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All Journal Folia Medica Indonesiana Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
John Wiwin
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Other

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MICROBIAL PATTERN AND ANTIBIOTIC SENSITIVITY TEST OF HOSPITALIZED CHILDREN John Wiwin; IGAA Putri Sri Rejeki
Folia Medica Indonesiana Vol. 51 No. 3 (2015): July - September 2015
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (42.511 KB) | DOI: 10.20473/fmi.v51i3.2837

Abstract

Infection often occurs in children with malignant hematology and causes morbidity and mortality in the children. Antibiotics given must be based on culture results and antibiotic sensitivity testing. This study was aimed to obtain the microbial pattern and sensitivity test in children hospitalized in the Hemato-Oncology Ward,  dr. Soetomo Hospital from September 2012 - February 2013. This was a descriptive study. Data were obtained from the  patients’ medical records  in Dr. Soetomo Hospital. There were 341 culture examinations (blood, urine, rectum swab, faecal, and others) from 88 patients (44 males and 44 females). Most of patients´ age was < 5 years (58%) and suffered from ALL (50%).There were microbial (83 of culture) and yeast (15 of culture) growth out of 98 cultures. Escherichia coli, Burkholderia cefacea, and Klebsiella oxytoca (Gram negative) dan CONS, Stapyloccocus aureus, and Stapylococcus sapropyticus (gram positive) were found in blood culture. S. aureus (gram positive) and E. coli, Klebsiella pneumoniae, and B. cefacea (gram negative) were found in urine culture. Only E. coli was found in rectal swab culture. CONS of gram positive cocci were mostly found in blood culture of children hospitalized in Hemato-Oncology Ward, Dr. Soetomo Hospital. E. coli was the mostly found gram negative rods. Gram positive cocci showed a high resistant to penicillin and co-trimoxazole. E. coli, mostly found in rectal swab and urine, has a high sensitivity to amikacin and meropenem, but highly resistant to  ampicillin and ampicillin sulbactam.
CD4+ DAN CD8+ INTERFERON GAMMA TUBERKULOSIS PARU AKTIF DAN TUBERKULOSIS LATEN Betty Agustina Tambunan; John Wiwin; Jusak Nugraha; Soedarsono Soedarsono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 2 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i2.1116

Abstract

Tuberculosis (TB) is a global health problem. Immune response through CD4+ T cells and CD8+T cells is needed to produce Interferongamma (IFN-γ). IFN-gamma is a cytokine that can kill Mycobacterium tuberculosis. Not all individuals will lead to illness or activediseases. The aim of this study was to know the cellular immune response like IFN-gamma expression of T-CD4+ cells and CD8+ cellsbetween active TB with latent TB. The design of the study was cross sectional obervational in a population suffering from active andlatent TB. The subjects consisted of 11 (eleven) active TB patients and 10 (ten) latent TB patients from the Special Pulmonary Hospitaland the Dr Soetomo Hospital, Surabaya. The examination of interferon gamma expression of CD4+ and CD8+ was by Flowcytometrymethod. These results were analyzed by Student t test or Mann-Whitney test. The mean CD4+ percentage of active TB (28.75%) waslower than the latent one (TB) (33.21%) but no significant difference (P value=0.114) was shown. The mean CD8+ percentage ofactive TB (30.46%) was higher than the latent one (TB) (28.87%) but no significant difference (P value=0.481) was found. Themean CD4+IFN-γ percentage of active TB (2.51%) was higher than latent one (TB) (1.10%) and there was a significant difference(P value=0.014). The mean CD8+IFN-γ percentage of active TB (2.91%) was lower than latent one (TB) (4.41%) and there was asignificant difference (P value=0.006). Based on this study, it can be concluded that the mean CD4+IFN-γ percentage of active TB washigher than latent TB and there was a significant difference. The mean of CD8+IFN-γ percentage of latent TB was higher than the activeone (TB). This suggested that CD8+ has a dominant part in latent TB and may be caused by the role of other cytokines, or genetics,nutrition, and body mass index factors.
Co-Authors betty Agustina Tambunan, betty Agustina IGAA Putri Sri Rejeki Jusak Nugraha Soedarsono Soedarsono