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All Journal Media Gizi Pangan Al-Madrasah: Jurnal Ilmiah Pendidikan Madrasah Ibtidaiyah Jurnal Golden Age Jurnal Bahana Kesehatan Masyarakat (Bahana of Journal Public Health) Al-Sharf: Jurnal Ekonomi Islam Jurnal Ilmiah Wahana Pendidikan Jurnal Ilmiah Berkala: Sains dan Terapan Kimia
Sarmila Sarmila
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Religion Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Ilmiah Berkala: Sains dan Terapan Kimia

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Effect of Kelakai (Stenochlaena palutris) Extract on Organophosphate Pesticide Exposure: Cytotoxic Studies in Ovo and in Silico Nafisah Nafisah; Sarmila Sarmila; Hanna Habibah; Indah Saputri; Indah Setiawati; Noer Komari
Jurnal Sains dan Terapan Kimia Vol 17, No 2 (2023)
Publisher : Program Studi Kimia, Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jstk.v17i2.14583

Abstract

Vegetable farmers in South Kalimantan use pesticides to protect crops from pests. The active ingredient of the pesticide has a broad toxic effect on target and non-target organisms. Continuous exposure to pesticides causes cancer. The plant of mantle (Stenochlaena palustris) is thought to have potential cytotoxic activity against cancer cell growth. The aim of this study was to examine the potential activity of chemical compounds in anaplastic lymphoma kinase (ALK) exposed to organophosphate pesticides in silico and in ovo. The in silico study used molecular docking and virtual screening methods. The methanol extract of malachite was obtained by maceration method. The in ovo study was carried out by injecting pesticide compounds and methanol extracts of methanol at doses of 0.5 and 1 ppm to free-range chicken eggs. The results of the in silico analysis showed that ethion and neophytadiene had the most negative G values, namely -8.62 kcal/mol and -8.39 kcal/mol, while the natural ligand 8 LY A 500 was -9.19 kcal/mol. The similarity of the type and number of residues in the binding complex between ethion and neophyadiene ligands with ALK protein indicates the potential for competition between ethion and neophyadiene when bound to ALK protein. Neofitadiene is suspected as a compound that has potential as anti-cancer by inhibiting the growth of ALK. Anchovy extract is considered to be able to slow down the rate of cell damage in chicken embryos caused by ethion with its inhibitory ability so that the cell surface is not damaged quickly.
Co-Authors Abdul Ganing Anastasya Ameliya Juventy Angelina Risa Sonia Mita Anjur Perkasa Alam Dhita Afifah Diyan Yusri Fajar Akbar Hanna Habibah Indah Saputri Indah Setiawati Jusman Jusman Miftah Chairani Hairuddin Muhammad Majdi Nafisah Nafisah Nazwa Silviani Noer Komari Pertiwi, Adharina Dian Ramlan Asbar Sukmawati Sukmawati Zakaria Zakaria