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Jon Kenedy Marpaung
Program Studi S1 Farmasi, Universitas Sari Mutiara Indonesia
Medicine & Pharmacology

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UJI AKTIVITAS ANTIJAMUR EKSTRAK ETANOL KULIT BAWANG PUTIH (Allium sativum) DENGAN METODE DIFUSI CAKRAM Panal Sitorus; Eka Margaret Sinaga; Jon Kenedy Marpaung; Ayu Vevariantina
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.636 KB) | DOI: 10.51544/jf.v5i2.2734

Abstract

Fungal infections rarely cause dangerous conditions, one of which is Candida albicans. The use of antifungal drugs for the treatment of infectious diseases caused by fungi is now quite a lot, but the problem faced now is the occurrence of side effects for users, such as allergies, to other toxic hazards. Garlic (Allium sativum) since antiquity has shown broad antibiotic properties against gram-positive and gram-negative bacteria, including against multi-antibiotic-resistant strains. The purpose of this study was to determine the antifungal activity and effectiveness of ethanol extract of garlic peel against the fungus Candida albicans. The results showed that the yield of fresh simplicia was 10%, the extract yield was 8%. Examination of simplicia characteristics resulted in water content of 7.98%, water-soluble extract content of 18.11%, ethanol-soluble extract content of 7.30%, ash content of 1.06%, and acid insoluble ash content of 0.27%. Phytochemical screening results stated that garlic peel simplicia contained secondary metabolites of alkaloids, flavonoids, and saponins. The results of the inhibition test against the fungus candida Albicans using ethanol extract of garlic peel found antifungal effectiveness on the fungus candida Albicans. The conclusion of this study is that the ethanolic extract of garlic peel at concentrations of 500%, 400%, 300%, 200%, and 100% was less effective against the fungus Candida albicans.
UJI AKTIVITAS ANTIBAKTERI MADU HUTAN TERHADAP BAKTERI Bacillus cereus Supartiningsih Supartiningsih; Jon Kenedy Marpaung; Yosy Cinthya Eriwaty Silalahi; Icha Wahyuni Turnip
Jurnal Farmanesia Vol 8 No 1 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (314.006 KB)

Abstract

Honey is a thick sweet liquid which comes from bees which can cure many diseases and is antibacterial. Antibacterial potential of honey caused by the content of active compounds, low moisture content, high osmolarity, hydrogen peroxide content, and low pH.The aim of this study was to determine the antibacterial activity of forest honey on Doloksaribu, Simalungun district on the growth of Bacillus cereus bacteria.Experiment research method includes the analysis quality of honey, includes checking moisture content, ash content, pH tested, acidity, viscosity, spesific gravityphytochemical screening, and antibacterial activity test ith disk diffusion method use blank disk with each concentration 25%, 35%, 45%, 55%, and 65%, positive control using erythromycin and negative control sterile distilled water. Organoleptic test conducted on forest honey gave results that honey reach the requirements for good quality. The result of moisture and ash content test and pH test reach of SNI 3545: 2013 about honey. Antibacterial activity test of forest honey with concentration 25%, 35%, 45%, 55%, and 65% against Bacillus cereus showed that there was an inhibitory around the blank disc, namely 10,16 mm, 13 mm, 15,6 mm, 21,6 mm, and 22,6 mm. The greatest inhibition of forest honey occurred at the highest concentration that is 65% (22,6 mm).
UJI AKTIVITAS ANTIJAMUR EKSTRAK ETANOL KULIT BAWANG PUTIH (Allium sativum) DENGAN METODE DIFUSI CAKRAM Panal Sitorus; Eka Margaret Sinaga; Jon Kenedy Marpaung; Ayu Vevariantina
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v5i2.2735

Abstract

Fungal infections rarely cause dangerous conditions, one of which is Candida albicans. The use of antifungal drugs for the treatment of infectious diseases caused by fungi is now quite a lot, but the problem faced now is the occurrence of side effects for users, such as allergies, to other toxic hazards. Garlic (Allium sativum) since antiquity has shown broad antibiotic properties against gram-positive and gram-negative bacteria, including against multi-antibiotic-resistant strains. The purpose of this study was to determine the antifungal activity and effectiveness of ethanol extract of garlic peel against the fungus Candida albicans. The results showed that the yield of fresh simplicia was 10%, the extract yield was 8%. Examination of simplicia characteristics resulted in water content of 7.98%, water-soluble extract content of 18.11%, ethanol-soluble extract content of 7.30%, ash content of 1.06%, and acid insoluble ash content of 0.27%. Phytochemical screening results stated that garlic peel simplicia contained secondary metabolites of alkaloids, flavonoids, and saponins. The results of the inhibition test against the fungus candida Albicans using ethanol extract of garlic peel found antifungal effectiveness on the fungus candida Albicans. The conclusion of this study is that the ethanolic extract of garlic peel at concentrations of 500%, 400%, 300%, 200%, and 100% was less effective against the fungus Candida albicans.
UJI AKTIVITAS ANTIBAKTERI MADU HUTAN TERHADAP BAKTERI Bacillus cereus Siti Maimunah; Supartiningsih Supartiningsih; Jon Kenedy Marpaung; Yosy Cinthya Eriwaty Silalahi; Icha Wahyuni Turnip
Jurnal Farmanesia Vol 8 No 1 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v8i1.2780

Abstract

Honey is a thick sweet liquid which comes from bees which can cure many diseases and is antibacterial. Antibacterial potential of honey caused by the content of active compounds, low moisture content, high osmolarity, hydrogen peroxide content, and low pH.The aim of this study was to determine the antibacterial activity of forest honey on Doloksaribu, Simalungun district on the growth of Bacillus cereus bacteria.Experiment research method includes the analysis quality of honey, includes checking moisture content, ash content, pH tested, acidity, viscosity, spesific gravityphytochemical screening, and antibacterial activity test ith disk diffusion method use blank disk with each concentration 25%, 35%, 45%, 55%, and 65%, positive control using erythromycin and negative control sterile distilled water. Organoleptic test conducted on forest honey gave results that honey reach the requirements for good quality. The result of moisture and ash content test and pH test reach of SNI 3545: 2013 about honey. Antibacterial activity test of forest honey with concentration 25%, 35%, 45%, 55%, and 65% against Bacillus cereus showed that there was an inhibitory around the blank disc, namely 10,16 mm, 13 mm, 15,6 mm, 21,6 mm, and 22,6 mm. The greatest inhibition of forest honey occurred at the highest concentration that is 65% (22,6 mm).
Co-Authors Ayu Vevariantina Ayu Vevariantina Eka Margaret Sinaga Eka Margaret Sinaga Icha Wahyuni Turnip Panal Sitorus Siti Maimunah Supartiningsih Supartiningsih Yosy Cinthya Eriwaty Silalahi