.Results: The result indicate that 9 subjects (7.8%) developedpreeclampsia and 106 subjects did not become preeclampsia. Thelevel of C-Reactive protein increased in preeclampsia group comparedto non preeclampsia group i.e 5.05  1.153 : 3.36  0.265,but statistically the result is not significant (value p>0.05).Conclusion: The average score of C-Reactive protein of preeclampsiagroup is 33.5% higher than non-preeclampsia group,even though these results cannot be used as the score to predictthe preeclampsia occurrence.Keywords: C-reactive protein, preeclampsia, second trimesterpregnancy

High Expression of Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) is Highly Correlated with Eclampsia Lukas, Efendi
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 3, July 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objectives: To understand the expression of placental vascular endothelial growth factor receptor (VEGFR-1) in severe preeclampsia with complication (eclampsia and HELLP syndrome). Methods: The study was an observational study with cross sectional design, performed at several hospitals of Department of Obstetrics and Gynecology Medical Faculty of University of Hasanuddin, Makassar. Subjects met to inclusion criteria were taken as samples. Placental tissue samples were taken from cord insertion site and fixated with formalin buffer solution. Immunohistochemical examination was performed at Center of Research University of Hasanuddin. Antibody used were primary antibody of Mouse monoclonal anti VEGFR-1 antibody (Santa Cruz) dissolved to 1:100 and link antibody (secondary antibody labeled with biotin) (Dakopatt). Placental tissues were examined in Streptavidin biotin peroxides and interpreted according to the intensity of trophoblast cytoplasmic dye. Results: High VEGFR-1 expression was found in 100% of the placenta from patients with eclampsia , 42.9&% in patients with HELLP syndrome and 37.8% in patients with severe preeclampsia. High VEGFR-1 expression was correlated to incidence of eclampsia (p=.000) and not correlated to severe preeclampsia and HELLP syndrome (p=0.734). Conclusion: High VEGFR-1 expression was correlated to eclampsia and not correlate to severe preeclampsia and HELLP syndrome. [Indones J Obstet Gynecol 2012; 36-3:116-20] Keywords: eclampsia, HELLP syndrome, severe preeclampsia, VEGFR-1 expression

Vascular Endothelial Growth FactorC Serum and Endostatin Serum as Predictors of Lympho Vascular Invasion in Early Stage Cervical Cancer Rusmardiani, Andhinna; Rauf, Syahrul; Lukas, Efendi
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the relationship of Vascular Endothelial Growth Factors-C (VEGF-C), endostatin and the ratio of VEGF-C/ endostatin with limfo vascular invasion in patient with early stage cervical cancer. Methods: This study used a cross sectional method. Samples were all patients with early stage cervical cancer who came to the several teaching hospitals of Obstetrics and Gynecology Department Universitas Hasanuddin Medical Faculty that meet the criteria, then we measured the levels of VEGF-C and endostatin. Results: We get 30 women with cervical carcinoma. The results showed that the serum levels of VEGF-C was higher in limfo vascular invasion positive (p = 0.017); the ratio of VEGF-C/ endostatin higher in limfo vascular invasion positive (p = 0.004); whereas serum levels of endostatin did not differ significantly in limfo vascular invasion positive or negative (p = 0.522). Conclusion: The level of VEGF-C and VEGF-C/ endostatin ratio was higher in patients with early stage cervical cancer with positive LVSI than negative LVSI. [Indones J Obstet Gynecol 2017; 5-2: 105-109] Keywords: cervix uteri cancer, endostatin, limfo vascular invasion, VEGF-C

The Association of Creactive Protein Levels in Second Trimester of Pregnancy with Preeclampsia Malinta, Umar; Chalid, Maisuri T; Nasruddin, Zulfaekasari; Lukas, Efendi
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 1. January 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine C-reactive protein in second trimesterof pregnancy women who preeclamptic and non-preeclampticwomen, and to determine the relationship between the level ofC-Reactive protein of trimester two pregnancy and preeclampsiaoccurrence.Methods: This was a prospective study conducted at the policlinicsof network of academic hospitals of the Department of Obstetricsand Gynecology of Faculty of Medicine, Universitas Hasanuddin andpoliclinic of child and mother, and some Public Health Centers inMakassar city from September 2015 - April 2016. The C-reactiveprotein 115 level of pregnant women in pregnancy age of 24-28weeks was checked, whether the subjects underwent preeclampsiauntil the childbirth process. Statistics analysis used Fisher’s exacttest and Mann Whitney test.Results: The result indicate that 9 subjects (7.8%) developedpreeclampsia and 106 subjects did not become preeclampsia. Thelevel of C-Reactive protein increased in preeclampsia group comparedto non preeclampsia group i.e 5.05  1.153 : 3.36  0.265,but statistically the result is not significant (value p>0.05).Conclusion: The average score of C-Reactive protein of preeclampsiagroup is 33.5% higher than non-preeclampsia group,even though these results cannot be used as the score to predictthe preeclampsia occurrence.Keywords: C-reactive protein, preeclampsia, second trimesterpregnancy

