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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Majalah Obstetri dan Ginekologi Biomolecular and Health Science Journal
Budi Utomo
Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Green tea extract reduces insulin level and folliculogenesis in insulin-resistant PCOS rats model Irma Maya Puspita; Budi Santoso; Budi Utomo
Majalah Obstetri dan Ginekologi Vol. 27 No. 3 (2019): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V27I32019.103-107

Abstract

Objectives: Polycystic ovary syndrome (PCOS) is an endocrine disorder with still unknown pathophysiology. Insulin resistance is one of major factors that affect the pathogenesis of PCOS (69%). Green tea has compounds that can be used to improve the condition of insulin resistance, so that folliculogenesis may recur in the case of PCOS.Materials and Methods: The subjects in this study were rats which were divided into 5 groups, consisting of 2 groups serving as a control group (negative and positive) and 3 groups as the treatment group. Each group consisted of 7 experimental animals. Negative control group was given with distilled water for 14 days. Positive control group was given with injections of testosterone propionate 1 mg/100 g BW intramuscularly in the thigh for 28 days to obtain a model of insulin-resistant PCOS and the distilled water was used as therapy. The treatment groups were given wth injections of testosterone propionate 1 mg/100gBW intra-muscularly for 28 days and then treated with green tea extract in doses of each 200 mg/kg, 400 mg/kg, and 800 mg/kg for 14 days. Rats were dissected on day 42 for harvesting the right and left ovary and heart blood sample was taken for examining insulin levels.Results: The results showed that administration of green tea extract on K5 can reduce insulin levels and increase folliculogenesis significantly (significance p <0.05).Conclusion: Green tea extract can reduce insulin levels and increase folliculogenesis in rats. PCOS - Insulin resistance at a dose of 800 mg/kg.
Fauna of Culex Mosquitoes In Salamwates Village Dongko Subdistrict, Trenggalek City Mardliyana Shalihah; Budi Utomo; Subagyo Yotopranoto; Heny Arwati
Biomolecular and Health Science Journal Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i1.19089

Abstract

Introduction: Mosquito-borne diseases are still a burden worldwide, including in Indonesia. Some of those diseases, such as filariasis and Japanese encephalitis, are transmitted by some species of Culex mosquitoes. We aimed to describe the fauna of Culex mosquitoes in Salamwates village, Dongko subdistrict, Trenggalek district. Methods: Female Culex mosquitoes were collected in Salamwates village at night using the methods of indoor human-baited double bed-net trap and outdoor cow-baited double bed-net trap. The spesies of collected Culex mosquitoes were identified based on identification guide published by Ministry of Health of Republic Indonesia. Results: There were 67 identifiable female mosquitoes collected using cow-baited methods and no female mosquitoes collected using human-baited methods. Those mosquitoes consisted of nine species. Culex tritaeniorhynchus (29.85%), C. gelidus (23.88%), C. vishnui (13.43%), C. pseudovishnui (11.94%) were the dominant species. The peaks of biting activities were at 18.45-19.00 and 23.45-24.00.  Conclusion: Nine species of Culex mosquitoes collected using cow-baited methods. C. tritaeniorhynchus was the dominant species. Those mosquitoes were zoophilic and exophagic. The peaks of biting activities of the Culex mosquitoes were at dusk and midnight.
Comparison of Antifungal Susceptibility Basil Leaves Extract (Ocimum sanctum Linn.), Eugenol, and Nystatin against Isolates of Candida spp. as Important Agent causing Oral Candidiasis in HIV/AIDS Patient Emma Hidayati Sasmito; Afif Nurul Hidayati; Rahmadewi; Sawitri; Budi Utomo; Sudjarwo; Pepy Dwi Endraswari; Diah Mira Indaramaya; Dwi Murtiastutik
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 3 (2022): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.3.2022.162-168

Abstract

Background: Oral candidiasis is an infection caused by Candida sp. in areas of the oral mucosa that are often found in HIV/AIDS patients. Increased antifungal resistance, it was important to find new antifungal candidates, especially from natural ingredients, basil leaf extract (Ocimum sanctum Linn.) which had major compound of eugenol that had an antifungal effect in inhibiting of Candida sp. Purpose: To evaluate the comparison of the antifungal susceptibility of nystatin, basil leaf extract (Ocimum sanctum Linn.) and eugenol against isolates of Candida sp. Methods: This study examined the comparison of the antifungal susceptibility of nystatin 100 IU, basil leaf extract (Ocimum sanctum Linn.) with doses equivalent to 800 µg/mL and 400 µg/mL eugenol, and eugenol 800 µg/mL and 400 µg/mL against 40 stored isolates of Candida sp. from the oral cavity of HIV/AIDS patient which was reactivated. Result: The mean inhibition zone of nystatin for all isolates was 22.98 mm, while the mean inhibition zone of eugenol with doses of 800 µg/mL and 400 µg/mL were 17.07 mm and 15.89 mm, and the mean inhibition zone of basil leaf extract (Ocimum sanctum Linn.) with doses equivalent to 800 µg/mL and 400 µg/mL eugenol are 14.87 mm and 14.01 mm. The inhibition zone of basil leaf extract (Ocimum sanctum Linn.) and eugenol was significantly lower than nystatin (p = 0.001; p < 0.05). Conclusion: The zone of inhibition of nystatin was significantly higher compared to basil leaf extract (Ocimum sanctum Linn.) and eugenol against Candida albicans and Candida non-albicans isolates.
Co-Authors Afif Nurul Hidayati Budi Santoso Diah Mira Indaramaya Dwi Murtiastutik Emma Hidayati Sasmito Heny Arwati Irma Maya Puspita Mardliyana Shalihah Pepy Dwi Endraswari Rahmadewi Sawitri Subagyo Yotopranoto Sudjarwo Sudjarwo