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PHENOL COEFFICIENT OF DISINFECTANT PRODUCTS DISTRIBUTED IN A SUPERMARKET OF LUBUK PAKAM Fahma - shufyani; Asti Pratiwi; Wantrio Pardomuan Siringoringo
Jurnal Penelitian Farmasi & Herbal Vol 1 No 1 (2018): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v1i1.58

Disinfectant products distributed in Lubuk Pakam vary in types from different manufacturers. The disinfectant ingredients are phenol and quartenary ammonium. The potency of disinfectant for killing microorganisms needs to be evaluated to assure the quality of the products. This study was carried out to determine the effectivity of disinfectant products based on phenol coefficient. Phenol coefficient testing of disinfectant products was microbiologically performed against Salmonella typhi. The disinfectant solutions were prepared by diluting the sample in sterile distilled water in ratio of 1:5, 1:10, 1:20, 1:30, 1:40, and 1:50. Phenol solution (5%, w/v) was used as disinfectant standard. The growth of bacteria was observed at the exposure time of 5, 10, and 15 minutes. The results indicated that the phenol coefficient of product A, B, C, D, E, F, and G were 2.38, 2.00, 3.00, 3.38, 2.38, 2.63, and 3.00, respectively. Statistical analysis using Kruskal-Wallis test showed that the quality of desinfectant products was significantly different (p < 0.05). This study revealed that product A, B, C, D, E, F and G distributed in many supermarket of Lubuk Pakam fulfilled the requirement of disinfectant activity. Product that contain HCl had the strongest activity than other disinfectant products.

PENETAPAN KADAR VITAMIN C PADA KULIT PISANG (Musa paradisiaca) DENGAN METODE SPEKTROFOTOMETRI UV-VISIBLE TAHUN 2018 Asti Pratiwi; Ardita Febrianty Manurung; Jhoti sumitra
Jurnal FARMASIMED (JFM) Vol 2 No 2 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v2i2.363

Background: Vitamin C is a vitamin that is water soluble qnd one vitamin that are needed by the body. To meet the intake of vitamin C needed source of vitamin a derived from fruits, one of which is banana. Part of the banana , which is still rarely used is its skin. Banana peel is very beneficial for health however the situation is only considered as waste that has not been utilized well. This study aims to determine the levels of vitamin C on the skin of the banana (Musa paradisiaca) by the method of spectrofotometry uv-visible wavelength 224,5 nm. Method: This research use experimental with purely research stage comprise sample preparation, qualitative test, making the solution of the parent raw, quantitative test, determination of wavelength of maximum vitamin and creation of calibration surve. Result: Based on the research that has been done obtained the result of the qualitative test to prove the presence of high content of vitamin C contained in banana peels, with the highest level obtained in the skin of the plantain by 0,0253 mg/ml and the levels of the lowest on a banana peel the wax by 0,0172 ng/ml. Discussion: Levels of vitamin C on the skin of the banana barangan of 0, 0219 mg/ml, sample a banana skin banten by 0, 0173 mg/ml, sample a banana peel wax by 0, 0172 mg/ml and sample the skin of plantain by 0, 0253 mg/ml.

EFEKTIVITAS FORMULASI SEDIAAN LOTION DARI EKSTRAK ETANOL DAUN ALPUKAT (PERSEA AMERICANA MILL) SEBAGAI PELEMBAB KULIT Hastrina Novasari; Asti Pratiwi; Nopri Mahmiara
Jurnal FARMASIMED (JFM) Vol 3 No 2 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i2.571

Avocado plant can be formulated into a lotion because preparation based on previous research avocado leavescontain high antioxidant is represented with flavonoid compound. The purpose of this study is to know avocado leaves can be formulated into the preparation of lotion and to know the preparation of lotion from extract etanol avocado leavescan moisturaize the skin. The research uses exsperimental method. Avocado leaves is exstrach by maceration process. Exanination of lotion preparation by this research is phytochemical screening test, pH test,irritation test and skin moisturaise test with concentration 3% and 5%. Extrach ethanol avocado leaves can be formulated into a skin moisturaizing lotion preparation with irritation test results showed no irritation on the skin, skin moisture examination result concentration 5% moist. The result showed that moisturaizing lotion preparation from avocado leaves ethanol extrach (Persea americana Mill) for skin moisture with different concentration can be formulated into skin moisturaizing lotion preparation

FORMULASI EKSTRAK DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb) SEBAGAI MASKER GEL PEEL OFF Dewi Kartika; Lulu Atikah; Asti Pratiwi
Jurnal FARMASIMED (JFM) Vol 4 No 1 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i1.801

