Garuda - Garba Rujukan Digital

p-Index From 2019 - 2024

4.219

P-Index

This Author published in this journals

All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences JURNAL KIMIA SAINS DAN APLIKASI Biotropika The Indonesian Green Technology Journal The Journal of Pure and Applied Chemistry Research Journal of Mathematical and Fundamental Sciences Jurnal Ekonomi dan Bisnis JURNAL CITRA KEPERAWATAN Indonesian Journal of Chemistry Berdikari: Jurnal Pengabdian Masyarakat Indonesia JSMARTech : Journal of Smart Bioprospecting and Technology Journal of Applied Veterinary Science and Technology Berkala Penelitian Hayati Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Makara Journal of Science Engagement: Jurnal Pengabdian Kepada Masyarakat

Safitri, Anna

Brawijaya University

Author-ID : 1414795

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

Published : 34 Documents Claim Missing Document

Claim Missing Document

Articles

1 2 3 4

Anti-Apoptotic Activity of Anthocyanins has Potential to inhibit Caspase-3 Signaling Sari, Dewi Ratih Tirto; Safitri, Anna; Cairns, James Robert Ketudat; Fatchiyah, Fatchiyah
Journal of Tropical Life Science Vol 10, No 1 (2020)
Publisher : Journal of Tropical Life Science

Caspase-3 is a biochemical marker for cell apoptosis. Several studies focused on exploring caspase inhibitor potential in natural compounds. Hence, in this study investigated the anthocyanins as anti-apoptotic potential activity through caspase-3 using molecular docking. Six types of anthocyanin were retrieved from PubChem database and caspase-3 protein was downloaded from Protein Data Bank. Anthocyanins and caspase-3 protein were docked using HEX 8.0 program and visualized using Discovery Studio 4.1 software. The interaction among cyanidin-3-O-glucoside, delphinidin-3-O-glucoside, pelargonidin-3-O-glucoside, peonidin-3-O-glucoside and petunidin-3-O-glucoside showed similar binding pattern on caspase-3 protein. All of them bind to BIR2 region and allosteric site of caspase-3, which are a crucial site for apoptosis regulation. Interestingly, malvidin-3-O-glucoside also interacted with caspase-3 in BIR1, BIR2 and BIR3 regions. In addition, anthocyanins-caspase-3 complex showed low energy and demonstrated several hydrogen bonds, hydrophobic interactions and van der Waals interactions, which indicated stable interaction. This study implies that all anthocyanins have potential as inhibitor of caspase-3 protein and might have potential as anti-apoptosis. Further in-vitro and in-vivo studies are need to confirm this experimental.

FRONT MATTER JSMARTECH APRIL 2020, VOL 01 NO 02 Safitri, Anna
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 1, No 2 (2020)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (750.176 KB)

MOLECULAR DOCKING APPROACH OF POTENTIAL ALPHA-GLUCOSIDASE INHIBITORS FROM EXTRACTS COMPOUNDS OF R. TUBEROSA L Safitri, Anna; Tirto Sari, Dewi Ratih; Roosdiana, Anna; Fatchiyah, Fatchiyah
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 1, No 2 (2020)
Publisher : JSMARTech

The present study investigates anti-diabetic capacity of compounds enclosed in the R. tuberosa L. root extracts by molecular simulation approach to examine the potential of those compounds acting as alpha-glucosidase inhibitors. Compounds chosen were cirsimarin, cirsimaritin, and sorbifolin; quercetin was used for the reference. Those compounds were downloaded from PubChem database, and human alpha-glucosidase 3D structure was obtained from Protein Data Bank. The protein was docked to the flavonoid compounds using HEX 8.0 software and visualized using Discovery Studio 4.1. The interactions of cirsimarin, cirsimaritin, sorbifolin, and quercetin on alpha-glucosidase showed similar binding patterns. They interacted with the active sites of the enzyme, causing inhibition on enzyme activity. The interactions between proteins and ligands were mostly through formation of hydrogen bonds and Van der Waals forces. The binding energy of cirsimarin cirsimaritin, sorbifolin, and quercetin to alpha glucosidase were comparable at -323.3, -279.4, -256.8, and -241.5 cal/mol, respectively. These confirm that compounds contained in the extracts of R. tuberosa L have capacity to be used as inhibitor for alpha glucosidase.

