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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal farmasi UIN Alauddin Makassar Journal of Pharmaceutical and Health Research Journal of Pharmaceutical Science and Herbal Technology

Shabran Hadiq

Institut Teknologi Kesehatan Dan Sains Muhammadiyah Sidrap

Author-ID : 5431845

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Articles

KETOPROFEN ETHOSOME PERCUTANEOUS PENETRATION TESTING IN IN-VITRO WITH VARIATIONS IN FORM BASE GEL PREPARATIONS Isriany Ismail; Haeria Haeria; Shabran Hadiq
Jurnal Farmasi UIN Alauddin Makassar Vol 3 No 1 (2015): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v3i1.2174

It has done research on percutaneous penetration test ethosome ketoprofen in vitro by variations in dosage forms a gel base. This study aims to determine the effect of the type of base gel penetration ability ethosome ketoprofen gel in vitro to produce a good flux. Ethosome ketoprofen gel prepared in dosage forms using two different types of bases, namely using hydrophilic gel base (formula 1) and lipophilic gel base (formula 2). Percutaneous penetration test performed by using Franz diffusion cells with human skin membranes (human cadaver skin) as a diffusion membrane. Ketoprofen assay that penetrate across the skin done for 12 hours. Receptor compartment fluid consisted of phosphate buffer solution pH 7.4, footage was analyzed using UV-Vis spectrophotometer at a wavelength of 308 nm. The test results showed that ketoprofen across the membrane to the formula 1 as 9701.062 μg.cm-2 with 14.10 μg.cm-2.menit-1 speed across the membrane (r=0.995), and the formula 2 as 1209.766 mg.cm-2 with 1,727 μg.cm-2.menit-1 speed across the membrane (r=0.991). Of the two types of base gel is used, it is known that by using a hydrophilic gel base has the ability to penetrate the best drug. It can be concluded that the formulation of ketoprofen gel ethosome can be used transdermally.

Direct medical cost of metformin and metformin-glimepiride in type 2 diabetes mellitus patients Sulastri Sulastri; Shabran Hadiq; Woro Supadmi; Dyah Aryani Perwitasari
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 2: September 2022
Publisher : Universitas Ahmad Dahlan

Diabetes mellitus (DM) requires long-term therapy. Selection of the right therapy was very important to provide optimal results at an affordable cost. One of the main standards of oral antidiabetic therapy prescribed for type 2 DM (T2DM) is metformin, either alone or in combination therapy. The purpose of this study was to describe the direct medical costs in type 2 DM patients between metformin and metformin-glimepiride therapy. This research was an observational and descriptive. Demographic and clinical data were taken prospectively from the complete medical records of data patients with the main diagnosis of DM who fulfilled the inclusion criteria in the period January 2019–November 2020 at RSU Nene Mallomo Sidenreng Rappang, South Sulawesi and the two Public Health Centers namely Puskesmas Galur. II and Panjatan II Kulon Progo Yogyakarta. Cost data includes total medical costs from the hospital/ healthcare perspective (cost of drugs, doctor's services and checkups, fees for checking Fasting Blood Glucose/ Gula darah Puasa (GDP) and Blood Glucose Level While/ Gula Darah Sewaktu (GDS)) and total costs from the Badan Penyelenggara Jaminan Sosial (BPJS)/ payer perspective (INA-CBG's rates) were covered by insurance. The results showed that the average direct medical costs at the hospital and the two Public Health Centers respectively were metformin therapy in IDR (Indonesian Rupiah) namely IDR 120.736 and IDR 9.072,- and metformin-glimepiride therapy of IDR 126.298,- and IDR 18.634,-. It can be concluded that the average direct medical cost of metformin therapy is lower than metformin-glimepiride therapy.

Cost-effectiveness analysis of metformin and metformin-glimepiride in patients with type 2 diabetes at nene mallomo sidrap general hospital Shabran Hadiq; Woro Supadmi; Dyah Aryani Perwitasari
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 2: September 2022
Publisher : Universitas Ahmad Dahlan

