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All Journal BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Pendidikan Kimia (JPKim) EKSAKTA : Jurnal Penelitian dan Pembelajaran MIPA Jurnal Pembelajaran dan Biologi Nukleus Jurnal Sains dan Teknologi Jurnal Pengabdian Masyarakat Bidang Sains dan Teknologi Herbal Medicine Journal Borneo Journal of Pharmacy

Kasta Gurning

Sekolah Tinggi Ilmu Kesehatan Senior Medan, Medan 20141, Indonesia

Author-ID : 3552969

Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Transportation Veterinary

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IDENTIFICATION OF SECONDARY METABOLIC AND TEST OF ACTIVITY ETHYL ACETATE FRACTION OF BANGUN¬- BANGUN (Coleus amboinicus Lour.) LEAVES AS ANTIOXIDANT Kasta Gurning
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol 7, No 1 (2020): August 2020
Publisher : Universitas Medan Area

Antioxidants have an important role in delaying the oxidation process and preventing the occurrence of degenerative diseases in the body. Antioxidants consist of synthetic and natural; the use of synthetic antioxidants in a relatively long period is hazardous so that the use of natural antioxidants is considered more potential and safe for the body. The process of extracting secondary metabolites from the leaves of bangun-bangun (Coleus amboinicus L.) is carried out by the maceration method with methanol, then partitioned in stages with n-hexane, chloroform, and ethyl acetate. This research intends to identify secondary metabolites and test antioxidant activity from the ethyl acetate fraction with the DPPH method. Phytochemical screening results of ethyl acetate fraction showed the different secondary metabolite groups such as alkaloids, phenolics & polyphenols, flavonoids, coumarin, and triterpenoids. Antioxidant activity (IC50) obtained is 64.97 with a healthy category, so that the potential to be used as a natural antioxidant.

Uji Aktivitas Antibakteri Sediaan Bedak Dingin Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa bilimbi Linn.) Terhadap Propionibacterium acnes || Antibacterial Activity of Cold Powder Preparation of (Ethanol Extract) Starfruit Leaf (Averrhoa bilimbi Linn.) Against Propionibacterium acnes Helen Anjelina Simanjuntak; Kasta Gurning; Verawati Br. Sinaga
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 6, No 2 (2020): Jurnal Pembelajaran Dan Biologi Nukleus September 2020
Publisher : Fakultas Keguruan dan Ilmu Pendidikan Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v6i2.1677

Jerawat adalah penyakit kulit yang terjadi akibat adanya peradangan menahun yang dipicu oleh bakteri Propionibacterium acnes. Daun belimbing wuluh (Averrhoa bilimbi Linn.) merupakan tanaman obat tradisional yang memiliki aktivitas sebagai antibakteri. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri dari sediaan bedak dingin ekstrak etanol daun belimbing wuluh (A. bilimbi Linn.) terhadap Propionibacterium acnes. Metode penelitian dilakukan dengan eksperimental, dan pengujian aktivitas antibakteri dilakukan dengan menggunakan metode difusi agar. Formulasi bedak dingin F1 (5%), F2 (10%), F3 (15%), F4 (20%), kontrol positif dengan klindamisin, kontrol negatif dengan akuades. Hasil menunjukkan bahwa formulasi sediaan F3 (15%) dan F4 (20%) lebih efektif dalam menghambat pertumbuhan bakteri Propionibacterium acnes dengan diameter zona hambat 13,66 mm dan 15,16 mm dengan kategori kuatAcne is a skin disease that occurs due to chronic trade that is triggered by the bacterium Propionibacterium acnes. Starfruit leaf (Averrhoa bilimbi Linn.) as a traditional medicinal plant that has antibacterial activity. The purpose of this study was to determine the antibacterial activity from ethanol extract in the preparations cold powder of starfruit leaf (A. bilimbi Linn.) against Propionibacterium acnes. The research method was carried out experimentally, and testing for antibacterial activity was carried out using agar diffusion methods. Cold powder formulation such as F1 (5%), F2 (10%), F3 (15%), F4 (20%), positive control with clindamycin, negative control with distilled water. The results showed that the F3 (15%) and F4 (20%) formulations were more effective in inhibiting the growth of Propionibacterium acnes bacteria with inhibition zone diameters of 13.66 mm and 15.16 mm in the strong category.

