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Immunodetection of EGF-receptor, C-erbB oncogenes and HSV-1 antigene in oral mucosal swab preparation from Kretek (Clove cigarette) smokers Kintawati, Silvi
Padjadjaran Journal of Dentistry Vol 20, No 2 (2008): July
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Smoking is the biggest factor for oral cavity malignancy. An oral cavity mucous swab was performed to 30 smokers (mild, moderate and severe) and 10 non-smokers which were followed by immunocytochemistry smear using the antibody for EGF-R, c-erbB, and HSV-1 antigens to reveal the effect of smoking on the occurrence of oral cavity malignancy. The results from this experiment are analyzed statistically using one-way Anava. It is discovered that based on the assessment of the expression level towards EGF-R, and C-erbB oncogene there is a very significant difference between the smoker group and non-smoker group (p < 0.01). Meanwhile, the results from the assessment towards HSV-1 oncogene do not show significant differences between the smoker group (mild, moderate and severe) and the non-smoker group (p > 0.05). The results of this study show that the more a person smokes, the higher possibility of oral cavity malignancy and that the antibody for EGF-R and c-erbB can be used as a marker for early detection of oral cavity malignancy caused by smoking.

The difference of salivary pH before and after toothbrushing with toothpaste containing Betel leaf (Piper Betle) Fu, Soo Ling; Kintawati, Silvi; Tjahajawati, Sri
Padjadjaran Journal of Dentistry Vol 26, No 3 (2014): November
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

There has been a long history of the use of plants to improve dental health and oral hygiene. The purpose of this research was to find out the difference of salivary pH before and after toothbrushing with toothpaste containing betel leaf (Piper betel). The type of research used was quasi-experimental. Data collected were analyzed by using a paired t-test. The result shows that there is an increase of salivary pH by an average of 0.48 after toothbrushing with toothpaste containing betel leaf (Piper betel). In conclusion, there is the difference between the salivary pH before and after toothbrushing with toothpaste containing betel leaf (Piper betel).

The effect of apple (Malus Domestica) juice on the damage of mice liver cells due to paracetamol treatment Hartanto, Anthony; Dardjan, Murnisari; Kintawati, Silvi
Padjadjaran Journal of Dentistry Vol 21, No 2 (2009): July
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

The liver is an important organ for body metabolism process. Liver disease is one of serious health problems in developing countries including Indonesia. Liver damage is caused by viral infection, toxic agent exposure (medications, alcohol), hormonal disturbance, neoplasm and autoimmune diseases. The use of high dose paracetamol to reduce pain also leads to liver damage. Apple (Malus domestica) juice is a natural anti oxidant agent. This laboratory experimental study was performed to discover the effect of giving apple juice on damaged cell regeneration due to the use of paracetamol. The study was performed in 21 male mice from Swiss-Webster strain that were divided into group I, II, and III. Group, I served as control while group II received 1 mg/ml paracetamol dose for 5 days and Group III received 1 mg/ml paracetamol for 5 days and 1 ml of apple juice on the 5th to 10th day. The observation of the mice liver cells was conducted using a light microscope with 400x magnification to get the number of necrotic liver cells per view field. The results of this study showed a difference in the number of necrotic liver cells between Group II and III. ANOVA statistical test ( = 0.05) concluded that apple juice significantly helps regeneration process in damaged liver cells caused by paracetamol.

The effect of apple (Malus Domestica) juice on the damage of mice liver cells due to paracetamol treatment Anthony Hartanto; Murnisari Dardjan; Silvi Kintawati
Padjadjaran Journal of Dentistry Vol 21, No 2 (2009): July 2009
Publisher : Faculty of Dentistry Universitas Padjadjaran

The liver is an important organ for body metabolism process. Liver disease is one of serious health problems in developing countries including Indonesia. Liver damage is caused by viral infection, toxic agent exposure (medications, alcohol), hormonal disturbance, neoplasm and autoimmune diseases. The use of high dose paracetamol to reduce pain also leads to liver damage. Apple (Malus domestica) juice is a natural anti oxidant agent. This laboratory experimental study was performed to discover the effect of giving apple juice on damaged cell regeneration due to the use of paracetamol. The study was performed in 21 male mice from Swiss-Webster strain that were divided into group I, II, and III. Group, I served as control while group II received 1 mg/ml paracetamol dose for 5 days and Group III received 1 mg/ml paracetamol for 5 days and 1 ml of apple juice on the 5th to 10th day. The observation of the mice liver cells was conducted using a light microscope with 400x magnification to get the number of necrotic liver cells per view field. The results of this study showed a difference in the number of necrotic liver cells between Group II and III. ANOVA statistical test ( = 0.05) concluded that apple juice significantly helps regeneration process in damaged liver cells caused by paracetamol.

Immunodetection of EGF-receptor, C-erbB oncogenes and HSV-1 antigene in oral mucosal swab preparation from Kretek (Clove cigarette) smokers Silvi Kintawati
Padjadjaran Journal of Dentistry Vol 20, No 2 (2008): July 2008
Publisher : Faculty of Dentistry Universitas Padjadjaran

Smoking is the biggest factor for oral cavity malignancy. An oral cavity mucous swab was performed to 30 smokers (mild, moderate and severe) and 10 non-smokers which were followed by immunocytochemistry smear using the antibody for EGF-R, c-erbB, and HSV-1 antigens to reveal the effect of smoking on the occurrence of oral cavity malignancy. The results from this experiment are analyzed statistically using one-way Anava. It is discovered that based on the assessment of the expression level towards EGF-R, and C-erbB oncogene there is a very significant difference between the smoker group and non-smoker group (p < 0.01). Meanwhile, the results from the assessment towards HSV-1 oncogene do not show significant differences between the smoker group (mild, moderate and severe) and the non-smoker group (p > 0.05). The results of this study show that the more a person smokes, the higher possibility of oral cavity malignancy and that the antibody for EGF-R and c-erbB can be used as a marker for early detection of oral cavity malignancy caused by smoking.

