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All Journal BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Pendidikan Kimia (JPKim) EKSAKTA : Jurnal Penelitian dan Pembelajaran MIPA Jurnal Pembelajaran dan Biologi Nukleus Jurnal Sains dan Teknologi Jurnal Pengabdian Masyarakat Bidang Sains dan Teknologi Herbal Medicine Journal Borneo Journal of Pharmacy

Kasta Gurning

Sekolah Tinggi Ilmu Kesehatan Senior Medan, Medan 20141, Indonesia

Author-ID : 3552969

Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Transportation Veterinary

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Determination of phenolic contents and antioxidant activity test of ethanol extract of Sirih merah (Piper crocatum Ruiz & Pav.) leaves using the DPPH method Kasta Gurning; Sifikal Lumbangaol; Risanti F. R Situmorang; Saronom Silaban
Jurnal Pendidikan Kimia (JPKim) Vol 13, No 2 (2021): August
Publisher : Pascasarjana Universitas Negeri Medan

The research objectives were to identify the secondary metabolite components, total phenolic content and determine the antioxidant activity of the ethanol extract of red betel leaf (Piper crocatum Ruiz & Pav.). The extraction process was carried out by materation using ethanol as a solvent. Determination of total phenolic content was carried out colorimetrically with Folin-Ciocalteu reagent measured at a maximum wavelength of 765 nm. Determination of antioxidant activity using the DPPH method measured by spectrophotometry at a maximum wavelength of 517 nm. The results of phytochemical screening of the ethanolic extract of red betel leaf contain secondary metabolites, including flavonoid, phenolic, tannin, alkaloids, steroids, and triterpenoids. The total phenolic content of the red betel leaf ethanol extract was 0.949±0.003 mg GAE/g d.w. and has antioxidant activity (IC50) 84,656 including strong category as an antioxidant. Keywords: Piper crocatum Ruiz & Pav., Antioxidant, Ethanol extract, Folin-Ciocalteu and DPPH

Determination antioxidant activities methanol extracts of bangun-bangun (Coleus amboinicus L.) Leaves with DPPH method Kasta Gurning
Jurnal Pendidikan Kimia (JPKim) Vol 12, No 2 (2020): August
Publisher : Pascasarjana Universitas Negeri Medan

Bangun-bangun (Coleus amboinicus Lour.) leaves is a plant that has various types of active compounds that can be utilized in various fields of health and food. The purpose of this research is to determine the components of the active compound contained in the sample when extract with methanol by maceration method and antioxidant activity test with DPPH method using a UV-Vis spectrophotometer. The value of antioxidant activity is determined by the amount of ability to inhibit 50% concentration of free radicals from DPPH. Phytochemical screening results of methanol extract active compounds contained alkaloids, tannins, flavonoids, terpenoids and steroids, as well as phenolic & polyphenols. The test activity of methanol extract of Coleus amboinicus leaves and ascorbic acid in the amount of 38.83 and 4.18 included in the very strong category as antioxidants. The extract of Coleus amboinicus leaves has lower activity compared to ascorbic acid and has the potential to be used as a natural antioxidant in preventing and minimizing the effects of free radicals. Keywords: Coleus amboinicus Lour, Antioxidant, Methanol extract, IC50, DPPH

In vitro test of antibacterial activity causing inhibition of wound healing from ethanol extract of nangka (Artocarpus heterophyllus, Lam.) leaf Esther Siringo-ringo; Indah Yani Tambunan; Mastiur Julianti Butar-butar; Kasta Gurning; Iksen Iksen
Jurnal Pendidikan Kimia (JPKIM) Vol 15, No 1 (2023): April
Publisher : Pascasarjana Universitas Negeri Medan

Nangka (Artocarpus heterophyllus, Lam.) is a plant that is rich in nutrients and contains phytochemicals that can be used in various fields, especially in the health sector. Traditionally, every part of this plant has been widely used for its anticarcinogenic, antimicrobial, antifungal, anti-inflammatory, wound healing, and hypoglycemic effects. Antibacterials are an important part of drug preparations to accelerate wound healing. Antibiotics inhibit the occurrence of infection and stimulate the process of forming fibroblast cells for wound closure. Bacteria that are often found in wounds and inhibit the acceleration of wound healing are Staphylococcus aureus and Escherichia coli. The purpose of this study was to test the activity of the ethanol extract of nangka leaf (Artocarpus heterophyllus, Lam.) in vitro on E. coli and S. aureus bacteria. The extraction method used was maceration with ethanol solvent and in vitro antibacterial activity testing using the paper disc method, as well as variations in extract concentrations, namely 12.5%, 25%, 50%, 75%, chloramphenicol as a positive control, and 5% DMSO as a negative control. The results showed that the ethanol extract contained various secondary metabolites, namely alkaloids, tannins, saponins, steroids/triterpenoids, and flavonoids. The ethanol extract of nangka leaf (Artocarpus heterophyllus, Lam.) has strong category potential as an antibacterial against E. coli and S. aureus.Keywords: Antibacterials; Escherichia coli; Nangka leaf; Staphylococcus aureus; Wound healing

Molecular docking analysis of six major compounds from sweet basil (Ocimum basilicum L.) extract as potential anti-hypertension therapy Bayu Cakra Buana; Iksen Iksen; Kasta Gurning
Jurnal Pendidikan Kimia (JPKIM) Vol 15, No 2 (2023): August
Publisher : Pascasarjana Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpkim.v15i2.43617

Hypertension is an abnormally high blood pressure condition that is the leading cause of preventable cardiovascular disease, chronic kidney disease, and cognitive impairment. In the case of hypertension, repressing the Angiotensin-Converting Enzyme (ACE) expression has been shown to be an effective method of controlling hypertension by inhibiting the conversion of angiotensin I to angiotensin II. Captopril is the most commonly used ACE inhibitor. It simultaneously inhibits the conversion of angiotensin I to the potent vasoconstrictor angiotensin II and the vasodilator peptide bradykinin. Sweet basil (Ocimum basilicum L.) on the other hand, is used in traditional Indian and Chinese medicine to treat a variety of diseases, including hypertension. The study aimed attempts to investigate the potency of 6 major compounds found in sweet basil (Ocimum basilicum L.) extract, as an anti-hypertension therapy. The analysis demonstrates that Ocimum basilicum L., extract is effective as an anti-hypertension therapy because it contains several compounds that may interact with ACE and inhibit its activity. The molecular docking analysis and drug-likeness prediction indicate that camphor could be a potential drug candidate because it does not violate the Lipinski rule, has a high Gastrointestinal (GI) absorption, a high affinity to interact with ACE, and a similar interaction site to the ACE-Captopril interaction.Keywords: ACE; Holly basil; Hypertension; Molecular docking

Co-Authors Bayu Cakra Buana Chyntia Glori Tania Dameria Siahaan Denny Satria Esther Siringo ringo Hariyadi Dharmawan Syahputra Helen anjelina simanjuntak Helen Anjelina Simanjuntak Iksen Indah Yani Tambunan Mastiur Julianti Maya Amelia Sinaga Nasri Nasri Nasri Nasri Risanti Situmorang Saronom Silaban Sifikal Lumbangaol Syahrina Syahrina Vera Estefania Kaban Verawati Br. Sinaga Vivi Asfianti Zulmai Rani

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