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All Journal Health Science Journal of Indonesia Indonesian Journal of Cancer The Indonesian Biomedical Journal Jurnal Gizi Klinik Indonesia JSFK (Jurnal Sains Farmasi & Klinis) Amerta Nutrition Acta Biochimica Indonesiana World Nutrition Journal Indonesian Journal of Cancer Makara Journal of Science
Novi Silvia Hardiany
Departemen Biokimia Fakultas Kedokteran Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Relationship between iron intake and iron status to stunted in children aged 24-35 months during the COVID-19 pandemic in Jakarta Akbar Husaini Angkat; Dian Novita Chandra; Novi Silvia Hardiany
World Nutrition Journal Vol. 5 No. S3 (2022): Selected conference proceedings of the Nutri Virtual Symposium 2021
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V05.S3.0023

Abstract

Covid 19 pandemic has caused changes in the socioeconomic conditions, affects parents' ability to sustain their children nutritious food. If nutrients are insufficient for a long term is causing growth to be stunted.
Ekspresi Relatif mRNA Hypoxia Inducible Factor-1? pada Sel Glioma Penderita Novi Silvia Hardiany; Mohamad Sadikin; Septelia Inawati Wanandi
Indonesian Journal of Cancer Vol 7, No 1 (2013): Jan - Mar 2013
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (530.441 KB) | DOI: 10.14414/ijoc.v7i1.272

Abstract

Glioma merupakan tumor otak primer yang cukup sering ditemukan di Indonesia di antara keganasan otak lainnya. Penderita glioma mempunyai angka harapan hidup yang rendah dikarenakan seringnya mengalami resistansi terapi. Hipoksia merupakan salah satu faktor yang mempengaruhi respons terapi radiasi. Penelitian ini menganalisis ekpresi mRNA HIF-1?, sebagai petanda jaringan hipoksia, pada glioma derajat rendah dibandingkan dengan glioma derajat tinggi. Sampel terdiri dari 15 jaringan glioma derajat rendah, 6 jaringan glioma derajat tinggi, dan 21 sel lekosit dari penderita glioma sebagai kontrol sel normal. Ekspresi relatif mRNA HIF-1? ditentukan secara kuantitatif dengan menggunakan Real Time RT-PCR. Hasil penelitian menunjukkan bahwa ekspresi mRNA HIF-1? pada glioma derajat tinggi lebih tinggi dibandingkan dengan glioma derajat rendah, namun tidak bermakna secara statistik. Hal yang menarik yaitu ditemukan peningkatan ekspresi mRNA HIF-1? dengan nilai yang bervariasi pada 73 % sampel glioma derajat rendah dibandingkan dengan sel lekosit sebagai kontrol sel normal. Begitu juga pada glioma derajat tinggi ditemukan peningkatan mRNA HIF-1? dengan nilai yang bervariasi pada 100% sampel. Dengan demikian, dapat disimpulkan bahwa terdapat variasi derajat hipoksia pada glioma derajat rendah dan derajat tinggi yang mungkin mempengaruhi keberhasilan terapi radiasi.Kata kunci: Glioma, mRNA HIF-1?, hipoksia
The Difference of Hypoxia Inducible Factor 2α mRNA Expression in High-Grade and Low-Grade Glioma Tissue Bagus Ramasha Amangku; Syaiful Ichwan; Septelia Inawati Wanandi; Novi Silvia Hardiany
Indonesian Journal of Cancer Vol 13, No 2 (2019): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (967.349 KB) | DOI: 10.33371/ijoc.v13i2.633

Abstract

Background: HIF-2α is a transcription factor in hypoxic condition, and high expression levels of it correlate with the concepts of metastasis, therapy opposition and reduced quality of prognosis in various forms of cancerous growth. Due to the exceedingly infiltrative ability of brain glioma cells, gliomas cannot be completely deteriorated with surgery and the relapse rate is high. This study goal to identify the relative expression of HIF-2α gene in the direction of glioma malignancy and its classification. Methods: Specimens used in this research comprise of 20 glioma samples obtained from glioma patients in Cipto Mangunkusumo Hospital. Relative expression of HIF-2α was measured by utilizing quantitative Real Time-Polymerase Chain Reaction (RT-PCR). Cycle threshold (CT) values were achieved correlated with the amplified DNA, and then the relative expression was attained by using Livak method of calculation. Results: The results produced a greater average of relative expression of HIF-2α in the grade III and IV types (18.64; n=7) rather than in the lower grades (5.68; n=13). However, the data is statistically inconsequential. Conclusions: High-grade glioma tends to express HIF-2α mRNA higher compared to the lower grade. Therefore, it is possible to use HIF-2α as a prognostic marker for glioma- diagnosed patients, although additional experiments need to be performed to strengthen these facts.
The impact of fasting toward oxidative stress marker in the liver and plasma of new zealand white rabbit Novi Silvia Hardiany; Stephanie Gosal; Damayanti Angelina; Engelbert Julyan Gravianto; Radiana Dhewayani Antarianto
Acta Biochimica Indonesiana Vol. 5 No. 2 (2022): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.112

