Article Per Year (5 Year)
p-Index From 2019 - 2024
0.23
P-Index
This Author published in this journals
All Journal Indonesian Journal of Cancer Chemoprevention Makara Journal of Science
Zalinar Udin
Research Center for Chemistry, Indonesian Institute of Sciences, Indonesia
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Cytotoxicity Assay From Fractions of Hedyotis corymbosa Extract Against Breast Cancer Cell Line T47D Andriyani, Rina; Risdian, Chandra; Udin, Zalinar
Indonesian Journal of Cancer Chemoprevention Vol 2, No 1 (2011)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

Abstract

Drug discovery for cancer medication is the most important effort that researcher do  at  this time. Indonesia bio diversities  have  possibility  as  a cancer medicine  sources. Finding a herbal medicine for cancer treatment is a first step to find a right cancer medicine in the future.This research has already completed for the earlier another research.Some fractions of Hedyotis corymbosa extract has been analyzed using Sulforhodamine B method with  UV wavelength  515 nm against T47D cell line, a human breast cancer. There are Hexane extract, Methylene chloride extract and Ethyl acetate extract,and give inhibitory concentration 50 (IC50) of 33.45 1g/ml, 54.59 1g/ml and 52.58 1g/ml, respectively. Ethanolic extract,  itself  has  IC50 of 61.57 1g/ml, whereas IC50 value of  Cisplatinum is 9.63 1g/ml. There is a difference between the ethanolic extracts with the other fraction.
Molecular Docking of Robustaflavone Derivatives on Pi3k Protein Target and The Correlation With Its Cytotoxic Activity on Cancer Cells Handayani, Sri; Udin, Zalinar
Indonesian Journal of Cancer Chemoprevention Vol 2, No 3 (2011)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

Abstract

Robustaflavone  derivatives  have  cytotoxic  effect  on  cancer  cell.  Inhibition  of  PI3K  on cancer  cell  has  correlation  with  apoptotic  induction.  The  aim  of  this  research  is  to  observe interaction  from  robustaflavone  derivatives  on  PI3K  receptor  that  may  give  contribution  to  the cytotoxic effect of the compounds on cancer cell line. Geometric optimization of robustaflavone derivatives  structured  was  done  used  Hyperchem  7.5  software.  Arguslab  4.01  software  with GAdock  method  applied  for  the  docking  step.  The  docking  result  showed  that  robustaflavone 7,4,7-  trimethyl  ether  (RTE)  has  affinity  on  PI3K  target  receptor  which  gave  the  lowest  Gibbs free energy (∆G -10,855 kcal/mol).Key words: robustaflavone, PI3K, cancer, docking
Lemongrass (Cymbopogon citratus) Ethanolic Extract Exhibited Activities That Inhibit -glucosidase Enzymes and Postprandial Blood Glucose Elevation Gunawan Puteri, Maria Dewi Puspitasari Tirtaningtyas; Tjiptadi, Felicia Melissa; Hendra, Phebe; Santoso, Filiana; Udin, Zalinar; Artanti, Nina; Florence Ignatia, Florence Ignatia
Makara Journal of Science Vol. 24, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Lemongrass is a common ingredient in Indonesian traditional herbal medicine that potently inhibits carbohydrate hydrolysis. In this study, the in vitro α-glucosidase inhibitory (AGI) activity of lemongrass was compared with its in vivo activity to retard postprandial blood glucose elevation, and the bioactive compounds responsible for these activities were observed. Both water and ethanolic extracts of lemongrass (WLG and ELG, respectively) were tested in vitro for its inhibition of the sucrose and maltose hydrolyzing activities of rat intestinal glucosidase. ELG was observed to exert higher inhibitory activities (Sucrase IC50 = 8.74 mg/mL; Maltase IC50 = 18.93 mg/mL) than WLG. ELG was evaluated for its in vivo activity to retard blood glucose elevation in mice after sucrose, maltose, and glucose consumption. ELG was also fractionated using activity-guided chromatography, followed by liquid chromatography–mass spectrometry and high-performance liquid chromatography (HPLC). In vivo sugar tolerance test confirmed the AGI activity in a non-dose-dependent manner and showed potential additional mechanisms that may prevent postprandial hyperglycemia. The active principles were acquired in methanol-soluble fraction and purified using preparative thin-layer chromatography. HPLC analysis with commercial standards identified caffeic acid and kaempferol as the compounds responsible for the bioactivity of ELG. Results showed that lemongrass has the potential as herbal medicine ingredient in the management of diabetes.
Co-Authors Chandra Risdian Filiana Santoso Florence Ignatia, Florence Ignatia Gunawan Puteri, Maria Dewi Puspitasari Tirtaningtyas Nina Artanti Phebe Hendra, Phebe Rina Andriyani Sri Handayani Syafruddin Syafruddin Tati Herlina Tjiptadi, Felicia Melissa