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All Journal Majalah Kedokteran Bandung The Indonesian Journal of Infectious Diseases International Journal Mathla'ul Anwar of Halal Issues Jurnal Kesehatan Rajawali
Fitri Rahmi Fadhilah
Institut Kesehatan rajawali
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Analisis Filogenetik Gen L1 Human Papillomavirus 16 pada Penderita Kanker Serviks di Bandung Fadhilah, Fitri Rahmi; Sahiratmadja, Edhyana K.; Safitri, Ratu; Maskoen, Ani Melani; Susanto, Herman
Majalah Kedokteran Bandung Vol 47, No 3 (2015)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Infeksi human papillomavirus (HPV) tipe high risk (hr) yang kronik dapat menyebabkan kanker serviks. Berbagai genotipe hrHPV telah teridentifikasi dan HPV-16 merupakan genotipe yang tersering menginfeksi serviks. Fragmen L1 HPV dapat digunakan untuk mengidentifikasikan asal usul HPV. Tujuan penelitian ini adalah mengeksplorasi asal usul HPV-16 dengan membuat pohon filogenetik. Metode penelitian yang digunakan adalah metode deskriptif analisis. Penelitian dilakukan di Laboratorium Genetika Molekuler Unit Penelitian Kesehatan, Fakultas Kedokteran Universitas Padjadjaran Bandung pada Februari hingga Agustus 2013. Isolat biopsi dari pasien kanker serviks disumbangkan oleh Departemen Kebidanan Fakultas Kedokteran Universitas Padjadjaran, Bandung. Isolasi DNA dibuat dari biopsi jaringan kanker serviks dan fragmen L1 diamplifikasi dengan desain primer sendiri. Infeksi dengan HPV-16 dikonfirmasi dengan Linear Array test (Roche). Sekuens urutan basa kemudian dimasukkan dalam program filogenetik (MEGA5). Hasil konstruksi menunjukkan isolat pasien kanker serviks dari Bandung berada dalam satu subgrup dengan HPV asal Asia dan Asia Timur. Simpulan, cluster HPV Indonesia berada pada galur Asia dan Asia Timur. [MKB. 2015;47(3):174–78]Kata kunci: Filogenetik, fragmen L1,  human papillomavirus 16 (HPV-16)Phylogenetic Analysis of Human Papillomavirus 16 L1 Gene from Cervical Cancer Patient in BandungAbstractChronic infection with high-risk (hr) human papillomavirus (HPV) can lead to cervical cancer. Various hrHPV genotypes have been identified and HPV genotype 16 is the most common genotypes that infect cervical cancer. HPV L1 fragment can identify the origin of HPV. The purpose of this study was to explore the origins of HPV-16 by making a phylogenetic tree. This study used analytical descriptive method and was  was conducted at the Laboratory of Molecular Genetics, Health Research Unit, Faculty of Medicine, Universitas Padjadjaran Bandung in the period of February to August 2013. Biopsy from cervical cancer patient was donated by the Department of Obstetrics, Faculty of Medicine, Universitas Padjadjaran, Bandung. Isolation of DNA was prepared from tissue biopsies of cervical cancer and L1 fragment was amplified with the specific primer. Infection with HPV-16 was confirmed by Linear Array test (Roche) design. The sequence then was constructed using the phylogenetic program (MEGA5). Results showed that the isolate from patient with cervical cancer from Bandung was in one subgroup with HPV from Asia and East Asia. In conclusion, cluster HPV of Bandung is in the same strain as the strain in Asia and East Asia. [MKB. 2015;47(3):174–78]Key words: Human papillomavirus 16 (HPV-16), L1 fragment, phylogenetic DOI: 10.15395/mkb.v47n3.598
UJI DAYA HAMBAT PERTUMBUHAN BAKTERI Escherichia coli MENGGUNAKAN EKSTRAK RIMPANG KUNYIT Curcuma domestica val Fitri Rahmi Fadhilah
Jurnal Kesehatan Rajawali Vol 9 No 2 (2019): September
Publisher : Sekolah Tinggi Ilmu Kesehatan Rajawali

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (654.225 KB) | DOI: 10.54350/jkr.v9i2.33

