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All Journal International Journal of Biosciences and Biotechnology Indonesian Journal of Pharmaceutical Science and Technology WIDYABHAKTI Jurnal Ilmiah Populer Manuju : Malahayati Nursing Journal Jurnal Ilmiah Medicamento Jurnal Pengabdian kepada Masyarakat COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Usadha
Puguh Santoso
Fakultas Farmasi Universitas Mahasaraswati Denpasar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : International Journal of Biosciences and Biotechnology

 1 
IN VIVO ANTI-INFLAMMATORY ACTIVITY OF DADAP LEAVES (Erythrina subumbrans (Hassk.) Merr) Ni Luh Kade Arman Anita Dewi; Ni Luh Sintya; Maria Malida Vernandes Sasadara; Erna Cahyaningsih; Putu Era Sandhi Kusuma Yuda; Puguh Santoso
International Journal of Biosciences and Biotechnology Vol 9 No 1 (2021): INTERNATIONAL JOURNAL OF BIOSCIENCES AND BIOTECHNOLOGY
Publisher : Central Laboratory for Genetic Resource and Molecular Biology, Faculty of Agriculture, Udayana University in cooperation with Asia-Oceania Bioscience and Biotechnology Consortium (AOBBC)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/IJBB.2021.v09.i01.p03

Abstract

Leguminosae is widely known for its anti-inflammatory properties due to the presence of several beneficial phytochemicals, including alkaloids, flavonoids, steroids, and saponins. Dadap (Erythrina subumbrans (Hassk.) Merr), a Leguminosae member, has empirically been used to treat inflammation. This research aimed to prove the anti-inflammatory effect of Dadap leaves scientifically. Dadap leaves were macerated in 96% ethanol to produced crude ethanol extract, followed by in vivo anti-inflammatory assay with the paw edema method. Three different doses of extract: 200, 300, and 400mg/kg BW, were administrated to Wistar rats to observed its ability in reducing carrageenan-induced inflammatory. All extract doses produced similar anti-inflammatory activity as compared to diclofenac sodium as a positive control. There is no significant difference among the three different doses. The results indicated that all treatment doses produced anti-inflammatory activity, but 200mg/kg BW administration was most efficient.
Co-Authors Ade Dwi Karisma Maharani Agus Adrianta Debby Juliadi Dewa Ayu Ika Pramitha Erna Cahyaningsih Fitria Megawati Gusti Ayu Putu Eka Darmayanti I Gede Yodhi Trismawan I Gusti Agung Ayu Kusuma Wardani I Gusti Agung Ayu Kusuma Wardani I Made Agus Sunadi Putra I Putu Pasek Jaya Separsa I Putu Tangkas Suwantara Ida Ayu Gede Syntya Mahayani Ketut Agus Adrianta Ni Kadek Linda Paramita Ni Luh Kade Arman Anita Dewi Ni Luh Kade Arman Anita Dewi Ni Luh Sintya Ni Nyoman Wahyu Udayani Ni Putu Dewi Agustini Ni Wayan Cintya Purnama Sari Putra, I Made Agus Sunadi Putu Era Sandhi K.Yuda Putu Era Sandhi Kusuma Yuda Putu Windra Gunawan Sasadara, Maria Malida Vernandes