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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Nexus Kedokteran Klinik Majalah Kesehatan Pharmamedika JOSSAE (Journal of Sport Science and Education) Cermin Dunia Kedokteran
Nanang Wiyono
Fakultas Kedokteran, Universitas Sebelas Maret
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health Other

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Hubungan Endometriosis dengan Dismenore pada Pasien Poliklinik Obstetri dan Ginekologi di RSUD Dr. Moewardi Rachmawan, Dian Fikri; Oepomo, Tedja Danudjo; Wiyono, Nanang
Nexus Kedokteran Klinik Vol 3, No 2 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.046 KB)

Abstract

Background: Generally, reproductive-aged and unpregnant women experience menstruation which is able to be accompanied by dysmenorrhea. Dysmenorrhea prevalence ranged from 1.7% – 97% in 106 studies, which is involving 125.249 women. In 20 high-quality studies with representative samples, dysmenorrhea prevalence was reported between 16.8% – 81%. Approximately, there were 60% – 70% of Indonesian women who  experienced dysmenorrhea during menstruation with 15% of them complained that their activities were limited due to dysmenorrhea. One of the significant risk factors that cause dysmenorrhea is endometriosis. Nevertheless, there is no definitive data on dysmenorrhea caused by endometriosis in Indonesia. In fact, endometriosis would greatly impact the quality of life of a woman. The present study aims to determine the association between endometriosis and dysmenorrhea among patients admitted on the Obstetrics Gynecology Clinic of RSUD Dr. Moewardi. Methods: The present study was as an analytical observational study with cross sectional approach. A total of 45 subjects were selected from medical records of RSUD Dr. Moewardi by stratified random sampling technique, which subsequently were divided into 2 groups, namely; 15 patients of endometriosis group and 30 patients of gynecologic malignancies other than endometriosis group. Data was collected by interviewing patients and asking them to fill out the questionnaire. Data was analyzed by using Chi Square test and processed with Statistical Product and Service Solutions (SPSS) 19.00 for Windows. Results: Chi Square test showed OR = 24,182; CI 95% = 2,788 – 209,764; and p = 0,000. Patients diagnosed by endometriosis are at risk for dysmenorrhea 24,182 times greater than patients with gynecologic malignancies other than endometriosis. Conclusions: There is a significant association between endometriosis and dysmenorrhea among patients admitted on the Obstetrics Gynecology Clinic of RSUD Dr. Moewardi. Keywords: Endometriosis, dysmenorrhea, stratified randim sampling.  
Pengaruh Ekstrak Etanol Pegagan (Centella asiatica ) Terhadap Volume Hippocampus Tikus (Rattus norvegicus) Pasca Stres Kronik Zulhamidah, Yenni; Wiyono, Nanang; Ratna Sari, Dwi Cahyani; Partadiredja, Ginus
Majalah Kesehatan Pharmamedika Vol 5, No 1 (2013): JUNI 2013
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/mkp.v5i1.1103

Abstract

Background. Chronic stress caused by restraint stress induces an increase in corticosterone (glucocorticoid) that result decreased hippocampal vollume. Centella asiatica has long been used for various neurological disturbances in Southeast Asian countries. Aims. The research aims to investigate the effects of ethanol extracts of Centella Asiatica to prevent the decrease of hippocampal vollume after chronic stress. Methods. Thirty male adult rats (Sprague Dawley) with body weight of 250-350 gram was randomly subdivided into six groups of treatments: Nonstress control group was given 2% Pulvis Gummi Arabicum (PGA), Stress control groups( PGA 2 %), groups treated with fluoxetine 10mg/kgbw/day , and Ca150,  Ca300, Ca600 containing ethanol extracts of Centella asiatica with doses 150 mg/kgbw/day, 300 mg/kgbw/day, 600 mg/kgbw/day a, respectively followed by restraint stress.  After 21 days of stress, rats underwent Morris Water Maze test for 6 days, perfused, and hippocampus was collected for histological processing. Toluidine blue staining is used to asses the estimation of hippocampal volume. Results. The estimated hippocampal volume were 3.1512 ± 1.01 (nonstress), 2.4736 ± 0.10 (stress), 2.7018 ± 1.06 (Ca150), 2.7405 ± 1.19 (Ca300), 2.2678 ± 0.82  (Ca600) and 2.5818 ± 0.70 (Fluoxetine). Statistic test showed that there were no significant diferrence between stress control group and groups treated. Conclusion. There is no the significant effects of Ethanol extracts of Centella Asiatica to prevent the decrease of hippocampal vollume after chronic stress.
Hubungan Tingkat Kecemasan dengan Tingkat Efikasi Diri Pada Atlet Renang Kusumadewi, Isnindri Annisa; Ghozali, Dhoni Akbar; Hastami, Yunia; Wiyono, Nanang
Journal of Sport Science and Education Vol 6, No 1 (2021)
Publisher : Fakultas Ilmu Olahraga, Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/jossae.v6n1.p107-114

