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All Journal Jurnal Pengabdian UntukMu NegeRI Jurnal Sains dan Teknologi Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Denny Satria
Universitas Sumatera Utara
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Sosialisasi Pembuatan Virgin Coconut Oil Sebagai Suplemen Peningkat Imunitas Untuk Menghadapi Covid-19 Di Kelurahan Gedung Johor Medan Rosidah Rosidah; Mahatir Muhammad; Effendy De Lux Putra; Denny Satria; Panal Sitorus; M. Fauzan Lubis
Jurnal Pengabdian UntukMu NegeRI Vol 5 No 1 (2021): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jpumri.v5i1.2263

Abstract

Pengabdian kepada masyarakat ini bertujuan untuk memberikan pengetahuan mengenai pembuatan Virgin Coconut Oil secara sederhana dan memberikan pengetahuan bahwa Virgin Coconut Oil dalam meningkatkan imunitas tubuh sehingga dapat menangani atau mencegah semakin berkembangnya pasien positif Covid-19. Melalui kegiatan pengabdian kepada masyarakat yang ditujukan kepada masyarakat di Kelurahan Gedung Johor, Kecamatan Medan Johor, Medan. Pemahaman masyarakat terhadap manfaat dan kandungan VCO serta cara pembuatan VCO yang benar, sederhana dan dengan tetap memperhatikan kualitas dari VCO yang dibuat, dilihat berdasarkan mutu fisik meliputi warna, bau dan rasa yang dihasilkan VCO buatan sendiri dan VCO dari Palm Mustika yaitu normal untuk bau dan rasa serta berwarna putih hingga kuning pucat. Mutu kimia VCO buatan sendiri yang didominasi asam laurat yaitu 53,2% sedangkan VCO dari Mustika Palem yaitu 49,4%. asam lemak bebas (FFA) VCO buatan sendiri yaitu 0,38% sedangkan asam lemak bebas (FFA) VCO Mustika Palem yaitu 0,08%, bilangan peroksida VCO buatan sendiri yaitu 0,06 meq/kg sedangkan bilangan peroksida VCO Mustika Palem yaitu 0,00 meq/kg dan bilanga penyabunan VCO buatan sendiri yaitu 252,74 mg KOH/gram sedangkan bilangan penyabunan VCO Mustika Palem yaitu 253,13 mg KOH/gram.
Aktivitas Antibakteri Ekstrak Etanol Daun Pepaya (Carica papaya Linn.) Terhadap Bakteri Pseudomonas aeruginosa Nasri Nasri; Vera Estefania Kaban; Kasta Gurning; Hariyadi Dharmawan Syahputra; Denny Satria
INSOLOGI: Jurnal Sains dan Teknologi Vol. 1 No. 3 (2022): Juni 2022
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (376.277 KB) | DOI: 10.55123/insologi.v1i3.438

Abstract

Pseudomonas aeruginosa is a Gram-negative bacterium that can cause nosocomial infections. The use of antibiotics in the treatment of non-adherent P. aeruginosa infections increases the risk of antibiotic resistance. Efforts to find new antibiotic compounds from plants continue to be carried out. Papaya leaves are widely spread among the public, which are often used as ingredients for vegetables and have antibacterial potential because they contain papain enzymes and a class of flavonoid compounds. The purpose of this study was to analyze the antibacterial activity of the ethanol extract of papaya leaves (Carica papaya Linn.) against P. aeruginosa by finding the value of the Minimum Inhibitory Concentration (MIC) and calculating the index activity value against the positive control. The method used in this research is Kirby-Bauer (disc diffusion method) with several variations of the test concentration. The results showed that the diameter of the inhibition zone at a concentration of 500 mg/mL was in the strong category with an inhibition zone diameter of 10.87 ± 0.06 mm. MIC at a concentration of 3.125 mg/mL. The index activity value was greatest at a concentration of 500 mg/mL with a value of 0.668. So it can be concluded that the ethanol extract of papaya leaves (Carica papaya Linn.) has inhibitory activity against Pseudomonas aeruginosa.
The Immunomodulatory Activities of Saurauia vulcani Korth Leaves towards RAW 264.7 cell R Rosidah; Y Yuandani; Sri Suryani Widjaja; Muhammad Fauzan Lubis; Denny Satria
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Saurauia vulcani Korth is an actinidiaceae family plant that is used as traditional medicine by the community. Testing the immunomodulatory effect of Saurauia vulcani Korth extract was done in vitro on RAW cells line by stratified extraction using n-hexane, ethyl asetat, and ethanol solvents. Determination of nitric oxide levels by the griess method and inhibition of gene expression TNF-α, IL6, COX-2, IL-1β, and iNOS by RT-PCR method. Saurauia vulcani Korth extract (NESVL, EAESVL, and EESVL) at a concentration of 25 ug / ml was able to reduce the value of nitric oxide in RAW cells 246.7 and was able to inhibit the expression of genes TNF-α, IL-6, COX-2, IL-1β, and iNOS. Where the density value of each band formed by 1.21 ± 0.005; 1.15 ± 0.005; 0.88 ± 0.003 on TNF-α, 1.23 ± 0.003; 1.64 ± 0.005; 0.55 ± 0.003 on IL-6, 0.38 ± 0.003; 0.55 ± 0.003; 0.38 ± 0.003 on COX-2, 0.18 ± 0.003; 0.04 ± 0.003; 0.03 ± 0.003 on IL-1β, and 0.30 ± 0.003; 0.41 ± 0.003; 0.11 ± 0.005 on iNOS.
Co-Authors Effendy De Lux Putra Hariyadi Dharmawan Syahputra Kasta Gurning M. Fauzan Lubis Mahatir Muhammad Muhammad Fauzan Lubis Nasri Nasri Panal Sitorus* R Rosidah Rosidah Rosidah Sri Suryani Widjaja Vera Estefania Kaban Y Yuandani