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Optimization of sorbitol, glycerol, and propyleneglycol mixture in sunscreen gel of ethanolic extract of Curcuma mangga Yuliani, Sri Hartati Hartati
INDONESIAN JOURNAL OF PHARMACY Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The research about optimization of sorbytol, glycerol, and propyleneglycol mixtureÂ inÂ sunscreenÂ gelÂ ofÂ ethanolicÂ extractÂ ofÂ CurcumaÂ mangga hasÂ been done.Â TheÂ aimsÂ ofÂ thisÂ researchÂ wasÂ toÂ discoverÂ the optimumÂ mixtureÂ of sorbytol,Â glycerolÂ andÂ propyleneglycolÂ thatÂ gaveÂ goodÂ physycalÂ characteristicÂ of theÂ gel.Â First, made the ethanolic extract of Curcuma mangga as active ingredient.Â The SPF value of the ethanolic extract of Curcuma mangga was measured.Â SimplexÂ latticeÂ designÂ wasÂ employedÂ toÂ createÂ theÂ optimum compositionÂ ofÂ sorbitol,Â glycerolÂ andÂ propyleneglycolÂ inÂ theÂ sunscreenÂ gel. Physical characteristic of the gel including spreadability, viscosity and the alteration of the gel viscosity was measured. The result showed that there were optimum composition between sorbytol, glycerol and propyleneglycol which gave goodÂ physicalÂ characteristicsÂ basedÂ onÂ theÂ shadingÂ areaÂ atÂ theÂ counterplot superimposed.Keywords: sorbitol, glycerol, propyleneglycol, Curcuma mangga, sunscreen gel

Computer-aided Design of Chalcone Derivatives as Lead Compounds Targeting Acetylcholinesterase Riswanto, Florentinus D. Octa; Hariono, Maywan; Yuliani, Sri Hartati; Istyastono, Enade Perdana
INDONESIAN JOURNAL OF PHARMACY Vol 28 No 2, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

One of well-established biological activities for chalcone derivatives is as acetylcholinesterase inhibitors, which can be developed for the therapy of Alzheimerâs disease. Assisted byretrospectively validated structure-based virtual screening (SBVS) protocol to identify potent acetylcholinesterase inhibitors, 80chalcone derivatives were designed and virtually screened. The F-measure value as the parameter of the predictive ability of the SBVS protocol developed in the research presented in this article was 0.413, which was considerably better than the original SBVS protocol (F-measure = 0.226). Among the screened chalcone derivatives two were selected as potential lead compounds to designpotent inhibitors for acetylcholinesterase: 3-[4-(benzyloxy)-3-methoxyphenyl]-1-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one(3k) and 3-[4-(benzyloxy)-3-methoxyphenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one (4k).

Analytical method validation and determination of dexamethasone in divided powder using reverse phase HPLC Riswanto, Florentinus Dika Octa; Virginia, Dita Maria; Putri, Dina Christin Ayuning; Yuliani, Sri Hartati
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Dexamethasone as glucocorticoids has been widely used to reduce inflammation and tissue damage in a variety of conditions. It was commonly prescribed in combination with the other compounds such as chlorpheniramine maleate for the relief of asthma. It was important to observe the quality and safety of the combination dosage form, called pulveres or puyer in order to serve the patient oriented medication. This research aimed to develop analytical method validation and determine the content uniformity of the divided powder containing dexamethasone compounded by pharmacy in Yogyakarta and hospital in Central Java, Indonesia. A validated high performance liquid chromatography (HPLC) method was chosen to determine dexamethasone in the samples. The column of ACE 5 C18 (250 x 4.6 mm) was used in this research and the methanol:water (65:35) was used as the mobile phase at the flow rate of 1 mL/min. The UV detection was performed at 239 nm. Analytical method validation was performed on the parameters of system suitability, limit of detection, limit of quantification, accuracy, precision, and linearity. The results showed that dexamethasone contains in divided powder compounded by pharmacy in Yogyakarta and hospital in Central Java were met the acceptance requirement.Â Â

PENGARUH SUHU DAN LAMA STERILISASI METODE PANAS KERING TERHADAP VISKOSITAS DAN DAYA SEBAR BASIS GEL ALGINAT Putri, Dina Christin Ayuning; Dwiastuti, Rini; Yuliani, Sri Hartati
Pharmaceutical Journal of Indonesia Vol 2, No 2 (2017)
Publisher : Brawijaya University

