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UJI AKTIVITAS ANTIOKSIDAN DALAM BEBERAPA MINUMAN YOGHURT DENGAN METODE DPPH (1,1-Diphenyl-2-Picryhydrazil) Yettrie Simarmata; Eka Margaret Sinaga; Maringan Silitonga
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Antioksidan merupakan senyawa kimia yang dapat menyumbangkan satu atau lebih electron(electrondonor) kepada radikal bebas untuk menghambat reaksi oksidatif. Salah satu contoh yang berpotensi sebagai antioksidan adalah yoghurt. Yoghurt merupakan pangan yang mengandung sejumlah bakteri hidup yang member efek yang menguntungkan bagi kesehatan karena memiliki aktivitas antioksidan, antimikroba, antidiare serta dapat meningkatkan system kekebalan tubuh. Ada beberapa factor yang dapat mempengaruhi aktivitas antioksidan yoghurt diantaranya suhu, kondisi penyimpanan, dan bahan tambahan yang digunakan seperti penambahan cita rasa buah-buahan. Tujuan penelitian ini adalah untuk mengetahui aktivitas antioksidan probiotik dari minuman yoghurt dengan berbagai merk. Sampel diambil dari Pasar Swalayan yang terdapat di Kota Medan dengan 3 merk yang berbeda yang diberikode A, B, dan C. Aktivitas antioksidannya ditentukan dengan metode DPPH (1,1-diphenyl-2-picryhidrazyl) menggunakan spektrofotometervisible yang diukur pada panjang gelombang 516 nm. Hasil penelitian menunjukkan bahwa ada dua sampel minuman yoghurt yang diberi kode A dan B termasuk dalam kategori kuat dan sampel kode C termasuk dalam kategori lemah. Minuman Yoghurt dengan merek kode A memiliki aktivitas antioksidan yang paling kuat dibandingkan dengan minuman yoghurt merek lain (B dan C) dengan nilai IC50 dari sampel kode A(80,52ml), B(90,14ml), dan C(194,81ml).

PEMERIKSAAN Escherichia coli PADA DEPOT AIR MINUM ISI ULANG DIKECAMATAN KOTA KUALA SIMPANG Eka Margaret Sinaga; Erly Sitompul; Elly Sitorus
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

The availability of clean water is decreasing along with the development of dense population growth. Many households choose Refill Drinking Water as an alternative because the price is relatively cheap. However, no one can guarantee the pathogenic bacteria contained in Refill Drinking Water. This study aims to determine the presence of Escherichia coli bacteria in refill drinking water in Kualasimpang City. This type of research is descriptive with an observational approach. The population in this study were all Refill Drinking Water Depots (DAMIU) in Kualasimpang City in 2018, totaling 21 Refill Drinking Water Depots (DAMIU). The research sample was distributed gallon water, this sample was taken from 5 Refill Drinking Depots which were selected using the Random Sampling method. The results of the study did not show the presence of Escherichia coli bacteria in refilled drinking water but only Coliform pathogenic bacteria. The quality of the water means that it is in accordance with the standards of the Minister of Health of the Republic of Indonesia No.492/MENKES/PER/IV/2010 concerning the requirements for the quality of drinking water, where drinking water must not contain bacteria in it.

FORMULASI SEDIAAN ANTISEPTIK DARI BUAH RIMBANG (Solanum torvum) SEBAGAI HAND SANITIZER Siti Maimunah; Yettrie Simarmata; Eka Margaret Sinaga; Kristini Siboro
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Rimbang fruit (Solanum torvum) has properties as a skin antiseptic. Rimbang fruit extract (Solanum torvum) which has been isolated has antibacterial activity against Staphylococcus aureus bacteria. This is because the Rimbang fruit extract (Solanum torvum) contains compounds such as solasonins, glucosides, saponins, and sterolins. Formulation and testing of antibacterial activity of hand sanitizer gel preparations of Rimbang fruit extract and evaluation of the physical quality of hand sanitizer preparations. Rimbang fruit extract was made by the maceration method using 70% ethanol. Then it was evaporated using a rotary evaporator and the remaining solvent was evaporated until a thick extract was formed. Testing of antibacterial activity by agar diffusion method using disc paper against Staphylococcus aureus by measuring the diameter of the zone of inhibition of bacterial growth. The concentration of Rimbang fruit extract and hand sanitizer gel formula used (F1) 0.5% and (F2) 1%; Evaluation of the physical quality of the hand sanitizer preparation includes organoleptic test, homogeneity test, and pH test. The results of the antibacterial activity test of Rimbang fruit extract against Staphylococcus aureus at a concentration of 0.5% with an inhibitory diameter of 5.2 mm. Meanwhile, the results of the gel hand sanitizer activity test of Rimbang fruit extract obtained the inhibition of Staphylococcus aureus bacteria at a concentration of 1% with a diameter of 9.0 mm.

