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All Journal IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Akta Kimia Indonesia Molekul: Jurnal Ilmiah Kimia Molekul: Jurnal Ilmiah Kimia
Suryati Suryati
Department Of Chemistry Faculty Of Mathematics And Natural Sciences Universitas Andalas, Kampus Limau Manis, Padang 25163, West Sumatra, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Materials Science & Nanotechnology

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A Cytotoxic Compound from n-Hexane Fraction of Lantana camara Linn Leaves Suryati Suryati; Yuni Malasari; Mai Efdi; Elida Mardiah
Molekul Vol 14, No 1 (2019)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.155 KB) | DOI: 10.20884/1.jm.2019.14.1.477

Abstract

In this study, one triterpenoid compound from n-hexane fraction of Lantana camaraLinn leaves has cytotoxic activity was isolated. Isolation was carried out using gravity chromatographycolumnand purification by recrystallization method. Isolated compound was obtained white solid with melting point 252-253oC. The structure of isolated compound was elucidated using spectroscopic analysis Ultraviolet (UV), Infrared (IR), 1H-Nuclear Magnetic Resonance (1H-NMR), 13C-Nuclear Magnetic Resonance (13C-NMR) Heteronuclear Multiple Bond Connectivity (HMBC),  Heteronuclear Multiple Quantum Correlation (HMQC), Distortionless Enhancement Polarization Transfer (DEPT) and comparative literature data, identified as Lantadene A (22β-angeloyloxy-3-oxoolean-12-en-28-oic-acid) with molecule formula C35H52O5. The Lantadene A compound was evaluated for cytotoxic activity against shrimp larvae Artemia SalinaLeach using Brine Shrimp Lethality Test(BSLT) method, showed strong cytotoxic activity with an LC50value of 48.97 µg/mL.
DETERMINATION OF SECONDARY METABOLITE CONTENT, TOTAL PHENOLIC ANTIOXIDANT TEST, AND TOXICITY OF ULIN LEAF EXTRACT (Eusideroxylon zwageri Teijsm. & Binn) Yayan Rabbani Kurniawan; adlis santoni; suryati suryati
Akta Kimia Indonesia Vol 7, No 2 (2022)
Publisher : LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j25493736.v7i2.14346

Abstract

Ulin leaf (Eusideroxylon zwageri Teijsm. & Binn) is one of the traditional Indonesian medicinal plants. In this research, the secondary metabolite content, antioxidant activity, cytotoxic and total phenolic content were tested. The extraction process by maceration starts from hexane, ethyl acetate and methanol. The content of secondary metabolites of ironwood leaves are flavonoids, phenolics, steroids, terpenoids, and alkaloids. The results of the antioxidant activity test using the DPPH method (1,1-Diphenyl-2-Picrylhydrazil), methanol extract showed very strong activity IC50 10.96 mg/L, moderate ethyl acetate extract 115,409 mg/L and weak hexane extract IC50 368,555 mg/L. L. This result correlated with the total phenolic yield, methanol extract had the highest value of 162.95 mg GAE/Gram, followed by ethyl acetate extract of 96.7 mg GAE/Gram and hexane with a value of 19.85 mg GAE/Gram. The results of the cytotoxic test using the (BSLT) method on hexane extract had very strong toxicity LC50 82.1675 mg/L, methanol extract and weak ethyl acetate LC50, respectively; 683,282; and 812.456 mg/L.Key word : Ulin, Antioxidants, Total Phenolic, cytotoxic
Isolasi Senyawa Metabolit Sekunder dari Ekstrak Etil Asetat Daun Pulai (Alstonia scholaris (L.) R. Br.) berdasarkan Sifat Toksisitas dengan Metode BSLT (Brine Shrimp Lethality Test) Emil Salim; Suryati Suryati; Rini Ramadani; Wini Sukrila
Akta Kimia Indonesia Vol 7, No 2 (2022)
Publisher : LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j25493736.v7i2.14532