EFFECTIVENESS OF USING TRICHODERMA VIRIDE AS BIOSORBENT FOR REMAZOL BRILLIANT PURPLE IN BATIK WASTEWATER TREATMENT Safitri, Anna; Febrianti, Wiwin Dwi; Rahmaniah, Galuh
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 1, No 2 (2020)
Publisher : JSMARTech

Synthetic dyes used in the batik industry cause negative impacts to the environment. One type of synthetic dyes used in batik industry is remazol brilliant violet. This synthetic dye is reactive, carcinogenic, and non-biodegradable. Therefore, a strategy to degrade this synthetic dye is needed. In this study, the potential application of Trichoderma viride for biosorption of remazol brilliant violet (RBZ) in batik wastewater was investigated. The current work aimed on determination of the optimum biosorption conditions, including pH, contact time, and RBZ concentration. Biosorption of RBZ were carried out at pH 4 to 9; with contact times of 12, 24, 30, 36, and 42 h, with concentrations of dye solutions were 40, 60, 70, 80, and 90 mg/L. Results showed that the optimum biosorption of RBZ was obtained at pH 4, for 30 h, and optimum concentration of RBZ at 60 mg/L, with the RBZ absorbed was 79.27%. The FTIR analysis suggested that RBZ biosorption changed the chemical functional groups in the T. viride. The FTIR spectra revealed that the biomolecules that are affected during the process of biosorption were mainly lipids and proteins, and slightly from nucleic acids and carbohydrates.

Front Matter JSMARTech, October 2020, Vol. 2 No.1 Safitri, Anna; Sari, Dewi Ratih Tirto
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 1 (2020)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2020.002.01.0

Front Matter JSMartech Vol.02., No.02 Fatchiyah, Fatchiyah; Safitri, Anna
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 2 (2021)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2021.002.02.0

Front Matter Volume 2 No.3 Fatchiyah, Fatchiyah; Safitri, Anna; Sari, Dewi Ratih Tirto
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 3 (2021)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2021.002.03.0

Biosorption of Lead (Pb) from Aqueous Solution by Immobilized Aspergillus niger: A Green Technology for Heavy Metals Removal Avander Alexander Nuban; Anna Safitri; Ulfa Andayani
The Indonesian Green Technology Journal Vol 10, No 1 (2021)
Publisher : Program Pascasarjana Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Lead has very toxic properties and cannot be degraded in waters that leads to health problems, such as disorders of the nervous system, heart, kidneys, digestive tract, and causing memory loss. One of the environmentally friendly methods that can reduce and even eliminate Pb is the biosorption. One of the microorganisms that can be utilized in biosorption technology is Aspergillus niger. In the current study, Pb biosorption was carried out by modifying Aspergillus niger which was immobilized in the Ca-alginate matrix. This study aims to determine the optimum biosorption conditions which include pH, contact time, initial Pb concentration, and amount of adsorbent. Results showed that the optimum conditions for Pb biosorption were pH 6.0, with contact time of 4 h, Pb concentration was 80 ppm, and at adsorbent concentration of 3 g, with the percentage of Pb adsorbed was 98.40%. FTIR spectra results show that the Pb biosorption process causes shifts in certain wavenumbers, from 1296.16 cm-1 to 1307.74 cm-1 which was a characteristic of the amine amide (CN) group, and a shift in wavenumber from 1122.57 cm-1 to 1168.86 cm-1 which was from carboxyl functional group. The interaction between Pb and the adsorbent surface was suggested through a physical adsorption, and hence the adsorption process was reversible.

Antibacterial Activity and Phytochemical Analysis of Edible Seaweed Eucheuma spinosum Against Staphyloccocus aureus Anna Safitri; Arie Srihardyastutie; Anna Roosdiana; Sutrisno Sutrisno
The Journal of Pure and Applied Chemistry Research Vol 7, No 3 (2018): Edition September-December 2018
Publisher : Chemistry Department, The University of Brawijaya

