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Setyo Dwi Santoso
Universitas Maarif Hasyim Latif
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

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IDENTIFIKASI HASIL MAKROSKOPIS DAN MIKROSKOPIS URIN PADA PASIEN TUBERKULOSIS Setyo Dwi Santoso; Christina Destri Wiwis Wijayanti; regina Linesiana
Jurnal SainHealth Vol 6, No 1 (2022): Maret 2022
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51804/jsh.v6i1.1724.22-25

Abstract

Tuberculosis (TB) is an infectious disease directly transmitted through the air. This disease is caused by the bacterium Mycobacterium tuberculosis. Tuberculosis requires an incubation period of 3-6 months from initial exposure to the bacteria. Patients identified with tuberculosis will be given anti-tuberculosis drugs intensively for 6 months. Long treatment time resulting in drug accumulation can affect the kidneys. Microscopic examination or urine sediment aims to detect kidney and urinary tract abnormalities and monitor the results of treatment. This study used an experimental research type, then the primary data were analyzed descriptively. Identification of the results of macroscopic and microscopic urine in tuberculosis patients in the hospital. Lungs Surabaya, showed the largest percentage of 75% macroscopic results of clear yellow urine. Microscopic results showed normal values compared to normal macroscopic and microscopic ranges of urine.Keywords :Tuberkulosis, Mikroskopis Urin, Makroskopis Urin
RASIO ALBUMIN KREATININ URIN SEBAGAI DETEKSI DINI GANGGUAN FUNGSI GINJAL PADA DIABETES MELITUS Selvy Laocta Afera; Setyo Dwi Santoso; Rahajoe Imam Santosa
Jurnal SainHealth Vol 5, No 2 (2021): September 2021
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51804/jsh.v5i2.1516.1-5

Abstract

Diabetes Mellitus is a group of metabolic diseases of impaired glucose intolerance that is closely related to renal vascular breast milk degener abnormalities that begin with the presence of microalbuminuria. Increased serum creatinine levels indicate impaired kidney function. Serum microalbuminuria and creatininelevels are important tocheck because they are indicators of the course of diabetes mellitus. The goal of this study was to examine the ratio of albumin-creatinine urine in people with diabetes mellitus can be used as an early detection of impaired kidney function and see an association between the ratio of urinary creatin albumin and serum creatinine levels. The urine albumin examination method uses immunoturbidimetric assay using the Jaffe method. The subjects of the examination were dm sufferers who conducted fasting blood glucose and HbA1c examinations at Pramita Clinic Laboratory Surabaya. From the results of the study obtained the ratio of albumin creatin urine and serum creatinine in people with DM mostly showed an increase in the ratio of urinary creatin creatin of 117.10 mg / g, while the average results of serum creatinine examination are still within the normal limit, which is 1.0 mg / dl. From this study proves that examination of the ratio of creatin creatin urine can be used as an early detection of kidney function disorders. Keywords: diabetes mellitus, microalbumin urine, serum creatinine
DAYA BUNUH EKSTRAK DAUN TOMAT (Solanum lycopersicum L.) TERHADAP LARVA NYAMUK Aedes aegypti Setyo Dwi Santoso; Abdul Chamid; Dwi Viddi Kusuma Pratiwi
Jurnal SainHealth Vol 2, No 1 (2018): Maret 2018
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51804/jsh.v2i1.176.36-39

Abstract

Dengue hemorrhagic fever (DHF) is a very dangerous disease, caused by Aedes aegypti mosquitoes. One alternative to controlling Aedes aegypti mosquitoes is to use insecticides. But it would be much better if the insecticides used are natural and environmentally friendly, one of them by using Tomato Leaf Extract (Solanum lycopersicum l.). Tomato leaves contain chemical compounds class Alkaloids and Saponins and can serve as anti larvacide. This research is a laboratory experiment which aims to find out the effect of tomato leaf extract (Solanum lycopersicum L.) activity on the death of III instar larvae of Aedes aegypti mosquito. the effectiveness of samples on Aedes aegypti mosquito larvae by treatment of variation of extract concentration 0.2%, 0.4%, 0.6%, 0.8%, 1% with repetition 2 times. In the results of research showed that the smallest concentration that can kill Aedes aegypti mosquito larvae is 0.6% at 16 hours and probit analysis showed that significance is 0,608 greater than intercept 0.003, it shows that the extract of tomato leaves affects the death of III instar larvae of Aedes aegypti mosquito.
KOMBINASI EKSTRAK DAUN KEMANGI DENGAN DAUN PEPAYA SEBAGAI INSEKTISIDA KUTU PINJAL Setyo Dwi Santoso; Maulia Yunia Aisyah; Siti Nur Husnul Yusmiati; Dheasy Herawati
Jurnal SainHealth Vol 6, No 1 (2022): Maret 2022
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51804/jsh.v6i1.1725.13-16

