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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia Jurnal Sains dan Teknologi Pangan Science and Technology Indonesia JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) AL MUNIR : Jurnal Komunikasi dan Penyiaran Islam
Lili Fitriani
Department Of Pharmaceutics, Faculty Of Pharmacy, Universitas Andalas
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences

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Formulasi Mikroenkapsulasi Protein dalam Poli(D,L-Laktida) dengan Teknik Penguapan Pelarut Fitriani, Lili; Rachmawati, Heni; Suciati, Tri
Jurnal Sains dan Teknologi Farmasi Vol 15 No 1 (2010)
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Poly (D,L-lactide acid) has been used as scaffold and controlled release device for protein such as growth factor in tissue engineering. In this study, PDLLA microparticles were made and papain was used as model protein. Protein was encapsulated in microparticles using water-oil-water (W1/O/W2) and solid-oil-water (S/O/W) emulsification-solvent evaporation. Types of encapsulation methods and ratios of papain-PEG 20000 were observed in this study to provide the highest encapsulation efficiency. The entrapment efficiency made by W1/O/W2 method was 6,38%±0,025,  whilst S/O/W using ratios of papain-PEG 20000 1:1 ; 1:4 ; and 1:5 were 6,24%±0,91 ; 30,15%±1,66 and 60,67%±4,93, respectively. To conclude, S/O/W is the best method to encapsulate protein with highest entrapment efficiency.
FORMULASI MIKROPARTIKEL BERPORI DALAM POLI (D,L-Laktida) SEBAGAI SCAFFOLDDENGAN TEKNIK EMULSIFIKASI PENGUAPAN PELARUT Fitriani, Lili; Suciati, Tri
Jurnal Riset Kimia Vol 4, No 2 (2011): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v4i2.120

Abstract

 ABSTRACT Poly (D,L-lactide acid) has been used as scaffold for tissue engineering. In this study, PDLLA microparticles were made into porous microparticles. Porous microparticles were proposed to reduce burst release of protein and to prevent diffusion of released protein into non-target tissue. Formulation of porous microparticles was made by water-oil-water (W1/O/W2) emulsification-solvent evaporation using gas foamed as porogen. Variations of the amount of sodium bicarbonate, volume of citric acid solution and time for homogenization were optimized to produce optimum formulation. Evaluation for this microparticles included morphology of particles, particle size distribution and porosity. Porous microparticle produced by ratio volume of acid : dichloromethane : poly(vynil alcohol) (PVA) = 1:3:3 and the ratio of  sodium bicarbonate : PDLLA = 2:3 was the optimum formulation.  Keywords :Porous Microparticles, PDLLA,Gas Foamed, Scaffold, Solvent Evaporation 
Mengkaji Program Padi Tanam Sabatang (Pts) dari Kaca Mata Teori Difusi Inovasi Fitriani, Lili
AL MUNIR : Jurnal Komunikasi dan Penyiaran Islam Volume 4 Nomor 2 Tahun 2013
Publisher : Universitas Islam Negeri Imam Bonjol Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15548/amj-kpi.v0i0.743

Abstract

Pengelolaan Tanaman Terpadu (PTT) or better known as a Paddy Cultivation (Padi Tanam Sabatang/PTS) is an flagship program of the Ministry of Agriculture in order to self-sufficiency in West Sumatra. This program was introduced on 2007. Since the program was introduced in the last 7 years, there are still a lot of farmers who are interested in applying this technology. Thus, the author is interested in reviewing the PTS program from perspective of the diffusion of innovation theory within communication science.Therefore, the author conducted a qualitative research to examine the issu. Data collection conducted by in-depth interview, observation, and documentation, then presented in descriptive qualitative method.The research concluded that Padang government performs the difusion of innovation by applied conventional mass media and interpersonal media, while the hybrid media has not been used. The medium considered effective is the Field School (Sekolah Lapang/SL). The inhibiting factors are 1). Complexity of the PTS Program, 2). The government has not attempted to perform diffusion programs to to the land owners who are not farmers.
KAJIAN PENGEMBANGAN PRODUK COOKIES BERBASIS TEPUNG UBI JALAR UNGU (Ipomoea batatas L) FERMENTASI DENGAN SUBSTITUSI BUBUK KAKAO (Theobroma cacao) UNTUK MENGHASILKAN PRODUK COOKIES Fitriani, Lili; tamrin, tamrin; Sadimantara, Muhammad Syukri
Jurnal Sains dan Teknologi Pangan Vol 5, No 2 (2020): JURNAL SAINS DAN TEKNOLOGI PANGAN
Publisher : JURUSAN ILMU DAN TEKNOLOGI PANGAN, UNIVERSITAS HALU OLEO

