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All Journal PHARMACON Jurnal Ilmiah Sains
Paulina V.Y Yamlean
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Mathematics Medicine & Pharmacology Physics

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FORMULASI DAN UJI KELAYAKAN SEDIAAN KRIM ANTI INFLAMASI GETAH TANAMAN PATAH TULANG (Euphorbia tirucalli L) Agral, Omega; Fatimawali, Fatimawali; Yamlean, Paulina V.Y; Supriati, Hamidah Sri
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2313

Abstract

ABSTRACTHas been formulated the latex of pencil tree plant (Euphorbia tirucalli L) to be a cream.Pencil tree plant latex cream formulated with various concentrations of the active substancesi.e 5%, 10%, and 15%. The formulation of pencil tree plant latex cream produced the cramwith good parameter values.Key words : Cream, Pencil Tree Plant (Euphorbia tirucalli L)
FORMULASI DAN UJI EFEKTIVITAS ANTIBAKTERI SEDIAAN GEL EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) SEBAGAI ANTISEPTIK TANGAN Manarisip, Thesya; Yamlean, Paulina V.Y; Lolo, Widya Astuty
PHARMACON Vol 8, No 3 (2019): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.8.2019.29335

Abstract

Kerson Fruit (Muntingia calabura L.) contains bioactive compounds, such as flavonoids, saponins, triterpenes, steroids, and tannins, which are potentially as antibacterial compounds. The aim of this study was to make a formulation of hand antiseptic gel from kerson leaf extracts with three variations in extract concentrations of 5%, 10%, and 15%, and to test the effectiveness of antibacterial preparations against Staphylococcus aureus bacteria. The method of this research is laboratory experimental research. Kerson extracts was obtained by maceration using 96% ethanol. The results showed that kerson leaf extract can be formulated as a hand antiseptic gel preparation that meets organoleptic requirements, like homogeneity, pH, dispersion, consistency, adhesion, cycling test, and antiseptic power testing using a colony counter. On the results of antibacterial effectiveness testing, there is a clear zone that presents the ability to inhibit the growth of gel test bacteria. The average diameter of the hand antiseptic gel preparation of kersen leaf extract at concentrations of 5%, 10%, and 15% respectively were 10.00 mm, 11.66 mm and 12.00 mm so that the ability of inhibition of gel test bacteria in all concentrations was categorized strong. Keywords: Kerson, Muntingia calabura L, Hand Antiseptic Gel, Staphylococcus aureus.  ABSTRAK Kersen (Muntigia calabura L.) mengandung senyawa bioaktif yaitu senyawa flavonoid, saponin, triterpen, steroid, dan tannin yang merupakan senyawa yang berpotensi sebagai antibakteri. Penelitian ini bertujuan untuk membuat formulasi sediaan gel antiseptik tangan dari ekstrak daun kersen dengan tiga variasi konsentrasi ekstrak yakni 5%, 10%, dan 15%, serta menguji efektivitas antibakteri sediaan terhadap bakteri Staphylococcus aureus. Metode penelitian ini merupakan penelitian eksperimental laboratorium. Ekstrak tanaman kersen diperoleh dengan cara maserasi menggunakan pelarut etanol 96%. Hasil penelitian menunjukkan bahwa ekstrak daun kersen dapat diformulasikan sebagai sediaan gel antiseptik tangan yang memenuhi persyaratan organoleptik, homogenitas, pH, daya sebar, konsistensi, daya lekat, cycling test, dan pengujian daya antiseptik dengan menggunakan alat colony counter. Pada hasil pengujian efektivitas antibakteri, terdapat zona bening yang mempresentasikan kemampuan penghambatan pertumbuhan bakteri uji oleh gel. Diameter rata-rata sediaan gel antiseptik tangan ekstrak daun kersen pada konsentrasi 5%, 10%, dan 15% berturut-turut yaitu 10,00 mm , 11,66 mm dan 12,00 mm sehingga kemampuan penghambatan bakteri uji oleh gel disemua konsentrasi dikategorikan kuat. Kata kunci: Kersen, Muntingia calabura L, Gel Antiseptik Tangan, Staphylococcus aureus.
FORMULASI KRIM EKSTRAK ETANOL DAUN LAMUN (Syringodium isoetifolium) Juwita, Anisa Puspa; Yamlean, Paulina V.Y; Edy, Hosea Jaya
PHARMACON Vol 2, No 2 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.1414