Abstract

Cats that roam free and are not cared for are very susceptible to disease and do not rule out the possibility of being contagious to humans. Fleas as parasites that host cats can also interfere with human life directly or indirectly. Wrong a form of protection against flea attacks by using vegetable insecticides. This study aimed to determine the effect caused by the combination of basil leaves with papaya leaves against lice fleas on cats. This research is experimental research by macerating the basil leaves with the papaya leaves to take the extract. The extract formed was made in several concentrations of 30%, 40%, and 50% with the addition of aquadest as a diluent. Then the extract results were tested for their ability to affect fleas by spraying a sprayer. The results showed that. Basil leaves with papaya leaves are effective for controlling fleas. The combination of basil and papaya leaves can be used as a vegetable insecticide for fleas on the cat. Keywords: basil, papaya, insecticide, the flea
EFEKTIVITAS EKSTRAK DAUN BASIL (Ocimum Basilicum) SEBAGAI LARVASIDA TERHADAP LARVA NYAMUK Aedes Aegypti INSTAR III. Yuliati Yuliati Yuliati; Setyo Dwi Santoso; Abdul Chamid
Jurnal SainHealth Vol 5, No 2 (2021): September 2021
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51804/jsh.v5i2.1519.%p

Abstract

The Aedes aegypti mosquito is a type of mosquito that carries dengue hemorrhagic fever (DHF) and carriers of other diseases. AEdes aegypti mosquitoes usually breed in clean water containers that are used for daily needs - today. Vector control programs around the world are a strategic key in the eradication oflarvae Aedes sp. The use of larvicides is one way to control dengue vectors, while as an alternative to the control Aedes aegypti of resistant, biological insecticides can be used, using basil leaf extract (Ocimum basilicum) which has a larvicidal character. The purpose of this experiment was to determine the effectiveness of basil leaf extract (Ocimum basilicum) as a biolarvicide against mosquito larvae of Aedes aegypti instar III from each concentration. This study uses a type of laboratory experimental research and the sample in this study was the larvae ofmosquito Aedes Aegypti the third instarwhich was divided into several groups, namely the control group and the treatment group with variations in concentration observed at 24 hours repeating 3 times in the same way. The results of this experimentthere was a significant effect on the addition of a solution of basil (leaf extractshowedOcimum bacillicumthat)starting with a concentration of 20% to 100% on the percentage of mortality ofthird instar larvae. Aedes aegypti. Keywords: Aedes aegypti, Ocimum basilicum, larvacide
GONADOTROPIN, ANTI MULLERIAN HORMON DAN ESTRADIOL PADA SINDROM OVARIUM POLIKISTIK Maria Tri Setiani; Setyo Dwi Santoso; Rahajoe Imam Santosa
Jurnal SainHealth Vol 5, No 2 (2021): September 2021
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51804/jsh.v5i2.1518.13-18

Abstract

PCOS (Polycystic Ovary Syndrome) is an endocrine disorder characterized by anovulation and hyperandrogenism. It was found that about ±10% of women of reproductive age cause infertility so that it becomes a burden for partners physically, psychologically and materially. Increasing age affects a woman's fertility and menstrual cycle. The menstrual cycle in women is influenced by hormones, depression, weight, and lifestyle. Gonadotropin Releasing Hormone (GnRH) is released by the hypothalamus through a secretory process every 90 – 120 minutes which then binds to gonadotropin cells and stimulates Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH). FSH, LH levels will increase after puberty, FSH, LH, Anti Mullerian Hormone (AMH) and estradiol are very important in folliculogenesis. However, the interactions between the four hormones are not yet fully understood. The purpose of this review was to determine the correlation between LH/FSH Ratio, AMH and Estradiol in women with Polycystic Ovarian Syndrome (PCOS). This understanding is expected to increase knowledge about the pathophysiology of PCOS. This study uses secondary data from the Pramita Surabaya Clinic laboratory which is examined for reproductive hormones. Data from 228 women aged < 35 years with an average LH/FSH ratio (0.61), AMH (3.56 ng/dL), and estradiol (34.42 pg/mL) and 172 women aged 35 years with a mean ratio of LH/FSH (0.54), AMH (2.93 ng/dL), and estradiol (36.60 pg/mL). LH, FSH, AMH and Estradiol examinations were performed on the 2-4th day of menstruation. Bivariate correlation analysis was used to see the relationship between AMH and the LH/FSH ratio and AMH and estradiol. From the results, there was a positive correlation between the AMH value and the LH/FSH ratio and a positive correlation between AMH and Estradiol which showed that AMH had an effect on the secretion of LH, FSH and Estradiol. Keywords: infertility, LH/FSH, AMH, estradiol, SOPK
HUBUNGAN GANGGUAN FUNGSI TIROID TERHADAP KADAR LDL-KOLESTEROL Gristine Arie Arie; Setyo Dwi Santoso; Rahajoe Imam Santosa
Jurnal SainHealth Vol 5, No 2 (2021): September 2021
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51804/jsh.v5i2.1018.6-12