Abstract

Penelitian ini bertujuan untuk mengisolasi senyawa metabolit sekunder dari ekstrak etil asetat daun pulai (Alstonia scholaris) berdasarkan sifat sitotoksik terhadap larva udang Artemia salina. Pemisahan senyawa aktif dilakukan menggunakan kromatografi kolom, eluen petroleum eter:etil asetat (10:0-0:10) dan etil asetat:metanol (10:0–9:1), dan menghasilkan 8 fraksi (F1-F8). Fraction 6 paling aktif dengan nilai LC50 9,47 mg/L, kemudian direkromatografi dengan eluen petroleum eter:etil asetat (7:3) , diperoleh 5 sub-fraksi (F6.1-F6.5). Sifat toksisitas tertinggi ditunjukkan oleh subfraksi F6.5 dengan LC50 7,694 mg/L. Subfraksi F6.5 kemudian dimurnikan dan dikarkterisasi dengan UV dan FTIR. Senyawa hasil isolasi diketahui merupakan senyawa alkaloid.
Analysis of Chemical Content, Cytotoxic and Anti-Bacterial Activity Essential Oil of Lantana Camara Linn Leaves from Various Regions Suryati suryati; Adlis Santoni; Bustanul Arifin; Norman Ferdinal; Emil Salim; Asri Amelia; Leidina Zein; Silfani Mairanti; Indah Putri Lestari
Molekul Vol 17 No 2 (2022)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2022.17.2.5143

Abstract

Lantana camara Linn is a family of Verbenaceae that grows in tropical and subtropical areas and spread in about 50 countries in the world. This plant contains essential oils with different contents based on the difference in the place of growth. The purpose of this study was to isolate and determine the chemical content of the essential oil of L. camara Linn leaves obtained from Agam, Tanah Datar, Kampar Regency, Padang Panjang City and to determine its cytotoxic and antibacterial activity. Isolation was carried out by hydro distillation method and chemical content analysis using Gas Chromatography-Mass Spectrometry (GC-MS). The high yield from the isolation of essential oil from leaves of L. camara Linn obtained from Tanah Datar Regency was 0.095% (w/w). The results of the analysis of the essential oil content with the main compounds for all Regency and City being caryophyllene with the high area percent was Tanah Datar Regency (19.74%). Cytotoxic activity test using the Brine Shrimp Lethality Test (BSLT) method showed that L. camara Linn essential oil was highly toxic with an LC50 value of 28.34 µg/mL from Padang Panjang City. Antibacterial activity test by disc diffusion method showed that L. camara Linn essential oil had moderate antibacterial activity againts Staphylococcus aureus and Escherichia coli bacteria, with high clear zone from Agam Regency was 12.9 mm and Tanah Datar Regency was 7.8 mm, respectively, at concentration of 100%.
Phytochemical Constituent and Cytotoxic Activity of Eusideroxylon zwageri Teijsm & Binn Extract and Sub-Fraction on Human Breast Cancer Cell Line T47D Yayan Rabbani Kurniawan; Adlis Santoni; Suryati Suryati
Molekul Vol 18 No 2 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.2.7112

Abstract

Eusideroxylon zwageri Teijsm. & Binn T has been reported to have bioactivity, one of which is the potential as an excellent cytotoxic agent using the BSLT method. So far, stage tests using cancer cells and analysis of the content of secondary metabolites have not been reported, Therefore, it is essential to analyze the content of secondary metabolites using Liquid Chromatography – Tandem Mass Spectrometry (LC-MS/MS) and determination of cytotoxic activity using Brine Shrimp Lethality Test (BLST) mwthod with various solvent polarities. Then separation by bioassay-guided isolation using column chromatography of the active extract assay BSLT. Furthermore, the cytotoxic activity of the active extract and the active isolate was tested against T47D cancer cells with Microculture Tetrazolium (MTT) method. The results of the analysis of the content of secondary metabolites using LC-MS/MS identified senbusine B and 6,7-Dehydroartemisinic acid on hexane extract, while the ethyl acetate extract produced 4 compounds, and 15 compounds were identified in the methanol extract. The results of the cytotoxic activity test using the BSLT method on each extract showed that the hexane extract was the most active, with an LC50 of 17.56 mg/L. Furthermore, the cytotoxic activity of hexane extract against T47D cells showed weak activity with an IC50 value of 237.5 mg/L, while the AB1 sub-fraction showed moderate activity with an IC50 value of 138.4 mg/L. The results of the analysis using HPLC indicated that the active isolate in the form of sub-fraction AB1 contained the compound senbusine B.
Cytotoxic Potential of Essential Oil Isolated from Clibadium Surinamese L Leaves Against T47D Breast and HeLa Cervical Cancer Cells Rahmi Vika Ulia; Suryati suryati; Adlis Santoni
Molekul Vol 18 No 2 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.2.7816

