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All Journal Majalah Kedokteran Bandung Althea Medical Journal Jurnal Sistem Kesehatan Majalah Kedokteran Andalas Journal Orthopaedi and Traumatology Surabaya (JOINTS)
Dicky Mulyadi
Departemen Orthopaedi Dan Traumatologi, Fakultas Kedokteran, Universitas Padjadjaran
Health Professions Medicine & Pharmacology Public Health

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Knowledge and Risk of Osteoporosis among Pre-elderly at Cipacing Village Jatinangor District in 2014 Ramdhani, Muhammad; Mulyadi, Dicky; Arisanti, Nita
Althea Medical Journa Vol 2, No 4 (2015)
Publisher : Althea Medical Journa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (29.126 KB)

Abstract

Background: Osteoporosis is a disease characterized by abnormal loss of bone density resulting inbones that are brittle and liable to fracture. Most cases of fracture in the world are due to osteoporosis. InIndonesia, the prevalence of osteopenia (early osteoporosis) and of osteoporosis are relatively high. Oneof the causes of this situation is the low level of public knowledge about how to prevent osteoporosis. Thisstudy was conducted to identify the knowledge and risk of osteoporosis among pre-elderly at CipacingVillage Jatinangor District in 2014.Methods: This descriptive study was conducted at Cipacing Village Jatinangor District to 160 respondentswho were classified as pre-elderly (aged 45-59 years) and assessed on knowledge and risk factors forosteoporosis through questionnaire-guided interviews after the informed consent was obtained.Thecollected data were presented using frequency distribution.Results: A total of 100 respondents (62.5%) had good knowledge about osteoporosis-related information,including definitions, causes, risk factors, signs and symptoms, impacts, and prevention. Most respondents,79 respondents (49.4%), are at risk for osteoporosis.Conclusions: Knowledge of osteoporosis among pre-elderly at Cipacing Village Jatinangor District arelargely classified into “good knowledge” category. [AMJ.2015;2(4):608–14]
Knowledge and Risk Factors for Osteoporosis among Pre-elderly Ramdhani, Muhammad; Mulyadi, Dicky; Arisanti, Nita
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (572.81 KB)

Abstract

Background: Osteoporosis is a disease characterized by abnormal loss of bone density resulting in bones that are brittle and liable to fracture. Most cases of fracture in the world are due to osteoporosis. In Indonesia, the prevalence of osteopenia (early osteoporosis) and of osteoporosis are relatively high. One of the causes of this situation is the low level of public knowledge about how to prevent osteoporosis. This study was conducted to identify the knowledge and risk of osteoporosis among pre-elderly at CipacingVillage Jatinangor District in 2014.Methods: This descriptive study was conducted at Cipacing Village Jatinangor District to 160 respondents who were classified as pre-elderly (aged 45-59 years) and assessed on knowledge and risk factors forosteoporosis through questionnaire-guided interviews after the informed consent was obtained. The collected data were presented using frequency distribution.Results: A total of 100 respondents (62.5%) had good knowledge about osteoporosis-related information, including definitions, causes, risk factors, signs and symptoms, impacts, and prevention. Most respondents,79 respondents (49.4%), are at risk for osteoporosis.Conclusions: Knowledge of osteoporosis among pre-elderly at Cipacing Village Jatinangor District are largely classified into “good knowledge” category. [AMJ.2015;2(4):608–14] DOI: 10.15850/amj.v2n4.659
POTENSI FRAKSINASI SARANG SEMUT PAPUA (MYRMECODIA PENDANS) PADA PENURUNAN TNF-α DAN PERBAIKAN SECARA HISTOPATOLOGI KARTILAGO OSTEOARTRITIS LUTUT KELINCI Hidajat, Nucki Nursjamsi; Mulyadi, Dicky; Tandjung, Fachry A.; Sulaeman, Asep
Majalah Kedokteran Bandung Vol 50, No 3 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v50n3.1320

