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All Journal Biotropika Berdikari: Jurnal Pengabdian Masyarakat Indonesia
Nia Kurniawan
Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Business model analysis and determination of production cost of Micro, Small and Medium Enterprises (MSME) Product Businesses Talok Village, Turen Distric, Malang with Business Model Canvas (BMC) Fatchiyah Fatchiyah; Nia Kurniawan; Ary Mustofa Ahmad; Irfan Mustafa; Lidwina Faraline Triprisila; Rista Nikmatu Rohmah; Anna Safitri; Nia Kurnianingsih; Tri Wahyu Nugroho
Berdikari: Jurnal Pengabdian Masyarakat Indonesia Vol. 1 No. 2 (2018): Berdikari: Jurnal Pengabdian Masyarakat Indonesia
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (442.961 KB)

Abstract

Talok is a partner district with economic conditions that have developing status according District Development Index values. The developing status related with susceptible of economic shocks, natural disasters and social conflicts will be effect to underdeveloped district. This Community Empowerment Program is purpose to develop Micro, Small and Medium Enterprises (MSME) product businesses can expect to income increasing of enterprise through the Business Model Canvas (BMC) approach. Mapping survey of local potentials from partner district was observed to achieve the success of community service activity. In this survey, we collaborate with MSME partners are (1) Samiler Crackers MSME group, (2) Cassava Chips MSME group, (3) Lempeng Crackers MSME group. The data was analyses using descriptive and qualitative method by using the in-depth interview in collecting primary data needed during the research process. The BMC analysis on each element of business model canvas could improve the service quality, marketing activity, infrastructure and financial ability. Business model canvas focuses on business ideas to create value in the business. In addition, the cost of production calculation is very important for selling price determination of the product to avoid the losses condition.
In silico Exploration of Bioactive Compounds from Withania somnifera as Inhibitor for Alpha Delta Bungarotoxin of Bungarus candidus Venom Kartika Prabasari; Nia Kurnianingsih; Nia Kurniawan
Biotropika: Journal of Tropical Biology Vol. 11 No. 2 (2023)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2023.011.02.01

Abstract

The antivenom for Malayan krait (Bungarus candidus) venom has not yet been available in Indonesia, leading to many fatal snakebite cases. Alternative treatment approaches using medicinal plants are needed to be explored. This study investigated the potential of medicinal plants’ natural bioactive compounds as toxic alpha-delta bungarotoxin protein inhibitors in B. candidus venom. The approach taken is using the 3D structure of the alpha-delta protein of bungarotoxin B. candidus predicted by SWISS-MODEL. Knapsack Family Database and PubChem were used for bioactive compounds datamining. ADME analysis and drug-likeness of the compounds were carried out with SWISS-ADME. Docking between alpha-delta-Bungarotoxin protein and bioactive compounds was carried out with Pyrx 0.9.5. Visualization of docking results was performed with PyMOL and Discovery Studio 2016 was used to evaluate docking interactions. The docking results showed that a compound with the potential inhibitor of alpha-delta bungarotoxin came from Ashwagandha (Withania somnifera) with a binding energy ranging from -6.6 to -6.9. The compound with the best inhibitor potential, namely withanolide D, was seen from the stability of the interaction based on hydrogen bonding at three amino acid residues: THR59, SER62, and THR63. The evaluation is supported by the results of molecular dynamics simulations which show stability in almost all aspects. Our results suggest the potential for exploratory research in the field of bioinformatics related to bioactive compounds from herbal plants as an alternative to antivenom.
Co-Authors Ary Mustofa Ahmad Fatchiyah Fatchiyah Irfan Mustafa Kartika Prabasari Lidwina Faraline Triprisila Nia Kurnianingsih Nia Kurnianingsih Rista Nikmatu Rohmah Safitri, Anna Tri Wahyu Nugroho