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (665.348 KB) | DOI: 10.33772/jstp.v5i2.12027

Abstract

The purpose of this research was to develop cookies based on fermented purple sweet potato (Ipomoea batatas) flour with cocoa (Theobroma cacao) powder substitution. The study was conducted using a Completely Randomized Design (CRD) with the formulation of purple sweet potato flour with cocoa powder of 100% (K0), 95%:5% (K1), 90%:10% (K2), 85%:15% (K3), and 80%:20% (K4). Data were analyzed using analysis of variance (ANOVA) followed by DMRT (Duncan's Multiple Range Test) at a 95% confidence level (α = 0.05). The results show that the composition of 95% fermented purple sweet potato flour and 5% cocoa powder had a very significant effect on the organoleptic assessment of color, aroma, and taste but it had no significant effect on texture. The most preferred treatment was the K1 (90 + 5%) samples with organoleptic scores of color, aroma, taste, and texture reached 1.36 (very dislike), 3.69 (like), 3.69 (like), and 3.41 (slightly like), respectively. The nutritional analysis shows that the K1 sample had 4.53% water, 3.05% ash, 9.27% protein, 31.22% fat, 51.93% carbohydrate, and antioxidant activity of 1609 ppm. The results show that cookies made from fermented purple sweet potato flour and cocoa powder substitution was accepted (preferred) by panelists and met national standards, except for carbohydrate content.  Keywords: cookies from fermented purple sweet potato flour, organoleptic, nutritional valueABSTRAKTujuan dari penelitian ini adalah untuk pengembangan produk cookies berbasis tepung ubi jalar ungu (Ipomoea batatas) fermentasi dengan penambahan bubuk kakao (Theobroma cacao), penelitian dilakukan menggunakan Rancangan Acak Lengkap (RAL). Dengan formulasi Tepung Ubi jalar ungu dengan bubuk kakao100%(K0), 95% : 5% (K1), 90% : 10% (K2), 85% : 15% (K3), 80% : 20% (K4).Data dianalisis menggunakan analysis of variances (ANOVA) dilanjutkan dengan uji beda nyata yaitu DMRT (Duncan’s Multiple Range Test) pada taraf kepercayaan 95% (α=0,05). Hasil penelitian menunjukan bahwa komposisi tepung ubi jalar ungu fermentasi 95% dan bubuk kakao 5% berpengaruh sangat nyata terhadap penilaian organoleptik warna, aroma dan rasa serta tidak berpengaruh nyata pada tekstur. Perlakuan terpilih diperoleh pada penambahanK1(90+5%) dengan kategori penilaian warna dengan nilai 1,36 (sangat tidak suka), aroma 3,69 (suka), rasa 3,69 (suka), dan tekstur 3,41 (agak suka). Nilai gizi yaitu kadar air sebesar 4,53%, kadar Abu 3,05%, kadar protein 9,27%, kadar lemak 31,22%, kadar karbohidrat 51,93%, dan aktivitas antioksidan 1609 ppm.Berdasarkan hasil penelitian produk cookies formulasi tepung ubi jalar ungu fermentasi dan substitusi bubuk kakao dapat diterima (disukai) oleh panelis dan telah memenuhi standar SNI terkecuali kadar karbohidrat.
PEMBENTUKAN MULTIKOMPONEN KRISTAL PIPERIN DAN KUERSETIN Adhitya Jessica; Rifka Naura; Uswatul Hasanah; Erizal Zaini; Lili Fitriani
JURNAL FARMASI DAN MAKANAN Vol 4 No 2 (2021): Journal Of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v4i2.1881