Abstract

Reaksi seluler kondrosit osteoartritis pada lutut ditandai dengan peningkatan sitokin tumor necrosis factor-? (TNF-?).TNF-? mengaktifkan fibroblas dan makrofag sinovial untuk menyekresi enzim degradasi dan menekan sintesis proteoglikan rawan sendi sehingga memberikan gambaran histopatologik kartilago yang mengalami perubahan. Osteoartritis sekunder terjadi akibat trauma sendi yang menyebabkan nyeri. Terapi obat seperti non-steroidal anti-inflammatory drugs (NSAIDs) yang digunakan menyebabkan efek samping merugikan jika digunakan dalam jangka panjang. Fraksinasi sarang semut papua (Myrmecodia pendans) diketahui memiliki kandungan salah satunya flavonoid yang berfungsi sebagai anti-inflamasi, antioksidan dan pelindung sel. Berdasar hal tersebut maka ingin diketahui potensi fraksinasi sarang semut papua pada osteoartritis kartilago lutut kelinci dalam menghambat enzim proinflamasi, yaitu TNF-? dan memberikan perbaikan secara histopatologik dibanding dengan kontrol. Penelitian menggunakan uji eksperimental hewan dengan desain experimental comparative menggunakan 8 kelinci ras New Zealand yang dibagi menjadi 2 kelompok, yaitu kelompok kontrol dan kelompok yang diberikan fraksinasi sarang semut papua dengan dosis 2,5 mg/kgBB intra-artikular. Kemudian dilakukan pengukuran kadar TNF-? dan skoring secara histopatologik. Penelitian dilakukan di Fakultas Kedokteran, Universitas Padjadjaran periode Februari-Maret 2017. Pada Uji-t tidak berpasangan untuk TNF-? didapatkan nilai p=0,011; Uji Mann Whitney untuk skoring histopatologik dengan nilai p=0,034 pada kelompok yang diberian fraksinasi sarang semut papua. Terdapat penurunan TNF-? dan perbaikan secara histopatologik pada kartilago osteoartritis lutut kelinci yang diberikan fraksinasi sarang semut papua.Potential of Fractionated Papuan Ant Nest (Myrmecodia Pendans) to Decrease TNF-? and Improve Osteoarthritis Cartilage Histopathological Features in Rabbits Knee Condrocyte cellular reaction in knee with osteoarthritis is characterized by increased tumor necrosis factor-? (TNF-?) cytokine level. TNF-? activates fibroblasts and synovial macrophages to secrete degradation enzymes and supress cartilage proteoglycan synthesis, leading to histopathological changes in cartilages. Secondary osteoarthritis is triggered by a joint trauma that leads to pain. Long term drug therapy, such as non-steroidal anti-inflammatory drugs (NSAIDs), will lead to adverse effects. Fractionated Papuan ant nest (Myrmecodia Pendans) is known as containing flavonoid that plays a role as anti-inflamatory agent, antioxidang, and cell protector. This study aimed to identify the potential of fractionated Papuan ant nest to inhibit pro-inflamatory enzyme, i.e. TNF-?, and improve the histopathological features in rabbit knee cartilage with osteoarthritis. This was a comparative animal experiment on 8 New Zeland rabbits that were divided into 2 groups: control group and treatment group conducted at the Faculty of Medicine, Universitas Padjadjaran, in February-March 2017. The treatment group received 2.5 mm/kgBW fractionated Papuan ant nest as treatment. Measurement was then performed on TNF-? level and histopathological scoring. Statitical analysis was performed using unpaired t-test for TNF-? and Mann Whitney test for histopathological scoring. The results showed that the p-values for TNF-? and histopathological scoring were 0.011 and 0.034, respectively, in the group receiving fractionated Papuan ant nest. Reduction of TNF-? level and histopathological improvement are found in rabbit knee cartilage with arthritis when fractionated Papuan ant nest is given.  
Platelet-Rich Fibrin Enhances Fracture Healing in Tibial Long Bone: An Experiment in Rabbit Nucki Nursjamsi Hidajat; Dicky Mulyadi; M. Rizal Chaidir; Taufan Herwindo Dewangga
Althea Medical Journal Vol 7, No 4 (2020)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v7n4.1960

