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All Journal Jurnal Natur Indonesia Journal of Medicine and Health
Andreanus A. Soemardji
Department of Pharmacy Bandung Technology Institute Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Subchronic Treatment of Combination Extract Detam 1 Soybean and Jati Belanda Leaves has No Toxic Effect on Function, Weight, and Histopathological of Wistar Rat Kidney Hidayat, Meilinah; Prahastuti, Sijani; Chikita, Vibiola; Safitri, Dewi; Rahmawati, Siti F.; Soemardji, Andreanus A.
Journal of Medicine and Health Vol 1, No 4 (2016)
Publisher : Maranatha Christian University

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Abstract

The combination of Detam 1 soybean and Jati Belanda leaves proved to have effect of weight loss. Since it will become longterm using, toxicity effectvresearch is needed.  This study was conducted to determine the effect of subchronic combination of ethanol extract of soybean Detam 1 (EEDS) and Jati belanda (EEJB) on kidney function, with parameters: urea and creatinine, macroscopic and histopathological of kidney. This study were conducted on 120 Wistar rats (60 males, 60 females), 90 days (treatment group) and 120 days (satellite group). Rats were divided into six treatment groups. Test results of urea and creatinine levels of all treatment groups was lower than control group (p <0.05). The treatment turned out to have a good effect on kidney function. Kidney weight of all groups showed no significant difference with the control group (p> 0.05). Histopathological score interpretation’s result of low dose group male and female kidney rats were not disturbed. In conclusion, the combination of EEDS and EEJB  have a good effect on kidney function, did  not lead to changes in organ weight and at low doses did not cause disturbance of  renal histopathology. Key words: combination of soybean jati Belanda, subchronic treatment, kidney function, kidney’s  weight, kidney’s histopathology
STUDY ON RUMPUT MUTIARA (Hedyotis Corimbosa) HERBS AS MEDICINE Soemardji, Andreanus A.; Anisa, Ita N.; Damayanti, Nareswari Alka
Journal of Medicine and Health Vol 1, No 2 (2015)
Publisher : Maranatha Christian University

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“Rumput Mutiara” or Pearl grass (Hedyotis corymbosa) is one of medicinal plants used empirically by the Indonesian people to cure disease to maintain health. Many people have used pearl grass for a long time. This plant contains hentriacontane, stigmasterol, ursolic acid, oleanolicacid, β-sitosterol, sitisterol-D-glucoside, p-coumaric acid, flavonoid-glycosides, “baihua she she cao su” (possibility coumarin analog), iridoid glycosides, alizarin, korogenin, and bonding antragalol.  Herbaceous plant is used and effetive as a relieve fever (antipyretic), anti-inflammatory, antibacterial, laxative urine(diuretic), removes heat and toxins (detoksikan), blood circulation, anti-cancer, the treatment of peptic ulcers, dysentery, exhausted maternity, and indigestion. This review article is a compilation of Hedyotis corymbosa herb as traditional medicinal plant and pharmacological researches of this herb that can be use as ethnopharmacological and pharmacological information of this medicinal herb. Keywords:  Pearl grass, Hedyotis corymbosa, medicinal plants, ethnopharmacology, pharmacology.
Subchronic Treatment of Combination Extract Detam 1 Soybean and Jati Belanda Leaves has No Toxic Effect on Function, Weight, and Histopathological of Wistar Rat Kidney Hidayat, Meilinah; Prahastuti, Sijani; Chikita, Vibiola; Safitri, Dewi; Rahmawati, Siti F.; Soemardji, Andreanus A.
Journal of Medicine and Health Vol. 1 No. 4 (2016)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (452.042 KB) | DOI: 10.28932/jmh.v1i4.530

Abstract

The combination of Detam 1 soybean and Jati Belanda leaves proved to have effect of weight loss. Since it will become longterm using, toxicity effectvresearch is needed.  This study was conducted to determine the effect of subchronic combination of ethanol extract of soybean Detam 1 (EEDS) and Jati belanda (EEJB) on kidney function, with parameters: urea and creatinine, macroscopic and histopathological of kidney. This study were conducted on 120 Wistar rats (60 males, 60 females), 90 days (treatment group) and 120 days (satellite group). Rats were divided into six treatment groups. Test results of urea and creatinine levels of all treatment groups was lower than control group (p <0.05). The treatment turned out to have a good effect on kidney function. Kidney weight of all groups showed no significant difference with the control group (p> 0.05). Histopathological score interpretation’s result of low dose group male and female kidney rats were not disturbed. In conclusion, the combination of EEDS and EEJB  have a good effect on kidney function, did  not lead to changes in organ weight and at low doses did not cause disturbance of  renal histopathology. Key words: combination of soybean jati Belanda, subchronic treatment, kidney function, kidney’s  weight, kidney’s histopathology
Penapisan Aktivitas dan Senyawa Antidiabetes Ekstrak Air Daun Dandang Gendis (Clinacanthus nutans) Nurulita, Yuana; Dhanutirto, Haryanto; Soemardji, Andreanus A.
Jurnal Natur Indonesia Vol 10, No 2 (2008)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (156.499 KB) | DOI: 10.31258/jnat.10.2.98-103

Abstract

An investigation of the antidiabetic activity of Aqueous Extract and its fractions from a different polarity solvent:ethanol, ethyl acetate, and n-hexane of Dandang Gendis Leaves (Clinacanthus nutans Lindau) on Mile SwissWebster Mice has been carried out. The effect of aqueous extract of dose of 50, 100, and 150 mg/kg BW wastested on glucose serum level of alloxan induced that mice. Its fractions were tested by glucose tolerance method.Aqueous extract (150 mg/kg BW) significantly decreased blood glucose serum level (pd”0,05) that had the sameeffect as oral glibenclamide (0,65 mg/kg BW) administrated once a day for 9 days. Aqueous extract that wasfractionated has 5 fraction. Fraction of ethanol extract that was insoluble in ethyl acetate at a dose of 100 mg/kgBW was the most active fraction, that significantly (p<0,05) decreased blood glucose serum level of mice atglucose tolerance method of 18,4% in 3 hours after 2 g/kg BW of glucose administration. Thin layer chromatography(TLC) of that fraction ethanol 95%-chloroform 9:2 as eluent gave 5 spots under ultraviolet ray and showed spesificcompounds by qualitative test. Spot 1 (steroid) gave Rf 0,14; spot 2 and spot 3 that gave Rf 0,53 and 0, 67 wereflavonoid, spot 4 (triterpenoid) gave Rf 0,77; and spot 5 (chlorophyll) gave Rf 0,89. This research show that this plantcan used for hipoglicemic traditional medicine.
Co-Authors Dewi Safitri Haryanto Dhanutirto Ita N. Anisa, Ita N. MEILINAH HIDAYAT Nareswari Alka Damayanti, Nareswari Alka Sijani Prahastuti Siti F. Rahmawati, Siti F. Vibiola Chikita, Vibiola Yuana Nurulita