Metformin and metformin-glimepiride are cost-effective therapy options and are most commonly prescribed to treat type 2 diabetes mellitus (DM). This study aims to determine the cost-effectiveness of using metformin and metformin-glimepiride in patients with type 2 DM at Nene Mallomo Sidenreng Rappang General Hospital. This analytical descriptive observational research employed a retrospective cohort design. The data of type 2 DM patients, new and old patients, were obtained from the medical record unit. The target population was data of outpatients for the period January-December 2019. The parameter of the therapeutic effectiveness is the random blood sugar levels of the patients after receiving treatment. The data on cost from the hospital perspective were obtained from the administration and finance unit. Cost-effectiveness analysis employed calculations of the average cost-effectiveness ratio (ACER) and the incremental cost-effectiveness ratio (ICER). Meanwhile, the risk ratio (RR) employed the analytical chi-squared method to determine the relationship between the two types of therapies and their effectiveness. This study has revealed that 30 patients met the inclusion criteria; 14 patients received metformin therapy and 16 patients received metformin-glimepiride therapy. Metformin therapy is more effective (64.29%) and more costly (IDR120,736). The metformin's ACER value is 1877.99, and its ICER value is -3107.26. The cost-effectiveness analysis has revealed that metformin therapy is more cost-effective than metformin-glimepiride therapy. Meanwhile, the chi-squared analysis has discovered no relationship between the two therapies and their effectiveness. The RR value of 1.080 concludes that metformin has 1.080 as much therapeutic effectiveness as the metformin-glimepiride.

Uji Efektivitas Antidiabetes Rebusan Daun Belimbing Wuluh (Averrhoa bilimbi L.) pada Mencit (Mus musculus) Washliaty Sirajuddin; Shabran Hadiq; Rahmatullah Rahmatullah
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3315

Diabetes mellitus is a condition where blood glucose levels increase due to the body's metaboIism of protein, fat, and carbohydrates. The purpose of this study was to determine the antidiabetic effectiveness of star fruit leaf decoction (Averrhoa bilimbi L.) on mice (Mus musculus). This type of research is a laboratory experimental study using 15 male mice divided into 5 groups of mice, each of which is fed for ± 8 hours. Then, the blood glucose level of mice was measured after being fed. Then, a glucose solution of 0.195 mg/0.2 ml was given. Next, blood glucose was measured, if each group of mice had experienced an increase in blood glucose levels, then given a negative control solution, positive control, and 10%, 15% and 20% decoction of starfruit leaves. Then measured the glucose levels of mice using a glucometer at 30, 60, and 90 minutes. The results showed that giving a 20% concentration of star fruit leaf (Averrhoa bilimbi L) decoction was effective as an antidiabetic with a percentage reduction of 42% in mice (Mus musculus).

SKRINING FITOKIMIA EKSTRAK METANOL DAUN PANDAN WANGI (Pandanus amarillyfolius Roxb) Rahmasiahi; Shabran Hadiq; Tika Yulianti
Journal of Pharmaceutical Science and Herbal Technology Vol. 1 No. 1 (2023): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35892/jpsht.v1i1.1456

Daun pandan wangi memiliki banyak manfaat yang secara empiris dikenal di kalangan penduduk sekitar sebagai pengawet makanan, pewarna alami, pewangi, pencerah rambut, dan obat tradisional untuk berbagai penyakit. Penelitian ini bertujuan untuk mengetahui adanya senyawa fIavonoid, saponin, tanin, triterpenoid/steroid, aIkaIoid, gIikosida, dan minyak atsiri pada ekstrak metanoI daun Pandan Wangi (Pandanus amaryIIifoIius Roxb) di Kabupaten Sidrap. Penelitian ini merupakan penelitian eksperimental pada proses ekstraksi dilakukan dengan metode maserasi menggunakan pelarut metanol dan dilanjutkan dengan skrining fitokimia. Hasil penelitian menunjukkan bahwa ekstrak metanol daun pandan wangi mengandung senyawa flavonoid, saponin, tanin, triterpenoid, alkaloid, glikosida, minyak atsiri dan negative mengandung steroid. Berdasarkan penelitian yang telah dilakukan, maka dapat disimpulkan bahwa uji skrining fitokimia ekstrak metanol daun pandan wangi (Pandanus amaryllifolius Roxb) mengandung senyawa flavonoid, saponin, tanin, triterpenoid, alkaloid, glikosida dan minyak atsiri sedangkan senyawa steroid negatif mengandung senyawa, hal ini dapat disebabkan oleh lingkungan tempat tumbuh, unsur hara, ketinggian, suhu, kelembapan udara, intensitas cahaya dan pH tanah.

Co-Authors Dyah Aryani Perwitasari Haeria Haeria Isriany Ismail Rahmasiahi Rahmatullah Rahmatullah Sulastri Sulastri Tika Yulianti Washliaty Sirajuddin Woro Supadmi

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