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Panal Sitorus
Program Studi S1 Farmasi, Universitas Sumatera Utara
Medicine & Pharmacology

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UJI AKTIVITAS ANTIJAMUR EKSTRAK ETANOL KULIT BAWANG PUTIH (Allium sativum) DENGAN METODE DIFUSI CAKRAM Panal Sitorus; Eka Margaret Sinaga; Jon Kenedy Marpaung; Ayu Vevariantina
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.636 KB) | DOI: 10.51544/jf.v5i2.2734

Abstract

Fungal infections rarely cause dangerous conditions, one of which is Candida albicans. The use of antifungal drugs for the treatment of infectious diseases caused by fungi is now quite a lot, but the problem faced now is the occurrence of side effects for users, such as allergies, to other toxic hazards. Garlic (Allium sativum) since antiquity has shown broad antibiotic properties against gram-positive and gram-negative bacteria, including against multi-antibiotic-resistant strains. The purpose of this study was to determine the antifungal activity and effectiveness of ethanol extract of garlic peel against the fungus Candida albicans. The results showed that the yield of fresh simplicia was 10%, the extract yield was 8%. Examination of simplicia characteristics resulted in water content of 7.98%, water-soluble extract content of 18.11%, ethanol-soluble extract content of 7.30%, ash content of 1.06%, and acid insoluble ash content of 0.27%. Phytochemical screening results stated that garlic peel simplicia contained secondary metabolites of alkaloids, flavonoids, and saponins. The results of the inhibition test against the fungus candida Albicans using ethanol extract of garlic peel found antifungal effectiveness on the fungus candida Albicans. The conclusion of this study is that the ethanolic extract of garlic peel at concentrations of 500%, 400%, 300%, 200%, and 100% was less effective against the fungus Candida albicans.
ISOLASI DAN IDENTIFIKASI PEKTIN DARI KULIT PISANG MAS (Musa acuminata Colla) Panal Sitorus; Supartiningsih Supartiningsih; Jon Kenedy Marpaung; Bernadetta R. Munthe
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (565.14 KB)

Abstract

Pectin is one of the types of carbohydrate from polysacharide compound derivatives found in plan cell walls. pectin can be used in the viscosity, stability, texture and appearance of the food. The use of pectin in pharmacy is used for diarrhea, where pectin works as absordent in the intestine and also used as wound medicine as the hemostatic agent. The purpose of this research is utilize the mas banana peel as the source of pectin. This research was conducted by using the reflux extraction method using 1N hydrochloric acid as a solvent. Pectin isolation at pH 2, temperature 70-80-C for 60 minutes. The result of the precipitate is then added ethanol into the filtrate to precipitate the pectin and the final process is drying to obtain dry pectin which is 2.2975 gr. Dried pectin is obtained in the form of a fine powder, reddish brown in color and practically insoluble in ethanol. From the result of the identification that was carried out positive for the reaction with the addition of 96% ethanol and 2N NaOH, there was a gel which when added with 3N HCI and heated it formed brownish yellow lumps and had a distinctive odor. Physical specific characterization of pectin was also carried out, including moisture content (31.37%) and ash content (38.79%). Pure pectin standard for maximum moisture content of 12%, and maximum ash content of 10%. Pectin from mas banana (Musa acuminataColla) does not meet IPPA (International Pectin Producers Association) quality standards. Keywords: Banana peel, pectin, extraction, Reflux
KARAKTERISASI DAN SKRINING FITOKIMIA SERTA ANALISIS FLAVONOID DARI BUAH MENGKUDU (Morindacitrifolia L) SECARA KROMATOGRAFI LAPIS TIPIS Panal Sitorus; Suharyanisa Suharyanisa; Devina Chandra; Berton Sitanggang
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (456.727 KB) | DOI: 10.51544/jf.v8i2.2793

Abstract

Noni fruit (Morindacitrifolia L.) is a medicinal plant that is well known by the people in Indonesia. Noni is efficacious as an immune enhancer, normalizes blood pressure, anti-cancer, analgesic, diabetes mellitus, heart disease, stroke, antimicrobial. To know the characteristics of simplicia and the class of compounds from the noni fruit as well as to analyze the flavonoid compounds contained in the noni fruit using the thin layer chromatography method. The flavonoid compounds were extracted by maceration using ethanol solvent and then the ethanol extract was tested by thin-layer chromatography using 1% HCl mobile phase and spotting with 1 N H2SO4 reagent and methanol pa (1: 1% v/v). Result of simplicia characterization of fruit Noni, obtained 1.32% water content, 38.41 % water soluble extract content, 16.7% ethanol soluble extract content, 6.09% total ash content, and 0.45 acid insoluble ash content. %. Noni fruit simplicia contains chemical compounds of alkaloids, tannins, flavonoids, triterpenoids/steroids, anthraquinones, saponins with phytochemical screening tests. The value of Rf from the analysis of noni fruit flavonoid compounds using the Thin Layer Chromatography method with 3 repetitions is 0.75; 0.68 and 0.62. This indicates the presence of flavonoid compounds in the noni fruit.
UJI AKTIVITAS ANTIJAMUR EKSTRAK ETANOL KULIT BAWANG PUTIH (Allium sativum) DENGAN METODE DIFUSI CAKRAM Panal Sitorus; Eka Margaret Sinaga; Jon Kenedy Marpaung; Ayu Vevariantina
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v5i2.2735

