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All Journal Jurnal NERS Indonesian Journal of Tropical and Infectious Disease Paediatrica Indonesiana Biomolecular and Health Science Journal Indonesian Journal of Anesthesiology and Reanimation (IJAR) Indian Journal of Forensic Medicine & Toxicology

Arina Setyaningtyas

Departemen Ilmu Kesehatan Anak, Fakultas Kedokteran Universitas Airlangga Kampus A Jl. Mayjen Prof. Dr. Moestopo Surabaya

Author-ID : 3370258

Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 7 Documents Claim Missing Document

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Articles

Evaluation of the PaO2/FiO2 Ratio as a Risk Factor for Hypoxemia against Septicemia Mortality in Children who Treated at Dr. Soetomo General Hospital Yuli Astika; Arina Setyaningtyas; Dominicus Husada; Retno Asih Setyoningrum
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17142

Background: Severe septicemia can result in impaired oxygen perfusion to the tissues. The PaO2/FiO2 ratio(P/F ratio) is one of the measurement parameters for hypoxemia. This study aims to evaluate the P/F ratio asa risk factor for hypoxemia against septicemia mortality in children.Method: An observational with a prospective cohort design was conducted. Thirty-six patients withsepticemia, consisting of 18 patients who living (survivor) and 18 patients who died (non-survivor). TheP/F ratio is obtained based on blood gas analysis carried out in the first 24 hours of treatment recorded onmedical records and calculated manually. The P/F ratio has an area under the curve (AUC) of 0.83 (95%CI 0.71–0.95) with a cut-off of 226. Septicemia children with P/F ratio < 226 who have a mortality riskof up to 6.9 times (RR 6.9; 95% CI 1.719-27.957; p= 0.005) with sensitivity 72.70%; specificity 72.20%;PPV 76.19%; NPV 68.42%. The mean P/F ratio in the non-survivor group was significantly lower than thesurvivor group 161.60 (95% CI 1.05) compared to 391.09 (95% CI 2.13); p= 0.005).Conclusion: The P/F ratio can be a risk factor for hypoxemia on septicemia mortality.

Clinical Profile of Children Presenting with Intoxication on Emergency Departement Soetomo Hospital in 2011 Ira Dharmawati; Neurinda Permata Kusumastuti; Arina Setyaningtyas
Jurnal Ners Vol. 7 No. 1 (2012): April 2012
Publisher : Universitas Airlangga

Introduction: Acute poisoning in children is an important pediatric emergency and is a world wide problem, the majority of these poisoning incidents are unintentional and preventable. Based on data from WHO, the mortality of children under 4 years varies between 0.3–7% per 100,000 population in some countries in the world. The incidence, clinical proﬁle and the type of poison and the output of poisoning cases in children in Surabaya until now there is no deﬁnitive data. The objective of the study was to study the clinical proﬁle and outcome of childhood poisoning and intoxication in Soetomo hospital.Method: Design used in the study was a retrospective study done in children between 1 month and 18 years old of age who were admitted in emergency departement Soetomo hospital with diagnosis of acute poisoning between January until Desember 2012. Patients were proﬁled according to age, sex, poison consume and outcome.Result: There were 12 patients enrolled in the study. Male: female ratio was 2:1. The mean age of presentation was 53 months. Hydrocarbon poisoning was the commonest poisoning seen in (41.7%) patients followed by organophospat (33.3%) poisoning. During treatment, 58.3% received antibiotics, 25% patients who poisoning with organophosphat received antidots and 50% from all sample received antagonist histamin H2 because of stomached. Overall survival was 91,6%.Discussion: Hydrocarbon is the commonest agent involved in childhood poisoning. Overall, the outcome is good with 91,6% survival in our hospital.

Profile of Patients at Pediatric Emergency Services Soetomo Hospital Surabaya Ira Dharmawati; Arina Setyaningtyas; Neurinda Permata Kusumastuti
Jurnal Ners Vol. 7 No. 2 (2012): Oktober 2012
Publisher : Universitas Airlangga

Introduction: Installation service system at the Emergency Department (ED) Soetomo Hospital is a coordinated and integrated system under one roof. Include emergency medical and emergency surgery in a very important component of health services at each hospital. The information published on the patient proﬁle and the usefulness of emergency care services indeveloping countries and developed countries is still very rare. This study aimed to describe the characteristic of patients attending the ED at Soetomo hospital Surabaya.Method: This study was a retrospective study. The proﬁle of patients visiting the ED for 1 year were recorded and presented descriptively.Result: The total number of patients visiting the hospital was 5,835, with a monthly average of 486 patients. The children at the age of 1–5 years presented the largest age group (33.6%). The main diagnosis was respiratory tract infection (31%), diarrhea (17.%), followed by seizure (12.4%). The overall mortality rate was 1.7%.Discussion: Respiratory tract infection in children at the age of 1–5 years still count as a major problem at Soetomo Hospital Surabaya.

