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Retno Asih Setyoningrum
Departement Of Pediatric, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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IDENTIFICATION OF INFLUENZA VIRUSES IN HUMAN AND POULTRY IN THE AREA OF LARANGAN WET MARKET SIDOARJO-EAST JAVA, INDONESIA Frederika, Edith; Mareta, Aldise; Poetranto, Djoko; Wulandari, Laksmi; Setyoningrum, Retno Asih; Setyowati, Lucia Landia; Yudhawati, Resti; Soegiarto, Gatot; Yamaoka, Masaoki
Indonesian Journal of Tropical and Infectious Disease Vol 4, No 4 (2013)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2006.144 KB)

Abstract

Background: Influenza is a viral infection that attacks the respiratory system (nose, throat, and lungs) that commonly known as “flu”. There are 3 types of influenza viruses, such as type A, type B, and type C. Influenza virus type A is the type of virus that can infect both human and animals, virus type B are normally found only in human, and Influenza virus type C can cause mild illness in human and not causing any epidemics or pandemics. Among these 3 types of influenza viruses, only influenza A viruses infect birds, particularly wild bird that are the natural host for all subtypes of influenza A virus. Generally, those wild birds do not get sick when they are infected with influenza virus, unlike chickens or ducks which may die from avian influenza. Aim: In this study, we are identifying the influenza viruses among poultry in Larangan wet market. Method: Around 500 kinds of poultry were examined from cloacal swab. Result: Those samples were restrained with symptoms of suspected H5. The people who worked as the poultry-traders intact with the animal everyday were also examined, by taking nasopharyngeal swab and blood serum. Conclusion: Identification of influenza viruses was obtained to define the type and subtype of influenza virus by PCR.
PROFILE OF COMMUNITY ACQUIRED PNEUMONIA IN CHILDREN AT SOETOMO HOSPITAL SURABAYA IN 00–00 Setyoningrum, Retno Asih
Indonesian Journal of Tropical and Infectious Disease Vol 2, No 1 (2011)
Publisher : Institute of Topical Disease

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Abstract

Background: Community Acquired Pneumonia (CAP) is one of the most important health problem affecting children all over the world. Clinical findings, laboratory and radiological examination of CAP may largely vary from mild to severe. Objective: To report profile of CAP in children hospitalized at Soetomo Hospital Surabaya in 2007–2008 Methods: This research was a retrospective study. Data of children with primary diagnosis of CAP in 2007–2008 were obtained from medical records of the Department of Child Health Soetomo Hospital Surabaya. The diagnosis CAP was based on WHO criteria (pneumonia clinical syndrome). The clinical features of illness, laboratory and radiological examination were recorded and presented descriptively. Results: During the study period, 438 patients were diagnosed as CAP. More than half (83.4%) patients aged 3 months– 3 year. Beside cough and tachypnea, most common symptom and signs were chest indrawing (76.2%) and fever (23.8%). Leucocytosis (39.6%). Bacteria was found in 8.2%. Accompanying diseases (i.e congenital heart disease, neurological and gastroenterological disorders) were found in 36.4%. One hundred fifty seven patients (35.8%) had malnutrition. Patchy infiltrate was found in 80.8% chest X-ray examination. Mortality was found in 4.3%. Conclusions: Community acquired pneumonia in children still count as a major problem at Soetomo Hospital Surabaya.
CELLULAR IMMUNITY ACTIVATION METHOD BY STIMULATING RD1 COMPLEX PROTEINS AS VIRULENCE MARKER ON Mycobacterium tuberculum TO ESTABLISH DIAGNOSIS ON TUBERCULOSIS AND LATENT TUBERCULOSIS INFECTION Setiabudi, Rebekah; Mertaniasih, Ni Made; Didik Handijatmo, Didik; Setyoningrum, Retno Asih
Indonesian Journal of Tropical and Infectious Disease Vol 5, No 7 (2015)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v5i7.1205