Abstract

Seagrass (Syringodium isoetifolium) is a plant that lives submerged at sea, this floweringplant, leaves, and stems that are plugged into a powerful in water. The chemical content ofthe leaves of the Seagrass is a flavonoid, phenol, hydroquinone, and antioxidants.This studyaims to determine the quality of the cream of seagrass leaf extracts using a concentration of5%, 10%, 20% dan 40%. on organoleptic testing conducted cream, homogeneity test, testdispersive power, pH and absorbance test. results obtained in the organoleptic seen from thecolor green, semi-solid dosage forms and distinctive smell seagrass cream. homogeneity test.homogeneity test cream seagrass leaf extract with a concentration of 5% 10% 20% and 40%did not experience any clumping or phase separation dispersive power test creams rangedfrom 2.5 cm - 3.5 cm. pH ranged from 4.93 - 5.96 and test absorption ranged from 3.7 ml - 5ml. seagrass leaf extract cream with type W/O creams that meet the test of homogeneity testquality, dispersive power test, test and test pH absorptionKeyword : Syringodium isoetifolium, Seagrass Leaves, Cream W/O
FORMULASI DAN UJI EFEKTIVITAS ANTIOKSIDAN SEDIAAN KRIM EKSTRAK ETANOL DAUN BELIMBING WULUH (Averrhoa bilimbi L. ) DENGAN MENGGUNAKAN METODE DPPH (1,1-diphenyl-2-picrylhydrazyl) Ariem, Feiby; Yamlean, Paulina V.Y; Lebang, Julianri Sari
PHARMACON Vol 9, No 4 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.31355

Abstract

ABSTRACTBelimbing wuluh leaves (Averrhoa bilimbi L.) Contains  flavonoids, phenols, alkaloids, tannins and coumarin. The aim of this research is formulated ethanol extract of Belimbing Wuluh leaves in the form of cream preparations, as well as test the effectiveness of antioxidants using the DPPH method. Extract was made by maceration method using ethanol 96% formulated into a cream with a concentration of 3%, 5%, 7%. The results of the cream preparations evaluation before and after cycling test meet the requirements of organoleptis, homogeneity, pH, adhesiveness, coverage. The test results of antioxidant activity with the DPPH method using the most effective UV-Vis spectrophotometer as the antioxidant cream of the leaves extract Belimbing Wuluh is 7% has a value of IC50 = 0.118 ppm and vitamin C as comparator has a value of IC50 = 0.0327 ppm. From this research can be concluded that Belimbing Wuluh leaves ethanol extract cream can be formulated as a stable cream and has a very strong antioxidant activity. Keywords: : Belimbing Wuluh Leaves,cream, antioxidant,DPPH ABSTRAK Daun Belimbing Wuluh (Averrhoa bilimbi L.)  mengandung senyawa flavonoid, fenol, alkaloid, tanin dan kumarin. Tujuan penelitian ini membuat formulasi ekstrak etanol daun Belimbing Wuluh dalam bentuk sediaan krim, serta menguji efektivitas antioksidan menggunakan metode DPPH. Pembuatan ekstrak dilakukan dengan metode maserasi menggunakan etanol 96 % diformulasi menjadi krim dengan konsentrasi 3%, 5% ,7%. Hasil evaluasi sediaan krim sebelum dan sesudah cycling test memenuhi persyaratan organoleptis, homogenitas, pH, daya lekat, daya sebar. Hasil uji aktivitas antioksidan dengan metode DPPH menggunakan spektrofotometer UV-Vis yang paling efektif sebagai krim antioksidan dari ekstrak daun Belimbing Wuluh adalah 7 % memiliki nilai IC50 = 0,118 ppm dan vitamin C sebagai pembanding memiliki nilai IC50 = 0,0327 ppm. Dari penelitian ini dapat disimpulkan bahwa krim ekstrak  etanol daun Belimbing Wuluh dapat diformulasikan sebagai sediaan krim yang stabil dan memiliki aktivitas antioksidan yang sangat kuat.  Kata kunci : Daun Belimbing Wuluh, Krim, Antioksidan, DPPH
UJI EFEKTIVITAS EKSTRAK ETANOL DAUN JARAK PAGAR (Jatropha curcas L.) SEBAGAI ANTIHIPERGLIKEMIA TERHADAP TIKUS PUTIH JANTAN (Rattus norvegicus) Pingkan, Aprilia; Yamlean, Paulina V.Y; Bodhi, Widdhi
PHARMACON Vol 9, No 4 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.31359