Abstract

Background: Fracture on long bone is a complicated case to manage. Bone graft procedure involving growth factors has been widely studied with promising results. Recently, platelet-rich fibrin (PRF) has been introduced as having potential in healing process. This study aimed to explore the quality of fracture healing on long bones treated with bone graft with and without PRF combination.Methods: This study was conducted between October to November 2018 on 18 rabbits that were divided into 2 groups. A 5 mm fracture was created on tibial bones and the fracture was stabilized using a 2.0 mm mini plate. The defect was then treated by an autogenic bone graft with and without  PRF. Histological analysis was conducted 3 weeks after the treatment and a scoring was performed using the Salkeld system. The quality of union; cortex development and remodeling; and bone graft incorporation and new bone formation were then analyzed.Results: There were significant differences between fractures in rabbits given PRF than those without PRF in terms of  union quality (p 0.040), cortex growth and remodeling (p 0.0001), bone graft and new bone union (p 0.0001), as well as in the total Salkeld score (p 0.0001).Conclusion: PRF given with bone graft therapy can enhance the quality of fracture healing of a long bone. Further studies on how the PRF content influences fracture healing process needs to be performed to further explore this effect. 
Knowledge and Risk Factors for Osteoporosis among Pre-elderly Muhammad Ramdhani; Dicky Mulyadi; Nita Arisanti
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (572.81 KB)

Abstract

Background: Osteoporosis is a disease characterized by abnormal loss of bone density resulting in bones that are brittle and liable to fracture. Most cases of fracture in the world are due to osteoporosis. In Indonesia, the prevalence of osteopenia (early osteoporosis) and of osteoporosis are relatively high. One of the causes of this situation is the low level of public knowledge about how to prevent osteoporosis. This study was conducted to identify the knowledge and risk of osteoporosis among pre-elderly at CipacingVillage Jatinangor District in 2014.Methods: This descriptive study was conducted at Cipacing Village Jatinangor District to 160 respondents who were classified as pre-elderly (aged 45-59 years) and assessed on knowledge and risk factors forosteoporosis through questionnaire-guided interviews after the informed consent was obtained. The collected data were presented using frequency distribution.Results: A total of 100 respondents (62.5%) had good knowledge about osteoporosis-related information, including definitions, causes, risk factors, signs and symptoms, impacts, and prevention. Most respondents,79 respondents (49.4%), are at risk for osteoporosis.Conclusions: Knowledge of osteoporosis among pre-elderly at Cipacing Village Jatinangor District are largely classified into “good knowledge” category. [AMJ.2015;2(4):608–14] DOI: 10.15850/amj.v2n4.659
Perbandingan Derajat Osteoarthritis Lutut Yang Mengalami Putusnya Anterior Cruciate Ligament (Acl) Dengan Dan Tanpa Disertai Robekan Total Medial Meniskus Pada Model Lutut Kelinci Fadlyansyah Farid; Hermawan Nagar Rasyid; Dicky Mulyadi; Fachry A. Tandjung
Jurnal Sistem Kesehatan Vol 4, No 2 (2018): Volume 4 Nomor 2 Desember 2018
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.767 KB) | DOI: 10.24198/jsk.v4i2.20672