Abstract

Anxiety might give the tremendous impact on swimming athletes such as loss of concentration and motor ability which could result in lowering athlete’s performance level in competition. Therefore, there was self efficacy as a psychological aspect which decreasing anxiety level on swimming athletes. A high self efficacy might enable athletes to face and handle the hard situations and also manage their anxiety in competition. This study aimed to determine whether there was a relationship between anxiety amd self efficacy in swimming athlete. This research was an observational study using a cross sectional approach. The subjects were 40 swimming athletes from Pyramid Swimming Club, Bogor aged 10-18 years old. The dependent variable was anxiety which measured using the Taylor Minnesota Anxiety Scale (TMAS) Questionnaire. The independent variable was self-efficacy which measured using a General Self-Efficacy (GSE) Questionnaire. Statistical analysis was performed using Product Moment Pearson test. The result showed there was correlation between anxiety and self-effcicay in swimming athletes as indicated with significance value of 0.031 and the correlation strength was low at 0.298 and the direction of correlation was negative. Based on these result it can be conclude that, there was negative correlation between anxiety and self-efficacy in swimming athletes. 
Modulasi Neurogenesis untuk Pengembangan Terapi Depresi -, Muthmainah; Wiyono, Nanang
Cermin Dunia Kedokteran Vol 44, No 12 (2017): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.776 KB) | DOI: 10.55175/cdk.v44i12.694

Abstract

Depresi merupakan salah satu penyebab morbiditas dan mortalitas yang paling sering, diperkirakan 10-15% penduduk dunia pernah mengalami episode depresi selama hidupnya. Patofisiologi depresi kompleks dan melibatkan tingkat molekuler, seluler dan jaringan. Salah satu teori mekanisme depresi dan kerja antidepresan adalah proses neurogenesis. Neurogenesis pada masa dewasa di gyrus dentatus hippocampus dipengaruhi oleh stres yang berperan dalam patofisiologi depresi; proses neurogenesis ini dapat dimodulasi oleh antidepresan sehingga dapat dimanfaatkan untuk penatalaksanaan depresi. Antidepresan tersebut adalah Selective Serotonine Reuptake Inhibitors (SSRIs) dan Norepinephrine Reuptake Inhibitors (NRIs).Depression is one of the most common causes of mortality and morbidity; it is estimated that 10-15% of world population ever experienced an episode of depression. The pathophysiology of depression is very complex involving mechanism in the molecular and cellular level. The neurogenesis hypothesis postulates that decreased neurogenesis results in depressive phenotype and that neurogenesis is crucial for the behavioural effect of antidepressant. Decreased adult neurogenesis in the dentate gyrus of the hippocampus is induced by stress. Modulation of neurogenesis in this area through administration of antidepressant such as SSRIs and NRIs has been used for the treatment of depression.
The Effect of Reading Activity on Verbal Fluency in Older Adults Herawati, Fitriana; Wiyono, Nanang; Munawaroh, Siti; Hastami, Yunia
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 1 (2021): January - June 2021
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (903.639 KB) | DOI: 10.30659/sainsmed.v12i1.13127

Abstract

Introduction: The high prevalence of dementia affecting verbal fluency have been one of the global major concerns. Therefore, strategies to maintain or improve the verbal fluency in older adults is needed. Neuroplasticity-based program in the form of reading has been shown to affect the verbal fluency. Objective: This study aims to evaluate the effect of reading activity on verbal fluency in the older adults.Methods: This was a quasi-experimental study with pretest-posttest control group design. Thirty older adults were included. The inclusion criteria were more than 60 years of age, being to speak, being able to read, scores > 24, for the Mini-Mental State Examination (MMSE) score, having intention to fill out the reading habits questionnaire criteria. The exclusion criteria were the history of hypertension, diabetes mellitus, and psychiatric disorders, head trauma injury of neurological disorders, hearing loss and alcohol use. The patients were assigned into three groups: the control group (C-G), the 15-minute reading intervention group (G-15), and 30-minute reading intervention group (G-30). The reading aloud activity was given for 14 days. The verbal fluency was evaluated. Statistical analysis was performed using oneway ANOVA, Post Hoc, and paired T-test.Results: There were significant differences among groups in post-test phonemic score (p<0.05). post-test phonemic score in G-15 and G-30 increased significantly compared to that of pre-test phonemic score (p<0.05). Meanwhile, there were no significant difference in semantic score in all groups (p>0.05).Conclusion: The reading activity intervention for two weeks affects verbal fluency in older adults by increasing the phonemic score but not semantic score.
Co-Authors -, Muthmainah Dhoni Akbar Ghozali Dian Fikri Rachmawan Dwi Cahyani Ratna Sari Ginus Partadiredja Hastami, Yunia Herawati, Fitriana Kusumadewi, Isnindri Annisa Siti Munawaroh Tedja Danudjo Oepomo Yenni Zulhamidah, Yenni