Abstract

Latar Belakang:Rimpang kunyit merupakan bagian dari tanaman dengan berbagai khasiat salah satunya dapat menurunkan jumlah bakteri Escherichia coli. Kandungan senyawa bermanfaat dalam rimpang kunyit salah satunya yang bersifat antibakteri yang meliputi fenol, saponin dan flavonoid.Tujuan Penelitian:Untuk mengetahui zona hambat yang terbentuk pada bakteri Escherichia coli dengan menggunakan ekstrak rimpang kunyit (Curcuma domestica val).Metode Penelitian:Penelitian eksperimentaldenganmetode difusi cakram (Kirby Bauer) dengan 3 perlakuan.Hasil penelitian: Penelitian yang telah dilakukan menunjukan bahwa konsentrasi daya hambat pertumbuhan bakteri Escherichia coli pada konsentrasi 20% (8,6 mm), 33,3% (16 mm) dan 42,8% (25,3 mm).Simpulan: Terdapat zona hambat bakteri Escherichia coli dengan menggunakan ekstrak rimpang kunyit, Sehingga ekstrak rimpang kunyit dapat dijadikan antibakteri baru dengan memanfaatkan bahan alam atau herbal yang dapat mengurangi risiko resistensi bakteri terhadap antibakteri.
PENENTUAN NILAI LC50 EKSTRAK KULIT MANGGA(Mangiferasp.) SEBAGAI LARVASIDA TERHADAP NYAMUK AEDES AEGYPTI Fitri Rahmi Fadhilah
Jurnal Kesehatan Rajawali Vol 10 No 1 (2020): Jurnal Kesehatan Rajawali
Publisher : Sekolah Tinggi Ilmu Kesehatan Rajawali

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Abstract

Latar Belakang:Pemberantasan larva merupakan salahsatupengendalian vektor Aedes aegypti.Insektisida dari tumbuhan merupakan sarana pengendalian alternatif yang layak dikembangkan,karena mudah terurai di lingkungan dan aman.Salah satu insektisida dari tumbuhan yaitu ekstrak kulit mangga(Mangiferasp.)yang mengandung senyawa flavonoid, saponin dan tanin. Tujuan Penelitian:Tujuan dari penelitian ini yaitu untuk mengetahui kondisi larva sebelum dan sesudah pemberian ekstrak dan memperoleh nilai LC50 ekstrak kulit mangga(Mangiferasp.) terhadap larva Aedes aegypti. Metode Penelitian: Metode pada penelitian ini menggunakan metode eksperimental. Populasi sampel yaitu larva instar III Aedes aegypti.Sampel didapat dari pembiakan yang dilakukandi Laboratorium Poltekkes Bandung sebanyak 250 ekor dengan teknik simple random sampling. Konsentrasi ekstrak kulit mangga yang digunakan yaitu 0,01%,0,02%,0,04%,0,06% dan 0,08%. Setiap perlakuan berisi 10 larva uji dan diamati selama 24 jam. Hasil:Hasil menunjukkan terdapat pengaruh biolarvasida ekstrak kulit mangga(Mangiferasp.) terhadap kematian larva Aedes aegypti dengan nilaiLC50 terletak pada konsentrasi 0,039%. Kesimpulan:Dapat disimpulkan bahwa terdapat perbedaan kondisi larva sebelum dan sesudah pemberian ekstrak kulit mangga serta didapatkan nilai LC50 ekstrak kulit mangga(Mangifera sp.)terhadap larva Aedes aegypti terdapat pada konsentrasi 0,039%.
PENGARUH TINGKAT KEPATUHAN SUMBER DAYA MANUSIA TERHADAP MUTU INTERNAL PELAYANAN LABORATORIUM DI PUSKESMAS KABUPATEN GARUT Fitri Rahmi Fadhilah; Ni'matul Murtafia'ah
Jurnal Kesehatan Rajawali Vol 11 No 1 (2021): Jurnal Kesehatan Rajawali
Publisher : Sekolah Tinggi Ilmu Kesehatan Rajawali

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Abstract

Compliance with human resources, in this case health workers, greatly affects the quality of health servicesin providing health services, therefore all health service processes are expected to refer to the establishedstandard operating procedures. Internal Quality Consolidation is a laboratory system to identify andminimize errors from Pre-Analytical, Analytical and Post-Analytical. This type of research aims todetermine the relationship between the level of compliance of human resources with the internal quality oflaboratory services at the Garut district health center. The method of this research is qualitative by usingthe analytical research method of rank sperman correlation with a total of 30 respondents conducted at thePuskesmas Laboratory in Garut district. The results of this study indicate that there is a relationship of 0.378between the level of compliance of human resources with the internal quality of laboratory services at theGarut district health center, with a level of closeness as evidenced by the coefficient of determination,namely 14.30%, the level of compliance of human resources with the internal quality of laboratory services.has a significant effect with p-value 0,040. The conclusion of this study is that there is a significant effectbetween the level of compliance of human resources to the internal quality of laboratory services at theGarut district health center.
NARRATIVE REVIEW: METODE ANALISIS PRODUK VAKSIN YANG AMAN DAN HALAL BERDASARKAN PERSPEKTIF BIOTEKNOLOGI Fitri Rahmi Fadhilah; Firman Rezaldi; M Fariz Fadillah; Muhammad Faizal Fathurohim; Usman Setiawan
International Journal Mathla’ul Anwar of Halal Issues Vol. 1 No. 1 (2021)
Publisher : Universitas Mathla’ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (643.66 KB) | DOI: 10.30653/ijma.202111.12

