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All Journal Medicina E-Jurnal Medika Udayana ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Journal of Perinatology Journal Research of Social Science, Economics, and Management
Evert Solomon Pangkahila
Department Of Obstetrics And Gynecology, Division Of Maternal-Fetal Medicine,Udayana University Hospital-Bali
Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Medicine & Pharmacology Nursing

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Journal : Journal Research of Social Science, Economics, and Management

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Performance of Rapid Antibody Test and RT-PCR as Frontline Test for COVID-19 Diagnosis in Pregnancy: an Experience in Indonesia Evert S. Pangkahila; Ryan S. Mulyana; Hariyasa Sanjaya; Mulyantari K; Daniel H. Susanto
Journal Research of Social Science, Economics, and Management Vol. 1 No. 7 (2022): Journal Research of Social Science, Economics, and Management
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2051.354 KB) | DOI: 10.59141/jrssem.v1i7.106

Abstract

Ensuring an accurate diagnosis is critical for limiting the spread of SARS-CoV-2 and for the clinical management of COVID-19, especially in pregnant women. For now real-time reverse transcription polymerase chain reaction (RT-qPCR) is the currently recommended laboratory method for the diagnosis of acute SARS-CoV-2 infection. More recently, several easy-to-perform rapid antigen detection tests have been developed and are recommended as first-line screening test in several countries. The purpose of this study was to evaluate the comparative performance of a rapid antibody test and RT-PCR for the detection of SARS-CoV-2 infection, as a front-line test for the diagnosis of COVID-19 in pregnancy. This research method is a descriptive study to describe comparation of sensitivity and specificity between rapid SARS-CoV-2 antibody test to the gold standard nasopharyngeal RT-PCR swab test. Of the 271 samples, only 257 were eligible and fourteen cases were excluded from the study due to a lack of rapid antibody test and RT-PCR results. The results of this study showed that the rapid SARS-CoV-2 antibody test sensitivity was 80.95%, and the specificity was 90.68%, the NPV (negative predictive value) and the PPV (positive prognosis value) were 98.17% and 43.59%, respectively. Based only on the results of IgM and IgG, IgM and IgG sensitivity were 33.33% (7/21) and 71.43% (15/21), respectively, and the specificity was 91.1% (215/236, 21 false positive) and 91.53% (216/236, 20 false positive), respectively. The use of rapid antibody tests during pregnancy is a screening tool and is not currently applicable for diagnostic tool. To minimize false positives and negatives results, the use of rapid antibody tests should be combined with the RT-PCR test results.
Co-Authors Agrifa Eko Albert Sembiring Daniel H. Susanto Denni Prasetyo Endang Sri Widiyanti Hartanto Hartanto I Gde Sastra Winata I Ketut Surya Negara I Ketut Suwiyoga I Nyoman Gede Budiana I Nyoman Hariyasa Sanjaya Ida Bagus Gde Fajar Manuaba Ida Bagus Putra Adnyana Ni Kadek Mulyantari Nyoman Gede Dikawijaya Satriawan Putu Doster Mahayasa Rey Jauwerissa Ryan S. Mulyana Ryan Saktika Mulyana Tjokorda Gde Agung Suwardewa