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All Journal Health and Medical Journal Nusantara Hasana Journal Ophthalmologica Indonesiana Scientific Journal
Naima Lassie
Universitas Baiturrahmah
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health

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Journal : Ophthalmologica Indonesiana

 1 
Progesterone Receptor Expression in Histopathological Subtypes of Beningn Orbitocranial Meningiomas Naima Lassie; Agus Supartoto
Majalah Oftalmologi Indonesia Vol 42 No 1 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (423.635 KB) | DOI: 10.35749/journal.v42i1.72

Abstract

Background: Meningioma is the most common benign brain tumor which has several subtypes histopathologically.Previous studies indicate that progesterone receptors (PR) plays important role in thetumor behavior and may determine its prognosis. However, whether different subtypes show similarPR expression remains unclear. This study aimed to evaluate PR expression, in many histopathologicalsubtypes of benign orbitocranial meningiomas.Methods: Eighty one patients visiting Sardjito General Hospital with benign orbitorcranial meningioma(WHO grade I) between 2010-2013 were included. Tumor specimens were obtained for histopathologyassessment and PR expression using immunohistochemistry examination, including the intensity ofexpression.Results: There were 72 (88.9%) women and 9 (22.2%) men, aged between 21-72 years old. PR waspositive in 71.6% patients (76.4% women). There were different subtypes of meningioma as follows:meningotheliomatous (44.4%), transitional (33.3%), and fibrous (14.8%). PR was positive in 72.2%meningotheliomatous, 70.4% in transitional, and 66.7% fibrous subtype. Other subtypes of benignmeningioma (microcystic, angiomatous, lymphoplamocyte-rich, and metaplastic) were not found inour study. But, this finding was not statistically significant using Pearson correlation test (p>0.05).Conclusion: The majority of patients with meningioma were women. The most common histopathologicalsubtypes were meningotheliomatous and transitional, of which more than 70% was PR positive.However, there were very little variations in PR expression among different subtypes of benign orbitocranialmeningioma. Keywords: orbitocranial meningioma, progesterone receptor (PR) expression, histopathological subtype
Co-Authors Agus Supartoto Annisa Lidra Maribeth Eko Perdana Putra Hartono Hartono Irma Primawati M. Novalfi Deswanto M. Nur Huda Rika Amran Siti Felia Tambunan Veronika Puteri Yuni Handayani Gusmira