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All Journal BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Jurnal Kesehatan Kusuma Husada
Marisadonna Asteria
Universitas Bengkulu
Education Health Professions Nursing Public Health

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Efek Daun Etlingera hemisphaerica pada Perbaikan Skoring Spermatogenesis Tikus Putih (Rattus norvegicus) yang Diinduksi HgCl2 Liya Agustin Umar; Siti Habiburrahmah Ash Shadar; Kartika Sari; Hilda Taurina; Marisadonna Asteria; Aceng Ruyani
BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Vol 4 No 2 (2021): BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (490.203 KB) | DOI: 10.31539/bioedusains.v4i2.2169

Abstract

This study aims to determine the effect of administration of Etlingera hemispharica leaf extract on white rats (Rattus norvegicus) induced by mercury chloride as seen from the histopathological description of the testes. The research method used is experimental post-test-only control group design. The extract was administered for seven days by gavage. Testicular organ harvesting was carried out on the 9th day after the rats were euthanized and continued with making testicular preparations. Testicular damage was assessed using the Johnsen score. Data were analyzed using non-parametric statistical tests. The results showed that the test groups had a p-value of 0.000. The histopathological description of the testes induced by HgCl2 had a p-value of 0.005 and the administration of E. hemisphaerica leaf extract in HgCl2-induced mice showed a p-value of 0.008. In conclusion, administration of E. hemisphaerica leaf extract to R. norvegicus induced by mercury chloride improved spermatogenesis on the histopathological features of the R. norvegicus testes. Keywords: Etlingera hemispharica, HgCl2, Johnsen Score, Rattus norvegicus
Polimorfisme Gen VEGF-A (rs2010963) pada Turunan Pertama Penderita Penyakit Jantung Koroner (PJK) Aurora Fajria Anwari; Novriantika Lestari; Marisadonna Asteria; Sipriyadi Sipriyadi; Ismir Fahri; Elvira Yunita
BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Vol 4 No 2 (2021): BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (705.435 KB) | DOI: 10.31539/bioedusains.v4i2.2630

Abstract

This study aims to identify the VEGF-A gene polymorphism (rs2010963) in the first generation of patients with coronary heart disease (CHD) and non-CHD in Bengkulu City. The method used is molecular analysis of polymorphism through Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP). This type of research is descriptive observational with a cross-sectional research design. The results of this study indicate that the genotype frequency of the VEGF-A gene polymorphism (rs2010963) in the first generation of patients with CHD is genotype CC = 11 (52.4 %), GG = 7 (33.3%) and CG = 3 (14.3%). ). The distribution of the VEGF-A genotype (rs2010963) in the first non-CHD offspring, namely GG = 9 (42.9%), CC = 7 (33.3%) and GC = 5 (23.8%). The statistical analysis results showed that the p-value obtained was 0.460 for the VEGF-A gene polymorphism genotype (rs2010963) in the first CHD and Non-CHD derived samples. In conclusion, there was no significant difference in the VEGF-A gene polymorphism in the first generation of CHD and non-CHD groups in Bengkulu City. Keywords: PCR-RFLP, Coronary Heart Disease, Gene Polymorphism, VEGF-A
ANALISIS FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN HEPATITIS B PADA PENDONOR DI UNIT TRANSFUSI DARAH KOTA BENGKULU Dessy Triana; Besly Sinuhaji; Connya Talitha Rambe; Marisadonna Asteria; Maria Eka Patri Yuliyanti
Jurnal Kesehatan Kusuma Husada Vol. 13 No. 1, Januari 2022
Publisher : Universitas Kusuma Husada Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (223.165 KB) | DOI: 10.34035/jk.v13i1.800

Abstract

Angka kejadian Hepatitis B masih sangat tinggi di dunia dan Indonesia, perjalanan penyakit secara kronis menjadi kanker hati. Kejadian Hepatitis B memiliki banyak faktor risiko seperti faktor sosiodemografi, gaya hidup dan golongan darah. Tujuan penelitian adalah menganalisis pengaruh faktor sosiodemografi dan golongan darah terhadap kejadian hepatitis B. Jenis penelitian adalah penelitian retrosprektif dari tahun 2018-2020. Subjek penelitian sebanyak 100 orang. Teknik pengambilan data dengan teknik simple random sampling dari data rekam medis PMI Kota Bengkulu. Hasil penelitian menunjukkan jenis kelamin laki-laki sebanyak 84 orang (84%) dan perempuan sebanyak 16 orang (16%). Usia subjek penelitian paling banyak ada pada rentang 20-29 tahun (43%). Pekerjaan yang terbanyak mengalami infeksi hepatitis B adalah wiraswasta (28%). Golongan darah yang paling banyak mengalami infeksi Hepatitis B adalah golongan darah A+ (41%). Analisis multivariat dengan metode PCA menunjukkan secara statistik bahwa faktor eksternal (faktor pekerjaan) dan faktor internal (golongan darah, usia dan jenis kelamin) mempengaruhi kejadian Hepatitis B sebesar 36,3% dan 27,5%. Hasil regresi logistik menunjukkan terdapat pengaruh faktor eksternal dan internal terhadap kejadian Hepatitis B sebesar 26%. The incidence of Hepatitis B is still very high globally, and in Indonesia, the chronic manifestations become liver cancer. The incidence of Hepatitis B has many risk factors such as sociodemographic factors, lifestyle, and blood type. The research aimed to analyze the influence of sociodemographic factors and blood type on the incidence of hepatitis B. This study was a retrospective study from 2018-2020. The research subjects were 100 people. The data collection technique used a simple random sampling technique from the medical record data of PMI Bengkulu City. The results showed 84 men (84%) and 16 women (16%). The age of most research subjects is in the range of 20-29 years (43%). The occupation with the most hepatitis B infection is entrepreneurs (28%). The blood group with the most hepatitis B infection was blood type A+ (41%). Multivariate analysis using the PCA method showed statistically that external factors (occupational factors) and internal factors (blood type, age, and sex) affected the incidence of Hepatitis B by 36.3% and 27.5%, respectively. The logistic regression results showed an influence of external and internal factors on the incidence of Hepatitis B by 26%.
Co-Authors ACENG RUYANI Aurora Fajria Anwari Besly Sinuhaji Connya Talitha Rambe Dessy Triana Elvira Yunita Hilda Taurina Ismir Fahri Kartika Sari Liya Agustin Umar Maria Eka Patri Yuliyanti Novriantika Lestari Sipriyadi Siti Habiburrahmah Ash Shadar