Abstract

ABSTRACTHyperglicemia is condition where blood sugar levels surge or excessive, which will eventually become a disease called Diabetes Mellitus (DM). One of the plants that can be used for antidiabetic activity or to repair pancreatic β cells is jarak pagar. The study conducted using 15 rats induced with 3 mL of 60% glucosa. Animals then divided into 5 groups, Metformin(10.557 mg), Na-CMC, 125 mg/kg BW, 250 mg/kg BW and 375 mg/kg BW of ethanol extract of jarak pagar leaves. The results showed the percentage value of decrease in blood sugar D1 (19.46%), D2 (15.91%), D3 (53.17%) and the positive group (Metformin) (10.24%). Conclusion: the extract group dose 375 mg/kgBW can reduce blood sugar levels better that the group given extracts dose D1 and D2.  Keywords: Jarak Pagar Leaves (Jatropha curcas L.), Ethanol Extract, Antihyperglycemia, Diabetes.  ABSTRAKHiperglikemia adalah keadaan dimana kadar gula darah melebihi nilai normal dan merupakan salah satu indikasi pada penyakit Diabetes Melitus. Salah satu tumbuhan yang dapat dimanfaatkan untuk aktifitas antidiabetes atau memperbaiki sel β pankreas adalah jarak  pagar. Penelitian dilakukan untuk mengetahui efektivitas ekstrak etanol daun jarak pagar dalam menurunkan kadar gula darah tikus putih jantan. Penelitian menggunakan hewan uji sebanyak 15 ekor untuk diinduksikan dengan glukosa 60% sebanyak 3 mL/ekor. Hewan uji kemudian dibagi menjadi 5 kelompok, kelompok positif, kelompok negatif, dosis 125 mg/kgBB, dosis 250 mg/kgBB, dan dosis 375 mg/kgBB. Hasil penelitian menunjukkan nilai persentase penurunan gula darah D1 (19.46%), D2 (15.91%), D3 (53.17%) dan kelompok positif (Metformin) (10.24%). Kesimpulan: kelompok ekstrak dosis 375 mg/kgBB dapat menurunkan kadar gula darah lebih baik dibandingkan kelompok yang diberikan ekstrak dosis D1 dan D2. Kata kunci :    Daun Jarak Pagar (Jatropha Curcas L.) , Ekstrak Etanol, Antihiperglikemia, Diabetes.          
UJI EFEK ANTIINFLAMASI EKSTRAK ETANOL DAGING BUAH LABU KUNING (Cucurbita moschata D.) TERHADAP EDEMA PADA TELAPAK KAKI TIKUS PUTIH JANTAN GALUR WISTAR (Rattus novergicus) Senewe, Merry; Yamlean, Paulina V.Y; Wiyono, Weny
PHARMACON Vol 2, No 1 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.1016

