Garuda - Garba Rujukan Digital

Yusthinus T. Male

Patimura University

Author-ID : 313107

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Engineering Environmental Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology

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PREDIKSI POTENSI ANTIKANKER SENYAWA TURUNAN XANTHON MENGGUNAKAN HUBUNGAN KUANTITATIF STRUKTUR DAN AKTIVITAS (HKSA) Male, Yusthinus; Sutapa, I Wayan; Pusung, Yulian A. D.
CHEMISTRY PROGRESS Vol 11, No 1 (2018)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.11.1.2018.27907

ABSTRAKÂ Telah dilakukan penelitian untuk memprediksi potensi antikanker senyawa turunan xanthon menggunakan hubungan kuantitatif struktur dan aktivitas (HKSA) (Quantitative Structure Activity Relationship-QSAR) dengan deskriptor elektronik berupa muatan bersih atom, momen dipol, polarisabilitas, energi HOMO-LUMO, dan Log P yang dihitung menggunakan metode semi empirik PM3. Hasil analisis HKSA menunjukan bahwa model persamaan HKSA terbaik adalah Log IC50 = 18,730 + (-1,042.qC1) + (1,633.qC2) + (3,369.qC3) + (1,257.qC4) + (29,759.qC8) + (53,543.qC9) + (2,337.qC10) + (-0,161.momen dipol) + (1.550.Ehomo) + (-2,919.Elumo) +(0,140.Polarisabilitas) + (0.892. Log P) (n=27; r=0,997; r2=0,993; SE=0,08530; Fhitung/Ftabel=9,1588; PRESS= 50,04021). Penelitian ini menunjukkan bahwa pusat aktif senyawa turunan xanthon terletak pada atom karbon C1, C2, C3, C4 C8, C9 dan C10 sehingga modifikasi substituen pada posisi-posisi ini akan memberikan dampak signifikan terhadap aktifitas antikanker senyawa turunan xanthonÂ Â ABSTRACTÂ The research has been done to predict anti cancer potential of xanthon derivative compounds using Quantitative Structure Activity Relationship (QSAR) with electronic descriptor such as : atomic net charge, dipole moment, polarizability, HOMO-LUMO energy and Log P were calculated by semi-empirical PM3 method. The best QSAR model equation were determined from analysis of multiple linear regression. The result of QSAR analysis shows that best QSAR model equation is Log IC50 = 18,730 + (-1,042.qC1) + (1,633.qC2) + (3,369.qC3) + (1,257.qC4) + (29,759.qC8) + (53,543.qC9) + (2,337.qC10) + (-0,161.momen dipol) + (1.550.Ehomo) + (-2,919.Elumo) +(0,140.Polarisabilitas) + (0.892. Log P) (n=27; r=0,997; r2=0,993; SE=0,08530; Fcal/Ftable=9,1588; PRESS= 50,04021). This research also shows that active site of the xanthon derivatives is located on carbon atom C1, C2, C3, C4 C8, C9 and C10 so that the modification of the substituents in these positions will have a significant impact on the anticancer activity of xanthon derivatives.Â

ANALISIS KANDUNGAN MERKURI (Hg) PADA PADA EKOSISTEM SUNGAI WAELATA DAN SUNGAI ANAHONI YANG TERDAMPAK AKTIFITAS PERTAMBANGAN EMAS DI PULAU BURU, MALUKU ., Irsan; Male, Yusthinus T.; Selanno, Debby A. J.
CHEMISTRY PROGRESS Vol 13, No 1 (2020)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.13.1.2020.29062

