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All Journal Health and Medical Journal Jurnal Kesehatan Saintika Meditory Scientific Journal
Eko Perdana Putra
Universitas Baiturrahmah
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Health and Medical Journal

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Functional Evaluation of Sciatic Nerve Anastomosis Wraped by Freeze Dried Human Amniotic Membrane in Sprague Dawley Rat Eko Perdana Putra; Pamudji Utomo; Mujaddid Idulhaq
Health and Medical Journal Vol 2, No 1 (2020): HEME January 2020
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (680.567 KB) | DOI: 10.33854/heme.v2i1.259

Abstract

Background. Peripheral nerve injury (PNI) is a common medical condition. The defected nerve, if not repaired as early as possible, can cause long-term denervation and neurotrophy failure for the target organ. This leads to a series of denervation manifestations, such as muscle atrophy, loss of sensory function, etc. and ultimately, these manifestations seriously affect the patient’s sensorimotor function.1,2  Amniotic membranes have been widely used in ophthalmology and skin injury repair because of their anti-inflammatory properties. In this study, we measured therapeutic efficacy and determined if amniotic membranes could be used for sciatic nerve repair.Material and methods. A post test only control group design has been done  in 10 healthy Sprague Dawley rats. In all rats, a unilateral right side sciatic nerve transection was performed and reanastomosed by different methods: Group I (control group): included 5 rats, the anastomosis was done by epineural microsutures using 8/0 nylon. Group II: included 5 rats, the anastomosis was done by epineural microsutures using 8/0 nylon and  then wraped by freeze dried human amniotic membrane. Functional evaluation of nerve recovery was done over 3 weeks postoperatively using walking tract analysis and calculate using Sciatic Functional Index.Result. Functional results showed that there was no significant difference of the sciatic functional index (SFI) between group I and group II.Conclusion. We can conclude that during 3 weeks functional evaluation, there is no significant difference between control group and  experimental group that achieved freeze dried human amniotic membrane.Keywords: sciatic nerve injury, freeze dried human amniotic membrane, walking tract analysis, sciatic functional index.
Ulkus kaki Diabetik: Sebuah Laporan Kasus Budi Yulhasfi Febrianto; Eko Perdana Putra; Aryaldi Zulkarnaini; Dita Hasni
Health and Medical Journal Vol 5, No 1 (2023): HEME January 2023
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v5i1.1266

Abstract

Ulkus kaki diabetik merupakan salah satu komplikasi dari penyakit diabetes mellitus yang paling ditakuti. Sangat penting bagi pasien diabetes untuk mendapatkan kontrol glukosa yang optimal dengan secara ketat mematuhi terapi pengobatan, diet dan olahraga untuk mengurangi komplikasi jangka panjang yang terkait dengan ketidakpatuhan terhadap rekomendasi pengobatan. Pada kasus ini, seorang Perempuan berusia delapan puluh tiga tahun, menderita Diabetes Melitus Tipe-II dan mengkonsumsi obat-obatan secara tidak teratur, kemudian dirawat dengan riwayat nekrosis jari kaki kanan kedua yang kemudian diamputasi. Kadar gula darah sewaktu bervariasi dari 70-210 mg/dl selama masa rawatan. Kurang nya adeherensi terhadap pengobatan diabetes akibat usia  dan lamanya menderita diabetes lebih dari 30 tahun merupakan penyebab  terjadinya komplikasi seperti diabetes ulkus kaki pada pasien kasus diabetes ini . Dokter berperan memberikan terapi pasien baik farmakoterapi ataupun non-farmakoterapi, juga mengedukasi pasien dan keluarga mengenai penyakitnya, pentingnya kepatuhan terhadap pengobatan, pemantauan kadar glukosa darah yang tepat waktu, serta perawatan kaki dan luka yang tepat untuk mencegah keparahan penyakit.
Co-Authors Annisa Lidra Maribeth Aryaldi Zulkarnaini Budi Yulhasfi Febrianto Dita Hasni Irma Primawati Mujaddid Idulhaq Naima Lassie Pamudji Utomo Rendri Bayu Hansah Riki Nova Safira Mardatillah Yolla Adelina Utami