Abstract

Penggunaan klinis piperin masih terbatas karena memiliki kelarutan rendah di dalam air. Kuersetin dikenal sebagai bioenhancer yang dapat meningkatkan bioavailibilitas senyawa lain. Penelitian ini bertujuan untuk meningkatkan kelarutan piperin dengan memodifikasinya menjadi bentuk multikomponen kristal bersama kuersetin. Pembentukan multikomponen kristal piperin-kuersetin dilakukan menggunakan metode solvent drop grinding (SDG). Multikomponen dikarakterisasi dengan Differential Scanning Calorimetry (DSC), Powders X-Ray Diffraction (PXRD) dan spektroskopi FTIR.Evaluasi multikomponen dilakukan dengan uji kelarutan dan hasilnya dianalisis menggunakan KCKT.Termogram DSC menunjukkan tidak adanya puncak endotermik baru yang berbeda nyata dari kedua komponen. Pola difraksi sinar-X multikomponen kristal piperin-kuersetin menunjukkan difraktogram yang serupa dengan komponen penyusun, yang mengindikasikan tidak terbentuknya fase kokristalin. Karakterisasi menggunakan FTIR menunjukkan hampir tidak ada pergeseran puncak serapan gugus fungsi piperin pada multikomponen kristal. Uji kelarutan dilakukan terhadap senyawa tunggal piperin, campuran fisik piperin-kuersetin dan multikomponen piperin-kuersetin (1:1) yang dibuat dengan metode SDG. Campuran fisik dan multikomponen piperin-kuersetin yang dibuat dengan metode SDG meningkatkan kelarutan piperin sebesar 1,475 kali lipat dan 1,389 kali lipat jika dibandingkan dengan piperin murni.
Studi Awal Sediaan Gel Ekstrak Etanol Kayu Angin (Usnea Sp) untuk Penyembuhan Luka Bakar Lili Fitriani; Fauzi Saputra; Melisa Melisa; Erizal Zaini
Jurnal Sains Farmasi & Klinis Vol 5, No 2 (2018): J Sains Farm Klin 5(2), Agustus 2018
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6808.499 KB) | DOI: 10.25077/jsfk.5.2.83-87.2018

Abstract

Telah dilakukan studi awal formulasi dari ekstrak etanol kayu angin (Usnea sp) dalam bentuk sediaan gel dan uji efektivitas sediaan gel terhadap penyembuhan luka bakar pada mencit. Sediaan gel dibuat menggunakan hidroksipropil metilselulosa (HPMC) sebagai gelling agent. Gel dibuat dalam dua formula yaitu tanpa mengunakan ekstrak etanol Usnea sp (F1) dan mengunakan ekstrak etanol Usnea sp sebanyak 1% (F2). Evaluasi gel berupa organoleptis, homogenitas, pemeriksaan pH, uji daya sebar dan iritasi kulit. Uji aktivitas luka bakar dilakukan pada tiga kelompok hewan uji dimana masing-masing kelompok terdiri dari lima ekor mencit. Hasil penelitian menunjukkan bahwa ekstrak etanol kayu angin dapat dijadikan sebagai gel. Uji organoleptis gel ekstrak etanol kayu angin menunjukkan gel homogen dengan pH 5 - 5,5 dandaya sebar 5,6 – 6 cm2. Uji iritasi pada kulit menunjukkan hasil tidak terjadi iritasi pada kulit. Hasil uji aktivitas penyembuhan luka bakar menunjukkan bahwa kelompok hewan uji yang diberikan sediaan gel yang mengandung ekstrak etanol Usnea sp mampu menyembuhkan luka bakar lebih cepat dibandingkan dengan kelompok hewan uji yang diberikan sediaan gel tanpa ekstrak dan kelompok hewan uji tanpa perlakuan (kontrol). Hasil studi awal ini menunjukkan bahwa ekstak etanol Usnea sp dapat dibuat dalam bentuk gel dan dapat mempercepat proses penyembuhan luka bakar. 
Formulation of Metformin HCl Floating Tablet using HPC, HPMC K100M, and the Combinations Lili Fitriani; Rudi Abdillah; Elfi Sahlan Ben
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (661.156 KB) | DOI: 10.29208/jsfk.2017.4.1.201

Abstract

Floating tablet is one of the most suitable dosage forms that used for delivering long term drug release. The objective of this study was to evaluate Hydroxypropyl cellulose (HPC), Hydroxypropyl Methyl Cellulose (HPMC) K100M, and the combination as matrix in manufacturing floating tablets. Metformin HCl, an anti-diabetic, was used as a drug model. Metformin HCl floating tablet was manufactured by wet granulation method in three formulas using variation of matrix, which were 40% of HPC (F1), 40% of HPMC K100M (F2), combination of 20% HPC and 20% HPMC K100M (F3). Prior to tablet compaction, evaluation for granules were done which included moisture content, angle of repose using, bulk and tapped density, Hausner ratio, and compressibility. The evaluations of floating tablet were physical properties, floating ability, and in vitro drug release. The average of floating lag time for F1, F2, F3, were 7 minutes 13 seconds; 5 minutes 27 seconds; and 14 minutes 5 seconds, respectively. In addition, the floating time for F1 was 3 hours 16 minutes whereas F2, F3 were more than 48 hours. F2 showed the best floating ability to retain the drug release, which was 84.68% over 8 hours, while F1 and F3 were completely dissolved less than 6 hours. 
Formulasi Mikrokapsul Ranitidin HCl Menggunakan Rancangan Faktorial dengan Penyalut Etil Selulosa Lili Fitriani; Ulfi Rahmi; Elfi Sahlan Ben
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1677.032 KB) | DOI: 10.29208/jsfk.2014.1.1.18