Abstract

Hormon tiroid mempunyai peran yang penting terhadap berbagai proses metabolisme tubuh (protein, karbohidrat, lipid) dan aktivitas fisologis pada hampir seluruh organ tubuh manusia. Kekurangan atau kelebihan hormon tiroid dapat mengganggu metabolisme organ tubuh. Hipotiroid merupakan suatu keadaan dimana hormon tiroid di jaringan tubuh menurun, sedangkan hipertiroid adalah kelebihan hormon tiroid yang beredar dalam sirkulasi akibat kelenjar tiroid yang hiperaktif. Hal tersebut juga memberikan efek spesifik terhadap metabolisme lipid. Pada gangguan fungsi tiroid, metabolisme lipid akan terganggu sehingga menimbulkan faktor resiko penyakit kardiovaskular salah satunya arterosklerosis (penyumbatan/plak) pada pembuluh darah. Pada kasus kelainan   hipotiroid seringkali terjadi peningkatan kadar LDL-Kolesterol sedangkan hipertiroid seringkali terjadi penurunan kadar LDL-Kolesterol.Diagnosa gangguan fungsi tiroid pemeriksaan laboratorium FT4 dan TSH menjadi standar penegakkan diagnosa tiroid yang tepat. Penelitian ini bertujuan untuk melihat hubungan gangguan tiroid terutama FT4 dan TSH terhadap kadar LDL-Kolesterol. Penelitian menggunakan data deskriptif yang diambil di Laboratorium Klinik Pramita Surabaya pada bulan Januari – Desember 2019. Data dikumpulkan berasal dari rekam medis pasien yang melakukan pemeriksaan FT4, TSH dan LDL-Kolesterol sebanyak 80 orang yang terdiri dari 22 laki-laki dan 58 perempuan dengan rentang usia 22-81 tahun. Dari data diperoleh karakteristik jenis kelamin laki-laki (27,5%), perempuan (72,5%). Pada kelainan hipertiroid diperoleh rerata kadar TSH (0,0612 µIU/mL), FT4 (1,53 ng/dl), LDL-Kolesterol (99 mg/dl) sedangkan hipotiroid rerata kadar TSH (17,427 µIU/mL), FT4 (0,92 ng/dl), LDL-Kolesterol (130 mg/dl). Analisa korelasi bivariat digunakan untuk melihat hubungan antara kadar FT4 dengan LDL-Kolesterol serta TSH dengan LDL-Kolesterol. Dari data yang diperoleh didapatkan korelasi positif antara kadar TSH dan LDL-Kolesterol pada kelainan hipotirod serta korelasi  negatif antara kadar FT4 dan LDL pada hipertiroid. Dalam penelitian ini menunjukkan hasil gangguan fungsi tiroid berpengaruh pada peningkatan/penurunan kadar LDL Kolesterol.
KOMPARASI EFEK PEMBERIAN MINYAK JINTAN HITAM (Nigella sativa) DENGAN MINYAK ZAITUN (Olea europea) TERHADAP PENURUNAN GLUKOSA DARAH PADA MENCIT (Mus musculus) STRAIN Balb/c Setyo Dwi Santoso; Imam Suryanto
Jurnal SainHealth Vol 1, No 1 (2017): Maret 2017
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51804/jsh.v1i1.76.36-42