Abstract

Osteoarthritis (OA) menjadi permasalahan di dunia, termasuk di Indonesia. Instabilitas pada putus ACL dengan atau tanpa robekan meniskus merupakan penyebab OA. Kelemahan biomekanik ini terjadi saat axial loading karena tidak mampu menahan tenaga yang diberikan. Tujuan penelitian ini, yaitu untuk mengetahui perbandingan derajat OA lutut pada cedera putusnya ACL yang disertai robekan meniskus dibandingkan hanya putusnya ACL. Penelitian ini merupakan penelitian laboratoium eksperimental murni yang dilakukan di Laboratorium Farmakologi Fakultas Kedokteran Universitas Padjadjaran, selama September-Desember 2017. Hewan percobaan dibagi tiga kelompok, yaitu putusnya ACL disertai robekan total medial meniskus (AM) dan putusnya ACL (AC) dan operasi Sham. Kemudian dilakukan perlakuan sesuai kelompok percobaan dan pemeriksaan marker infeksi Nitrat Oxide (NO) dan histopatologi H&E pada minggu ketiga. Hasil penelitian sebagai berikut : pemeriksaan NO kelompok AM : 0.77±0.138 (rata-rata : 0.77)ng/L, kelompok AC : 0.44±0.120 (rata-rata : 0.41), p-value 0.0001 (nilai P<0.05), pemeriksaan Histopatologi kelompok AM : inflamasi berat 7 (77.7%), p-value 0.008 (p <0.01) dan kelompok AC : inlamasi ringan 2 (22.2%), inflamasi sedang 4 (44.4%) dan inflamasi berat 3 ekor (33.3%), p-value 0.011 (nilai P<0.05), signifikan atau bermakna secara statistik. Kesimpulan dari penelitian ini adalah derajat OA lebih berat pada lutut kelinci yang dilakukan putusnya ACL disertai robekan meniskus dibandingkan dengan hanya pututsnya ACL. Kata Kunci : ACL, Meniskus, Nitrat Oxide, Osteoarthritis
Perbandingan Tingkat Penyembuhan Defek Kortikal Tibia Kelinci Yang Diselubungi Membran Amnion Liofilisasi Dibandingkan Periosteum Bangkit Primayudha; Nucki Nursjamsi Hidajat; Fachry Tandjung; Dicky Mulyadi
Jurnal Sistem Kesehatan Vol 5, No 1 (2019): Volume 5 Nomor 1 September 2019
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.54 KB) | DOI: 10.24198/jsk.v5i1.23928

Abstract

Pada kasus defek tulang disertai hilangnya periosteum dapat menggunakan lapisan lain, yaitu membran amnion liofilisasi, yang merupakan biodegradable tissue engineering yang mengandung berbagai macam growth factor bersifat osteoinduktif dan lapisan membran basal yang berfungsi mencegah lolos berbagai jenis mikroorganisme dan sel nonosteogenik ke dalam defek tulang. Penelitian ini merupakan uji eksperimental hewan yang bertujuan untuk mengetahui peranan membran amnion liofilisasi dibandingkan dengan periosteum pada penyembuhan defek tulang panjang yang diberikan tandur tulang autograft secara radiologis dengan skor Lane-Shandu dan histopatologis dengan skor Salked. Kelinci dibagi menjadi dua kelompok yang dilakukan defek sebesar 5 mm pada tulang tibia, stabilisasi dengan mini plate 2.0 mm, diberikan autogenic bone graft, pada kelompok I diselimuti dengan membran amnion liofilisasi, kelompok II dijahitkan kembali perisoteumnya. Empat minggu setelah perlakuan, tulang tibia dianalisis secara radiologis dan histopatologis. Hasil statistik dengan menggunakan uji Mann-Whitney untuk mengetahui adanya perbedaan di antara dua kelompok, didapatkan nilai p= 0.634 pada skor Lane-Shandu dan nilai p=0.823 pada skor Salked, yaitu tidak ada perbedaan yang signifikan diantara kedua kelompok. Kesimpulan penelitian ini bahwa tingkat penyembuhan defek kortikal tulang panjang dengan autograft yang diselubungi Membran Amnion Liofilisasi hasilnya sama dengan Periosteum yang dinilai secara radiologis dan histopatologis.Kata Kunci: Defek Tulang, Membran Amnion Liofilisasi, Periosteum
Perbandingan efek pemberian ekstrak kunyit dengan ibuprofen terhadap pencegahan pembentukan adhesi pasca penyambungan tendon Diki Julkarnain; Dicky Mulyadi; Fathurachman Fathurachman
Majalah Kedokteran Andalas Vol 43, No 1 (2020): Published in January 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (116.616 KB) | DOI: 10.25077/mka.v43.i1.p15-22.2020

