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All Journal Biota Pharmascience JFL : Jurnal Farmasi Lampung JPSCR : Journal of Pharmaceutical Science and Clinical Research
Siti Nurjanah
Universitas Tulang BAwang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Cream Formulation Of Extract Of Maja Leaves (Crescentia cujete) As An Antimicrobial Against Staphylococcus aureus Siti Nurjanah; Yuli Wahyu Tri Mulyani; Laila Susanti; Samsuar Samsuar; Mashuri Yusuf; Meidaliyantisyah Meidaliyantisyah
Biota Vol 7 No 2 (2021): Jurnal Biota 2021
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/Biota.v7i2.7070

Abstract

Maja (Crescentia cujete L) is a plant that has medicinal properties for various diseases. Leaves of Maja contain some compounds such which are thought to have the potential to be antibacterial. The purpose of this study was to determine the potential of maja leaf extract in cream dosage form and to prove the presence of Antibacterial activity against Staphylococcus aureus. The cream of Maja leaf extract was made into several formulations; (5, 10, 15 %) The results was the cream of Maja leaf extract was able to inhibit the growth of S. aureus with the largest inhibition zone at a concentration of 15% with an average of 11.52 ± 0.95mm. Cream formulations were evaluated physically; organoleptic was resulting F1 in brownish-green, F2 in brown, and F3 in dark brown. Homogeneity tests show that all formulations were homogeneous. The pH value of all formulations following the cosmetic standard was about 4.5 – 6.5. The standard viscosity value was between 2000 – 4000 cps. The stability test of cream preparations shows no changes in the form of low-temperature storage (4ºC), room temperature, and high temperature (40ºC), so that maja leaf extracts can be formulated in cream preparations and cream formulations
Isolasi Jamur Endofitik Rumput Mutiara (Hedyotis corymbosa (L.) Lamk.) dan Analisis Potensi Sebagai Antimikroba Pratika Viogenta; Siti Nurjanah; Yuli Wahyu Tri Mulyani
Jurnal Pharmascience Vol 7, No 1 (2020): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8076

Abstract

ABSTRAK Jamur endofit merupakan jamur yang hidup di dalam jaringan atau organ tanaman yang tidak bersifat patogen. Jamur ini dapat menghasilkan beberapa zat yang sama seperti tanamannya.  Rumput mutiara (Hedyotis corymbosa (L.) Lamk)  merupakan jenis rumput liar yang biasa hidup di tanah lembab. Tujuan penelitian ini adalah untuk mengetahui keanekaragaman mikroba endofit rumput mutiara. Metode dari penelitian ini meliputi isolasi jamur endofit dari batang, daun, akar, bunga rumput mutiara,  identifikasi jamur yang berhasil diisolasi, pengukuran diameter laju pertumbuhan jamur endofit dan uji daya hambat antimikroba dari jamur endofit. Hasil penelitian didapatkan tujuh jenis jamur endofit yang berhasil diisolasi dari rumput mutiara (batang, daun, akar dan bunga). Setelah diindentifikasi ketujuh jenis kapang, yaitu 2 jenis dari genus Aspergillus yaitu A. niger dan A. parasiticus yang berhasil diisolasi dari akar, batang, daun rumput mutiara, Penicillium berasal dari akar rumput mutiara, Geotrchihum dari batang, Chrysosporium dari daun, Rhizoctonia  dan Phytophthora dari bunga. Pada ketujuh jamur endofit ini fase lag terjadi hari pertama dan fase eksponensial terlihat pada hari kedua sampai hari ketujuh. Aspergillus niger memiliki daya hambat terhadap E.coli, St. aureus, Sh. disentriae,dan P.aeruginosa masing-masing 9.95mm, 8.96mm, 10.51mm,  dan 9.26mm. Chrysosporium dan Phytophthora mengahambat C. albicans sebesar 11.3mm dan 3.63mm.  Kata Kunci: Rumput mutiara, jamur endofit, antimikroba. ABSTRACT Endophytic fungi are fungi that live in plant tissues or organs that are not pathogenic. This fungus can produce some of the same substances as the plant. Pearl grass (Hedyotis corymbosa (L.) Lamk) is a type of weed that normally lives in moist soil. The purpose of this study was to determine the diversity of endophytic pearl grass microbes. The methods of this study include the isolation of endophytic fungi from stems, leaves, roots, and flowers  of pearl grass, identification, measurement of the diameter of endophytic fungi growth rate and antimicrobial inhibition test of endophytic fungi. The results showed seven types of endophytic fungi that were isolated from pearl grass. After identifying the seven types of molds, namely 2 types of the genus Aspergillus namely A.niger and A.parasiticus which were successfully isolated from roots, stems, pearl grass leaves, Penicillium derived from pearl grass roots, Geotrchihum from the stems, Chrysosporium from leaves, Rhizoctonia and Phytophthora from flowers. In these seven endophytic fungi the lag phase occurs the first day and the exponential phase is seen on the second day to the seventh day. Aspergillus niger has inhibitory properties against E.coli, St.aureus, Sh.disentriae, and P.aeruginosa 9.95mm, 8.96mm, 10.51mm and 9.26mm, respectively. Chrysosporium and Phytophthora inhibit C. albicans by 11.3mm and 3.63mm. Keywords: Pearl grass, endophytic fungus, antimicrobial
EKSTRAK DAUN KEMBANG BULAN (Tithonia diversifolia (Hemsl.) A. Gray) SEBAGAI ANTIBAKTERI TERHADAP Streptococcus mutans dan Streptococcus sanguinis Siti Nurjanah; Isbiyantoro Isbiyantoro; Heni Fadillah
JFL : Jurnal Farmasi Lampung Vol. 7 No. 1 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (190.415 KB) | DOI: 10.37090/jfl.v7i1.35