Determination of phenolic contents and antioxidant activity test of ethanol extract of Sirih merah (Piper crocatum Ruiz & Pav.) leaves using the DPPH method Kasta Gurning; Sifikal Lumbangaol; Risanti F. R Situmorang; Saronom Silaban
Jurnal Pendidikan Kimia (JPKim) Vol 13, No 2 (2021): August
Publisher : Pascasarjana Universitas Negeri Medan

The research objectives were to identify the secondary metabolite components, total phenolic content and determine the antioxidant activity of the ethanol extract of red betel leaf (Piper crocatum Ruiz & Pav.). The extraction process was carried out by materation using ethanol as a solvent. Determination of total phenolic content was carried out colorimetrically with Folin-Ciocalteu reagent measured at a maximum wavelength of 765 nm. Determination of antioxidant activity using the DPPH method measured by spectrophotometry at a maximum wavelength of 517 nm. The results of phytochemical screening of the ethanolic extract of red betel leaf contain secondary metabolites, including flavonoid, phenolic, tannin, alkaloids, steroids, and triterpenoids. The total phenolic content of the red betel leaf ethanol extract was 0.949±0.003 mg GAE/g d.w. and has antioxidant activity (IC50) 84,656 including strong category as an antioxidant. Keywords: Piper crocatum Ruiz & Pav., Antioxidant, Ethanol extract, Folin-Ciocalteu and DPPH

Determination antioxidant activities methanol extracts of bangun-bangun (Coleus amboinicus L.) Leaves with DPPH method Kasta Gurning
Jurnal Pendidikan Kimia (JPKim) Vol 12, No 2 (2020): August
Publisher : Pascasarjana Universitas Negeri Medan

Bangun-bangun (Coleus amboinicus Lour.) leaves is a plant that has various types of active compounds that can be utilized in various fields of health and food. The purpose of this research is to determine the components of the active compound contained in the sample when extract with methanol by maceration method and antioxidant activity test with DPPH method using a UV-Vis spectrophotometer. The value of antioxidant activity is determined by the amount of ability to inhibit 50% concentration of free radicals from DPPH. Phytochemical screening results of methanol extract active compounds contained alkaloids, tannins, flavonoids, terpenoids and steroids, as well as phenolic & polyphenols. The test activity of methanol extract of Coleus amboinicus leaves and ascorbic acid in the amount of 38.83 and 4.18 included in the very strong category as antioxidants. The extract of Coleus amboinicus leaves has lower activity compared to ascorbic acid and has the potential to be used as a natural antioxidant in preventing and minimizing the effects of free radicals. Keywords: Coleus amboinicus Lour, Antioxidant, Methanol extract, IC50, DPPH

UJI AKTIVITAS ANTIBAKTERI DARI SEDIAAN KRIM EKSTRAK ETANOL HERBA TUMBUHAN BALSEM (Polygala paniculata L.) TERHADAP BAKTERI Propionebacterium acnes PENYEBAB JERAWAT Helen Anjelina Simanjuntak; Kasta Gurning
Eksakta : Jurnal Penelitian dan Pembelajaran MIPA Vol 5, No 2 (2020): Eksakta : Jurnal Penelitian dan Pembelajaran MIPA
Publisher : Fakultas Keguruan Dan Ilmu Pendidikan, UM-Tapsel

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/eksakta.v5i2.133-140

Acne is a skin disorder that occurs due to chronic inflammation, which is triggered by the growth of bacteria Propionibacterium acnes. The Balm plant (Polygala paniculata L.) is a small shrub originating from Indonesia. The purpose of this research is to determine the antibacterial activity of the formulation of a cream extract of the herbal ethanol extracts of the balm to the growth of bacteria Propionebacterium acnes. This research is an experimental study with five dosage formulations where the used concentration of extract consists of 0% (F1), 2% (F2), 4% (F3), 6% (F4), VitaCid as a positive control. The testing of antibacterial activity conducted by the CUP-plate technique method. Results showed that the extract of the balm plant in the preparation of cream could inhibit the growth of Propionibacterium acnes, visible with the formation of clear zones. The F1 cream preparations and F2 have stable and F3 categories, F4 has a dominant type.