Abstract

This study was intended to invent a simpler and more affordable method to establish diagnosis on Tuberculosis (TB) and Latent Tuberculosis infection (LTBI). Similar to “Quantiferon TB Gold In Tube” (QFT-GIT) and T.SPOT.TB methods, the researchers also utilized “early secreted antigenic target 6kDa” (ESAT-6) and “cultur filtrate protein 10kDa” (CFP-10) proteins to be induced on the specimen. ESAT-6 and CFP-10 are commercial products used to induce interferon gamma (INF-γ) which were to be read using sophisticated and expensive equipment. This study was intended to conduct an analysis on effective cocktail protein modification, i.e. ESAT-6, CFP-10 and Ag85A/B/C, with high validity to detect cellular immunity activity through in vitro examination on peripheral blood monocyte cells of Tuberculosis-suspected patients or patients with latent tuberculosis infection. Peripheral Blood Monocyte Cells (PBMCs) activity on children tuberculosis patient or Latent Tuberculosis Infection (LTBI), adult tuberculosis patient or LTBI, which induced by cocktail protein modification and not induced, were analyzed microscopically. The activity of PBMCs on children and adult tuberculosis patient or LTBI induced by RD1 secretory proteins: ESAT-6, CFP-10, Ag85A/B/C was higher compared to PBMCs which had not been induced by the secretory proteins. Cellular debris and monocyte cells with abnormal shapes were found on PBMCs which had been induced by RD1 secretory proteins at 8 th day after culture.
Three Characterisctics of Atopy to Diagnose Allergy in Children with Respiratory Symptomps Far-Far, Imanuel; Endaryanto, Anang; Setyoningrum, Retno Asih; Soegiarto, Gatot
Jurnal Kedokteran Brawijaya Vol 31, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2020.031.02.9

Abstract

The prevalence of allergic diseases has increased in the last decade. Therefore, precise and reliable in predicting allergy in children were needed. However, in daily practice, most misdiagnosis occurs because it is only based on a family history of allergy. This study aims to evaluate the chronicity, recurrence of symptoms with similar exposure, and family history of allergy to be used as a predictor of allergy in children with respiratory symptoms. Cross sectional study was conducted in children who referred to the Pediatric Allergy and Immunology Outpatient Clinic, Dr. Soetomo General Hospital, Surabaya from January 1st - July 31st 2019. Children with a suspected allergy who developed respiratory symptoms was included. The data was taken from standardized medical record. The sensitivity and specificity of the 3 characteristics of atopic with positive SPT were calculated. A total of 115 children were admitted and 109 children fulfill the inclusion criteria. Gender 60% male and 40% female. The most common group of age founded was age 5-<10 years 39.4%, followed by 1-<3 years (25.8%), 3-<5 years (22.9%), 10 years 8.3%, and <1 year (3.6%). Fifty-four patients (49.5%) fulfilled 3 characteristics of atopy and there were 64 patients (58.7%) with positive SPT results. The sensitivity, specificity, positive predictive value and negative predictive value were 81.3%, 95.6%, 96.3%, and 78.2%, respectively. The 3 characteristics of atopy have good sensitivity and specificity to predict allergy in children.
Evaluation of the PaO2/FiO2 Ratio as a Risk Factor for Hypoxemia against Septicemia Mortality in Children who Treated at Dr. Soetomo General Hospital Yuli Astika; Arina Setyaningtyas; Dominicus Husada; Retno Asih Setyoningrum
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17142

Abstract

Background: Severe septicemia can result in impaired oxygen perfusion to the tissues. The PaO2/FiO2 ratio(P/F ratio) is one of the measurement parameters for hypoxemia. This study aims to evaluate the P/F ratio asa risk factor for hypoxemia against septicemia mortality in children.Method: An observational with a prospective cohort design was conducted. Thirty-six patients withsepticemia, consisting of 18 patients who living (survivor) and 18 patients who died (non-survivor). TheP/F ratio is obtained based on blood gas analysis carried out in the first 24 hours of treatment recorded onmedical records and calculated manually. The P/F ratio has an area under the curve (AUC) of 0.83 (95%CI 0.71–0.95) with a cut-off of 226. Septicemia children with P/F ratio < 226 who have a mortality riskof up to 6.9 times (RR 6.9; 95% CI 1.719-27.957; p= 0.005) with sensitivity 72.70%; specificity 72.20%;PPV 76.19%; NPV 68.42%. The mean P/F ratio in the non-survivor group was significantly lower than thesurvivor group 161.60 (95% CI 1.05) compared to 391.09 (95% CI 2.13); p= 0.005).Conclusion: The P/F ratio can be a risk factor for hypoxemia on septicemia mortality.
Zinc Administration Affects Bronchial Mucosal NF-κB p105/p50, p-NF-κB p65, IL-8, and IL-1β of Zinc-deficient Rats Reza Gunadi Ranuh; Andy Darma; Alpha Fardah Athiyyah; Ergia Latifolia; Retno Asih Setyoningrum; Boerhan Hidajat; Siti Nurul Hidayati; Anang Endaryanto; Ferry Sandra; Subijanto Marto Sudarmo
The Indonesian Biomedical Journal Vol 12, No 3 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i3.1041