FORMULASI KRIM ANTI-AGING DARI EKSTRAK KULIT BUAH JERUK LEMON (Citruslimon) Yosy Cinthya Eriwaty Silalahi; Zuhairiah Zuhairiah; Eka Margaret Sinaga; Isra Kristina Sitohang
Jurnal Farmanesia Vol 6 No 1 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Anti-aging is a preparation that is useful for preventing or slowing down the effects of aging such as wrinkles, dark spots, rough skin, and enlarged pores. Lemon peel contains flavonoids, namely hesperidin which can prevent aging and can improve skin health. This study aims to formulate anti-aging cream preparations, test the anti-aging effect, and determine the best concentration of anti-aging cream from lemon peel extract. The concentration of lemon peel extract used as a cream ingredient are: 2.5%, 5%, 7.5%, 10%. The tests carried out were homogeneity test, determination of emulsion type, pH, stability observation, skin irritation test. The test was carried out for 4 weeks. The results showed that the anti-aging cream preparations produced were homogeneous and showed an o/w type. The pH test when the cream was made was: 6-7 and after 12 weeks of storage, it was: 5-7. Anti-aging cream preparations have shown a significant increase in skin effects after 1 week, 2 weeks, 3 weeks, and 4 weeks. F5 (10% cream) provides the best anti-aging effectiveness. Lemon peel extract can be formulated into an o/a cream preparation that is able to provide anti-aging effects on the skin. Formula 5 (F5) with a concentration of 10% lemon peel extract was the most.

PENETAPAN KADAR PROTEIN DALAM SUSU FORMULA BAYI DAN ASI DI MEDAN SECARA KJELDAHL Eka Margaret Sinaga; Siti Maimunah; Erly Sitompul
Jurnal Farmanesia Vol 6 No 1 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Breast milk (ASI) is the best food for babies. Breast milk has advantages compared to other milk, including guaranteed cleanliness, the composition of breast milk is also very suitable for digestion, growth, and development of babies, one of the compositions contained in breast milk is protein. Currently, many mothers cannot breastfeed their own babies, so they choose infant formula as a substitute for breast milk. The purpose of this study was to determine differences in protein levels in infant formula and breast milk. Determination of protein content was carried out using the Kjeldahl method which is a simple method for determining total nitrogen in protein and other nitrogen-containing compounds. The Kjeldahl method is carried out through 3 processes, namely: the destruction process, the distillation process, and the titration process according to the procedures and tools used in the Chemistry Laboratory of the Sari Mutiara Indonesia University. The results of the determination of protein levels using the Kjeldahl method contained a protein with average levels in infant formula brand A (10.10 ± 0.96) %, infant formula brand B (10.95 ± 2.43) %, infant formula brand C (11.0666 ± 1.6932) %, and breast milk (20.5733 ± 3.1828) %.

FORMULASI DAN EVALUASI SEDIAAN PERONA PIPI (Blush on) CREAM DARI EKSTRAK ETANOL BIJI BUAH TERONG BELANDA (Solanum betaceumCav.) SEBAGAI PEWARNA ALAMI Adiansyah Adiansyah; Eka Margaret Sinaga; Lestari Sitohang
Jurnal Farmanesia Vol 6 No 2 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Tamarillo contains red anthocyanin pigments which can be used as an alternative natural dye. The purpose of this study was to formulate a blush preparation from Tamarillo (Solanum betaceum) seed extract in the form of a cream and to determine the ethanol extract of Tamarillo(Solanum betaceum) seeds can be used as a natural dye in the formulation of a cream blush preparation. The study used Tamarillo seed extract with concentrations of 3.75%, 5%, 7, 5%. Data analysis used descriptive analysis by presenting the frequency distribution table of each study. The results obtained indicate that all preparations, namely blanks, preparations with concentrations of 3.75%, 5%, and 7.5% have good organoleptic, meet the requirements of the homogeneity test, have good stability during storage, meet the requirements of the smear power test, meet the requirements for skin pH requirements, not irritating to the skin and the most preferred by panelists is a formula with a concentration of 7.5%. The conclusion of this preparation is that the blush preparation from the ethanol extract of the Tamarillo seeds is good and the most preferred is the color of the preparation with a concentration of 7.5%.

PEMBUATAN KERTAS RAMAH LINGKUNGAN KOMBINASI LIMBAH AMPAS TAHU DAN LIMBAH KULIT PISANG KEPOK DENGAN METODE PEMISAHAN ALKALISASI Eka Margaret Sinaga; Supartiningsih Supartiningsih; Elly Sitorus; Sriadiprastio Sriadiprastio
Jurnal Farmanesia Vol 6 No 2 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Tofu dregs waste contains 30.4% cellulose content, while kepok banana peel has high cellulose content (60-65%), hemicellulose 6-8%, and lignin 5-10%. The purpose of this study was to determine the process of making natural paper from tofu dregs waste and kepok banana peel waste as an alternative raw material for wood substitutes and to find out the characteristics of natural paper produced from tofu waste fiber and kepok banana peel waste based on SNI 287:2010 (including test water content) and SNI 6588-1:2010 (including pH acidity test). Based on the results of research that has been carried out, the optimum composition in making paper from tofu dregs and kepok banana peels is 50:50% variation. The temperature and time of heating and the optimum concentration of sodium hydroxide solution was 120 oC for 90 minutes with sodium hydroxide solution concentration of 10.0%, pulp content of 46.45%, cellulose content of 53.3%, and lignin content of 46.67%. All levels obtained have met the requirements of SNI. Based on the FT-IR spectrum analysis, tofu dregs and kepok banana peels are suitable for use as raw materials for making paper because they contain cellulose. Based on the SEM analysis, the morphological surface structure, the tighter the fiber bonds, this proves that the diameter of the resulting fiber is very small, because the smaller the fiber diameter, the better the mechanical properties.

