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L N Sutardi
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Agriculture, Biological Sciences & Forestry

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Stabilitas Fisikokimia dan Sifat Antipenuaan Kulit Formula Krim Berbahan Aktif Alami (Physicochemical stabilities and Skin Antiaging Properties of Bioaktive-based Cream Formulas) Rita K Sari; Nyoman J Wistara; Deded S Nawawi; Nopen Meisaroh; Ietje Wientarsih; D R Agungpriyono; L N Sutardi; Mawar Subangkit; Vetnizah Juniantito
Jurnal Ilmu dan Teknologi Kayu Tropis Vol 15, No 1 (2017): Jurnal Ilmu dan Teknologi Kayu Tropis
Publisher : Masyarakat Peneliti Kayu Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (525.345 KB) | DOI: 10.51850/jitkt.v15i1.366

Abstract

 The purpose of this study was  to analyze the physicochemical stabilities  and in vivo antiaging  properties of the cream formulas of F1, F2, and F3 which contained the active compound of 0.1% 0.18, and 0.36%, respectively. The active compound was the combination of  ethyl acetate fraction of  Toona sinensis, Centella asiatica, and Acacia mangium  leaf (1:2:1). For physicochemical stability tests (color, odor, acidity, and antioxidant activity), the creams were stored for 21 days in the refrigerator, room temperature,   and extreme temperature (±40 ⁰C). For in vivo antiaging test,  the mice skin  were smeared with cream and UV irradiated for 15 minutes per day. After two and four weeks, the mice skins were  biopsied. The results showed that the physicochemical properties of creams stored in the refrigerator were  stable. The storage of creams at room and  extreme temperature decreased the physicochemical properties.  The application of cream formulas on mice skin after two to four weeks were able to increase the thickness of epidermis, but has not been able to increase the collagen skin of mice.Keywords: Acacia mangium, Centella asiatica, ethyl acetate fraction of leaf, physicochemical and antiaging properties of cream, Toona sinensis
Aktivitas Antioksidan Ekstrak Daun Surian, Mangium, dan Pegagan serta Kombinasinya dalam Formula Krim (Antioxidant Activities of Mangium, Surian, and Pegagan Leaf Extracts and Its Combination in Cream Formulas) Rita K Sari; Nyoman J Wistara; Deded S Nawawi; Itje Wintarsih; Dewi R Agungpriyono; L N Sutardi; Mawar Subangkit; Vetnizah Juniantito
Jurnal Ilmu dan Teknologi Kayu Tropis Vol 14, No 2 (2016): Jurnal Ilmu dan Teknologi Kayu Tropis
Publisher : Masyarakat Peneliti Kayu Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (428.87 KB) | DOI: 10.51850/jitkt.v14i2.398

Abstract

The simplicia properties of toona (TS), mangium (AM), and centella (CA) leaves and antioxidant activities of their ethanolic leave extract and their combinations in cream formulas were examined in the present reserach. The ethanolic extracts were partitioned with n-hexane and ethyl acetate. The antioxidant activity of the fractions and their combinations were tested against DPPH. The best combination was formulated in F1, F2, and F3 cream formulas with 0.1, 0.18, and 0.36% of extract, respectively. The formulas antioxidant activity was then tested. The results showed that the water content, ash content, and acidic insoluble ash content of TS, AM, and CA simplicias were ±10%, 3.8-9.7%, and 0.9-1.2% respectively. The yields of n-hexane (FN), ethyl acetate (FEA), and residues (FR) fractions were 6-9, 2, and 5-6% respectively. The antioxidant activity of FEA, FR, and FN was very strong, strong, and weak to inactive, respectively. The best combination was the mixture of 2/3CA, 1/6AM, and 1/6TS (IC50 9 μg ml-1). The antioxidant activity of all cream formulas were higher than refered commercial cream. The IC50 values of formula 1, 2, and 3 were 1109, 596, and 202 μg ml-1, respectively, while the IC50 of refered commercial cream was 2372 μg ml-1.Keywords: antioxidant, centella, cream, extract, mangium, toona
Co-Authors D R Agungpriyono Deded Sarip Nawawi Dewi R Agungpriyono I Nyoman Jaya Wistara IETJE WIENTARSIH Itje Wintarsih Nopen Meisaroh Rita Kartika Sari Subangkit, Mawar Vetnizah Juniantito