Abstract

Diabetes mellitus is a disease in humans characterized by an increase in blood glucose levels exceeds the normal limits. Cumin oil and olive oil is an alternative drug to a decrease in blood glucose levels for people with diabetes mellitus. Cumin oil and olive oil has several compounds that can lower blood glucose levels in excess. This study was conducted in January 2015 for 3 weeks in PUSVETMA Surabaya. Animals used in the study were female mice 2-3 months old with an average weight of 20-25 grams of a much as 30 individuals. At a dosage of dextrose 40% is 0.4 cc/ head/ day and the dosage of cumin oil and olive oil is 0.7 cc/ head/ day. This a study conducted of mice that had been induced dextrose 40% by using a sample of a much as 30 female mice. The results of statistical independent t-test, there was no difference or both of the test sample may lower blood glucose levels among female mice were treated with cumin oil and treated with olive oil. While the results of the data was tested using SPSS statistical Paired t-test showed that effectively lower blood glucose levels are olive oil, because there is a significant difference between before and after administration of olive oil after 7 days of dosing.
PERBEDAAN KADAR HEMOGLOBIN DAN INDEKS ERITROSIT PADA PASIEN GAGAL GINJAL KRONIK PRE DAN POST HEMODIALISIS DI RSPAL Dr. RAMELAN SURABAYA Rut Jusrena Marweri; Evy Ratnasari Ekawati; Setyo Dwi Santoso
Jurnal SainHealth Vol 6, No 2 (2022): September 2022
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51804/jsh.v6i2.1886.39-44

Abstract

Chronic Kidney Disease can cause a progressive decline in kidney function which can lead to kidney failure. One of the therapies for patients with chronic kidney failure is hemodialysis, but this method can cause complications, including worsening of anemia. This study aims to determine differences in hemoglobin levels and erythrocyte index in patients with chronic renal failure before and after hemodialysis. This study is an experimental using data on hemoglobin and erythrocyte index results pre and post hemodialysis in patients with chronic kidney failure undergoing hemodialysis therapy at RSPAL dr. Ramelan Surabaya. Paired Sample T-test was used to determine differences in hemoglobin levels and erythrocyte index in patients with chronic renal failure pre and post hemodialysis. In this study, there were differences in hemoglobin levels and erythrocyte index in patients with chronic renal failure before and after hemodialysis.
Perbandingan Metode Membran Filter dan Metode Tabung Ganda Terhadap Kandungan Escherichia coli pada Air Bersih Lathifa Azkhiyati; Dheasy Herawati; Setyo Dwi Santoso; Esti Rizkiana Pratiwi; Elsa Mega Suryani
Jurnal SainHealth Vol 7, No 1 (2023): Maret 2023
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51804/jsh.v7i1.6732.15-21

Abstract

Escherichia coli bacteria are bacteria used as indicators of contamination. Bacteriological water testing can use a Membrane Filtration (MF) and a Multiple Tube-Fermentation (MTF). This study aims to compare the membrane filtration and Multiple Tube-Fermentation methods on the presence of Escherichia coli in clean water. The two methods are compared to determine the percentage difference in the results of the two tests. The research methodology uses a description of observation. 20 samples of water boreholes were used and tested for the presence of Escherichia coli. Calculation of bacterial groups uses SNI standard references regulated by the Minister of Health of the Republic of Indonesia. The results showed that the average number of  Escherichia coli bacteria by the Multiple Tube-Fermentation method was less than the Membrane Filtration method. There is a difference in the percentage of the results of the two tests by 40%. Multiple Tube Fermentation is more sensitive than the Membrane Filtration method for detecting the presence of Escherichia coli in clean water.Keywords : Water, Escherichia coli, Membrane filtration, Multiple tube-fermentation
Co-Authors Abdul Chamid Abdul Chamid Christina Destri Wiwis Wijayanti Dheasy Herawati Dheasy Herawati Dinata Muthmainnata Dwi Viddi Kusuma Pratiwi Elsa Mega Suryani Elsa Mega Suryani Esti Rizkiana Pratiwi Evy Ratnasari Ekawati Gristine Arie Arie Imam Suryanto Indra Adi Wira Prasetya Lathifa Azkhiyati Maria Tri Setiani Maulia Yunia Aisyah Muhammad Sungging Pradana Nadiah Al Batati regina Linesiana Rut Jusrena Marweri Santosa, Rahajoe Imam Selvy Laocta Afera Siti Nur Husnul Yusmiati Yuli Novianti Sunarko Yuliati Yuliati Yuliati