Hypertriglyceridemia is associated with the incidence of preeclampsia Dahlan, Intje S; Tahir, Mardiah; Lukas, Efendi; T Chalid, St. Maisuri
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 4 October 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Abstract Objective: to find out  the correlation between lipid profille at trimester II of pregnancy and the incidence.of preeclampsia Method : The research  was conducted in the Polyclinic of Hasanuddin University Teaching Hospital, Department of Obstetrics and Gynecology of the Faculty of Medicine, and it network in Makassar city from March, 2015 through March, 2016. The research used was the prospective cohort design. Results : The examination of the lipid levels of 115 pregnant mothers, aged 24-28 weeks. The mothers were then observed whether they experienced preeclampsia up to the time they gave birth or not. In the end, 8 subjects (6.9%) experienced preeclampsia and 107 subjects (93.1%) have no preeclampsia. The statistical analyses used Fisher’s Exact test and Mann Whitney test. The research results indicated that the mean value of the total cholesterol and Low Density Lipoprotein (LDL) was higher in the preeclampsia group compared to the non-preeclampsia group: 267.37 ± 64.12 : 238 ± 37.98; 177.38 ± 55.38 : 157.24 ± 35.08 (p>0.05). The mean value of High Density Lipoprotein (HDL) was lower in the preeclampsia group compared to the non-preeclampsia group: 64.75 ± 14.64 : 67.86 ± 16.72 (p>0,05). The mean value of trigliserida in preeclampsia group was significantly higher (19,5%) compared thanin the non-preeclampsia group: 260.12 ± 58.86 vs 209.14 ± 65.10 (p=0,027). Conclusion : The hypertrigliseridemia was correlated with the preeclampsia incidence. Keywords:preeclampsia, lipid profile, trimester II of pregnancy   Abstrak Tujuan: mengetahui hubungan antara profil lipid kehamilan trimester II dengan kejadian preeklamsia. Metode : Penelitian dilaksanakan di Poliklinik RS jejaring pendidikan Departemen Obstetri dan Ginekologi Fakulltas Kedokteran Universitas Hasanuddin dan Poliklinik Kesehatan Ibu dan Anak di beberapa Puskesmas Kota Makassar selama Maret 2015 sampai dengan Maret 2016. Rancangan penelitian yang digunakan adalah prospektif  kohort. Hasil: dari 115 ibu hamil dilakukan pemeriksaan  kadar lipid, 115 ibu hamil pada usia kehamilan 24 – 28 minggu, kemudian diamati apakah subyek mengalami preeklamsia hingga proses persalinan. Terdapat delapan subyek (6,9%) berkembang menjadi preeklampsia dan 107 subyek tidak preeklamsia. Data dianalisis secara statistik dengan menggunakan uji Fisher’s Exact dan uji Mann Whitney. Hasil penelitian menunjukkan bahwa nilai mean kolesterol total dan Low Density Lipoprotein (LDL) lebih tinggi pada kelompok preeklampsia dibandingkan kelompok tidak preeklamsia, yaitu 267,37 ± 64,12 : 238,01 ± 37,98; 177,38 ± 55,38 : 157,24 ± 35,08 (p>0,05). Nilai mean High Density Lipoprotein (HDL) lebih rendah pada kelompok preeklamsia dibandingkan tidak preeklamsia yaitu 64,75 ± 14,64 : 67,86 ± 16,72 (p>0,05). Nilai mean trigli seri daripada kelompok preeklamsia secara signifikan lebih tinggi 19,5 % dibandingkan kelompok tidak preeklamsia, yaitu 260,12 ± 58,86 : 209,14 ± 65,10 (p=0,027). Kesimpulan : Hiper trigli seridemia berhubungan dengan kejadian preeklamsia. Kata kunci : preeklamsia, profil lipid, kehamilan trimester II    

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