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All Journal Pharmascience JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Jamu Indonesia Jurnal Farmamedika (Pharmamedica Journal) SULUH: Jurnal Abdimas Abdi Implementasi Pancasila: Jurnal Pengabdian kepada Masyarakat
Anarisa Budiati
Fakultas Farmasi, Universitas Pancasila
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Control & Systems Engineering Education Environmental Science Immunology & microbiology Library & Information Science Medicine & Pharmacology Social Sciences Other

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Formulasi dan Aktivitas Gel yang Mengandung Nanopartikel Ekstrak Temulawak sebagai Antiacne Anastasya Anastasya; Deni Rahmat; Anarisa Budiati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (400.066 KB) | DOI: 10.35814/jifi.v18i1.846

Abstract

Javanese turmeric is one of the Indonesia’s authentic plant that has many benefits, antimicrobial effect is one of them. Curcuminoid and xanthorrhizol contents are responsible for it's antimicrobial activity. Acne vulgaris is one of skin’s disorder that caused by bacteria, the major cause is Propionibacterium acnes. This study aimed to compare antimicrobial activity difference between nanoparticle and extract gel. Javanese turmeric was extracted and then formulated into nanoparticles. Javanese turmeric extract and it's nanoparticles were then formulated in gel preparation. Gel preparations were evaluated physically (organoleptic, homogeinity, spreadibility, and viscosity and rheology), chemically (pH value), and tested for their antimicrobial activity. Gel evaluations showed that both formula (nanoparticle and extract gel formula) did not show any discoloration and still homogeny. Extract gel formula had viscosity about 1540–1600 Ps, while nano extract gel had viscosity in the range of 487.63–501.01Ps. Extract gel formula had spreadability in the range of 51.75-53.35 mm, while nano extract gel has viscosity in the range of 65.125-72.75 mm. Extract gel formula had pH value in the range of 5.98–6.02, while nano extract gel had pH value in the range of 5.88–5.93. Extract gel formula has inhibition zone in the range of 10.0 mm–10.3 mm, while nanoextract gel has inhibition zone in the range of 13.0 mm–13.4 mm. Based on statistical paired sample t-test analysis, nano extract gel formula was signifi cantly different from extract gel formula in antimicrobial activity.
Pengembangan Produk Gel Sabun Wajah Ekstrak Buah Belimbing Wuluh (Averrhoa bilimbi L.) dan Daun Sosor Bebek (Kalanchoe pinnata (Lam.) Per.) sebagai Anti Bakteri Penyebab Jerawat ANARISA BUDIATI; ANNY VICTOR PURBA; SHIRLY KUMALA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (369.098 KB)

Abstract

Averrhoa bilimbi L. fruits and Kalanchoe pinnata (Lam.) Per. leaves are useful as anti bacterial. The extracts containing the compound bufadienolides have the potential to be used as an anti bacterial. The purpose of this study to fi nd the best formula of the preparation facial wash gel with the active substance from the combination of extracts. Search methods extract concentration using the agar diff usion to obtain regional Diameter Inhibition (DDH) of each extract and the combinations. Research conducted with 3 forrmula containing extracts with diff erent concentrations. The results of the evaluation of the preparation at room temperature storage does not change the color, shape and scent. Retrieved best formula is the formula I containing a concentration of 0.7% resulting extract preparations light green and scented perfume. The results of the evaluation of the formula I at room temperature after 3 month storage include: high foam in hard water 17 mL, high foam in distilled water >25 mL, the specifi c gravity 1.0386 g/cm3, surface tension 19, 3627 dyne/cm, viscosity 853,33-1103,33 cPs, pseudoplastis fl ow properties, pH 5.16, anti bacterial test results using Diameter test Inhibitory Region shows constraints on Staphylococcus aureus by 5,0±0 mm.
Antioxidant and Sunscreen Activity from Nanoparticles Extract of Temulawak Rhizome (Curcuma Xanthorrhiza Roxb.) And Formulation in The Form of A Cream Anarisa Budiati; Deni Rahmat; Zahirah Alwiyah
Jurnal Jamu Indonesia Vol. 6 No. 2 (2021): Jurnal Jamu Indonesia
Publisher : Pusat Studi Biofarmaka Tropika LPPM IPB; Tropical Biopharmaca Research Center - Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v6i2.212

