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All Journal Jurnal Kimia Terapan Indonesia Pharmacology and Clinical Pharmacy Research Agroplantae: Jurnal Ilmiah Budidaya dan Pengelolaan Tanaman Perkebunan Jurnal Ilmiah Wahana Pendidikan

Abdul Mutalib

Unknown Affiliation

Author-ID : 3628241

Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Other

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Articles

Zingiber officinale var. Rubrum Reduces the Rate of Prostaglandin Production Fauzan Fikri; Nyi M. Saptarini; Jutti Levita; As'ari Nawawi; Abdul Mutalib; Slamet Ibrahim
Pharmacology and Clinical Pharmacy Research Vol 1, No 1
Publisher : Universitas Padjadjaran, Indonesia

In Indonesia, red ginger (Zingiber officinale var. Rubrum) is usually used as topical pain reducer by directly applying the fresh rhizome. The aim of this research was to provide information regarding the pharmacological activity of Z. officinale var. Rubrum rhizome infusion on the rate of prostaglandin production. The Z. officinale var. Rubrum rhizome used in this research was purchased from Research Institute for Spices and Medicinal Plants (Balittro) Manoko Lembang, West Java, Indonesia. This research was conducted by applying TMPD (N,N,N’,N’-tetramethyl-p-phenylendiamine) as the reagent. COX-1 and COX-2 enzyme inhibitory activity can be seen from TMPD chromogenic changes that occur during PGG2 reduction to PGH2. Phytochemical screening showed that flavonoid, quinone, and monoterpenoid/sesquiterpenoid were detected in both dried rhizomes and the water extract. Three spots were detected on thin-layer chromatography system which employing chloroform-methanol (5:5) as the eluent. The rate of prostaglandin formations either by Z. officinale var. Rubrum rhizome infusion or acetylsalicylic acid on COX-1 is slower (at 25th minutes) rather than COX-2 (5th minutes). We concluded that the rhizome of Z. officinale var. Rubrum reduces the rate of prostaglandin production. The rhizome of red ginger reduces the rate of prostaglandin production, which is slower in COX-1 than in COX-2. This plant could be further developed as anti-inflammatory drug candidate.Keywords: acetosal, antiinflammation, cyclooxygenase, NSAIDs, red ginger

Inhibitory Activity of Andrographolide and Andrograpanin on the Rate of PGH2 Formation Sri A. Sumiwi; Eli Halimah; Nyi M. Saptarini; Jutti Levita; As'ari Nawawi; Abdul Mutalib; Slamet Ibrahim
Pharmacology and Clinical Pharmacy Research Vol 1, No 3
Publisher : Universitas Padjadjaran, Indonesia

Cyclooxygenase (COX) or prostaglandin H2 synthase (PGHS) catalyzes the conversion of arachidonic acid into prostaglandins. Nonsteroidal anti-inflammatory drugs (NSAIDs) work by inhibiting both COX-1 and COX-2 isoforms, thus disturbing this reaction. In Indonesia, Andrographis paniculata (local name: sambiloto), is empirically used to reduce inflammation by consuming the herb tea of this plant. This work studied the inhibitory activity of andrographolide and andrograpanin, diterpenoids of the plant, on the rate of prostaglandin formation. Previous works have proven that andrographolide inhibited PGE2 production in LPS-induced human fibroblast cells. This study was performed by measuring the absorbance of TMPD (tetramethyl-p-phenyldiamine) oxidized by andrographolide and andrograpanin. Acetosal was used as a control drug. The rate of PGH2 formations on either COX-1 or COX- 2 was affected by andrographolide and andrograpanin. Andrographolide and andrograpanin interact longer with COX-1 than COX-2. Andrographolide shows weak inhibition on the rate of PGH2 formation, whilst andrograpanin might be further developed for potential antiinflammatory drugs.Keywords: Andrographis paniculata, anti-inflammatory, COX, cyclooxygenase, prostaglandin

Kebijakan Adopsi Nilai-Nilai Agama (Islam) dalam Pembaharuan Hukum Pidana Indonesia Abdul Mutalib; Nur Azizah Rahman
Jurnal Ilmiah Wahana Pendidikan Vol 6 No 3 (2020): JURNAL ILMIAH WAHANA PENDIDIKAN
Publisher : Peneliti.net

The first principle shows that Indonesia is a country that recognizes the existence of God, a religious state, a state that has criminal rules, which in practice should not have conflict with religious values and laws adhered to by society. This research discusses the criminal provisions on offense of living together by not having married (zina) in the Criminal Code Bill (RUU KUHP), which is based on religious values and criminal policies in the formulation of the Criminal Code. This research is intended to answer the problems regarding: what are the challenges, opportunities and formulation construction (ideas) in the policy of the Bill on the Criminal Code article 485 concerning about living together without being married (zina). The research method used is normative juridical method with qualitative analysis. The data analysis uses normative qualitative analysis by interpreting and constructing the statements contained in the Criminal Code Bill (RUU KUHP) which become positive legal norms. While qualitative, namely analyzing data that has the starting point of the discovery effort. The results of the study state that the current provisions of criminal acts of decency are not based on religious values.

