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All Journal JFL : Jurnal Farmasi Lampung JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Inovasi Pembangunan
Samsuar User
Jurusan Farmasi, Universitas Tulang Bawang Lampung
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Fraksi Kloroform Ekstrak Buah Mentimun (Cucumis sativusL.) Sebagai Anti Bakteri Terhadap Staphylococcus epidermidis Samsuar User; Pratika Viogenta; Ahmad Ferry Yeriza Utama
Inovasi Pembangunan : Jurnal Kelitbangan Vol 5 No 02 (2017): August 2017
Publisher : Balitbangda Provinsi Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (198.317 KB)

Abstract

The use of antibiotics massively in the community triggered resistance to bacteria insoas to need researchforother alternatives, especially herbal medicine as an antibacterial. One of the medicinal plants was cucumber fruit that was widely available in Indonesia. The purpose of this study was to scientifically prove the antibacterial activity of chloroform fraction of cucumber fruit extract against Staphylococcus epidermidis. The extraction of the cucumber fruit was done through maceration with ethanol 70 % followed with the extract was fractionated with chloroform. The fraction was performed in the chloroform at the concentration of 5, 10, 15, 20 and 25 %. The fraction was tested for the antibacterial strength and determined the Minimum Inhibitory Concentration (MIS). The results of antibacterial strength of the extract chloroform of cucumber fruit againstS.epidermidisshowed a zone of inhibition at concentration of 5, 10, 15, 20, 25 %each having diameter of 5.86, 6.5, 7.05, 7.43, and 9.92 mm, respectively. In addition to calculate the concentration, the research also determined the MIS. The MIS of chloroform fraction extract cucumber fruit against S. epidermidis wasattheconcentration of 3 %. The result obtained from the growth on the Nutrient Agar culture media indicated that the fraction of the chloroform extract of cucumber in 3% is bacteriostatic.
FRAKSI ETANOL DAUN SEMBUNG RAMBAT (Mikania micrantha Kunth) SEBAGAI ANTIINFLAMASI TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR Samsuar Samsuar; Akhmad Rokiban; Rafika Nur
JFL : Jurnal Farmasi Lampung Vol. 7 No. 1 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (331.077 KB) | DOI: 10.37090/jfl.v7i1.37

Abstract

Tanaman sembung rambat (Mikania micrantha Kunth) merupakan tanaman yang berasal dari family Anacardiaceae. Tanaman sembung rambat diketahui mengandung senyawa metabolit sekunder seperti alkaloid, flavonoid, saponin dan tannin. Flavonoid merupakan senyawa polifenol yang berfungsi sebagai antiinflamasi. Daun sembung rambat banyak mengandung flavonoid yang dapat berkhasiat sebagai antiinflamasi, antibakteri. Tujuan dari penelitian ini adalah untuk melihat pengaruh fraksi etanol daun sembung rambat (Mikania micrantha Kunth) berpengaruh terhadap antiinflamasi terhadap tikus putih jantan galur wistar. Pada penelitian ini daun sembung rambat diekstraksi dengan cara maserasi menggunakan etanol 70%. Setelah didapatkan ekstrak selanjutnya dilakukan prosen fraksinasi. Dari fraksi yang didapat kemudian dibuat 3 varian dosis yaitu 112.5 mg/kgBB, 225 mg/kgBB dan 450 mg/kbBB. Dari 3 dosis tersebut dosis 450 mg/kgBB memiliki pengaruh yang lebih bagus daripada yang lain. Kontrol positif menggunakan Asetosal dan kontrol negatif menggunakan larutan CMC 1%. Hasil penelitian ini menunjukkan bahwa fraksi etanol daun sembung rambat dapat menghambat pembengkakan terhadap kaki tikus putih jantan galur wistar. Makin besar konsentrasi fraksi, maka semakin besar penghambatan bengkak pada kaki tikus. Dosis 450 mg/kbBB memiliki nilai rata-rata AUC - 8,22 mm.menit. Hasil analisis menunjukkan fraksi etanol daaun sembung rambat berpengaruh sebagai antiinflamasi terhadap tikus putih jantan galur wistar. Kata kunci : Mikania micrantha Kunth. Jangka Sorong, Antiinflamasi, Flavonoid
ANALISIS KANDUNGAN BORAKS PADA KERUPUK NASI YANG DIJUAL DI PASAR TRADISIONAL KABUPATEN TANGGAMUS SECARA SPEKTROFOTOMETRI UV-Vis Samsuar Samsuar; Akhmad Rokiban; Suparsi Suparsi
JFL : Jurnal Farmasi Lampung Vol. 7 No. 2 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (524.488 KB) | DOI: 10.37090/jfl.v7i2.59