Abstract

Semambu (C. surinamense L) plant is a shrub plant that is easy to find. Several terpenoid compounds have been isolated from this plant, previous studies have shown cytotoxic activity of terpenoid class compounds. Terpenoid compounds in a plant are mostly found in essential oils (monoterpenes and sesquiterpenes). So far, there has been no report on the cytotoxic potential of essential oils from the leaves of this plant. It is necessary to isolate the essential oils from C. surinamense L leaves and test their cytotoxic potential. Isolation of essential oil of C. surinamense L leaves was carried out by hydrodistillation method, the oil was obtained in the form of a light yellow liquid with a specific gravity of 0.968 g/mL. Analysis of chemical components with Gas Chromatography-Mass-Spectrometry (GC-MS) through comparison of data from the National Institute of Standards and Technologies (NIST) found that there were 55 compounds (monoterpene and sesquiterpene groups) with six main compounds, namely β-caryophyllene (30.4%), β-sesquiphellandrene (8.46%), 3 carene (8.16%), α-bisabolene (4.05%), α-humulene (4.0%), and epi- bicyclosesquiphellandrene (4.0%). The potential cytotoxic test of essential oil from isolation showed highly cytotoxic activity with the Brine Shrimp Lethality Test (BSLT) method against Artemia salina L shrimp larvae with LC50 value of 0.9261 μg/mL and Microculture tetrazolium test (MTT) method against T47D breast cancer cells and HeLa cervix with IC50 values of 12.72 μg/mL and 30.14 μg/mL.
Antibacterial Activity of Triterpenoid from The Leaves of Tahi Ayam (Lantana camara Linn) Kartika MZ; Suryati Suryati; Mai Efdi
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 8, No 3 (2023): October 2023
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v8.i3.110

Abstract

Tahi Ayam (Lantana camara Linn) is known as the herbal plant to cure several diseases and has been used in folk medicine. The result of this study indicates that the isolated compound and the ethyl acetate fraction are components having antibacterial activity. The isolated compound from the ethyl acetate fraction from the leaves of the Lantana camara Linn plant is 9-hydroxy-Lantadene A. The compound includes the triterpenoid compound group, the molecular formula is C35H52O6, and another name is 22-angeloiloxy-9-hydroxy-3-oxo-olean-12-en-28-oat. The antibacterial activity of this compound was determined by looking at the inhibition zone of the test bacteria, namely Staphylococcus aureus as gram-positive and Escherichia coli as gram-negative. The treatment has been using the disc diffusion method and using amoxicillin as a control positive. The result of the antibacterial activity test revealed that both 9-hydroxy-Lantadene A and the ethyl acetate fraction exhibited antibacterial activity. Becouse there are inhibition zones around the discs at concentrations of 10 μg/disk and 5 μg/disk.
Co-Authors Adlis Santoni Asri Amelia Bustanul Arifin Elida Mardiah Indah Putri Lestari Kartika MZ Leidina Zein Mai Efdi Norman Ferdinal Rahmi Vika Ulia Rini Ramadani Salim, Emil Silfani Mairanti Wini Sukrila Yayan Rabbani Kurniawan Yayan Rabbani Kurniawan Yuni Malasari