Abstract

BACKGROUND: Risk of acute respiratory infections in children less than 5 years of age is up to 95%. Zinc deficiency is one of the main risk factors. This study aimed to explore the effect of zinc on the bronchial mucosae inflammatory status expressed by nuclear factor (NF)-κB p105/p50, NF-κB p65, interleukin (IL)-8, and IL-1β.METHODS: Twenty-four Wistar rats were divided into 4 groups: normal zinc diet group without zinc supplementation (Z1), normal zinc diet group with zinc supplementation (Z2), zinc deficient diet group without zinc supplementation (Z3), and zinc deficient diet group with zinc supplementation (Z4). NF-κB p105/p50, p-NF-κB p65, IL-8, and IL-1β were measured by immunohistochemical staining.RESULTS: The inflammatory status of bronchial mucosae between Z1 and Z2 groups showed no difference (p=0.055). However, the inflammatory status of bronchial mucosae between Z3 and Z4 groups showed significant difference (p<0.01). Multivariate factorial design showed that zinc supplementation was beneficial when given to zinc deficient diet group with regard to decrease p-NF-κB p65, IL-8 and IL-1β levels (p<0.001) and increase dendritic cell (p=0.022).CONCLUSION: Zinc administration under conditions of zinc deficiency affects the inflammatory status, as shown by the decrease of p-NF-κB p65, IL-8 and IL-1β and the increase of NF-κB p105/p50.KEYWORDS: zinc, NF-κB, p105/p50, p65, IL-8, IL-1β, rat
Zinc Supplementation Effect on the Bronchial Cilia Length, the Number of Cilia, and the Number of Intact Bronchial Cell in Zinc Deficiency Rats Andy Darma; Alpha Fardah Athiyyah; Reza Gunadi Ranuh; Wiweka Merbawani; Retno Asih Setyoningrum; Boerhan Hidajat; Siti Nurul Hidayati; Anang Endaryanto; Subijanto Marto Sudarmo
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.998

Abstract

BACKGROUND: Airway epithelium is the first line of defense against a variety of exposures. Inflammatory processes, hyperresponsiveness and zinc deficiency cause epithelial damage. Zinc is involved in apoptosis and microtubule formation. However, its role in the integrity of bronchial mucosa and cilia is unclear.METHODS: To assess the effect of zinc on the integrity of the bronchial epithelium, 24 male Rattus norvegicus strain Wistar rats were randomized into four experimental groups: normal zinc diet group without zinc supplementation, normal zinc diet group with 60 ppm zinc supplementation, zinc deficient diet group without zinc supplementation, and zinc deficient diet group with 120 ppm zinc supplementation. Bronchial mucosal integrity was measured with the number of epithelial cells, and the number and length of cilia.RESULTS: Number of cell in normal zinc diet group was 8.8±1.82, while it was only 8.1±1.08 in zinc deficient diet group (p<0.001). Number of cilia per cell was 4.6±1.08 in normal zinc diet group, compared to 4.0±0.79 in zinc deficient diet group (p<0.001). Ciliary length also differ by 7.68±0.66 μm in normal zinc diet group and only 5.16±0.91 μm in zinc deficient diet group (p<0.001).CONCLUSION: Zinc supplementation of the normal zinc diet group affected the length of bronchial cilia. Zinc supplementation of the zinc deficient diet group affected the integrity of the bronchial epithelium, which was shown by the number and length of cilia, and the number of epithelial cells.KEYWORDS: zinc, bronchial epithelial integrity, cilia length, number of cilia, epithelial cell 
Red-Cell Distribution Width (RDW) dan Mean Platelet Volume (MPV) sebagai Biomarker Keparahan Pneumonia Anak Wigit Kristianto; Retno Asih Setyoningrum; Agoes Boediono
Sari Pediatri Vol 19, No 6 (2018)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (157.071 KB) | DOI: 10.14238/sp19.6.2018.335-41