MICROBIAL PATTERN AND ANTIBIOTIC SUSCEPTIBILITY IN PEDIATRIC INTENSIVE CARE UNIT DR. SOETOMO HOSPITAL, SURABAYA I Wayan Putra A.A.W.; Irwanto Irwanto; ira Dharmawati; Arina Setyaningtyas; Dwiyanti Puspitasari; Agung Dwi Wahyu; Kuntaman Kuntaman
Indonesian Journal of Tropical and Infectious Disease Vol. 7 No. 5 (2019)
Publisher : Institute of Topical Disease Universitas Airlangga

Gram-negative bacterial are known as common pathogen caused infection in Pediatric Intensive Care Unit (PICU). Microbial Pattern and Antibiotic Susceptibility are needed as clinical data for selected appropriate antibiotic therapy. In PICU Dr. Soetomo hospital until now still lacking of Microbial Pattern and Antibiotic Susceptibility data. This descriptive study is to recognized Microbial Pattern and Antibiotic Susceptibility in PICU patients from blood, urine, sputum, stool, cerebrospinal fluid, endotracheal tube, pus swab and pleural fluid culture specimens. Patients whose admitted into PICU without signs of infections were excluded from the study. The inclusion criteria are patients with sign infection as follows: fever < 36,5°C or > 37.5°C, leukocyte < 4000/mm3 or > 10000/mm3, marker infections CRP >10 mg/L or PCT >0,3 ng/mL, bradycardia or tachycardia, tachypnea, infiltrates on chest X-ray, turbid urine, dysuria, thrombophlebitis, abdominal pain or tenderness, and mucous or skin lesion. Medical record data from 2011 to 2016, revealed 1138 patients had positive microbial culture result, wherein positive result came from blood 44.46%, urine 19.15%, sputum 11.59%, stool 8.96%, cerebrospinal fluid 7.50%, endotracheal tube 4.04%, pus swab 2.89%, and pleural fluid 1.41%. The microorganisms found in PICU Dr. Soetomo was dominated with gram negative bacteria. Commonest bacterial that recognized from blood was B. cepacea, urine was E. coli, sputum was P. aeruginosa, Stool was E. coli, Cerebrospinal fluid was S. cohnii, endotracheal tube was K. pneumoniae ESBL, pus swab was S. aureus, and pleural fluid was S. maltophilia. Both gram-negative bacteria and gram-positive bacteria isolates revealed multiple drug resistance to commonly used antibiotic, but still had good susceptibility for antibiotic such as; amikacin, cefoperazone-sulbactam, linezolid, vancomycin and carbapenem group.

Profile of Patients With Respiratory Failure at Pediatric Intensive Care Unit (PICU) Dr. Soetomo General Hospital Cindy Aprilia Eka Prasanty; Arina Setyaningtyas; Arie Utariani
Indonesian Journal of Anesthesiology and Reanimation Vol. 3 No. 2 (2021): Indonesian Journal of Anesthesiology and Reanimation (IJAR)
Publisher : Faculty of Medicine-Universitas Airlangga

Introduction: Respiratory failure is the respiratory system’s inability to maintain its gas exchange functions, oxygenation, and carbon dioxide elimination. Infant and children are more susceptible to develop respiratory failure. Respiratory failure can also be caused by several diseases/conditions, which is a common reason for pediatrics to be admitted to the intensive care unit. Objective: This study aims to describe patients’ demographic and clinical profile with respiratory failure at the PICU of Dr. Soetomo General Hospital, Surabaya. Materials and Methods: This is a prospective study with the descriptive method using the medical records of patients with respiratory failure who were admitted to the PICU from September 2019 to February 2020 and had arterial BGA data (PaCO2, PaO2), which were examined in the PICU or resuscitation room before the patients were admitted to the PICU. Results: This study showed that out of 35 patients, 24 (68.6%) were female, 19 (54.3%) were <1 year old, and 20 (57.1%) had normal nutritional status. Type I (hypoxemic) and type II (hypercapnic) respiratory failures were found in 13 patients (37.1%), respectively. The most common clinical signs were fever in 26 patients (74.3%), shortness of breath in 24 patients (68.6%), and chest retraction in 24 patients (68.6%). The primary diagnosis that commonly occurred was respiratory system disorders in 15 patients (42.9%). The other diagnosis that mainly occurred was nutrition and metabolic disorders of 19 patients (54.3%). The patients' outcome was that 24 patients were survived (68.6%), and ten patients died (28.6%). Conclusions: Various clinical signs and diagnoses can be found in patients with respiratory failure at PICU. The most common respiratory failure types are type I (hypoxemic) and type II (hypercapnic) respiratory failure.