Pandan wangi (Pandanus amaryllifolius Roxb) adalah tanaman yang mengandung alkaloid kimia, flavonoid, tanin, dan polifenol. Penelitian ini bertujuan untuk mengetahui apakah daun pandan wangi dapat diformulasikan sebagai masker gel peel of untuk melembabkan kulit. Ekstrak daun pandan wangi dibuat dalam konsentrasi 0% (blanko), 2,5%, dan 5% yang dibuat dalam sediaan 30 gram. Uji yang dilakukanmeliputi organoleptik, homogenitas, pH, persiapan waktu kering, dan kelembapan. Hasil penelitian menunjukkan bahwa ekstrak daun pandan wangi dapat dibuat sebagai bentuk masker gel dan memenuhi evaluasi fisik bentuk. Hasil tes homogenitas menunjukkan sediaan homogen, pH dalam kisaran 6.0 yang relatif aman pada permukaan kulit wajah. Waktu persiapan mengering selama 30 menit dan memenuhi persyaratan waktu pengeringan. Kemampuan untuk melembabkan kulit lebih besar dengan meningkatkan konsentrasi ekstrak yang ditambahkan. Kemampuan rata-rata tertinggi untuk melembabkan kulit adalah 39,0%. dalam tes kelembaban konsentrasinya adalah 5% ekstrak daun harum pandan karena kulit masker gel pelembab alami sangat baik. Kesimpulannya menunjukkan bahwa ekstrak daun pandan wangi dapat diformulasikan menjadi masker gel peel off yang memiliki kemampuan melembabkan kulit.

ANTI-BACTERIAL ACTIVITY TEST OF SURGERY RHIZOME (CURCUMA DOMESTICA VAL) AGAINST BACTERIA STREPTOCOCCUS MUTANS Asti Pratiwi; Zulfan Hardiansyah Ritonga
Jurnal FARMASIMED (JFM) Vol 4 No 2 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i2.1008

Abstract Turmeric (Curcuma domestica Val) contains various compounds such as alkaloids, flavonoids, curcumin, essential oils, saponins, tannins and terpenoids. The curcuminoids in turmeric rhizome are a group of phenolic compounds. Curcumin damages the cytoplasmic membrane and denatures cell proteins which causes the leakage of nutrients from the cells thereby inhibiting the growth of bacteria. The purpose of this study was to test the antibacterial activity of turmeric (Curcuma domestica Val) rhizome against Streptococcus mutans bacteria. In this study, its activity against Streptococcus mutans was seen through laboratory examination using the paper disc method. From the results of the four turmeric rhizome extracts, the average inhibition zone obtained a concentration of 10% produced an average of 14.48 mm. Concentration of 20% produces an average of 16.35 mm. concentration of 30% produces an average of 17.26 mm. Concentration of 40% produces an average of 19.47 mm. In this case, turmeric rhizome extract has strong activity against Streptococcus mutans bacteria. Turmeric rhizome contains secondary metabolites of flavonoids, alkaloids, and tannins. Which works as an antibacterial are flavonoids. Because flavonoids can inhibit nucleic acid synthesis, inhibit cell membrane function and inhibit energy metabolism.

SEMINAR TENTANG IDENTIFIKASI DRPs PADA PASIEN GERIATRI YANG MENERIMA RESEP POLIFARMASI PADA PENYAKIT STROKE Yanna Rotua Sihombing; Asti Pratiwi; Yosi Darmirani
JURNAL PENGMAS KESTRA (JPK) Vol 1 No 2 (2021): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

This study aims to determine the presence of DRPs in geriatric patients who are prescribed polypharmacy in stroke patients. This study is a prospective study with data presented descriptively. Data were obtained from medical records, drug information cards and patient interviews. The results of this study were 41 patients who were used as subjects. There were 3 people (7.32%) experienced DRPs and 38 people (92.68%) did not experience DRPs. Of the seven categories of DRPs, there were only 2 categories of DRPs, category 1, namely congenital drug therapy that was not localized (2.44%) and category 2, which was the incidence of too high a dose (4.88%)

SEMINAR ANTIBAKTERI EKSTRAK ETANOL DAUN PACAR AIR (Impatiens balsamina L.) TERHADAP BAKTERI Propionibacterium acne Debi Dinha Octora; Asti Pratiwi; Krismawati Waruwu
JURNAL PENGMAS KESTRA (JPK) Vol 1 No 2 (2021): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

The antibacterial activity of Impatiens balsamina L. has been studied for many years. Water henna leaves contain flavonoids, saponins and tannins which have the ability to inhibit bacterial growth. P. acnes is one type of bacteria that can cause infection in acne. One of the objectives of this study was to determine the antibacterial activity of the ethanol extract of henna water leaves and the most effective concentration in inhibiting P. acnes bacteria. This research is a pure experimental research. Water henna leaves were macerated with 96% ethanol as solvent. Antibacterial activity test was carried out by disc diffusion method. The research was conducted with 3 different concentration variations. The results showed that there was antibacterial activity at each concentration. The conclusion is that the ethanol extract of henna leaves with concentrations of 25%, 50% and 75% gave the most effective bacterial growth inhibition with concentrations of 25%, 50% and 75% which were included in the strong category.