Abstract

Latar belakang. Pneumonia masih menjadi salah satu penyebab utama morbiditas dan mortalitas anak balita di seluruh dunia. Red-cell distribution width (RDW) dan mean platelet volume (MPV) adalah dua parameter dalam pemeriksaan darah lengkap yang sederhana, murah, dan tersedia hampir di seluruh rumah sakit di Indonesia. Penggunaannya sebagai biomarker keparahan pneumonia dapat menjadi salah satu upaya untuk menurunkan morbiditas dan mortalitas akibat pneumonia.Tujuan. Menganalisis hubungan antara nilai RDW dan MPV dengan derajat keparahan pneumonia anak.Metode. Penelitian cross-sectional dilaksanakan pada Juni-November 2017 di RSUD Nganjuk, melibatkan 30 anak berusia 2-59 bulan dengan pneumonia. Nilai RDW dan MPV dihubungkan dengan klasifikasi diagnosis, derajat keparahan yang diukur menggunakan skor RISC (respiratory index of severity in children) dan PRESS (pediatric respiratory severity score), dan hasil terapi pneumonia.Hasil. Terdapat perbedaan bermakna pada nilai RDW antara subjek dengan pneumonia dan pneumonia berat (t28=-1,721, p=0,096). Nilai RDW antara kelompok dengan nilai PRESS rendah, sedang, dan tinggi juga berbeda bermakna (F(2,27)=4,083, p=0,028). Nilai RDW berhubungan bermakna kuat dengan klasifikasi diagnosis pneumonia (x(1)=0,530, p=0,004), dan berhubungan bermakna moderate dengan skor RISC (rs=0,369, p=0,023), serta skor PRESS (rs=0,318, p=0,043). Kesimpulan. Nilai RDW berhubungan dengan klasifikasi diagnosis pneumonia, skor RISC dan skor PRESS.
Akurasi Diagnostik Prokalsitonin Sebagai Petanda Serologis untuk Membedakan Infeksi Bakteri dan Infeksi Virus pada Anak Dominicus Husada; I Gusti Ngurah Twi Adnyana; Retno Asih Setyoningrum; Darto Saharso; Ismoedijanto Ismoedijanto
Sari Pediatri Vol 13, No 5 (2012)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (112.208 KB) | DOI: 10.14238/sp13.5.2012.316-23

Abstract

Latar belakang.Deteksi dini infeksi bakteri dan infeksi virus pada anak sangat penting untuk tata laksana antibiotik lebih dini. Prokalsitonin (PCT) merupakan suatu temuan baru sebagai petanda serologis yang bisa dipercaya. Belum banyak informasi tentang akurasi diagnostik PCT untuk spektrum penyakit infeksi di negara berkembang.Tujuan.Melakukan akurasi diagnostik PCT sebagai petanda serologis untuk membedakan infeksi bakteri dan infeksi virus pada anak. Metode.Penelitian prospektif dengan desain potong lintang dilakukan di Departemen Ilmu Kesehatan Anak RSU Dr. Soetomo Surabaya, dari September 2009 sampai November 2010. Pasien dibagi dalam kelompok infeksi bakteri dan infeksi virus (sebagai kontrol). Data demografi, pemeriksaan darah tepi, CRP and PCT dievaluasi. Analisis statistik menggunakan uji studentt dan uji Mann Whitney U dengan interval kepercayaan 95% dan bermakna jika nilai p<0,05. Dilakukan perhitungan sensitivitas, spesifisitas, nilai duga positif (NDP), nilai duga negatif (NDN) dan rasio kemungkinan (RK) Hasil.Di antara 130 pasien yang terkumpul didapatkan 54 sampel untuk tiap kelompok. Ditemukan perbedaan kadar PCT yang bermakna antara kelompok infeksi bakteri dibandingkan infeksi virus (rerata 18,34 dan 0,22 ng/ml, p<0,0001). Dengan menggunakan kadar 0,5 ng/ml sebagai kadar ambang (sesuai penelitian sebelumnya) didapatkan sensitivitas 88,9%, spesifisitas 94,4%, NDP 94,1%, NDN 89,4% dengan RK positif 15,87 dan RK negatif 0,09.Kesimpulan.Prokalsitonin merupakan petanda serologis dengan akurasi diagnostik yang tinggi untuk membedakan infeksi bakteri dan infeksi virus pada anak.
Faktor Risiko Pneumonia pada Anak dengan Penyakit Jantung Bawaan Tia Harelina; Retno Asih Setyoningrum; Yan Efrata Sembiring
Sari Pediatri Vol 21, No 5 (2020)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp21.5.2020.276-81

