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Journal : MOTORIK

PENGARUH VARIASI KONSENTRASI EKSTRAK BELIMBING WULUH (Averrhoa bilimbi L.) PADA SEDIAAN GEL TERHADAP STABILITAS FISIK Sholikhah Deti Andasari; Sutaryono Sutaryono; Isnaini Nur Hartanti
MOTORIK Jurnal Ilmu Kesehatan Vol 13 No 1 (2018): Maret
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/motorik.v13i1.9

Abstract

Abstract: Averrhoa bilimbi L. was used as an anti-acne drug. The content offlavonoid compounds in fruit have antibacterial activity. There were several waysfor utilization of Averrhoa bilimbi L. among others, made some preparations,especially gel formulation. Gel formulations made with HPMC base and add fruitextract 15%, 20%, and 25%. Fruit extract obtained from meserasi fruit Averrhoabilimbi L with 70% ethanol. The gel that has been made is then carried outquality control test such as organoleptic test, pH test, sticky test, spreading test,protection test and physical stability test by stressed condition. Organoleptic testresult, pH test, protection power test, and stability test analyzed descriptively. Theresults of sticky test and scatter power were analyzed with ANOVA with 95%confidence level. The result of this research showed that in the test of spreadingof formula II has good with mean of spreading value was 6,6 before stability testand 6.49 after stability test. In the protection test does not appear red stain. itmean the gel was able to provide protection of the skin.
STANDARISASI SPESIFIK DAN NON SPESIFIK EKSTRAK ETIL ASETAT DAUN DANDANG GENDIS (Clinacanthus nutans) Sholikhah Deti Andasari; Choiril Hana Mustofa; Shofia zahra
MOTORIK Jurnal Ilmu Kesehatan Vol 15 No 2 (2020): September 2020
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The leaves of dandang gendis (Clinacanthus nutans) have several pharmacological activities including antioxidants, anticancer, anti-inflammatory, analgesic, immune system boosting, antibacterial, antiviral, anti-venom (scorpion), and there is even cosmetic use. The purpose of this research was to see the test results for specific and non-specific parameters of the ethyl acetate extract of dandang gendis leaves (Clinacanthus nutans).This research is descriptive quantitative in nature and was carried out in an experimental laboratory. This research began with the maceration of 500 grams of dandang gendis leaf powder using 2000 ml ethyl acetate solvent while stirring every 24 hours, filtered with a flannel cloth, and evaporated until thick with a water bath. The parameters tested were the identity of the extract, organoleptic, parameters of air and ethanol dissolved compounds, chemical content of the extract, determination of air content, determination of drying losses, and specific gravity.The results showed that the ethyl acetate extract of dandang gendis leaves with the expression of the extract in the form of a thick extract, blackish green color, bitter taste, and characteristic aromatic odor; ethanol soluble compound content 21.881% ± 1.256; air-soluble compound content 21.959% ± 0.992; the chemical group indication indicates the presence of flavonoids, tannins and saponins; water content 14,915% ± 3,789; shrinkage in drying 29.105% ± 1.763; specific gravity 1.04 g / ml ± 0.0023. Extracts based on standardization testers include specific and non-specific parameters taking care of standardization of raw material quality.