Abstract

The use of additional subtance for food is to increase or to maintain nutritional value and quality of storability. Our govermment prohibits the use of borax as an additives subtance for food as appointed in Permenkes No.033, 2012. Borax is a chemical compound in white colorless crystalline with a chemical formula Na2B4O7.10H2O. Rice crackers are crackers made from rice with spices and flavor enhancer. In manufacturing crackers Borax is sometimes added to get savory crackers and to make them swelling. The purpose of this study is to find out the borax content on rice crackers in traditional markets Tanggamus district by using the qualitative method. It uses the flame test, cucurmin reagen test and ammonia steam test. It also applies quantitative test by using spectophotometry UV-Vis. There are 8 samples which were taken in tradisional markets Tanggamus district. The result of determination of the maximum length waves is 543 nm. This method has been validated before being used for the samples. The resulf of the research shows a curve with linear calibration,with the regression equalition y = 0,539x + 0,009 and correlation coefficient (r) = 0,9979. The average recorvery or accuracy value is 104,71 %. The precision or the result of standartd deviation and standard deviation relative or coeffecient of variation (CV) is 0,219%. The LOD acquistion value is 0,069 µg/ml and the LOQ is 0,320 µg/ml. The validation of the test shows that all methods have been done are valid, so it can be used to test the borax assay on the samples. Based on the analysis on 8 samples of rice crackers, quanlitative obtained sample testing shows 6 detected containing borax, then the result of quantitative obtained the level of borax ranged from 46,75 µg/g until 107 µg/g. Keywords : borax, rice crackers, Spectrofometry UV-Vis
ANALISIS KADAR NITRIT PADA SOSIS SAPI KEMASAN YANG BEREDAR DI PASAR TRADISIONAL KOTA BANDAR LAMPUNG SECARA SPEKTROFOTOMETRI UV-VIS Samsuar Samsuar; Akhmad Rokiban; Dodo Hardoyo
JFL : Jurnal Farmasi Lampung Vol. 9 No. 1 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i1.331

Abstract

Abstract The use of nitrite as a preservative and provider of the stable red color, aroma as well as taste for the meat is allowed within processed meat products, such as beef sausage. However, it should be noted that its use does not exceed the maximum permitted limit so as not to negatively impact human health. Excess nitrite in the human body can cause acute poisoning, namely methemoglobinemia and chronic poisoning as a result of the formation of carcinogenic nitrosamine derivatives. This research aims to determine whether the levels of nitrite contained in the packaged beef sausage distributed in the traditional market of Bandar Lampung is in accordance with the regulations of The Indonesia Food and Drug Authority or Indonesia FDA No. 36 of 2013 which is not more than 30 mg/kg. The analysis of nitrite levels in the sample was carried out using with UV-Vis Spectrophotometry method based on diazotation reaction between nitric acid and sulfanilamide forming diazonium salts. The products were then reacted again with naphthyl ethylenediamine to form a purplish red compound whose absorbance was measured at a wavelength 0f 543,8 nm. From the results of the analytical methods validation, it was obtained that the value of the correlation coefficient was 0,9997, the coefficient of determination 0,9994, the coefficient of variation 1,2121%, the range of percent recovery between 98,630-101,240%, and the detection and the quantitation limit respectively at 0,0187 ppm and 0,0623 ppm. This indicates that all test parameters meet the requirements for their use. The result of determining the average levels of nitrite in the samples show that there were two samples that had levels exceeding the maximum allowed limit, i.e sampel C=40,407 mg/kg and sample D=33,181mg/kg while sample A=18,963 mg/kg, sample B=9,427 mg/kg, sample E=9,423 mg/kg and sample F=8,689 mg/kg did not exceed the maximum allowed limit. Keywords: Beef Sausage, Nitrite, UV-Vis Spectrophotometry, Method AnalysisValidation
UJI AKTIVITAS ANTIBAKTERI ISOLAT SENYAWA GOLONGAN TERPENOID DARI BIJI PEPAYA (Carica papaya L.) TERHADAP Staphylococcus aureus SECARA IN VIVO PADA KELINCI JANTAN Samsuar Samsuar; Akhmad Rokiban; Adityo Hartono; Ratna Setianingsih
JFL : Jurnal Farmasi Lampung Vol. 10 No. 1 (2021): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v10i1.497