Abstract

Temulawak (Curcuma xanthorrhiza Roxb.) is a medicinal plant for the raw material of traditional medicine in Indonesia. Temulawak can be a source of antioxidants and natural sunscreen because of its curcumin content. This study was conducted to determine antioxidant and sunscreen activity on Curcuma rhizome extract and nanoparticles extract and making cream preparations. Extraction using the maceration methods with 96% ethanol solvent, concentrated with a rotary evaporator and the thick extract of Curcuma rhizome was made into nanoparticles by ionic gelation methods. Spray drying methods dried the nanosuspension of Curcuma rhizome extract. The nanoparticles formed were evaluated for particle size, zeta potential and particle morphology. The dry powder nanoparticles and extract of Curcuma rhizome were tested for antioxidant activity by DPPH (2,2-diphenyl-1-picrylhydrazyl) methods and sunscreen using a UV-Vis spectrophotometer at λ = 290-340 nm. The antioxidant activity showed the IC50 value of the Curcuma rhizome extract was 78.30 μg/mL and nanoextract was 116.51 μg/mL. The sunscreen testing result showed that the SPF (Sun Protective Factor) value of Curcuma rhizome extract at a concentration of 0,012% was 14.14 and nanoextracts at a concentration of 0.04% was 7.73. Curcuma rhizome extract has relatively strong antioxidant activity, while the nanoextract was moderate. The sunscreen activity of Curcuma rhizome extract and nanoextract has maximum protection and extra protection.
FORMULASI NANOSUSPENSI EKSTRAK KERING RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb.) DENGAN METODE GELASI IONIK DAN UJI AKTIVITAS ANTIOKSIDAN Moch Futuchul Arifin; Yuslia Noviani; Anarisa Budiati; Isnaini Hidayanti
Jurnal Farmamedika (Pharmamedika Journal) Vol 7 No 2 (2022): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v7i2.163

Abstract

Temulawak (Curcuma xanthorhiza Roxb.) mengandung kurkumin berkhasiat sebagai antioksidan. Rendahnya kelarutan, ketersediaan hayati dan stabilitas menjadi kendala untuk dikembangkan sebagai sediaan oral. Tujuan penelitian adalah memformulasi ekstrak kering menjadi nanosuspensi antioksidan dengan metode gelasi ionik. Dilakukan optimasi nanosuspensi terhadap empat formula yang mengandung konsentrasi ekstrak kering sebesar : 100-700 x IC50. Penetapan formula optimum dari ke-empat formula berdasarkan: stabilitas, ukuran partikel dan indeks polidispersitas. Formula optimum dikarakterisasi meliputi: morfologi, potensial zeta, efisiensi penjerapan dan aktivitas antioksidan dengan metode DPPH. Formula dengan 100 x IC50 paling stabil, ukuran partikel 300,4 nm dan indeks polidispersitas 0,292 ditetapkan sebagai formula optimum. Hasil karakterisasi nanosuspensi formula optimum: potensial zeta +47,7; efisiensi penjerapan 63,49% dan aktivitas antioksidan IC50, 30,22 bpj. Ekstrak kering dapat diformulasikan sebagai nanosuspensi antioksidan dan berpotensi dikembangkan sebagai sediaan oral.
PKM PENGEMBANGAN USAHA DESINFEKTAN DAN ANTISEPTIK BERBAHAN DAUN BIDARA PADA ASPEK PRODUKSI DAN E-MARKETING Diah Kartika Pratami; Agung Saputra; Anarisa Budiati; Desi Nadya Aulena; Safira Nafisa; Moordiani
SULUH: Jurnal Abdimas Vol 4 No 1 (2022): SULUH: Jurnal Abdimas Agustus
Publisher : FEB-UP Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/suluh.v4i1.3512