Abstract

Biotechnology is the application of the branch of biology that involves other applied sciences in applying the principles of living things to produce goods and services, both conventional and modern. The application of biotechnological methods that are increasingly rapid, especially in the health and pharmaceutical fields, has a lot to fight for, especially in developing vaccines with healthy and halal criteria according to the biotech perspective. Halal status in the world of modern science has become a global issue, including the use of peptide-based vaccines. The results of the review show that a healthy and halal vaccine certainly has criteria, namely that it is safe to use, does not produce allergic reactions in the human body such as those made from horses or pigs. PCR is one of the molecular biology methods in the study of modern biotechnological methods which has a high level of sensitivity in detecting the content of pig DNA in various products, both medicinal and food.
IDENTIFICATION OF ASPERGILLUS SP MUSHROOMS IN WHEAT FLOUR SOLD OPENLY IN CIROYOM MARKET AS RAW MATERIALS FOR HALAL AND MUNGLE-FREE Fitri Rahmi Fadhilah; Ally Kafesa; Sopi Napita
International Journal Mathla’ul Anwar of Halal Issues Vol. 1 No. 2 (2021)
Publisher : Universitas Mathla’ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (467.103 KB) | DOI: 10.30653/ijma.202112.19

Abstract

Wheat flour is used as the main ingredient of food which is often used by the wider community, one of which is as an ingredient for making various kinds of food products. Wheat flour is included in food products safe and halal for consumption. The wheat flour which is sold openly is packaged in transparent plastic. With the easy-to-open packaging, it is easy for microorganisms to enter the flour, one of them is fungus. This study was aim to determine the types of Aspergillus sp in wheat flour which is sold openly in the Ciroyom Market. Method The research used is descriptive by using 30 samples of wheat flour which are sold openly in the Ciroyom Market. This research was conducted in the laboratory of the Rajawali Health Institute, Bandung. Result and Discussion: The results of this study showed the presence of Aspergillus flavus (50%), Aspergillus fumigatus (50%), Aspergillus niger (16.7%), Aspergillus terreus (3.3%) and negative (26.7%) Aspergillus sp. Conclusion: From this research, it can be concluded that the species of Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger and Aspergillus terreus were found so we can conclude that the wheat flour that is sold openly is still a halal product but it is not mushroom-free products.
Potensi Antimikroba Pada Teh Kombucha Bunga Kecombrang (Etlangia elatior) Fitri Rahmi Fadhilah; Suyarta Pakpahan; Firman Rezaldi; Eny Kusmiran; Erika Cantika; Olvia Julinda; Riszal Muhammad
The Indonesian Journal of Infectious Diseases Vol. 10 No. 1 (2024): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v10i1.186

Abstract

Latar Belakang: Salah satu minuman probiotik yang terbuat dari bunga kecombrang yang difermentasi bersama scoby (biang kombucha), dan substrat gula disebut kombucha teh bunga kecombrang. Peningkatan konsentrasi gula dapat menghambat pertumbuhan bakteri dan jamur patogen. Tujuan penelitian ini adalah untuk mengetahui pengaruh kombucha bunga kecombrang terhadap aktivitas pertumbuhan bakteri patogen gram positif dan gram negatif serta jamur patogen berdasarkan variasi konsentrasi gula. Perlakuan konsentrasi gula yang digunakan adalah 20%, 30%, dan 40%. Metode: Penelitian menggunakan metode difusi cakram dengan menggunakan bakteri uji Escherichia coli dan Staphylococcus aureus serta jamur uji Candida albicans untuk mengetahui diameter zona bening yang terbentuk berdasarkan  sifat anti mikroba kombucha. Hasil: Hasil penelitian menunjukkan bahwa konsentrasi 40% merupakan konsentrasi gula pada fermentasi kombucha bunga kecombrang yang paling baik dalam menghambat pertumbuhan Staphylococcus aureus, Escherichia coli, dan Candida albicans dengan diameter masing-masing 14 mm, 10,3 mm dan 12 mm. Setelah data digabungkan dengan zona hambat terhadap C. albicans, diperoleh hasil yang berbeda nyata pada konsentrasi gula 40% dengan p-value (0,000). Kesimpulan: Fermentasi kombucha teh bunga kecombrang mempunyai spektrum yang luas dan berpotensi sebagai minuman probiotik dalam meningkatkan imunitas dengan menghambat laju pertumbuhan bakteri patogen dan ragi.
Co-Authors Ally Kafesa Ani Melani Maskoen Edhyana Sahiratmadja Eny Kusmiran Erika Cantika Firman Rezaldi Firman Rezaldi Fitri Rahmi Fadhilah, Fitri Rahmi Herman Susanto Krisdaryani, Rizka M Fariz Fadillah Muhammad Faizal Fathurohim NI'MATUL MURTAFI'AH Olvia Julinda Ratu Safitri Riszal Muhammad Sopi Napita Suyarta Pakpahan Usman Setiawan