Abstract

Fungal infections rarely cause dangerous conditions, one of which is Candida albicans. The use of antifungal drugs for the treatment of infectious diseases caused by fungi is now quite a lot, but the problem faced now is the occurrence of side effects for users, such as allergies, to other toxic hazards. Garlic (Allium sativum) since antiquity has shown broad antibiotic properties against gram-positive and gram-negative bacteria, including against multi-antibiotic-resistant strains. The purpose of this study was to determine the antifungal activity and effectiveness of ethanol extract of garlic peel against the fungus Candida albicans. The results showed that the yield of fresh simplicia was 10%, the extract yield was 8%. Examination of simplicia characteristics resulted in water content of 7.98%, water-soluble extract content of 18.11%, ethanol-soluble extract content of 7.30%, ash content of 1.06%, and acid insoluble ash content of 0.27%. Phytochemical screening results stated that garlic peel simplicia contained secondary metabolites of alkaloids, flavonoids, and saponins. The results of the inhibition test against the fungus candida Albicans using ethanol extract of garlic peel found antifungal effectiveness on the fungus candida Albicans. The conclusion of this study is that the ethanolic extract of garlic peel at concentrations of 500%, 400%, 300%, 200%, and 100% was less effective against the fungus Candida albicans.
ISOLASI DAN IDENTIFIKASI PEKTIN DARI KULIT PISANG MAS (Musa acuminata Colla) Panal Sitorus; Supartiningsih Supartiningsih; Jon Kenedy Marpaung; Bernadetta R. Munthe
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v7i1.2763

Abstract

Pectin is one of the types of carbohydrate from polysacharide compound derivatives found in plan cell walls. pectin can be used in the viscosity, stability, texture and appearance of the food. The use of pectin in pharmacy is used for diarrhea, where pectin works as absordent in the intestine and also used as wound medicine as the hemostatic agent. The purpose of this research is utilize the mas banana peel as the source of pectin. This research was conducted by using the reflux extraction method using 1N hydrochloric acid as a solvent. Pectin isolation at pH 2, temperature 70-80-C for 60 minutes. The result of the precipitate is then added ethanol into the filtrate to precipitate the pectin and the final process is drying to obtain dry pectin which is 2.2975 gr. Dried pectin is obtained in the form of a fine powder, reddish brown in color and practically insoluble in ethanol. From the result of the identification that was carried out positive for the reaction with the addition of 96% ethanol and 2N NaOH, there was a gel which when added with 3N HCI and heated it formed brownish yellow lumps and had a distinctive odor. Physical specific characterization of pectin was also carried out, including moisture content (31.37%) and ash content (38.79%). Pure pectin standard for maximum moisture content of 12%, and maximum ash content of 10%. Pectin from mas banana (Musa acuminataColla) does not meet IPPA (International Pectin Producers Association) quality standards. Keywords: Banana peel, pectin, extraction, Reflux
KARAKTERISASI DAN SKRINING FITOKIMIA SERTA ANALISIS FLAVONOID DARI BUAH MENGKUDU (Morindacitrifolia L) SECARA KROMATOGRAFI LAPIS TIPIS Panal Sitorus; Suharyanisa Suharyanisa; Devina Chandra; Siti Nurbaya; Berton Sitanggang
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v8i2.2793

Abstract

Noni fruit (Morindacitrifolia L.) is a medicinal plant that is well known by the people in Indonesia. Noni is efficacious as an immune enhancer, normalizes blood pressure, anti-cancer, analgesic, diabetes mellitus, heart disease, stroke, antimicrobial. To know the characteristics of simplicia and the class of compounds from the noni fruit as well as to analyze the flavonoid compounds contained in the noni fruit using the thin layer chromatography method. The flavonoid compounds were extracted by maceration using ethanol solvent and then the ethanol extract was tested by thin-layer chromatography using 1% HCl mobile phase and spotting with 1 N H2SO4 reagent and methanol pa (1: 1% v/v). Result of simplicia characterization of fruit Noni, obtained 1.32% water content, 38.41 % water soluble extract content, 16.7% ethanol soluble extract content, 6.09% total ash content, and 0.45 acid insoluble ash content. %. Noni fruit simplicia contains chemical compounds of alkaloids, tannins, flavonoids, triterpenoids/steroids, anthraquinones, saponins with phytochemical screening tests. The value of Rf from the analysis of noni fruit flavonoid compounds using the Thin Layer Chromatography method with 3 repetitions is 0.75; 0.68 and 0.62. This indicates the presence of flavonoid compounds in the noni fruit.
Co-Authors Ayu Vevariantina Ayu Vevariantina Bernadetta R. Munthe Berton Sitanggang Devina Chandra Eka Margaret Sinaga Eka Margaret Sinaga Jon Kenedy Marpaung Jon Kenedy Marpaung Siti Nurbaya Suharyanisa Supartiningsih Supartiningsih