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FORMULASI SEDIAAN LOTION EKSTRAK ETANOL BIJI KOPI ROBUSTA (Coffea cenephora) Erda Wati; uci dwi cahya; Yosi Darmirani
Jurnal FARMASIMED (JFM) Vol 3 No 2 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i2.570

Bean robusta coffee contains polyphenol compounds which are useful as antioxidants. Antioxidants can inactivate the development of oxidation reactions, by preventing the formation of free radicals. Robusta coffee bean plant (Coffea canephora) is an ingredient that can be formulated into lotion preparations. Cosmetic lotion aims to remove dead skin cells, brighten the skin and soften the skin. This research is to make lotion preparations from robusta coffee bean extract (Coffea Canephora) . This research uses pure experiment. Robusta coffee beans are extracted by maceration process. The lotion formulation is made with variations of robusta coffee bean powder (Coffea Canephora) with a concentration of 2%, 3%, and 4%. The characteristic test includes organoleptic test, homogeneity test, Ph test, and irritation test. The purpose of this study was to determine the lotion formulation for robusta coffee bean extract (Coffea Canephora). The results of the lotion test had a homogeneous concentration of 2%, 3% and 4%, light brown to blackish brown, with a distinctive smell of coffee. The ph lotion test had a PH of 5 in all formulations on the blank had a PH of 6. The irritation test on the lotion preparation showed no erythema and edema in 5 volunteers. From all the tests carried out, the lotion formulation has good characteristics.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN TALAS (Colococasia Esculenta L.) TERHADAP BAKTERI Escherichia coli Chandra Pranata; Sartika Noviani Tarihoran; Yosi Darmirani
Jurnal FARMASIMED (JFM) Vol 4 No 1 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i1.793

Salah satu tanaman yang sering dijadikan obat adalah daun Talas (Colocasia esculanta L.). Daun talas memiliki kandungan senyawa flavonoid, alkaloid, saponin dan tannin yang memiliki kemampuan untuk menghambat pertumbuhan bakteri. Eschericia coli adalah salah satu jenis bakteri yang dapat menyebabkan infeksi pada pencernaan. Salah satu tujuan penelitian ini untuk mengetahui aktivitas antibakteri daun talas dengan konsentrasi yang paling efektif dalam menghambat bakteri Eschericia coli. Penelitian ini adalah penelitian eksperimental murni. Daun talas aktivitas antibakteri dilakukan dengan metode difusi cakram. Penelitian dilakukan dengan 3 variasi konsentrasi yang berbeda. Hasil penelitian menunjukkan bahwa ada aktivitas antibakteri pada setiap konsentrasi. Kesimpulan pemberian aktivitas daun talas dengan konsentrasi 15%, 25%, dan 35% memberikan daya hambat pertumbuhan bakteri paling efektif dengan kosentrasi 25%, 35% yang termasuk dalam kategori kuat. Saran diharapkan kepada peneliti selanjutnya dapat melakukan uji terhadap bakteri lain dan membuat formulasi dari ekstrak daun talas.

SEMINAR TENTANG IDENTIFIKASI DRPs PADA PASIEN GERIATRI YANG MENERIMA RESEP POLIFARMASI PADA PENYAKIT STROKE Yanna Rotua Sihombing; Asti Pratiwi; Yosi Darmirani
JURNAL PENGMAS KESTRA (JPK) Vol 1 No 2 (2021): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

This study aims to determine the presence of DRPs in geriatric patients who are prescribed polypharmacy in stroke patients. This study is a prospective study with data presented descriptively. Data were obtained from medical records, drug information cards and patient interviews. The results of this study were 41 patients who were used as subjects. There were 3 people (7.32%) experienced DRPs and 38 people (92.68%) did not experience DRPs. Of the seven categories of DRPs, there were only 2 categories of DRPs, category 1, namely congenital drug therapy that was not localized (2.44%) and category 2, which was the incidence of too high a dose (4.88%)

SEMINAR UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL SABUT PINANG ( Areca catechu L.) TERHADAP Escherichia coli Asti Pratiwi; Cucu Arum Dwi cahya; Yosi Darmirani
JURNAL PENGMAS KESTRA (JPK) Vol 1 No 2 (2021): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Diarrhea one of the major diseases that still being a public health’s problem in Indonesia because of it’s high morbidity and mortality. The common agent of diarrhea is Escherichia coli. One of the many plants that are empirically is Areca catechu L. Coir nut is extracted macerating with ethanol solvent. Extracts obtained by phytochemical screening and this study consisted of 5 treatment groups: extract concentration 30 mg / ml, 60 mg / ml, 90 mg / ml, positive control (Amoxicilin) and negative control (DMSO), with 3 repetitions, antibacterial was performed by the Kirby-Bauer disc diffusion method. Ethanol extract of arco nut contains flavonoid and tannin compounds. Ethanol extract of arco nut has antibacterial activity at concentrations of 30 mg / ml, 60 mg / ml, and 90 mg / ml against Escherichia coli with mean inhibitory zone diameter 14.35 mm, 16.50 mm, 18.17 mm. The result of data analysis using Kruskal-wallis and continued with LSD test (p <0,05) showed that ethanol extract of areca nut had antibacterial activity which was significant to Escherichia coli and the higher concentration, the more area of inhibition zone was produced.