Abstract

Tujuan kegiatan PKM membantu UKM yang memproduksi antiseptik dan desinfektan yang mengandung daun bidara dan serai wangi dalam permasalahan standardisasi produk, pemenuhan SNI, dan membuat sistem penjualan distributor/kegenan/reseller dengan memanfaatkan sistem teknologi informasi. Metode yang digunakan pemenuhan standard produk dengan pengujian potensi antimikroba produk di laboratorium FFUP. Kedua, membangun sistem teknologi informasi dengan membuatkan sistem informasi untuk kegiatan manajerial, distribusi dan pemasaran dengan metode less contact economy. Ketiga, melakukan pendampingan pembuatan konten produk untuk mengoptimalkan pemasaran online dan digital branding sebagai sarana komunikasi dengan target konsumennya. Hasil yang diperoleh UKM memperoleh sertifikat analisis produksi yang memenuhi standard mutu dan keamanan; dapat tercapai transfer knowledge metode produksi, pemastian mutu dan kualiti kontrol agar produk yang dihasilkan sesuai standard; terbentuknya sistem teknologi informasi dalam kegiatan manajerial, distribusi dan pemasaran produk yang bersifat less contact economy; serta tercapainya media online yang berisi konten edukasi kepada masyarakat. Luaran yang dihasilkan berupa prototipe produk yang telah memenuhi standard mutu dan keamanan sesuai regulasi Kemenkes, video kegiatan PKM di Youtube, pemberitaan di media massa, materi narasumber untuk digital branding, dan satu publikasi artikel ilmiah.
SOSIALISASI PENCEGAHAN VIRUS COVID-19 MELALUI PROGRAM “SADAR, PEDULI, DAN LINDUNGI” Oktavian Dafa Kusuma; Anarisa Budiati
Abdi Implementasi Pancasila:Jurnal Pengabdian kepada Masyarakat Vol 2 No 1 (2022): Mei
Publisher : Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (178.274 KB) | DOI: 10.35814/abdi.v2i1.3511

Abstract

Pandemi Covid-19 merupakan sebuah fenomena global yang melanda dunia, termasuk Indonesia. Sebagai bentuk respon pemerintah terhadap kekhawatiran masyarakat, ditetapkanlah berbagai regulasi dengan harapan dapat memberikan rasa tenang. Masyarakat yang pada awalnya menolak, sekarang menjadi mengikuti tanpa paksaan. Program kerja Sadar, Peduli, dan Lindungi terdiri dari tiga kegiatan, yaitu Cuci Tangan, Masker Dobel, dan Literasi Digital: Hoaks dan Tautan Palsu. Program kerja dijalankan melalui tahap observasi, pelaksanaan, dan evaluasi selama 20 hari dengan metode observasi dan wawancara menggunakan instrumen pedoman wawancara. Media yang digunakan dalam kegiatan sosialisasi adalah poster, flyer, dan PowerPoint. Program kerja “Sadar, Peduli, dan Lindungi” berjalan lancar sesuai dengan harapan, masyarakat yang bergabung dan berpartisipasi merasa terbantu dengan informasi yang disampaikan.
FORMULASI SEDIAAN SUSPENSI EKSTRAK KERING UMBI TALAS JEPANG ( Colocasia esculenta (L.) Schott ) MENGGUNAKAN PENSTABIL NA – CMC UNTUK MENANGANI STUNTING Anarisa Budiati; Mochammad Futuchul Arifin; Yati Sumiyati; Dinda Indra Antika
Jurnal Farmamedika (Pharmamedika Journal) Vol 8 No 1 (2023): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v8i1.191

Abstract

Umbi talas jepang (Colocasia esculenta (L.) Schott) dibudidayakan di Indonesia mengandung zat besi dan zink yang digunakan untuk menangani stunting. Ekstak kering umbi talas dikembangkan menjadi sediaan cair suspensi, mudah digunakan serta lebih disukai oleh anak-anak. Formulasi sediaan suspensi dibuat dengan variasi suspending agent Na-CMC dengan konsentrasi 0,2% dan 0,4% serta variasi wetting agent Propilenglikol dengan konsentrasi 10% dan 15%. Dilakukan uji evaluasi yaitu: uji organoleptik, viskositas, pH, redispersi, dan volume sedimentasi. Didapat formula terbaik yaitu formula 1 dengan betuk cair, warna merah muda, rasa manis strawberry dan aroma strawberry, pH 6, viskositas 230 cPs, redispersi 7x kocokan, dan volume sedimentasi pada menit ke-15 yaitu 0,18 dan hasil uji stabilitas selama 14 hari pada suhu kamar (25 oC) dan suhu 40 oC menunjukkan terdapat perbedaan yang siginifikan dari suhu dan lamanya penyimpanan terhadap viskositas larutan dan sedimentasi larutan.
Formulasi Gel Ekstrak Daun Sosor Bebek (Kalanchoe pinnata (Lam.) Per.) dengan Kombinasi Carbophol 980 dan Cremophor RH 40 Kartiningsih Kartiningsih; Rika Damayanti; Anarisa Budiati
Jurnal Pharmascience Vol 10, No 1 (2023): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i1.13272