Abstract

Kembang bulan (Tithonia diversifolia (Hemsl.) A. Gray) merupakan salah satu tanaman obat yang digunakan sebagai obat tradisional di Indonesia dan diberbagai negara. Tanaman ini dimanfaatkan sebagai Antivirus, antidiabetes, liver, atau radang tenggorokan. Daun kembang bulan mengandung senyawa flavanoid, glikosida, saponin, tanin, dan triterpenoid/steroid. Tujuan dari penelitian ini adalah untuk menguji adanya daya hambat ekstrak daun kembang bulan terhadap pertumbuhan bakteri Streptococcus mutans dan Streptococcus sanguinis. Proses ekstraksi daun kembang bulan dilakukan dengan metode maserasi menggunakan penyari etanol 70%. Sementara pengujian aktivitas antibakteri menggunakan metode sumuran dengan konsentrasi 20%, 40%, 60%, 80%, dan 100%, kontrol positif menggunakan klorheksidin 0,2% dan kontrol negatif menggunakan aquades. Pengujian dilanjutkan dengan menentukan Konsentrasi Hambat Minimum (KHM). Hasil penelitian menunjukkan bahwa semua konsentrasi ekstrak dapat menghambat pertumbuhan bakteri S. mutans dan S. sanguinis. Aktivitas antibakteri paling besar pada ekstrak kembang bulan yaitu pada konsentrasi 100%, hasil diameter zona hambat yang terbentuk terhadap bakteri S. mutans (14.12 mm) dan S. sanguinis (14.52 mm). Nilai Konsentrasi hambat minimum pada S. mutans adalah 11% yang bersifat bakteriside sementara pada S. sanguinis adalah 16% bersifat bakteriostatik. Kata Kunci : Kembang Bulan, Streptococcus mutans, Streptococccus sanguinis
FORMULASI SEDIAAN KRIM EKSTRAK BIJI KAKAO (Theobroma cacao) SEBAGAI ANTIBAKTERI Propionibacterium acne Siti Nurjanah; Nopiyansyah Nopiyansyah; Ira Dwi Rahmawati
JFL : Jurnal Farmasi Lampung Vol. 8 No. 1 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (314.062 KB) | DOI: 10.37090/jfl.v8i1.86

Abstract

Cocoa bean is one part cocoa plant which has many benefit in the health field. Polyphenolic compounds cocoa bean proven to have activity antioxidants and antibacterial. This research purposes to prove that cocoa bean extract (Theobroma cacao) could be formulated become cream preparation and had antibacterial activity against Propionibacterium acne. In this research cocoa bean extract formulated in cream preparation with different extract concentration such as, F1 (3%), F2 (6%) and F3 (12%) with using stearic acid, paraffin liquid, adepslanae, as oil phase, TEA, aquadest as water phase, and methyl paraben as preservative. Then that were evaluated of homogenity, organoleptic, pH, viscosity dispersive power, glutinous power and inhibition power of antibacterial. Result of evaluation of stock had a pH range of between 6,4-8,1, the viscosity range from 2324-526 cps 1, dispersive power between 5,47-6,95 cm, and the glutinous power between 4,2-5,3 second. Each formula was stable in storage cycling testand temperature 40ºC ± 2ºC, 28ºC ± 2ºC, 4ºC ± 2ºC and the three formulas had antibacterial of Propionibacterium acne. The conclusion of this study is cocoa bean extract could be formulated in cream preparations and had a zone of inhibition against bacteria Propionibacterium acne. Keywords: Antibacterial cream, Propionibacterium acne, Theobroma cacao
Activity Test of Durian Peels Essential Oil (Durio zibethinus) as an Antipediculosis Against Pediculus humanus capitis Linn. (Anoplura: Pediculidae) Yuli Wahyu Tri Mulyani; Siti Nurjanah; Samsuar Samsuar; Laila Susanti
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 6, No 3 (2021)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v6i3.49900

Abstract

Pediculosis is a disease caused by infestation of head lice (Pediculus humanus capitis) which is a blood-sucking obligate ectoparasite. The essential oil of durian fruit peel has active compounds that have the potential as vegetable pediculosides that can kill head lice. This study aimed to find the best concentration of essential oil from durian fruit peels that can kill head lice. The research design used with an essential oil concentration of 100%, 75%, 50%, 25%, distilled water as negative control and permethrin 1% as positive control, three repetitions and each concentration consisting of 10 flea tails. The parameters observed were the condition of lice morphologically based on the activity of limb movement, antenna movement and digestion, then the calculation of mortality was observed based on the time of the test. The results showed that the concentration of durian peel essential oil as an antipediculosis had a significant effect on the time of death of head lice, limb movement and digestion. The test result showed that the concentration is 100%, has a death time of 12 minutes 32 seconds, 75% concentration was 16 minutes 28 seconds, 50% concentration was 21 minutes 11 seconds, 25% concentration was 32 minutes 23 seconds, negative control was 61 minutes 15 seconds. The fastest time of death in positive control for chemical pediculosides was 10 minutes 15 seconds. The conclusion in this study was that essential oils the dominan one is 1,5-naphthyridin-2-amine were proven to kill head lice and the best concentration was close to positive control, namely at a concentration of 100%.
Co-Authors Heni Fadillah Ira Dwi Rahmawati Isbiyantoro Isbiyantoro Laila Susanti Mashuri Yusuf Meidaliyantisyah Meidaliyantisyah Nopiyansyah, Nopiyansyah Samsuar Samsuar Samsuar User Susanti, Laila Viogenta, Pratika Yuli Wahyu Tri Mulyani Yuli Wahyu Tri Mulyani