Abstract

Latar belakang. Penyakit jantung bawaan (PJB) merupakan faktor risiko utama yang memperparah infeksi saluran pernapasan bawah akut. Infeksi saluran pernapasan bawah akut yang paling umum adalah pneumonia. Beberapa faktor predisposisi untuk pneumonia telah diidentifikasi, seperti pada malnutrisi berat.Tujuan. Untuk mengetahui faktor risiko kejadian pneumonia anak dengan penyakit jantung bawaan di RSUD Dr.Soetomo Surabaya.Metode. Jenis penelitian ini adalah analitik observasional dengan desain kasus kontrol berdasarkan data rekam medik pasien yang dirawat di Ruang Rawat Inap SMF Ilmu Kesehatan Anak RSUD Dr. Soetomo Surabaya selama periode Januari 2016 sampai dengan Desember 2016. Analisis data dilakukan dengan uji chi-square dan regresi logistik. Kriteria inklusi untuk kelompok kasus adalah pasien PJB dengan pneumonia, sedangkan kelompok kontrol pasien PJB tanpa pneumonia dengan umur 1 bulan sampai 60 bulan. Kriteria eksklusi adalah rekam medik yang tidak lengkap.Hasil. Diperoleh subjek sebesar 66 pasien, dengan perbandingan kasus-kontrol 1:1. Hasil analisis multivariat ditemukan adanya hubungan yang signifikan antara anemia dengan kejadian pneumonia pada anak dengan PJB (p=0,002) dan terdapat hubungan yang signifikan antara neuromuscular disease dengan kejadian pneumonia pada anak dengan PJB (p=0,015).Kesimpulan. Adanya hubungan antara anemia dan neuromuscular disease dengan pneumonia pada anak dengan penyakit jantung bawaaan.
Co-Authors Abdul Latief Azis Agoes Boediono Ahmad Suryawan Aida Fahira Rachma Aldise Mareta Aldise Mareta, Aldise Alpha Fardah Athiyyah Anang Endaryanto Anang Endaryanto Andri Kurnia Wahyudhi Andy Darma Andy Darma Arina Setyaningtyas Berlian Beatrix Rarome Boerhan Hidajat Boerhan Hidajat Budi Utomo Budi Utomo Citrawati Dyah Kencono Wungu Clarissa Cita Magdalena Darto Saharso Deasy Fetarayani Deby Kusumaningrum Didik Didik Handijatmo Didik Didik Handijatmo, Didik Diska Hanifah Nurhayati Djoko Poetranto Djoko Poetranto, Djoko Dominicus Husada Dominicus Husada Dwi Putri Lestari Dwi Susanti Edith Frederika Edith Frederika, Edith Eka Sri Handayani Ergia Latifolia Far-Far, Imanuel Ferry Sandra Gatot Soegiarto Hapsari Widya Ningtiar Hedi Mustiko Hedi Mustiko MD Hubah Asyiroh I Dewa Gede Ugrasena I Gusti Made Reza Gunadi Ranuh I Gusti Ngurah Twi Adnyana Ira Dharmawati Ismoedijanto Laksmi Wulandari Litiya Parahita Putri Firnadi Lucia Landia Setyowati Lucia Landia Setyowati, Lucia Landia Maranatha, Daniel Masaoki Yamaoka Masaoki Yamaoka, Masaoki Mohammad Yamin Sunaryo Suwandi Neurinda Permata Kusumastuti Ni Made Mertaniasih Nurul Aisah Pudji Lestari Ranti Dewanti Oktaviani Rebekah Setiabudi, Rebekah Resti Yudhawati Rifah Zafarani Soumena Shofia Ihtasya Siti Nurul Hidayati Subijanto Marto Sudarmo Tia Harelina Tutwuri Handayani Umiastuti, Pirlina Utariani, Arie Vania Ayu Puspamaniar Widati Fatmaningrum Wigit Kristianto Wiharjo Hadisuwarno Wiweka Merbawani Yan Efrata Sembiring Yuli Astika