KARAKTERISASI DAN SKRINING FITOKIMIA DAUN PIRDOT (Saurauia vulcani Korth.) Kasta Gurning; Helen Anjelina Simanjuntak
Eksakta : Jurnal Penelitian dan Pembelajaran MIPA Vol 5, No 2 (2020): Eksakta : Jurnal Penelitian dan Pembelajaran MIPA
Publisher : Fakultas Keguruan Dan Ilmu Pendidikan, UM-Tapsel

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/eksakta.v5i2.98-105

Pirdot (Saurauia vulcani Korth.) is a plant that has great potential to be developed as raw material for herbal medicines. This study aims to characterize, and phytochemical screening of (Saurauia vulcani Korth.) leaves. Characterization carried out on the simplistic powder and ethanol extract of pirdot (Saurauia vulcani Korth.). The extraction of pirdot (Saurauia vulcani Korth.) leaves using methanol by the maceration method. Characterization of simplistic and ethanol extract carried out to determine and ensure the appropriateness of the quality standard before it was made into the preparation of a standard drug, while the phytochemical screening was an essential first step in identifying the class of bioactive compounds to direct their potential activities as raw materials in the treatment of various diseases. The simplistic and ethanol extract leaves of pirdot (Saurauia vulcani Korth.) Contain bioactive compounds such as flavonoids, saponins, tannins, and steroids/triterpenoids and ethanol, including suitable solvents in extracting the contents of all bioactive compounds contained in leaves of pirdot simplisia (Saurauia vulcani Korth.).

Aktivitas Antibakteri Ekstrak Etanol Daun Pepaya (Carica papaya Linn.) Terhadap Bakteri Pseudomonas aeruginosa Nasri Nasri; Vera Estefania Kaban; Kasta Gurning; Hariyadi Dharmawan Syahputra; Denny Satria
INSOLOGI: Jurnal Sains dan Teknologi Vol. 1 No. 3 (2022): Juni 2022
Publisher : Yayasan Literasi Sains Indonesia

Pseudomonas aeruginosa is a Gram-negative bacterium that can cause nosocomial infections. The use of antibiotics in the treatment of non-adherent P. aeruginosa infections increases the risk of antibiotic resistance. Efforts to find new antibiotic compounds from plants continue to be carried out. Papaya leaves are widely spread among the public, which are often used as ingredients for vegetables and have antibacterial potential because they contain papain enzymes and a class of flavonoid compounds. The purpose of this study was to analyze the antibacterial activity of the ethanol extract of papaya leaves (Carica papaya Linn.) against P. aeruginosa by finding the value of the Minimum Inhibitory Concentration (MIC) and calculating the index activity value against the positive control. The method used in this research is Kirby-Bauer (disc diffusion method) with several variations of the test concentration. The results showed that the diameter of the inhibition zone at a concentration of 500 mg/mL was in the strong category with an inhibition zone diameter of 10.87 ± 0.06 mm. MIC at a concentration of 3.125 mg/mL. The index activity value was greatest at a concentration of 500 mg/mL with a value of 0.668. So it can be concluded that the ethanol extract of papaya leaves (Carica papaya Linn.) has inhibitory activity against Pseudomonas aeruginosa.

Pemeriksaan dan Pemberian Obat Anemia Kepada Ibu Hamil di Desa Kota Pari Pantai Cermin Nasri Nasri; Vera Estefania Kaban; Kasta Gurning; Chyntia Glori Tania
ABDIKAN: Jurnal Pengabdian Masyarakat Bidang Sains dan Teknologi Vol. 1 No. 3 (2022): Agustus 2022
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/abdikan.v1i3.787

The incidence of anemia in pregnant women carries a great risk because the fetus's need for iron and oxygen supply during development requires iron. This community service activity aims to examine and administer anemia drugs or blood boosters to pregnant women and provide education related to anemia and important nutritional intake for pregnant women to prevent risk factors for anemia. A total of 36 pregnant women patients checked themselves, with 12 in the first trimester, 15 in the second trimester, and 9 in the third trimester. A total of 7 people in the first trimester experienced anemia (19.44%), 10 people in the second trimester (27.77%), and 5 people in the third trimester (13.88%). The rest do not have anemia. This can be due to the fact that the intake of balanced nutrition and foods rich in iron is sufficient during pregnancy. Iron intake during pregnancy in the first trimester is recommended at as much as 0.8 mg/day, while in the second and third trimesters, as much as 6.3 mg/day. Thus, it is hoped that the imparted knowledge and information will be adhered to in order to limit the risk of anemia in pregnant women so that the process of pregnancy until birth will proceed without incident.