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Alginat merupakan polimer alami yang dapat digunakan dalam sediaan penutup luka. Penutup luka harus steril, sehingga tidak menimbulkan infeksi tambahan pada luka, sehingga perlu dilakukan sterilisasi. Proses sterilisasi dapat mempengaruhi sifat fisik sediaan yang terkait dengan penerimaan pasien. Penelitian ini bertujuan untuk mengetahui pengaruh suhu dan lama sterilisasi metode panas kering, terhadap viskositas dan daya sebar basis gel alginat. Gel alginat yang telah disterilisasi dengan variasi suhu dan durasi, diuji sterilitas, viskositas, dan daya sebarnya, Selisih (âˆ†) nilai viskositas dan daya sebar basis alginat, dengan dan tanpa sterilisasi dianalisis menggunakan Kruskal-Wallis test (âˆ† viskositas) dan ANAVA (âˆ† daya sebar). Data yang diperoleh menunjukkan bahwa suhu dan lama sterilisasi mempengaruhi penampilan, viskositas dan daya sebar basis gel algiant. Semakin tinggi suhu dan lama sterilisasi akan menyebabkan perubahan warna menjadi lebih gelap, menurunkan viskositas dan meningkatkan daya sebar basis gel alginat, yang ditunjukkan dengan meningkatnya nilai âˆ† viskositas dan âˆ† daya sebar. Proses sterilisasi dengan suhu terendah dan durasi terpendek yang tidak terlalu mempengaruhi sifat fisik basis gel alginat adalah pada suhu 130oC selama 120 menit.

PENGARUH SUHU DAN LAMA STERILISASI METODE PANAS KERING TERHADAP VISKOSITAS DAN DAYA SEBAR BASIS GEL ALGINAT Putri, Dina Christin Ayuning; Dwiastuti, Rini; Yuliani, Sri Hartati
Pharmaceutical Journal of Indonesia Vol 2, No 2 (2017)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Alginat merupakan polimer alami yang dapat digunakan dalam sediaan penutup luka. Penutup luka harus steril, sehingga tidak menimbulkan infeksi tambahan pada luka, sehingga perlu dilakukan sterilisasi. Proses sterilisasi dapat mempengaruhi sifat fisik sediaan yang terkait dengan penerimaan pasien. Penelitian ini bertujuan untuk mengetahui pengaruh suhu dan lama sterilisasi metode panas kering, terhadap viskositas dan daya sebar basis gel alginat. Gel alginat yang telah disterilisasi dengan variasi suhu dan durasi, diuji sterilitas, viskositas, dan daya sebarnya, Selisih (âˆ†) nilai viskositas dan daya sebar basis alginat, dengan dan tanpa sterilisasi dianalisis menggunakan Kruskal-Wallis test (âˆ† viskositas) dan ANAVA (âˆ† daya sebar). Data yang diperoleh menunjukkan bahwa suhu dan lama sterilisasi mempengaruhi penampilan, viskositas dan daya sebar basis gel algiant. Semakin tinggi suhu dan lama sterilisasi akan menyebabkan perubahan warna menjadi lebih gelap, menurunkan viskositas dan meningkatkan daya sebar basis gel alginat, yang ditunjukkan dengan meningkatnya nilai âˆ† viskositas dan âˆ† daya sebar. Proses sterilisasi dengan suhu terendah dan durasi terpendek yang tidak terlalu mempengaruhi sifat fisik basis gel alginat adalah pada suhu 130oC selama 120 menit.

LIPID AND SILVER NANOPARTICLES GELS FORMULATION OF TEMPEH EXTRACT Felicia Satya Christania; Rini Dwiastuti; Sri Hartati Yuliani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 2 (2019)
Publisher : Sanata Dharma University

Tempeh extract is used in this study as an active ingredient in lipid nanoparticles and reductant in silver nanoparticles because tempeh is an authentic Indonesian food ingredient and is known to have the main content of isoflavones. Gel preparations were chosen to increase the acceptability and stability of lipid and silver nanoparticles. This research is aimed to formulate lipid nanoparticle gel formulations with tempeh extract as active substances and silver nanoparticle gel formulations with tempeh extract as bioreduction. Lipid nanoparticles were made from soy lecithin phospholipids by heating at 600C and sonication method for 30 minutes then the tempeh extract was added just before sonication. Silver nanoparticles were made by adding tempeh extract to the AgNO3 solution at 900C for 30 minutes. The average particle size of tempeh extract lipid nanoparticles was 130.03 nm and silver nanoparticle was 94.76 nm. The average viscosity of tempeh extract lipid nanoparticles gel was 4.02 d.Pa.s and silver nanoparticles was 4.22 d.Pa.s. The average spreadability of tempeh extract lipid nanoparticles gel was 4.37 cm and silver nanoparticles was 4.05 cm. The average pH value of tempeh extract lipid nanoparticles was 7.70 and silver nanoparticles was 7.33.