The difference of blood pressure before and after consuming Green Kiwi (Actinidia deliciosa) in the young adult group Dian Lesmana; Ervin Rizali; Silvi Kintawati
Padjadjaran Journal of Dentistry Vol 25, No 3 (2013): November 2013
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol25no3.26808

Introduction: Green Kiwi fruit (Actinidia deliciosa) has a lot of nutritional content, one of them is potassium. Potassium helps maintain osmotic pressure in intracellular fluid, protect body’s electrolyte balance, regulate heartbeat, maintain muscle and nerve cell function, reduce the risk of stroke and heart disesase, and decrease blood pressure. Methods: This study is an experimental research, using pair t-test measurement to analize the difference of blood pressure before and after consuming Green Kiwi fruit (Actinidia deliciosa) in early adulthod. The sample are thirty five students of Faculty of Dentistry, Padjadjaran. The number of green kiwi fruit is consume as much as 1 fruits or 150 grams. Blood pressure measured by sphygmomanometer with auscultatory-palpation method. Results: The result of this study shows the averaged blood pressure before and after consuming green kiwi fruit Is 99,543/68,438 mmHg and 97,581/66,743mmHg. Conclusion: The conclusion of the study indicates the existence of difference in blood pressure before and after consuming Green Kiwi fruit (Actinidia deliciosa) in early adulthood (p<5%).

Relationship between filter cigarettes smoking habits with the appearance of smoker’s melanosis (Observation of smoking duration and the amount of cigarettes consumption) Rizal Rizky Akbar; Sunardhi Widyaputra; Silvi Kintawati
Padjadjaran Journal of Dentistry Vol 26, No 2 (2014): July 2014
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol26no2.26698

Introduction: Smoking is one of bad habits that are difficult to abandon. Cigarettes contain more than 59 known carcinogenic substances. Cigarettes also contain some metal components and free radicals. Cigarettes consist of several types, one of which is cigarettes filter, which is the most frequently consumed cigarettes. One of the adverse effects of cigarette smoker’s melanosis is a pigmentation disorder that appears in oral cavity. The study aims to look at the relationship between smoking habits of filter’s smoker with appearance of smoker’s melanosis. Methods: This was a descriptive analytic with chi-square test to analyze the relationship between smoking in filter smokers with appearance of smoker’s melanosis. The samples were 90 students of the Faculty of Geology University of Padjadjaran. The smokers who have the criteria of the sample are examined to see the oral condition whether there is a melanosis lesion or not. Results: The result showed an association between smoking habit in filter smokers with the onset of smokers melanosis that observe through the duration of smoking and the amount of cigarettes consumption. Conclusion: There is a relationship between smoking habits in filter smokers and the onset of smoker’s melanosis in terms of smoking duration and the number of cigarettes consumed.

Immunoexpression of Ki-67 in determining prognosis of oral cavity squamous cell carcinoma Silvi Kintawati; Hening Tjaturina Pramesti
Padjadjaran Journal of Dentistry Vol 31, No 2 (2019): July 2019
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol31no2.22888

Introduction: Several researchers have been stated that the right prognosis of oral squamous cell carcinoma (OSCC) can be achieved through assessment of tumor clinical staging and tumor histopathological grading as well. The use of biomarker in histopathological grading is obviously helpful to ensure the prognosis. Objective of this study was to determine the correlation between expression of Ki-67 and histopathological grading of OSCC. Methods: A retrospective study was conducted by assessing 20 cases of paraffin-embedded OSCC derived from the Department of Pathology Anatomy of Hasan Sadikin Hospital Bandung in 2013. The OSCC performing was stained by hematoxylin-eosin. While, antibodies Ki-67 was used in immunohistochemistry reaction to determine the relation of expression of Ki-67 with histopathologic grade of OSCC for predicting a prognosis. Results: The result show that distribution of Ki-67 expression were vary from 20% to 80% in each case. Ki-67 intensity was also distributed from weak, moderate and strong. Conclusion: There is a significant correlation between Ki-67 immunoexpression and the histopathological grading of squamous cell carcinoma (p < 0.01), thus, Ki-67 can be used to predict a prognosis.Keywords: Immunoexpression, Ki-67, prognosis, oral cavity squamous cell carcinoma

The difference of salivary pH before and after toothbrushing with toothpaste containing Betel leaf (Piper Betle) Soo Ling Fu; Silvi Kintawati; Sri Tjahajawati
Padjadjaran Journal of Dentistry Vol 26, No 3 (2014): November 2014
Publisher : Faculty of Dentistry Universitas Padjadjaran

There has been a long history of the use of plants to improve dental health and oral hygiene. The purpose of this research was to find out the difference of salivary pH before and after toothbrushing with toothpaste containing betel leaf (Piper betel). The type of research used was quasi-experimental. Data collected were analyzed by using a paired t-test. The result shows that there is an increase of salivary pH by an average of 0.48 after toothbrushing with toothpaste containing betel leaf (Piper betel). In conclusion, there is the difference between the salivary pH before and after toothbrushing with toothpaste containing betel leaf (Piper betel).

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