Profil Distribusi dan Klirens Pengkontras CT SCAN AuNP-PAMAM G4- NIMOTUZUMAB disimulasikan menggunakan Senyawa 198AuNP-PAMAM G4-NIMOTUZUMAB Adang H G; Anung Pujiyanto; Abdul Mutalib; Rista A S; Indrarini L; Rien L; Iyus M Y; Herlan S; Sutriyo C
Jurnal Kimia Terapan Indonesia Vol 18, No 01 (2016)
Publisher : Research Center for Chemistry - LIPI

Riset nanopartikel emas sebagai senyawa pengkontras CT-Scan telahdimulai sejak 3 tahun lalu di Indonesia. Riset interaksi antibodi monoklonal,khususnya nimotuzumab, dengan reseptor EGFR/HER1 dimulai sejak lima tahun lalu dan telah dimanfaatkan untuk penyiapan senyawa pengkontras MRI (Magnetic Resonance Imaging) spesifik target melalui pelabelan konjugat dendrimer-nimotuzumab dengan radionuklida. Sintesis senyawa AuNP-PAMAM G4-Nimotuzumab untuk diagnosis dan terapi pada kanker paru-paru telah berhasil dilakukan di PTRR dan hasil karakterisasinya dengan menggunakan beberapa metode seperti KCKT (Kromatografi Cair Kinerja Tinggi), SDS (Sodium Dodecyl Sulphate) page elektroforesa dan TEM (Transmission Electron Microscopy) menunjukkan bahwa senyawa yang terbentuk adalah sebagai AuNP-PAMAM G4-Nimotuzumab. Pada penelitian ini telah dilakukan uji pre klinis dari senyawa pengkontras AuNPPAMAM G4-nimotuzumab meliputi uji distribusi dan klirens dengan disimulasikan menggunakan senyawa radioaktiv 198AuNP-PAMAM G4- nimotuzumab. Hasil uji distribusi senyawa 198AuNP-PAMAM G4- nimotuzumab menunjukkan penimbunan pada beberapa organ seperti ginjal, hati dan limpa, sedangkan dari hasil uji klirens diperoleh waktu paruh biologis senyawa tersebut adalah 11.77 hari. Hasil pemeriksaan terhadap urin dengan menggunakan kolom PD-10 (Sephadex G25) menunjukkan bahwa ~ 85 % yang dikeluarkan lewat urin masih berbentuk AuNP-PAMAM G4- Nimotuzumab. Hasil pencitraan dengan alat autoradiography menunjukkan bahwa sampai dengan 48 jam setelah penyuntikan, akumulasi radioaktivitas yang terdeteksi masih terdapat pada hati.Â

EFEKTIFITAS BIOAMELIORAN SEBAGAI PEMBENAH TANAH PADA TANAMAN CABAI KERITING (Capsicum annuum L.) Mu'minah Mu'minah; Junyah Leli Isnaini; Baso Darwisah; Abdul Mutalib; Andi Besse Poleuleng; Syarif Ismail; Andi Mega Ayu Lestari; Muhammad Nasrul
Agroplantae: Jurnal Ilmiah Terapan Budidaya dan Pengelolaan Tanaman Pertanian dan Perkebunan Vol 12 No 2 (2023): Agroplantae: Jurnal Ilmiah Terapan Budidaya dan Pengelolaan Tanaman Pertanian da
Publisher : Jurusan Budidaya Tanaman Perkebunan, Politeknik Pertanian Negeri Pangkajene Kepulauan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51978/agro.v12i2.701

Bioameliorant as a soil enhancer acts as a bioferlizer because it can provide fertility to the soil and improve the physical, chemical and biological properties of the soil. This research aims to see and determine the effect of various concentrations of Bioameliorant (soil enhancer) and organic materials on the growth of curly red chili plants. This study used a Randomized Block Design (RAK) with 4 doses of bioameliorant treatment, namely: control (B0) without bioameliorant, (B1) 10 ml/l water (B2) 15 ml/l water and (B3) 20 ml/l water. Each treatment consisted of 2 units consisting of 3 groups so there were 24 experimental units. The dose of organic material given is 30 tons/ha or the equivalent of 53 grams/polybag. The experimental results showed that giving bioameliorant to curly chili plants with a concentration (B3) of 20 ml/l of water showed the highest growth in plant height (109.66 cm), large number of leaves (31.33), large number of branches (15.33 branches). , the highest number of fruit (22.66 pieces) and the heaviest fruit weight (61.96 grams) and the heaviest root weight (18.02 grams). Based on the experimental results, it can be concluded that the application of bioameliorants (soil amendments) and organic materials gave the best results in treatment with a concentration of 20 ml/liter of water on the growth of curly chili plant

Co-Authors Adang H G Andi Besse Poleuleng Andi Mega Ayu Lestari Anung Pujiyanto As'ari Nawawi Baso Darwisah Eli Halimah Fauzan Fikri Herlan S Indrarini L Iyus M Y Junyah Leli Isnaini Jutti Levita Mu'minah Mu'minah Muhammad Nasrul Nur Azizah Rahman Nyi M. Saptarini Nyi M. Saptarini Rien L Rista A S Slamet Ibrahim Sri A. Sumiwi Sutriyo C Syarif Ismail

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