SEMINAR UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL SABUT PINANG ( Areca catechu L.) TERHADAP Escherichia coli Asti Pratiwi; Cucu Arum Dwi cahya; Yosi Darmirani
JURNAL PENGMAS KESTRA (JPK) Vol 1 No 2 (2021): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Diarrhea one of the major diseases that still being a public health’s problem in Indonesia because of it’s high morbidity and mortality. The common agent of diarrhea is Escherichia coli. One of the many plants that are empirically is Areca catechu L. Coir nut is extracted macerating with ethanol solvent. Extracts obtained by phytochemical screening and this study consisted of 5 treatment groups: extract concentration 30 mg / ml, 60 mg / ml, 90 mg / ml, positive control (Amoxicilin) and negative control (DMSO), with 3 repetitions, antibacterial was performed by the Kirby-Bauer disc diffusion method. Ethanol extract of arco nut contains flavonoid and tannin compounds. Ethanol extract of arco nut has antibacterial activity at concentrations of 30 mg / ml, 60 mg / ml, and 90 mg / ml against Escherichia coli with mean inhibitory zone diameter 14.35 mm, 16.50 mm, 18.17 mm. The result of data analysis using Kruskal-wallis and continued with LSD test (p <0,05) showed that ethanol extract of areca nut had antibacterial activity which was significant to Escherichia coli and the higher concentration, the more area of inhibition zone was produced.

WORKSHOP FORMULATION OF LIQUID SOAP PREPARATIONS OF CITRUS LEAF EXTRACT PURUT (CITRUS HYSTRIX) AS AN ANTISEPTIC AGAINST STAPHYLOCOCCUS AUREUS BACTERIA asti pratiwi; Safrika Juliana Siahaan; Chandra Pranata; Yosi Darmirani
JURNAL PENGMAS KESTRA (JPK) Vol 2 No 2 (2022): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Kaffir lime leaves contain compounds such as flavonoids, saponins, and tannins. Staphylococcus aureus is a pathogenic bacterium associated with virulence. Pharmaceutical preparations used to maintain healthy skin are soaps. The purpose of this study was to determine the inhibitory power of the Liquid Soap Preparation Formulation of Kaffir lime Leaf Extract as an Antiseptic Against Staphylococcus aureus Bacteria. The study was carried out by making ethanol extract of purut orange leaves formulated with liquid soap preparations, then an inhibitory test was carried out on Staphylococcus aureus bacteria that had been bred 3 times with concentrations of 20%, 40%, and 60% and positive and negative controls were carried out. The results of the analysis showed that the formulation of liquid soap preparations of ethanol extract of purut orange leaves with a concentration of 60% has the strongest power against the growth of Staphylococcus aureus bacteria. In conclusion, the concentration of the formulation of liquid soap preparations of ethanol extract of purut orange leaves is directly proportional to the magnitude of the diameter of the inhibitory zone.

ANTIBACTERIAL ACTIVITY TEST OF CELERY LEAF ETHANOL EXTRACT (APIUM GRAVEOLENS L.) AGAINST BACTERIA STREPTOCOCCUS SANGUINIS Chandra Pranata; Renty Monica; Asti Pratiwi; Yosi Darmirani
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar

Kesehatan mulut, gigi penting bagi manusia. Bakteri penyebab terjadinya gingivitis adalah Streptococcus sanguinis. chlorhexidine sebagai larutan yang dimanfaatkan guna membersihkan rongga mulut serta mencegah terjadinya pembentukan plak pada gigi. Alternatif obat kumur yang berasal dari alam adalah daun seledri (Apium graveolens L.) dengan kandungan metabolit sekunder yaitu flavonoid, saponin, alkaloid, tanin. Guna mengetahui kegiatan dan konsentrasi efektif hambatan di ekstrak penelitian ini menggunakan difusi cakram sebagai metodenya dengan konsentrasi ekstrak 12,5%, 25%, 50%, 100% ditandai terbentuknya zona hambat (bening) dengan terbentuknya zona hambat (bening) dengan kontrol positif chlorhexidine dan kontrol negatif aquadest. Hasil uji aktivitas antibakteri ekstrak etanol daun seledri pada bakteri Streptococcus sanguinis adalah pada kelompok kontrol negatif (aquadest) adalah 0 mm, konsentrasi 12,5% adalah 8,15 mm, pada konsentrasi 25% sebesar 7,95 mm, konsentrasi 50% sebesar 9,05 mm, konsentrasi 100% sebesar 9,9 mm, sedangkan pada chlorhexidine (kontrol positif) didapatkan rata-rata sebesar 17,83 mm. Adanya aktivitas ekstrak etanol daun seledri terhadap pertumbuhan bakteri Streptococcus sanguinis dengan konsentrasi yang efektif menghambat pertumbuhan bakteri Streptococcus sanguinis ialah konsentrasi 100%.

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