The current work aims to determine antibacterial activities of ethanol extracts of Eucheuma spinosum against Staphylococcus aureus. These were showed through inhibition zones formation, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) values. The MIC was determined using dilution test tube method, and the MBC was calculated using streaking method. Qualitative test was applied to determine phytochemical compounds in ethanol extract of E. spinosum. Results showed that ethanol extracts of E. spinosum at concentrations of 1%; 2%; 5%, and 10% (v/v) resulted in inhibition zones of 1.98; 4.14; 7.42; and 10.27 mm, respectively. In addition, concentration of 10% (v/v) was the MIC, and 15% (v/v) was the MBC values of E. spinosum extracts against S. aureus. The phytochemical analysis showed that alkaloids and saponins were the main components detected. Alkaloids positive tests were observed by the formation of brown sediment with Wagner’s reagent, yellow sediment with Mayer’s reagent, and orange sediment with Dragendorff’s reagent. Saponins positive results were detected by the formation of stable foam when the extracts reacted with water and HCl. Overall, these results suggested that E. spinosum extracts have antibacterial properties against Gram-positive bacteria, i.e. S. aureus.

Biosorption of Lead(II) using Trichoderma viride in the Aqueous Solution Rensani Taloin; Anna Safitri; Sasangka Prasetyawan; Budi Kamulyan; Ulfa Andayani
The Journal of Pure and Applied Chemistry Research Vol 7, No 1 (2018): Edition January-April 2018
Publisher : Chemistry Department, The University of Brawijaya

Lead(II) is considered as the main cause of pollutant that is toxic, corrosive, and irritant. One method that can be applied for reducing Pb(II) in the environment is by using microorganisms. In this work, the study of biosorption of Pb(II) in the water samples was conducted using Trichoderma viride. The research is focused on determination of optimum conditions including pH, biosorption time, and initial concentration of Pb(II) used. The profiles in functional groups contained in the T. viride have been monitored using FT-IR spectrophotometry. Results showed that the maximum biosorption of Pb(II) achieved at pH 4.5, with equilibrium of contact time of 20 h, optimum concentration of 50 mg/L, and adsorption capacity of 85 mg/1x106 T. viride colonies. The FTIR results indicated that biosorption process changed the functional groups in the T. viride. These have shown in the absorption bands at ~3200 cm-1, ~2850 cm-1, ~2260 cm-1, ~1650 cm-1, ~1450 cm-1, 1180 cm-1, and in the finger printing regions. The biosorption mechanism was proposed through the adsorption process between positively charged metal ions and the negative charge on the functional groups, such as -COO-, -OPO32-, and –NH2-, on the cell surface.

Co-Authors Ainun Sajidah Ajeng Erika Prihastuti Haskito Akhmad Sabarudin Aldila Noviatri Andriana Kusuma Pertiwi Anna Roosdiana Anna Roosdiana Anna Roosdiana Anna Roosdiana Anna Roosdiana Annisa, Choirin Arie Srihardyastutie Arie Srihardyastutie Ary Mustofa Ahmad Aulanni`am Aulanni`am Avander Alexander Nuban Aviva Levina Aviva Levina Ayu Tri Agustin Budi Kamulyan Cairns, James Robert Ketudat Chanif Mahdi Choirin Annisa Citra Sari Dewi Ratih Tirto Sari Dian Siswanto Dian Siswanto Dian Siswanto Dwi Putri Woro Pamungkas Dzakiyyah Salmaa Eko Suyanto Ellya Indahyanti Ellysia Hitdatania Ernanin Dyah Wijayanti Ernanin Dyah Wijayanti Ernanin Dyah Wijayanti Eva Nur Laili Octaviana Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Febrianti, Wiwin Dwi Firza Rajasa Gunawan Handayu Untari Irfan Mustafa Jaka Nugraha James Robert Ketudat Cairns Lay, Peter A. Layta Dinira Levina, Aviva Lidwina Faraline Triprisila Lidwina Faraline Triprisila Nadiyah Zuhroh nasrullah wilutono Nia Kurnianingsih Nia Kurnianingsih Nia Kurniawan Peter A Lay Peter A Lay Rahmaniah, Galuh Rensani Taloin Rista Nikmatu Rohmah Sari, Dewi Ratih Tirto Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Savira Ayu Damayanti Sovia Rosalin Sri Wardhani Suci Amaliyah Sutrisno Sutrisno Tri Wahyu Nugroho Ulfa Andayani Ulfa Andayani Yenny Kornitasari Yoravika Dwiwibangga Zubaidah Ningsih Zubaidah Ningsih

Title

Found 34 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 34 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 34 Documents
Search