Abstract

Ranitidine HCl is a histamine H2-antagonist which is used in the treatment of benign gastric and duodenal ulceration. In order to improve its bioavailability and half life time, microcapsule is prepared to extend the dose regiment. The aim of this study was to formulate and optimize ranitidine HCl containing microcapsule to prepare a suitable sustained release delivery system using factorial design. Microspheres were prepared using ethylcellulose by solvent evaporation method. The effect of different formulation variables, including stabilizer concentration (1-2 %) and drug/polymer ratio (2:2-1:2) on appearance, and entrapment efficiency was investigated. Data analysis showed that microspheres with optimum entrapment efficiency could be prepared using 2 % span 80, and 1:2 drug/polymer ratio. The results showed spherical shaped microcapsules, and porous, with realeasing time up to 10,55 hours.
Dispersi Padat Asam Usnat dengan Teknik Freeze Drying menggunakan Poloxamer 188 sebagai Polimer Deni Noviza; Lili Fitriani; Riana Zikra Fauzi
Jurnal Sains Farmasi & Klinis Vol 5, No 1 (2018): J Sains Farm Klin 5(1), April 2018
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (874.228 KB) | DOI: 10.25077/jsfk.5.1.41-48.2018

Abstract

This study aimed to improve the solution of usnic acid, a poorly soluble drug using solid dispersions (SDs). The SDs were prepared by a freeze-drying technique with poloxamer 188 as a polymer. The physicochemical properties of the SDs were characterized using X-ray diffractometry (XRD) and Fourier transform-infrared (FT-IR) spectroscopy, Scanning Electron Microscopy (SEM),. In addition, drug content, solution test and dissolution profile  was evaluated by using usnic acid (pure drug) and physical mixture as a reference. The results from  XRD and SEM showed that usnic acid was molecularly dispersed in the SDs as an amorphous form. The FT-IR results suggested that intermolecular hydrogen bonding had formed between usnic acid and its carriers. The result of solubility test showed that solubility of solid dispersions 1:1; 1:2; 2:1 (5.80 µg/ml; 6.94 µg/ml ; 4.88 µg/ml) were higher than the physical mixture 1:1 ( 0.39 µg/mL) and pure asam usnat have the lowest solubility (0.34 µg/mL). In conclusion, SDs prepared by a freeze-drying technique used poloxamer as a polymer can be used to enhance solubility of usnic acid
Crystal Engineering Approach in Physicochemical Properties Modifications of Phytochemical Dhea Sultana Lutfiyah; Lili Fitriani; Muhammad Taher; Erizal Zaini
Science and Technology Indonesia Vol. 7 No. 3 (2022): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1878.126 KB) | DOI: 10.26554/sti.2022.7.3.353-371

Abstract

Phytochemicals have been used to reduce the risk of diseases and maintain good health and well-being. However, most phytochemicals have a limitation in their physicochemical properties, which can be modified by reforming the shape of the crystals. Therefore, crystal engineering is a promising approach to optimize physicochemical characteristics of the active pharmaceutical ingredients (APIs) in a phytochemical without altering its pharmacological efficacy. Hence, this paper reviews current strategies for the use of crystal engineering to optimize physicochemical properties of phytochemicals, which is followed by the design of the synthesis and characterization of particular phytochemicals, including piperine (PIP), quercetin (QUE), curcumin (CUR), genistein (GEN), and myricetin (MYR). The literature indicates that crystal engineering of multicomponent crystals (MCCs) enhances phytochemical physicochemical properties, including solubility, dissolution rate, stability, and permeability. The MCCs provide a lower lattice energy and noncovalent bonding, which translate into lower melting points and weak intermolecular interactions that generate greater solubility, higher dissolution rate, and better stability of the APIs. Nevertheless, the absence of reported studies of phytochemical crystal engineering leads to a lack of variation in the selection of coformers, methods of preparation, and improvement of physicochemical properties. Therefore, more extensive evaluation of the design and physicochemical characteristics of phytochemicals using MCCs is necessary and manifests the opportunity to enhance the application of phytochemicals in the pharmaceutical industry.
Co-Authors Adhitya Jessica Annisa Agustina Ben, Elfi Sahlan Deni Noviza Dhea Sultana Lutfiyah Erizal Zaini Fauzi Saputra HENI RACHMAWATI Melisa Melisa Muhammad Taher Riana Zikra Fauzi Rifka Naura Rudi Abdillah Sadimantara, Muhammad Syukri Tamrin Tamrin Tri Suciati Ulfi Rahmi Uswatul Hasanah Verlia Nisrina Putri