EFFECTS OF PARTICLE SIZE, EXTRACTION TIME, AND SOLVENT ON DAIDZEIN YIELD EXTRACTED FROM TEMPEH Sri Hartati Yuliani; Petrus Damiani Tosan Aji; Arini Safti Sandrapitaloka; Fransiska Revana Restiana; Michael Raharja Gani; Florentinus Dika Octa Riswanto
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 1 (2019)
Publisher : Sanata Dharma University

Daidzein, one of the isoflavone aglycones contained in tempeh, has several biological activities such as anti-inflammatory, anti-oxidant, anti-breast cancer, and suppression of expression of matrix metalloprotease-9. As a fermented product from soybeans, daidzein content in tempeh was found in higher concentration compared to the soybean raw material. It was important to optimize several factors affecting extraction process such as particle size of tempeh simplicia, extraction time, and solvent in order to develop an effective method for the daidzein isolation from the tempeh or other natural products. Evaluation of extraction factors was conducted by applying variations for each factor followed by quantitative analysis using HPLC methods. The optimization condition was performed by daidzein standard and achieved with the particle size of tempeh simplicia of 1.2 mm, extraction time of 360 minutes, and 70% ethanol was used as solvent. Furthermore, the optimized condition was applied for the daidzein isolation from tempeh, a soybean fermented product.

PEMBUATAN DAN UJI AKTIVITAS SEDIAAN UNGUENTA SCARLESS WOUND DENGAN EKSTRAK BINAHONG DAN ZAT AKTIF ASPIRIN Maria Faustina Sari; Sri Hartati Yuliani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 2 (2015)
Publisher : Sanata Dharma University

Wound is a defect of skin caused by physical or thermal damage. The inflammatory phase in the wound healing usually causes scars. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that has the ability to inhibit the activity of cyclooxygenase (COX) leading to reduced prostaglandin amount. Binahong (Anredera cordifolia) is one of the plants that is used as a wound healer. Binahong contains ascorbic acid which has an important role in collagen formation phase. In this study, binahong leaf extract ointment will be combined with aspirin to produce scarless wound ointment. The method used is a purely experimental method. The test method used is histopathology tests then processed by the method of calculating the area of collagen. The data are analyzed using T-test. The addition of aspirin in the preparation of wound healing ointment cant reduce scar formation allegedly with an incision method of white mice (Mus musculus) Swiss Webster. Statistically, the results showed that binahong ointment (UB) produces the least scar than ointment base (B), followed binahong-aspirin ointment (UBA), and aspirin ointment (UA).

PEMBUATAN DAN UJI AKTIVITAS SEDIAAN GEL SCARLESS WOUND DENGAN EKSTRAK BINAHONG DAN ZAT AKTIF IBUPROFEN Prita Patricia; Sri Hartati Yuliani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 2 (2015)
Publisher : Sanata Dharma University

Wound is a condition where the tissue was damaged. The body will repair this damage by wound healing mechanism which often leads to the formation of scar. The scar is caused by the inflammation phase of wound healing mechanism. Ibuprofen is one of the antiinflammatory agent that can inhibit or shorten the inflammatory phase by inhibit cyclooxygenase enzyme in prostaglandin synthesize. Prostaglandin has an important role on the formation of inflammatory phase. Binahong (Anredera cordifolia (Ten.) Steenis.) has a potential activity as a wound healing agent. Binahong contains ascorbic acid which is impotant for the activation of prolyl-hydroxygenase enzyme that support hydroxylation phase in the process of collagen formation, so that the wound healing process can be acceletared. In this research, a gel preparation with binahong extract was combined with ibuprofen to form a scarless wound gel. This research was purely experimental. The test method used is a histopahological test which continued with a calculation of collagen area and a physical properties test. The collagen area calculation data were analyzed by independent sample t-test with 95% confidence interval. In this research, the addition of ibuprofen was expected to reduce the scar formation on incisional wound of white Swiss Webster mice. The result showed that the gel preparation with binahong extract and ibuprofen formed statistically less scar when compared to the gel preparation with binahong extract only.

ANALISIS KUANTITATIF ISOFLAVON TEMPE SECARA CEPAT DAN SEDERHANA MENGGUNAKAN METODE KROMATOGRAFI LAPIS TIPIS- DENSITOMETRI Agustina Setiawati; Sri Hartati Yuliani; Enade Perdana Istyastono; Michael Raharja Gani; Evy Fenny Veronica; Dina Christin Ayuning Putri; Reza Eka Putra; David Chandra Putra; Agnes Mutiara Kurniawan
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 1 (2014)
Publisher : Sanata Dharma University

Rapid and simple quantitative analysis isoflavones tempe using densitometric TLChas been done. The mobile phase of the system was chloroform: methanol: ethylacetate (45: 5:0.75). Thin layer chromatography was performed on aluminium TLC plates.Ascending distanceof 1 ?L sample was performanced 10 cm. Then the plate was scanned at 261 nm. A linearrelationship obtained at 0.08 - 2 ?g/spot with r= 0.9986. The LOD and LOQ of isoflavone were0.014 ?g/spot and 0.048 ?g/spot. Genistein contained in tempe was 0.151 0.005 % b/b.

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