Abstract

Background: Fasting may increase the activity of endogenous antioxidants and protect against oxidative stress. However, the effects of different fasting durations on the liver have not been reported. Objective: The purpose of this study is to determine the effect of intermittent and prolonged fasting on oxidative stress markers in the liver tissue and plasma of New Zealand White rabbits. Methods: New Zealand White rabbits were divided into three groups: control, intermittent fasting (IF), and prolonged fasting (PF), with each group consisting of five rabbits. The control group was provided with food ad libitum; the IF group fasted for 16 hours, while the PF group fasted for 40 hours, followed by an eight-hour non-fasting period for six days. In liver tissue and plasma, oxidative stress indicators (catalase, carbonyl, GSH) were evaluated. Results: In the IF group, liver GSH was significantly higher than in the control group. However, neither liver carbonyl nor catalase levels changed significantly in the IF group. In the IF group, plasma carbonyl was significantly lower than in the PF group. In addition, there was no significant differences between groups in plasma catalase and GSH levels. Conclusion: Intermittent fasting and prolonged fasting could significantly increase liver GSH levels of New Zealand White rabbits. In addition, intermittent fasting is more effective than prolonged fasting at preventing oxidative stress.
Effect of Calorie Restriction on the Expression of Sirtuin1 as an Antiaging Biomarker Penantian, Raya Makarim; Antarianto, Radiana Dhewayani; Hardiany, Novi Silvia
Makara Journal of Science Vol. 27, No. 3
Publisher : UI Scholars Hub

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Abstract

Calorie restriction (CR) is the most effective method for delaying aging and preventing the onset of age-related diseases. Sirtuins constitute a family of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases. Their activity can be regulated by NAD+/NADH levels, which are influenced by nutrient intake, a variable acted upon by CR. This review elaborates on the link between CR and sirtuin1 (SIRT1). It retrieved articles from several sources, such as ClinicalKey, PubMed, and ScienceDirect. It discusses the up-to-date knowledge of how SIRT1 acts as a nutrient sensor and regulator of molecular mechanisms. These mechanisms include the control of the cell cycle, enhancing mitochondrial quality control, activating fatty acid oxidation, and stimulating anti-inflammatory effects. Disruptions in the aforementioned mechanisms are the basis of aging. CR increases the expression of SIRT1, which enhances the biogenesis and dynamics of mitochondria, resulting in an antiaging effect. In CR, SIRT1 is activated and stimulates different pathways, especially those related to mitochondrial activity and effectiveness, leading to an antiaging effect in collaboration with other antiaging biomarkers
Co-Authors Adisti Dwijayanti Akbar Husaini Angkat Antarianto, Radiana Dhewayani Bagus Ramasha Amangku Damayanti Angelina Dewi Sumaryani Soemarko Dian Novita Chandra Dimas Priantono Engelbert Julyan Gravianto Erfi Prafiantini Ernie Hernawati Purwaningsih Febriana Catur Iswanti Feby Fariska Savira Filda Vionita Irene de Lima Halim, Abdul Istiqomah Agusta Karima Yudhistina Lusiyana Dwi Rahmawati Mohamad Sadikin Muchtaruddin Mansyur Nanda Fauziyana Nanda Fauziyana Nina Indriyani Nasruddin Nurfitri Nurfitri Penantian, Raya Makarim Radiana Dhewayani Antarianto Reni Paramita Reni Paramita Retno Wahyu Nurhayati Septelia Inawati Wanandi Septelia Inawati Wanandi SEPTELIA INAWATI WANANDI Siregar, Fajri Marindra Sri Widia Azraki Jusman Stephanie Gosal Sucitra Sucitra Syaiful Ichwan Vivian Soetikno Wawan Mulyawan Wiji Lestari Yohana Yohana Yudhistina, Karima