Abstract

ABSTRACT Inflamation is a protective response of body from injury of cell.Edema is an indication of inflammation.Pumpkin pericarp contains of flavonoid which has potency to decrease edema.The aims of this research were to study antiinflamation effect of ethanolic extract of pumpkin pericarp (Cucurbita moschata D.) with concentration 5, 10 and 20%on edema of white rat legs strain wistar.The subjects in this research were 15 white male rat strain wistar which divided into 5 groups, namely negative control (CMC),  positive control (Piroksikam) and extract group with concentration 5, 10 and 20%.Induction of 5% of chicken albumin on rats left leg lead to edema formation, followed with induction of CMC, Piroksikam solution and extractper oral. Measurement of edema volume was done using plestimometer, and observation of edema were made every 6 hours. The result shows that there were significant administration effects of pumpkin pericarp extract with concentration 5 and 10%. As a conclusion, ethanol extract of pumpkin pericarp exhibit potency to decrease edema.
IDENTIFIKASI DAN PENETAPAN KADAR RHODAMIN B PADA JAJANAN KUE BERWARNA MERAH MUDA YANG BEREDAR DI KOTA MANADO Paulina V.Y Yamlean
JURNAL ILMIAH SAINS Volume 11 Nomor 2, Oktober 2011
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (265.105 KB) | DOI: 10.35799/jis.11.2.2011.221

Abstract

IDENTIFIKASI DAN PENETAPAN KADAR RHODAMIN B PADA JAJANAN KUE BERWARNA MERAH MUDA YANG BEREDAR DI KOTA MANADO Paulina V. Y. Yamlean1) 1)Program Studi Farmasi FMIPA Universitas Sam Ratulangi Manado, 95115; Email:olan_0506@yahoo.co.id ABSTRAK Rhodamin B adalah pewarna terlarang yang sering ditemukan pada makanan, terutama makanan jajanan. Rhodamin B, yaitu zat pewarna berupa serbuk kristal berwarna hijau atau ungu kemerahan, tidak berbau, serta mudah larut dalam larutan warna merah terang berfluoresan sebagai bahan pewarna tekstil atau pakaian. Jenis jajanan yang banyak dijumpai dan dicampuri dengan Rhodamin B, antara lain bubur delima, cendol, kolang-kaling, cincau dan kue-kue lainnya. Setelah dicampuri bahan ini makanan tersebut menjadi berwarna merah muda terang. Hasil penelitian yang diperoleh membuktikan bahwa sampel-sampel kue berwarna merah muda yang beredar di kota Manado ada yang positif menggunakan Rhodamin B. Kata kunci: kue berwarna merah muda, rhodamin B   IDENTIFICATION AND DETERMINATION LEVEL OF RHODAMIN B ON STREET FOOD PINC CAKE THAT CIRCULATION TO MANADO CITY ABSTRACT Rhodamin B is the illegal dyes that is often found in food, especially street foods. Rhodamin B, which is a dye form crystalline powder colored green or reddish purple, odorless, easily soluble in  bright red fluoroscence solution as dye of textiles or apparel. Types of street food that are often found and mixed with Rhodamin B, amon pomegranate porridge, cendol, fro, grass jelly and other pastries. After mix with Rhodamon B, all that food becomes light pink. The results of research has obtained prove that the samples pink cake that circulated in Manado citythere are positive use of Rhodamin B. Keywords: pink cake, rhodamin B
Co-Authors Anisa Puspa Juwita Ariem, Feiby Ba'u, Defrikson Dewa Gede Katja Fatimawali . Hamidah Sri Supriati Hosea Jaya Edy Julianri Sari Lebang, Julianri Sari Manarisip, Thesya Max R.J Runtuwene Merry Senewe Omega Agral Pingkan, Aprilia Vanda S Kamu Weny Wiyono Widdhi Bodhi Widya Astuty Lolo, Widya Astuty