Abstract

A research on the isolation of terpenoid class of compounds from the seeds of papaya (Carica papaya L.) and test its activity against Staphylococcus aureus in vivo in male rabbits. This research aims to prove that the terpenoid compounds isolated from the seeds of papaya (Carica papaya L.) can inhibit the growth of Staphylococcus aureus in vivo. Separation of terpenoid compounds by column chromatography ((eluent n-hexane: ethyl acetate: ethanol)) resulted in 25 eluates, and then merged based on the results of identification by TLC ((nhexane: ethyl acetate (8: 2)) and the color test reagent Lieburmann -Burchard produce 5 fraction groups. fraction D showed positive terpenoids with Rf 0.75 and the color purple with Lieburmann-Burchard reagent. study using 15 rabbits were divided into 5 groups: P1 (negative control), P2 (positive control) , P3 (5% of the test group), P4 (10% of the test group), P5 (test group 15%). each group was given the intracutaneous Staphylococcus aureus as 0,2ml on the backs of rabbits. Having symptoms of infection each group was given the test substance 3 times a day topically, the observed parameter is the diameter of the wound, and histopathological observations performed on days 3,6 and 9 Analysis of the results of research conducted using ANSIRA showed highly significant differences between groups (p <0.05). Then proceed with the analysis of the results of the analysis HSD test showed highly significant differences in the test group 5% to 10% of the test group and the test group 15%. Isolates terpenoid class of compounds from the seeds of papaya (Carica Papaya L.) with a concentration of 10% and 15% can inhibit the growth of Staphylococcus aureus. Keywords: Antibacterial, Staphylococcus aureus, male rabbits
Activity Test of Durian Peels Essential Oil (Durio zibethinus) as an Antipediculosis Against Pediculus humanus capitis Linn. (Anoplura: Pediculidae) Yuli Wahyu Tri Mulyani; Siti Nurjanah; Samsuar Samsuar; Laila Susanti
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 6, No 3 (2021)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v6i3.49900

Abstract

Pediculosis is a disease caused by infestation of head lice (Pediculus humanus capitis) which is a blood-sucking obligate ectoparasite. The essential oil of durian fruit peel has active compounds that have the potential as vegetable pediculosides that can kill head lice. This study aimed to find the best concentration of essential oil from durian fruit peels that can kill head lice. The research design used with an essential oil concentration of 100%, 75%, 50%, 25%, distilled water as negative control and permethrin 1% as positive control, three repetitions and each concentration consisting of 10 flea tails. The parameters observed were the condition of lice morphologically based on the activity of limb movement, antenna movement and digestion, then the calculation of mortality was observed based on the time of the test. The results showed that the concentration of durian peel essential oil as an antipediculosis had a significant effect on the time of death of head lice, limb movement and digestion. The test result showed that the concentration is 100%, has a death time of 12 minutes 32 seconds, 75% concentration was 16 minutes 28 seconds, 50% concentration was 21 minutes 11 seconds, 25% concentration was 32 minutes 23 seconds, negative control was 61 minutes 15 seconds. The fastest time of death in positive control for chemical pediculosides was 10 minutes 15 seconds. The conclusion in this study was that essential oils the dominan one is 1,5-naphthyridin-2-amine were proven to kill head lice and the best concentration was close to positive control, namely at a concentration of 100%.
Co-Authors Adityo Hartono Ahmad Ferry Yeriza Utama Akhmad Rokiban Dodo Hardoyo I Nyoman Sujana Ratna Setianingsih Rokiban, Akhmad Siti Nurjanah Suparsi Suparsi Susanti, Laila Viogenta, Pratika Yuli Wahyu Tri Mulyani