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All Journal BIOEDUKASI Biosaintifika: Journal of Biology & Biology Education Jambura Edu Biosfer Journal BIOSFER : Jurnal Biologi dan Pendidikan Biologi JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat)
Nadyatul Ilma Indah Savira
Biology Education, Faculty Of Teacher Training And Education, University Of Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Education Environmental Science Library & Information Science Public Health Social Sciences

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Journal : BIOEDUKASI

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POLYSACCHARIDE KRESTIN ACTIVITY FROM Coriolus versicolor EXTRACT AGAINST PHAGOCYTOSIS ABILITY ON MICE INFECTED BY Staphylococcus aureus Nadyatul Ilma Indah Savira; Sri Puji Astuti Wahyuningsih; Dewi Rahmawati
BIOEDUKASI Vol 19 No 1 (2021)
Publisher : PROGRAM STUDI PENDIDIKAN BIOLOGI FAKULTAS KEGURUAN DAN ILMU PENDIDIKAN UNIVERSITAS JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/bioedu.v19i1.22139

Abstract

Staphylococcus aureus is an opportunistic pathogen and cause of nosocomial infection, which has leukocidin and can reduce immunity. Because of antibiotic resistance, immunomodulator is an alternative treatment for S. aureus infection. Polysaccharide krestin (PSK) from Coriolus versicolor extract contains active β-glucan that triggers immune responses' effectiveness including phagocytosis. This research aimed to know the activity of PSK against phagocytosis ability on mice infected by S. aureus. There were six treatment groups. 100 mg/kg BW PSK was given to the mice strain Balb/C by gavage. S. aureus was infected once every two weeks. Phagocytosis ability consisted of phagocytic activity and capacity, counted on slide smears of mice intraperitoneal fluid. The results showed that PSK increased phagocytic activity in the group giving PSK after infection. Furthermore, the most effective giving PSK on phagocytic capacity was before and after infection. Based on this research, PSK increased immunity by phagocytosis ability and can be useful as an immunomodulator.
Co-Authors Aditya Kurniawan Aditya Kurniawan Bea Hana Siswati Dewi Rahmawati Dwi Winarni Dwi Winarni Firli Kusuma Wardaningsih Intan Permata Putri Intan Permata Putri Kamalia Fikri Listijani Suhargo Listijani Suhargo, Listijani Manikya Pramudya Manikya Pramudya Sri Puji Astuti Wahyuningsih Sri Puji Astuti Wahyuningsih Sri Puji Astuti Wahyuningsih, Sri Puji Astuti Win Darmanto Win Darmanto Win Darmanto