Abstract

Proses penyembuhan cedera pada tendon masih sering kali terganggu dengan kejadian adhesi. Adhesi dari tendon harus dikurangi agar proses penyembuhan tendon dapat kembali ke fungsi maksimal. Salah satu cara yang dapat digunakan untuk mengurangi adhesi adalah melalui penekanan proses inflamasi. Tujuan: Untuk melihat perbandingan pemberian ekstrak kunyit dengan ibuprofen terhadap pembentukan adhesi pasca penyambungan tendon achilles kelinci. Metode: Merupakan penelitian laboratorium eksperimental dengan rancang acak sederhana dengan menggunakan 27 ekor kelinci putih jantan (ras New Zealand) yang dibagi menjadi 3 kelompok perlakuan. Tendon achilles dipotong secara tajam kemudian dijahit kembali, kemudian di-imobilisasi dengan circular cast. Kemudian masing-masing kelompok perlakuan diberikan pemberian ekstrak kunyit, ibuprofen, dan placebo pasca tindakan selama 5 hari. Hasil: Didapatkan adanya perbedaan bermakna antara kelompok perlakuan dan kelompok kontrol (p=0.000), ditemukan kelompok perlakuan mengurangi adhesi lebih baik dibandingkan kelompok kontrol dan ekstrak kunyit lebih baik dibandingkan dengan ibuprofen. Simpulan: Dari penelitian ini, ekstrak kunyit lebih baik dibandingkan ibuprofen dalam pencegahan pembentukan adhesi pasca penyambungan tendon achilles kelinci.
THE EFFECTIVENESS OF ZINC AND RISEDRONATE ON BONE TURNOVER IN RAT MODEL OF OSTEOPOROSIS ASSESSED WITH THE EXPRESSION OF β-CROSSLAPS Adam Fajar; Mohammad Rizal Chaidir; Dicky Mulyadi; Ahmad Ramdan; Yoyos Dias Ismiarto
Journal Orthopaedi and Traumatology Surabaya Vol. 7 No. 2 (2018): October 2018
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v7i2.2018.114-124

Abstract

Background: Osteoporosis prevalence in Indonesia is high. Risedronate commonly used for treating the osteoporosis. Unfortunately, long term therapy can cause hazardous adverse effect to the patient. Previous research in rat model osteoporosis, Zinc have a potential effect to prevent and rebuild bone structure with osteoblast stimulation in bone formation and osteoclast activity inhibition in bone resorption by increasing Osteoprotegerin production, that inhibit bond between RANKL and RANK.Purpose: To determine the effectiveness of Zink and Risedronate on bone turnover in osteoporotic model rats assessed the β-CrossLaps expression.Methods: This research is conducted as experimental comparative method used 25 female Galur Wistar rat that divided into Non-ovariectomy and Ovariectomy group to induce osteoporosis. The treatment is divided into Zinc-Risedronate, and Zinc, or Risedronate only. One Way Anova and Independent T-test was used to analyzed the significant difference between groups.Result: One Way Anova statistic test forβ-CrossLaps expression value in the 3rd Taken blood sample showed that p is less than 0.05 (p<0.05), which indicated that are significant difference in the mean between variable at 3rd Taken blood sample in all group. Meanwhile, Independent T-test was used to compare β-CrossLaps expression in 3rd taken blood sample between Ovari and Ovari+Zinc, Ovari and Ovari+Zinc+Rise showed p is less than 0.05 (p<0.05), which indicated that there are significant difference in the mean between variable 2 groups.Conclusion: Zinc-Risedronate administration will decrease bone turnover and β-CrossLaps expression more than Zinc or Risedronate only in rat model osteoporosis.
Co-Authors Adam Fajar Ahmad Ramdan Asep Sulaeman, Asep Bangkit Primayudha Diki Julkarnain Fachry A. Tandjung Fachry Tandjung Fadlyansyah Farid Fathurachman Fathurachman Hermawan Nagar Rasyid M. Rizal Chaidir Mohammad Rizal Chaidir Muhammad Ramdhani Muhammad Ramdhani, Muhammad Nita Arisanti Nita Arisanti Nucki Nursjamsi Hidajat Nucki Nursjamsi Hidajat Nucki Nursjamsi Hidajat, Nucki Nursjamsi Tandjung, Fachry A. Taufan Herwindo Dewangga Yoyos Dias Ismiarto