Abstract

Daun sosor bebek (Kalanchoe pinnata P.) merupakan tanaman obat yang diketahui memiliki aktivitas antiseptik. Tujuan dari penelitian ini untuk melihat pengaruh konsentrasi Carbophol 980 dan Cremophor RH 40 terhadap mutu fisik dan pH sediaan gel ekstrak kental daun sosor bebek yang dianalisa dengan metode ANOVA satu arah. Daun sosor bebek diekstrasi dengan metode maserasi menggunakan etanol 96%, kemudian diformulasikan menjadi sediaan gel dengan kombinasi Carbophol 980 sebagai gelling agent dan Cremophor RH 40 sebagai wetting agent. Sediaan gel dibuat 8 formula dengan variasi konsentrasi Carbophol 980 0,5% dan 1,0%, dan Cremophor RH 40 0,5%; 1,0%; 1,5%; dan 2.,%. Sediaan gel yang diperoleh dilakukan evaluasi meliputi pemeriksaan organoleptik, homogenitas, viskositas dan sifat alir, kemampuan menyebar, dan pH. Sediaan gel yang diperoleh berwarna coklat, berbau parfum, dan jernih, viskositas pada rpm 0,5 berkisar 430,67–1015, 33 dPa.s, sifat alir plastis, kemampuan menyebar 2491,20–2111,77 mm2, pH 5,0–5,6. Hasil uji statistic menggunakan ANOVA satu arah dengan α 5%, didapat bahwa variasi konsentrasi Carbophol 980 dan Cremophor RH 40 memberikan perbedaan yang bermakna terhadap viskositas, kemampuan menyebar, dan pH. Berdasarkan hasil evaluasi didapatkan formula 5 yang menggunakan Carbophol 980 dan Cremophor RH 40 pada konsentrasi 0,5% sebagai formula terbaik.       Kata Kunci: Variasi onsentrasi, Carbophol 980, Cremophor RH 40, Gel, Ekstrak Daun Sosor Bebek  Duck bill leaf (Kalanchoe pinnata P.) is a medicinal plant known to have antiseptic activity. The purpose of this study was to examine the effect of the concentration of Carbophol 980 and Cremophor RH 40 on the physical quality and pH of the thick extract gel preparations of duck bill of leaf extract which was analyzed by one way ANOVA method. Duck bill leaves were extracted by maceration method using 96% ethanol, then formulated into a gel preparation with a combination of Carbophol 980 as a gelling agent and Cremophor Rh 40 as a wetting agent. The gel preparations were made of 8 formulas with various concentrations of Carbophol 980 0.5% and 1.0%, and Cremophor RH 40 0.5%, 1.0%, 1.5%, and 2.0%. The obtained gel preparations were evaluated including organoleptic examination, homogeneity, viscosity and flowability, dispersibility, and pH. The gel preparation obtained was brown in color, smelled of perfume, and was clear, viscosity at rpm 0.5 ranged from 430.67–1015, 33 dPa.s, plastic flowability, dispersibility 2491.20–2111.77 mm2, pH 5.0–5.6. The results of statistical tests using one-way ANOVA with 5%, it was found that variations in the concentration of Carbophol 980 and Cremophor RH 40 gave significant differences in viscosity, dispersibility, and pH. Based on the evaluation results obtained formula 5 which uses Carbophol 980 and Cremophor RH 40 at a concentration of 0.5% as the best formula.
Co-Authors Agung Saputra Anastasya Anastasya Anny Victor Purba Deni Rahmat Desi Nadya Aulena Diah Kartika Pratami Dinda Indra Antika Isnaini Hidayanti Kartiningsih Kartiningsih Moch Futuchul Arifin Mochammad Futuchul Arifin Moordiani Oktavian Dafa Kusuma Rika Damayanti Safira Nafisa Shirly Kumala Yati Sumiyati YUSLIA NOVIANI Zahirah Alwiyah