Sungai Waelata dan Sungai Anahoni merupakan dua sungai tempat beroperasinya trommel untuk pengolahan material emas Gunung Botak dan Gogrea. Melalui aliran sungai, limbah merkuri hasil pengolahan trommel terangkut dan terbawa ke muara yang pada akhirnya akan mencemari perairan laut Teluk Kayeli. Kerang Polymesoda erosa merupakan salah satu jenis kerang yang sering digunakan dalam pemantauan logam berat merkuri, terutama pada wilayah muara sungai. Penelitian ini bertujuan untuk menganalisis kadar logam berat merkuri(Hg) pada air, sedimen dan kerang Polymesoda erosadi Muara Sungai Waelata dan Sungai Anahoni Kabupaten Buru. Hasil penelitian menunjukan konsentrasilogamberat merkuripada air di Muara Sungai Waelata dan Sungai Anahoni tidak terdeteksi di semua stasiun penelitian dan dibawah baku mutu air laut untuk biota laut berdasarkan Kepmen LH No. 51 Tahun 2004 sebesar 0,001 ppm. Konsentrasilogamberat merkuripada sedimenmemilikikisaranrataÂratasebesar0,134Â0,874ppm dan dibawah baku mutu sedimen berdasarkan ANZECC/AMRCANZ (2000) sebesar 1,0 ppm. Konsentrasilogamberat merkuripada kerang Polymesoda erosamemilikikisaranrataÂratasebesar0,123Â0,206 ppm dan dibawah Batasan Maksimum Cemaran Logam Berat Dalam Pangan merujuk pada Standar Nasional Indonesia (SNI) No. 7387 Tahun 2009 sebesar 1,0 ppmABSTRACTÂ The Waelata River and the Anahoni River are the two rivers where trommel operates for the processing of gold material from Gunung Botak and Gogrea. By the river, mercury waste from the processing of trommel is transported through estuary which will ultimately pollute the waters of the Kayeli Bay. Polymesoda erosa shells are one type of shellfish that is often used in monitoring heavy metals of mercury, especially in the estuary region. This study aims to analyze the concentration of heavy metal mercury (Hg) in water, sediments and Polymesoda erosa shells in the Waelata River and Anahoni River in Buru Regency. The results showed that the concentration of mercury heavy metals in water in the Waelata River and Anahoni River were not detected at all research stations and were below sea water quality standard for marine biota based on Minister of Environment Decree No. 51 of 2004 which is 0.001 ppm. The concentration of mercury heavy metals in sediments has an average range of 0.1340.887 ppm and is below the sediment quality standard based on ANZECC/AMRCANZ (2000) of 1.0 ppm. The concentration of mercury heavy metals in Polymesoda erosa shells has an average range of 0.1230.206 mg/kg and under the Maximum Limit of Heavy Metal Contamination in Food refers to the Indonesian National Standard (SNI) No. 7387 of 2009 which is 1.0 ppm.

ANALISIS KANDUNGAN MERKURI (Hg) PADA PADA EKOSISTEM SUNGAI WAELATA DAN SUNGAI ANAHONI YANG TERDAMPAK AKTIFITAS PERTAMBANGAN EMAS DI PULAU BURU, MALUKU ., Irsan; Male, Yusthinus T.; Selanno, Debby A. J.
CHEMISTRY PROGRESS Vol 13, No 1 (2020)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.13.1.2020.29062

Sungai Waelata dan Sungai Anahoni merupakan dua sungai tempat beroperasinya trommel untuk pengolahan material emas Gunung Botak dan Gogrea. Melalui aliran sungai, limbah merkuri hasil pengolahan trommel terangkut dan terbawa ke muara yang pada akhirnya akan mencemari perairan laut Teluk Kayeli. Kerang Polymesoda erosa merupakan salah satu jenis kerang yang sering digunakan dalam pemantauan logam berat merkuri, terutama pada wilayah muara sungai. Penelitian ini bertujuan untuk menganalisis kadar logam berat merkuri(Hg) pada air, sedimen dan kerang Polymesoda erosadi Muara Sungai Waelata dan Sungai Anahoni Kabupaten Buru. Hasil penelitian menunjukan konsentrasilogamberat merkuripada air di Muara Sungai Waelata dan Sungai Anahoni tidak terdeteksi di semua stasiun penelitian dan dibawah baku mutu air laut untuk biota laut berdasarkan Kepmen LH No. 51 Tahun 2004 sebesar 0,001 ppm. Konsentrasilogamberat merkuripada sedimenmemilikikisaranrataÂratasebesar0,134Â0,874ppm dan dibawah baku mutu sedimen berdasarkan ANZECC/AMRCANZ (2000) sebesar 1,0 ppm. Konsentrasilogamberat merkuripada kerang Polymesoda erosamemilikikisaranrataÂratasebesar0,123Â0,206 ppm dan dibawah Batasan Maksimum Cemaran Logam Berat Dalam Pangan merujuk pada Standar Nasional Indonesia (SNI) No. 7387 Tahun 2009 sebesar 1,0 ppmABSTRACTÂ The Waelata River and the Anahoni River are the two rivers where trommel operates for the processing of gold material from Gunung Botak and Gogrea. By the river, mercury waste from the processing of trommel is transported through estuary which will ultimately pollute the waters of the Kayeli Bay. Polymesoda erosa shells are one type of shellfish that is often used in monitoring heavy metals of mercury, especially in the estuary region. This study aims to analyze the concentration of heavy metal mercury (Hg) in water, sediments and Polymesoda erosa shells in the Waelata River and Anahoni River in Buru Regency. The results showed that the concentration of mercury heavy metals in water in the Waelata River and Anahoni River were not detected at all research stations and were below sea water quality standard for marine biota based on Minister of Environment Decree No. 51 of 2004 which is 0.001 ppm. The concentration of mercury heavy metals in sediments has an average range of 0.1340.887 ppm and is below the sediment quality standard based on ANZECC/AMRCANZ (2000) of 1.0 ppm. The concentration of mercury heavy metals in Polymesoda erosa shells has an average range of 0.1230.206 mg/kg and under the Maximum Limit of Heavy Metal Contamination in Food refers to the Indonesian National Standard (SNI) No. 7387 of 2009 which is 1.0 ppm.

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