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All Journal MANDALA of Health Jurnal Keperawatan Soedirman Healthy Tadulako Journal (Jurnal Kesehatan Tadulako)
Joko Setyono
FK UNSOED
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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HUBUNGAN ANTARA MEROKOK DENGAN PENYAKIT PARKINSON DI RSUD PROF. DR. MARGONO SOEKARJO PURWOKERTO Setyono, Joko; Noviani, Erni; Gunarto, Untung
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Cigarettes contain 2,3,6-trimethyl-4-napthoquinone which can inhibit the breakdown of dopamine;therefore, smoking can reduce the risk of Parkinson’s disease. On the other hand, smoking is the secondcause of death in the world. This study was aimed to investigate the relationship between smoking status,smoking duration, smoking quantity, types of cigarettes and Parkinson’s disease. This study was ananalytical observational research using case control approach that involved 34 patients of Parkinson’sdisease as a case group and 34 respondents that were non Parkinson as a control group. The former and thelater were age- and sex-matched control subjects selected by using purposive sampling technique. InParkinson group it was obtained that as much as 64.7% of the respondents were non smokers, 14.7% wereformer smokers, 8.8% were current less than daily smokers, and 8.8% were current daily smokers. In nonParkinson group, 41.2% of the respondents were non smokers, 23.5% were former smokers, 8.8% werecurrent less than daily smokers, and 26.5% were current daily smokers. The data were analyzed usingWilcoxon test and it was found that there was a significantly negative relationship between smoking status,smoking duration, smoking quantity, types of cigarettes and Parkinson’s disease (p<0,05). There was asignificantly negative relationship between smoking status, smoking duration, smoking quantity, types ofcigarettes and Parkinson’s disease.
POLIMORFISME GENA RESEPTOR MCP-1 (CCR2) SEBAGAI FAKTOR RISIKO NEFROPATI DIABETIKA PADA PENDERITA DIABETES MELLITUS TIPE 2 DI RSUD PROF DR MARGONO SOEKARJO DAN RSUP SARDJITO Setyono, Joko; Sadewa, A Hamim; Madiyan, Maliyah
MANDALA of Health Vol 4, No 1 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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The infiltration of the glomeruli and interstitium by immunocompetent cells are common finding ofkidney with diabetic nephropathy. On the other hand, there is an increasing synthesis of chemokines andother inflammatory mediators by glomerular and tubular cells in hyperglycemic conditions. Single nucleotidepolymorphisms (SNPs) G46295A of MCP-1 (CCR2 are thought playing a key role in the development ofdiabetic nephropathy in type 2 diabetes. Therefore, the aim of this research is to determine whether the riskof diabetic nephropathy is influenced by polymorphisms of CCR2. In addition, this research is also aimed todetermine whether the gender in the diabetic nephropathy patient is influenced by polymorphisms of CCR2 intype 2 diabetes in Indonesian population especially ethnic of Java. A case-control study was performed,including 60 type 2 diabetes patients, 31 subjects with diabetic nephropathy and 29 subjects with nondiabetic nephropathy in Margono Soekarjo Hospital and Sardjito hospital. Polymorphisms of CCR2 wereanalyzed by PCR-RFLP method. The results were analyzed by chi-square. Amount of male in the casesubjects (67,7%) more than amount of male in control subjects (44,8%). G46295A of MCP-1 (CCR2)receptor gene had higher risk of developing diabetic nephropathy in type 2 diabetes (X2 = 12.308, p =0.002). Male individual carry the GA genotype of CCR2 had significant risk of developing diabeticnephropathy (p = 0.004, OR 9.6). This study showed that G46295A MCP-1 (CCR2) receptor gene had higherrisk of developing diabetic nephropathy in type 2 diabetes in Indonesian population especially ethnics ofJava. Male with G46295A MCP-1 (CCR2) receptor gene were more than female and had higher risk ofdeveloping diabetic nephropathy in type 2 diabetes in Indonesian population, especially Java ethnic.
Karakteristik Penderita Dispepsia di RSUD Prof. DR. Margono Soekarjo Purwokerto Setyono, Joko; Prastowo, Agus; Saryono,
Jurnal Keperawatan Soedirman Vol. 01 No. 1 (2006)
Publisher : Jurusan Keperawatan FIKES UNSOED

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jks.2006.1.1.54

Abstract

Life style and eat pattern changes are becoming one of the cause the digestive problems. Dyspepsia is one of the most digestive problems in patients. Dyspepsia can be caused by cigarettes, decreased of pressure of the lower sphincter oesophagus, emotionally stress, food which triggering sour secretion of abundant stomach like alcohol and coffee. This research aimed to know patient characteristic of dyspepsia at RSUD. Prof. Dr. Margono Soekarjo Purwokerto. This research is research of descriptive. This research has done in July 2005. Characteristic data of subject research taken by questionnaires. The Result shows that over a half of subject research is woman, of old age more than 40 year, lower education, and unemployed. Small parts of subject research are usually alcohol, coffee, and cigarette consumer. Almost ofall subject have normal nutrition status.
PERBEDAAN KESANGGUPAN KARDIOVASKULAR PADA KARYAWAN PRIA PEROKOK DAN NON PEROKOK DI FAKULTAS KEDOKTERAN UNIVERSITAS JENDERAL SOEDIRMAN Tiara Yusan, Rizak; Setyono, Joko; Kusuma, Moh Nanang Himawan; Wahyudin, Wahyudin; Zainuddin, Zainuddin; Nur, A Fahira
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 7 No. 3 (2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (839.046 KB) | DOI: 10.22487/htj.v7i3.459

Abstract

Aktivitas merokok merupakan salah satu faktor penyebab tingginya angka kejadian morbiditas dan mortalitas penyakit kardiovaskular. Adapun proporsi karyawan perokok cukup tinggi sebesar 34%. Aktivitas merokok menganggu kesehatan salah satunya dengan menurunkan kesanggupan kardiovaskular. Kesanggupan kardiovaskular yang buruk akan berpengaruh terhadap penurunan produktivitas dan efisiensi kerja karyawan. Metode : Desain penelitian ini adalah observasional analitik dengan pendekatan cross sectional. Jumlah sampel yang diteliti sebanyak 44 responden, dibagi menjadi 2 kelompok yaitu kelompok karyawan pria perokok dan non perokok masing-masing sebesar 22 responden, kemudian dilakukan pengukuran kesanggupan kardiovaskular dengan protokol Kasch Step Test. Kesanggupan kardiovaskular dinilai dengan menghitung Recovery Heart Rate. Adapun analisis data digunakan uji Chi Square dan Mann-Whitney. Hasil : Karyawan pria perokok memiliki kesanggupan kardiovaskular yang secara signifikan lebih rendah dibandingkan karyawan pria non perokok (p=0,001). Adapun hasil perhitungan Relative Risk didapatkan bahwa karyawan pria perokok memiliki risiko penurunan kesanggupan kardiovaskular 2,8 kali lebih besar dibandingkan karyawan pria non perokok. Kesimpulan : Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa kesanggupan kardiovaskular karyawan pria perokok lebih rendah dibanding karyawan pria non perokok
Co-Authors A Fahira Nur A Hamim Sadewa, A Hamim Agus Prastowo Erni Noviani, Erni Heru Ismaya K, Neneng Rika J. Kusuma, Muhammad Nanang Himawan Lintang, Ferlanda Maliyah Madiyan, Maliyah Nur Rohman Saryono, Sujiran Tiara Yusan, Rizak Untung Gunarto, Untung Wahyudin Wahyudin Zainuddin Zainuddin