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Upregulation of MRNA TNF-α in Skeletal Muscle Tissue of Streptozotocin-Induced Diabetic RAT Akbar Satria Fitriawan; Christin Wiyani; Endang Nurul Syafitri; Ririn Wahyu Widayati
Proceedings of the International Conference on Nursing and Health Sciences Vol 1 No 1 (2020): November 2020
Publisher : Global Health Science Group

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Inflammation is a molecular mechanism that linking obesity and ageing with insulin resistance in type 2 diabetes mellitus (DM). Although type 1 DM is primarily caused by insulin deficiency, but insulin resistance also prominent feature in this disease. It is not fully understood whether inflammation also contribute in insulin resistance phenotype in type 1 DM. This study aimed to assess mRNA TNF-α expression in the skeletal muscle tissue of type 1 diabetes mellitus rat model.This in-vivo study used 18 adults male wistar rats. The study conducted at Department of Anatomy, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada from July to October 2020. Male Wistar rats divided into control group (CDM, n=6), and diabetes mellitus group which is divided into 1-month DM group (DM1M, n=6), and 2-month DM group (DM2M, n=6). The DM model was conducted through single intraperitoneal injection of Streptozotocin 60 mg/kg Body Weight (BW). At the end of study, rats were sacrificed and the gastrocnemius muscle was harvested. The expression of mRNA TNF-α was measured by RT-PCR. Statistical analysis was conducted using One Way ANOVA test. Blood glucose level were significantly higher in DM groups compared to control group (p<0.05). The body weight of DM groups was significantly lower after 1 month and 2 months DM period compared to control group (p<0.05). DM groups demonstrated upregulation of mRNA TNF-α compared to control group (p<0.05). Type 1 diabetes mellitus model demonstrated upregulation of mRNA TNF-α in skeletal muscle tissue.

Upregulation of MRNA TNF-α in Skeletal Muscle Tissue of Streptozotocin-Induced Diabetic RAT Akbar Satria Fitriawan; Christin Wiyani; Endang Nurul Syafitri; Ririn Wahyu Widayati
Proceedings of the International Conference on Nursing and Health Sciences Vol 1 No 1 (2020): July-December 2020
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar

Inflammation is a molecular mechanism that linking obesity and ageing with insulin resistance in type 2 diabetes mellitus (DM). Although type 1 DM is primarily caused by insulin deficiency, but insulin resistance also prominent feature in this disease. It is not fully understood whether inflammation also contribute in insulin resistance phenotype in type 1 DM. This study aimed to assess mRNA TNF-α expression in the skeletal muscle tissue of type 1 diabetes mellitus rat model.This in-vivo study used 18 adults male wistar rats. The study conducted at Department of Anatomy, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada from July to October 2020. Male Wistar rats divided into control group (CDM, n=6), and diabetes mellitus group which is divided into 1-month DM group (DM1M, n=6), and 2-month DM group (DM2M, n=6). The DM model was conducted through single intraperitoneal injection of Streptozotocin 60 mg/kg Body Weight (BW). At the end of study, rats were sacrificed and the gastrocnemius muscle was harvested. The expression of mRNA TNF-α was measured by RT-PCR. Statistical analysis was conducted using One Way ANOVA test. Blood glucose level were significantly higher in DM groups compared to control group (p<0.05). The body weight of DM groups was significantly lower after 1 month and 2 months DM period compared to control group (p<0.05). DM groups demonstrated upregulation of mRNA TNF-α compared to control group (p<0.05). Type 1 diabetes mellitus model demonstrated upregulation of mRNA TNF-α in skeletal muscle tissue.

HOPELESSNESS AMONG NURSING STUDENTS DURING THE EARLY PHASE OF COVID-19 PANDEMIC : ONLINE CROSS SECTIONAL STUDY AT UNIVERSITAS RESPATI YOGYAKARTA Akbar Satria Fitriawan; Ririn Wahyu Widayati; Januar Rizqi; C.Riyan Alfrendo
Jurnal Keperawatan Respati Yogyakarta Vol 10 No 1 (2023): JANUARY 2023
Publisher : Universitas Respati Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35842/jkry.v10i01.716

Background: Global pandemic of COVID-19 caused unprecedented effect in education sector due to the university closure and distance education, which could significantly affected students mental health and increased suicidality. Nursing students are vulnerable population due to already stressful academic activities coupled with pandemic loneliness and financial difficulties. Hopelessness, a negative view of the self in relation to the world and the future, identified as consistent predictor of suicidality. This study aimed to explore the prevalence of hopelessness among nursing students and association between sociodemographic characteristic and hopelessness. Methods: Online cross sectional study was conducted in Universitas Respati Yogyakarta between June until September 2020, and involved 232 nursing students that selected using consecutive sampling method. Sociodemographic questionnare and Beck Hopelessness Scale (BHS) were used to collect the data. Chi square test was used to analyze association between sociodemographic characteristic and hopelessness. Result: Our study elucidated that the prevalence of hopelessness among nursing students at Universitas Respati Yogyakarta during the early phase of COVID-19 pandemic is 9.5%. Chi square test revealed that there is no significant association between any sociodemographic characteristic and hopelessness (p>0.05). Conclusion: The prevalence of hopelessness among nursing students is low, and sociodemographic profiles is not determinant of hopelessness.

Pelatihan Dan Pendampingan Kader Kesehatan Tentang Pengukuran Kadar Glukosa Darah Sebagai Upaya Deteksi Dini Diabetes Melitus Januar Rizqi; Akbar Satria Fitriawan
JURNAL SUAKA INSAN MENGABDI (JSIM) Vol 2 No 2 (2020): Jurnal Suaka Insan Mengabdi (JSIM)
Publisher : STIKES Suaka Insan Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51143/jsim.v2i2.191

Diabetes mellitus (DM) Tipe 2 menjadi salah satu masalah kesehatan di Dunia dan Indonesia yang jumlahnya terus meningkat. Pendidikan kesehatan manajemen diri DM dianggap sebagai komponen integral dalam perawatan diabetes. Upaya deteksi dini dan monitor kadar gula darah bagi penderita DM melalui kader kesehatan diperlukan untuk mendeteksi dan megurangi risiko terjadinya komplikasi serta kematian akibat DM. Solusi yang ditawarkan adalah pelatihan dan pendampingan kader tentang pengukuran kadar glukosa darah. Metode pemecahan masalah dilakukan dengan 1) melakukan pendidikan kesehatan tentang diabetes mellitus kepada kader kesehatan, 2) melakukan pelatihan pengukuran kadar glukosa darah kepada kader kesehatan, 3) melakukan pendampingan kegiatan pengukuran kadar glukosa darah. Hasil: Terdapat 5 warga yang resiko tinggi diabetes, sedangkan 16 warga diantaranya dengan kategori prediabetes. Terdapat perubahan pengetahuan dan kepercayaan diri kader kesehatan untuk deteksi dini serta pencegahan penyakit diabetes setelah diberikan pelatihan. Kesimpulan: Kader kesehatan mengalami peningkatan pengetahuan tentang penyakit diabetes mellitus dan secara mandiri dapat melakukan pengukuran kadar glukosa darah kepada warga sebagai upaya deteksi dini diabetes mellitus.

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