SEMINAR UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN TALAS (Colococasia Esculenta L.) TERHADAP BAKTERI Escherichia coli Chandra Pranata; Sartika .; Yosi Darmirani
JURNAL PENGMAS KESTRA (JPK) Vol 1 No 2 (2021): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Salah satu tanaman yang sering dijadikan obat adalah daun Talas (Colocasia esculanta L.). Daun talas memiliki kandungan senyawa flavonoid, alkaloid, saponin dan tannin yang memiliki kemampuan untuk menghambat pertumbuhan bakteri. Eschericia coli adalah salah satu jenis bakteri yang dapat menyebabkan infeksi pada pencernaan. Salah satu tujuan penelitian ini untuk mengetahui aktivitas antibakteri daun talas dengan konsentrasi yang paling efektif dalam menghambat bakteri Eschericia coli. Penelitian ini adalah penelitian eksperimental murni. Daun talas aktivitas antibakteri dilakukan dengan metode difusi cakram. Penelitian dilakukan dengan 3 variasi konsentrasi yang berbeda. Hasil penelitian menunjukkan bahwa ada aktivitas antibakteri pada setiap konsentrasi. Kesimpulan pemberian aktivitas daun talas dengan konsentrasi 15%, 25%, dan 35% memberikan daya hambat pertumbuhan bakteri paling efektif dengan kosentrasi 25%, 35% yang termasuk dalam kategori kuat. Saran diharapkan kepada peneliti selanjutnya dapat melakukan uji terhadap bakteri lain dan membuat formulasi dari ekstrak daun talas

WORKSHOP FORMULATION OF LIQUID SOAP PREPARATIONS OF CITRUS LEAF EXTRACT PURUT (CITRUS HYSTRIX) AS AN ANTISEPTIC AGAINST STAPHYLOCOCCUS AUREUS BACTERIA asti pratiwi; Safrika Juliana Siahaan; Chandra Pranata; Yosi Darmirani
JURNAL PENGMAS KESTRA (JPK) Vol 2 No 2 (2022): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Kaffir lime leaves contain compounds such as flavonoids, saponins, and tannins. Staphylococcus aureus is a pathogenic bacterium associated with virulence. Pharmaceutical preparations used to maintain healthy skin are soaps. The purpose of this study was to determine the inhibitory power of the Liquid Soap Preparation Formulation of Kaffir lime Leaf Extract as an Antiseptic Against Staphylococcus aureus Bacteria. The study was carried out by making ethanol extract of purut orange leaves formulated with liquid soap preparations, then an inhibitory test was carried out on Staphylococcus aureus bacteria that had been bred 3 times with concentrations of 20%, 40%, and 60% and positive and negative controls were carried out. The results of the analysis showed that the formulation of liquid soap preparations of ethanol extract of purut orange leaves with a concentration of 60% has the strongest power against the growth of Staphylococcus aureus bacteria. In conclusion, the concentration of the formulation of liquid soap preparations of ethanol extract of purut orange leaves is directly proportional to the magnitude of the diameter of the inhibitory zone.

ANTIBACTERIAL ACTIVITY TEST OF CELERY LEAF ETHANOL EXTRACT (APIUM GRAVEOLENS L.) AGAINST BACTERIA STREPTOCOCCUS SANGUINIS Chandra Pranata; Renty Monica; Asti Pratiwi; Yosi Darmirani
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar

Kesehatan mulut, gigi penting bagi manusia. Bakteri penyebab terjadinya gingivitis adalah Streptococcus sanguinis. chlorhexidine sebagai larutan yang dimanfaatkan guna membersihkan rongga mulut serta mencegah terjadinya pembentukan plak pada gigi. Alternatif obat kumur yang berasal dari alam adalah daun seledri (Apium graveolens L.) dengan kandungan metabolit sekunder yaitu flavonoid, saponin, alkaloid, tanin. Guna mengetahui kegiatan dan konsentrasi efektif hambatan di ekstrak penelitian ini menggunakan difusi cakram sebagai metodenya dengan konsentrasi ekstrak 12,5%, 25%, 50%, 100% ditandai terbentuknya zona hambat (bening) dengan terbentuknya zona hambat (bening) dengan kontrol positif chlorhexidine dan kontrol negatif aquadest. Hasil uji aktivitas antibakteri ekstrak etanol daun seledri pada bakteri Streptococcus sanguinis adalah pada kelompok kontrol negatif (aquadest) adalah 0 mm, konsentrasi 12,5% adalah 8,15 mm, pada konsentrasi 25% sebesar 7,95 mm, konsentrasi 50% sebesar 9,05 mm, konsentrasi 100% sebesar 9,9 mm, sedangkan pada chlorhexidine (kontrol positif) didapatkan rata-rata sebesar 17,83 mm. Adanya aktivitas ekstrak etanol daun seledri terhadap pertumbuhan bakteri Streptococcus sanguinis dengan konsentrasi yang efektif menghambat pertumbuhan bakteri Streptococcus sanguinis ialah konsentrasi 100%.

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