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All Journal CHEMISTRY PROGRESS JOPS (Journal Of Pharmacy and Science) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Pengabdian Masyarakat Nusantara Jurnal Sains dan Kesehatan
Ahlan Sangkal
Universitas Muhammadiyah Manado
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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Journal : JOPS (Journal Of Pharmacy and Science)

 1 
Aktivitas Antiinflamasi Gel Cabai Rawit (Capsicum frutescens L.) pada Tikus Putih (Rattus norvegicus) Rahmat Ismail; Abulkhair Abdullah; Ahlan Sangkal; Randi R. Toboleu
JURNAL FARMASI DAN MAKANAN Vol 6 No 1 (2022): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i1.3012

Abstract

Cayenne pepper (Capsicum frutescens L.) is a plant that has many benefits, one of which is as an anti-inflammatory. The anti-inflammatory effect of cayenne pepper was tested on white rats in the form of a gel. Two gel formulas were used with different concentrations of propylene glycol as additive, 25% and 30%, respectively. White rats were grouped into 4 groups, negative control group (gel base), positive control group (Voltaren® Emulgel), gel formula 1 group (enhancer 25%), and gel formula 2 (enhancer 30%). Albumen was induced on the backs of white rats then samples were given. Skinfold thickness measurements were taken every 1 hour for 6 hours. The data obtained in the form of skin thickness values ​​(mm). The % Inflammation Inhibition (% PI) was calculated for each sample. Formula 1 and Formula 2 gave %PI of 32.58 ± 1.80 and 40.75 ± 5.71, respectively. Both formulas had an anti-inflammatory effect against edema on the back of rats although not better than Voltaren® Emulgel. Based on One Way ANOVA test, Formula 2 has a better anti-inflammatory effect than Formula 1. LSD test results show that %PI Formula 2 is similar to %PI Voltaren® Emulgel with a significance value of 0.117 (>0.05).
Co-Authors Abulkhair Abdullah Adelin Liputo Agust Arthur Laya Ayu S. Jamal Hamidah Sri Supriati Mutmainnah Mutmainnah Nini M. Hanafi Nurfatima S. Marasabessy Rahmat Ismail Randi R. Toboleu