Clinical Profile and Outcome of Mechanically Ventilated Children in a Pediatric Intensive Care Unit Surabaya Qorri Aina; Arina Setyaningtyas; Atika Atika
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22143

Introduction: Ventilator is used as one of the most frequent life-supportive technology in Pediatric Intensive Care Unit (PICU). There are only few studies from Asian Countries, especially Indonesia regarding the use of ventilator in PICU. The aim of this study was to describe the demographic, indications, length of use, complication, and outcome of patients with ventilator in PICU Dr.Soetomo Hospital, Surabaya.Methods: This is a descriptive study. Collecting data was done retrospectively using medical records of patients using ventilator in PICU Dr. Soetomo General Hospital from January-December 2017 . Statistical analysed was performed using Microsoft Excel 2016.Results: 59 patients met the inclusion criteria. Of the 59 patients, 34 (57.63%) were female and 27 (45.76%) were infant (1-12 months). Common indication of ventilator were status epilepticus and shock that happened in 17 (28.81%) patients. 44 (74.58%) patient was using ventilator >48 hours. There are only 4 (6.78%) of 59 patients that happened to had Ventilator Associated Pneumonia (VAP) as a complication of using ventilator. Mortality occurred in 40 (67.80%) patients and mostly happened in female (60%) and infant (50%). Mortality occurred in 10 (90%) of 11 patients with cardiac failure as the indication of ventilator and in 11 (73.33%) patients who used ventilator ≤48 hours.Conclusion: Status epilepticus and shock was the most common reason for ventilation. Incidence of VAP as the complication of ventilator is relatively low. Relatively high mortality found in age group infants, patients with cardiac failure as indication of ventilator and in patient with short duration use of ventilator.

The CDC PNU-1 criteria for diagnosis of ventilator-associated pneumonia Hapsari Widya Ningtiar; Dwi Putri Lestari; Neurinda Permata Kusumastuti; Arina Setyaningtyas; Retno Asih Setyoningrum; Ira Dharmawati; Abdul Latief Azis
Paediatrica Indonesiana Vol 59 No 4 (2019): July 2019
Publisher : Indonesian Pediatric Society

Background Ventilator-associated pneumonia (VAP) is one of the most common nosocomial infections in the pediatric intensive care unit (PICU), with mortality rates of up to 50%. Post-mortem pulmonary examination is considered to be the gold standard for diagnosis of VAP, but is impossible for routine application. The sensitivity and specificity of Clinical Pulmonary Infection Score (CPIS) are considered to be similar to the those of the gold standard, but the Centers for Disease Control and Prevention PNU-1 (CDC PNU-1) is simpler and not invasive, compared to the CPIS. Objective To evaluate the level of agreement between CDC PNU-1 and CPIS criteria in diagnosing VAP. Methods This cross-sectional study was conducted in the PICU at Dr. Soetomo Hospital, Surabaya from June to October 2018. Subjects were children aged 1 monthâ€“18 years who had been intubated for more than 48 hours. The VAP diagnoses were made by CDC PNU-1 and CPIS criteria. The level of agreement between the two methods was evaluated by Cohen's Kappa test using SPSS Statistics Base 21.0 software. Results hirty-six subjects were evaluated using CDC PNU-1 and CPIS criteria. Subjects' mean age was 3.5 (SD 4.7) years. Amongst 19 patients with VAP, 14 were diagnosed by CPIS criteria and 17 were diagnosed by CDC PNU-1 criteria. The level of agreement between the CDC PNU-1 and CPIS criteria was good (Kappa 0.61; 95%CI 0.31 to 0.83). The CDC PNU-1 had sensitivity 0.85, specificity 0.77, positive predictive value (PPV) 0.70, and negative predictive value (NPV) 0.89. Conclusion The CDC PNU-1 criteria has a good level of agreement with CPIS criteria in diagnosing VAP.

Co-Authors Abdul Latief Azis Agung Dwi Wahyu Atika Atika Cindy Aprilia Eka Prasanty Dominicus Husada Dwi Putri Lestari Dwiyanti Puspitasari, Dwiyanti Hapsari Widya Ningtiar I Wayan Putra A.A.W. Ira Dharmawati Irwanto, Irwanto Kuntaman Kuntaman Neurinda Permata Kusumastuti Qorri Aina Retno Asih Setyoningrum Utariani, Arie Yuli Astika

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