IDENTIFIKASI ANTALGIN DALAM JAMU PEGAL LINU SECARA KROMATOGRAFI LAPIS TIPIS Supartiningsih Supartiningsih; Eka Margaret Sinaga; Maringan Silitonga; Hotvera Marianis
Jurnal Farmanesia Vol 6 No 2 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Traditional medicine is an ingredient or ingredient in the form of plant material, animal material, mineral material, preparation of extracts (galenic), or a mixture of these materials which have been used for generations. Jamu is traditional medicine, in general, herbal medicine cannot cure all kinds of diseases and its natural effect is not as fast as chemical drugs. Lately, medicinal chemicals are often added which are prohibited under the provisions of BPOM (Food and Drug Supervisory Agency). Antalgin is an analgesic-antipyretic and anti-inflammatory drug. Identification of antalgin in herbal aches and pains by thin layer chromatography aims to determine whether the herbal aches and pains circulating around Jalan Captain Muslim, Medan city contain levorphanoll drug chemicals or not. Antalgin identification in herbal pain relief was applied using Thin Layer Chromatography method with 60 F Silica gel stationary phase and chloroform-acetone-toluene (65: 25:10) mobile phase. From the results of identification by thin-layer chromatography (TLC) on herbal pain relief, it was found that the Rf value of the chromatogram spot on the levorphanol 0.16 reference standard was close to the sample Rf value (E) of 0.12. Based on the examination that has been carried out, it can be concluded that the positive herbal pain relief contains levorphanol drug chemicals so that the sample (E) tested does not meet the requirements.

FORMULASI SEDIAAN KRIM DEODORANT EKSTRAK ETANOL DAUN BELUNTAS (Plucea indica Less.) SEBAGAI PENCEGAH BAU BADAN Eka Margaret Sinaga; Supartiningsih Supartiningsih; Siti Maimunah; Nikmat Jayadi
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Beluntas is one of the plants that is often used as traditional medicine. Beluntas leaves have antimicrobial activity against various kinds of bacteria. This study aims to formulate Beluntas leaf extract (Plucea indica Less.) in the form of a deodorant cream that functions as a deterrent to body odor. The research method was carried out experimentally which included extract preparation, formulation using Beluntas leaf extract (Plucea indica Less.) with a concentration of 5%, 7.5%, 10%, preparation quality test, and hedonic test. The results of the formula The deodorant cream preparation can be used properly and can prevent sweating for 8 hours and the deodorant cream does not cause irritation and provides comfort when used, from formulas 1, 2, and 3, all the results are good to prevent sweating in the armpits but, the formula favored by the volunteers was formula 1 because the aroma was just right unlike formula 2, and formula 3 which had a slightly more pungent aroma, and similarly to the color in formula 1, the color was light green, unlike formula 2, and formula 3 which tended to be lighter in color. dark green. Beluntas leaf ethanol extract can be used to prevent body odor, and the extract can be used as a natural deodorant cream to prevent body odor.

ANALISIS MINERAL KALSIUM (Ca) DAN ZAT BESI (Fe) DENGAN VARIASI WAKTU PERENDAMAN PADA PEMBUATAN SUSU KEDELAI SECARA SPEKTROFOTOMETRI SERAPAN ATOM Eka Margaret Sinaga; Yosy Cinthya Eriwaty Silalahi; Artha Yuliana Sianipar
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Minerals, calcium, and iron are needed for humans to stay healthy and active and have various roles in the human body. The purpose of this study was to determine the levels of calcium and iron in SK1, SK2, SK3, and SK4 milk. To compare calcium and iron levels in SK1, SK2, SK3, and SK4 milk. The results of the determination of calcium and iron levels by atomic absorption spectrophotometry showed that there was a difference in the content of calcium and iron in SK3 soy milk (12.178 ± 46, 399 mg/100 ml), SK1 milk (5, 3008 ± 8, 798 mg/100). ml), SK2 milk (9, 8821 ± 55, 676 mg/100 ml), SK4 milk (4, 8634 ± 125, 845). The iron content of SK4 milk is (1.3851 ± 82.709 mg/100 ml), SK1 milk is (0.5501 ± 68.924 mg/100 ml), SK2 milk is (0.6450 ± 50.026 mg/100 ml), SK3 milk of (0.7464 ± 64 mg/100 ml). The results showed that SK3 soy milk contained more calcium than SK1, SK2, and SK4. The results of iron levels showed that SK4 soy milk contained greater iron than SK1, SK2, and SK3 soy milk.

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