Formulasi Sediaan Lip Cream Ekstrak Daun Miana (Coleus scuatellariodes [L] Benth.) sebagai Pewarna Alami Vera Estefania Kaban; Nasri Nasri; Kasta Gurning; Hariyadi Dharmawan Syahputra; Zulmai Rani
INSOLOGI: Jurnal Sains dan Teknologi Vol. 1 No. 4 (2022): Agustus 2022
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v1i4.719

Miana leaf (Coleus scutellarioides L.) is a plant that contains anthocyanins that can provide certain dyes. The purpose of this study was to formulate miana leaf extract in lip cream preparations as a natural dye. The research method includes the manufacture of ethanol extract of miana leaves (Coleus scutellarioides L.) by maceration method. The extract formulas used were 25%, 50%, and 75%. The tests carried out included organoleptic tests, homogeneity tests, physical tests, pH tests, irritation tests and color preference tests. The results of the lip cream preparation, the results of the organoleptic examination were declared to have a semi-solid dosage form, distinctive odor and varied colors F1 pink F2 purplish red, F3 blackish red, homogeneity test results were declared homogeneous, stability test results showed that the preparation did not change shape, color and the odor of the preparation for 14 days of storage, the results of the pH test showed that the preparation was still within the permissible pH range on the use of the skin, the test results were declared non-irritating. Miana leaf ethanol extract can be made as a colorant in lip cream preparations.

In vitro test of antibacterial activity causing inhibition of wound healing from ethanol extract of nangka (Artocarpus heterophyllus, Lam.) leaf Esther Siringo-ringo; Indah Yani Tambunan; Mastiur Julianti Butar-butar; Kasta Gurning; Iksen Iksen
Jurnal Pendidikan Kimia (JPKIM) Vol 15, No 1 (2023): April
Publisher : Pascasarjana Universitas Negeri Medan

Nangka (Artocarpus heterophyllus, Lam.) is a plant that is rich in nutrients and contains phytochemicals that can be used in various fields, especially in the health sector. Traditionally, every part of this plant has been widely used for its anticarcinogenic, antimicrobial, antifungal, anti-inflammatory, wound healing, and hypoglycemic effects. Antibacterials are an important part of drug preparations to accelerate wound healing. Antibiotics inhibit the occurrence of infection and stimulate the process of forming fibroblast cells for wound closure. Bacteria that are often found in wounds and inhibit the acceleration of wound healing are Staphylococcus aureus and Escherichia coli. The purpose of this study was to test the activity of the ethanol extract of nangka leaf (Artocarpus heterophyllus, Lam.) in vitro on E. coli and S. aureus bacteria. The extraction method used was maceration with ethanol solvent and in vitro antibacterial activity testing using the paper disc method, as well as variations in extract concentrations, namely 12.5%, 25%, 50%, 75%, chloramphenicol as a positive control, and 5% DMSO as a negative control. The results showed that the ethanol extract contained various secondary metabolites, namely alkaloids, tannins, saponins, steroids/triterpenoids, and flavonoids. The ethanol extract of nangka leaf (Artocarpus heterophyllus, Lam.) has strong category potential as an antibacterial against E. coli and S. aureus.Keywords: Antibacterials; Escherichia coli; Nangka leaf; Staphylococcus aureus; Wound healing

Co-Authors Bayu Cakra Buana Chyntia Glori Tania Dameria Siahaan Denny Satria Esther Siringo ringo Hariyadi Dharmawan Syahputra Helen anjelina simanjuntak Helen Anjelina Simanjuntak Iksen Indah Yani Tambunan Mastiur Julianti Maya Amelia Sinaga Nasri Nasri Nasri Nasri Risanti Situmorang Saronom Silaban Sifikal Lumbangaol Syahrina Syahrina Vera Estefania Kaban Verawati Br. Sinaga Vivi Asfianti Zulmai Rani

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