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All Journal Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
FX Hendriyono
Universitas Lambung Mangkurat
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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KORELASI KADAR KALSIUM DAN MASSA OTOT PADA PASIEN PENYAKIT GINJAL KRONIK YANG MENJALANI HEMODIALISIS RUTIN Triska Dianti Wahyuningrum; Mohammad Rudiansyah; FX Hendriyono
Homeostasis Vol 2, No 3 (2019)
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Abstract: Chronic kidney disease (CKD) is the 18th cause of death in the world in 2010. The decline in Glomerular Filtration Rate (GFR) in CKD patients causes hyperphosphatemia which can reduce blood calcium levels. Calcium is an important component in increasing the formation, homeostasis and regeneration of skeletal muscles so calcium can prevent muscle wasting. This study aims to determine the correlation between calcium and muscle mass in CKD patients undergoing routine hemodialysis. The study used an analytic observational design with a cross-sectional approach. This study involved 30 male CKD patients with range of age between 25-59 years old who performed hemodialysis twice a week for at least 3 months in a Hemodialysis Installation at Ulin Hospital Banjarmasin. Subjects were taken by purposive sampling method. The results obtained a median calcium level of 9.4 (8.0 -15.3) mg / dL and an average muscle mass of 34.31 ± 4.389%. From the results of the Spearman Somers'd Gamma correlation test, p = 0.301 which means there is no correlation. There is no correlation between calcium levels and muscle mass in CKD patients undergoing routine hemodialysis. Keywords:Chronic kidney disease, calcium, muscle mass, hemodialysis Abstrak:.Penyakit ginjal kronik (PGK) menjadi penyebab kematian peringkat ke-18 dunia tahun 2010. Penurunan Laju Filtrasi Glomerulus (LFG) pada pasien PGK menyebabkan hiperfosfatemia yang dapat menurunkan kadar kalsium darah. Kalsium merupakan komponen penting dalam peningkatan pembentukan, homeostasis dan regenerasi otot skeletal sehingga kalsium dapat mencegah pengecilan otot. Penelitian ini bertujuan untuk mengetahui korelasi kadar kalsium dan massa otot pada pasien PGK yang menjalani hemodialisis rutin. Penelitian menggunakan rancangan observational analitik dengan pendekatan cross-sectional. Penelitian melibatkan 30 pasien PGK berjenis kelamin laki-laki berusia 25-59 tahun yang melakukan hemodialisis 2 kali seminggu minimal selama 3 bulan di Instalasi Hemodialisis RSUD Ulin Banjarmasin. Subyek diambil dengan metode purposive sampling. Hasilnya didapatkan median kadar kalsium 9,4(8,0 -15,3) mg/dL dan rata-rata massa otot 34,31±4,389%. Dari hasil uji korelasi Spearman Somers’d Gamma didapatkan p=0,301 yang berarti tidak terdapat korelasi. Tidak terdapat korelasi antara kadar kalsium dan massa otot pada pasien PGK yang menjalani hemodialisis rutin. Kata-katakunci: Penyakit ginjal kronik, kalsium, massa otot, hemodialisis
GAMBARAN KADAR HORMON FT4 DAN TSH PADA ANAK SINDROM NEFROTIK DI RSUD ULIN BANJARMASIN Larissa Faisa Faisa; FX Hendriyono; Selli Muljanto
Homeostasis Vol 2, No 3 (2019)
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Abstract:. One of the complications of nephrotic syndrome is hypothyroidism. Hypothyroidism in nephrotic syndrome is caused by glomerular filtration damage and proximal tubule dysfunction which causes the FT4 loss into urine. Hypothyroidism in children can cause delay in growth and disruption of the body's metabolism. The aim of this study was to describe the hormone levels of FT4 and TSH in children with nephrotic syndrome in relapsing phase and steroid-resistant nephrotic syndrome in Ulin General Hospital Banjarmasin in the period January 2017 - August 2018. The study sample consisted of 12 pediatric nephrotic syndrome patients who had met the inclusion criteria. The research is the descriptive research with a retrospective cross sectional approach. Result shown that of 12 patients consisting of 6 NS in relapsing phase and 6 SRNS, the overall FT4 levels were 20.31 ± 7.72, and TSH 4.5 ± 4.3 The mean FT4 levels in relapsing were 17.34 ± 3 and in SRNS 17.34, while TSH levels in relapsing  4.9 ± 5.3 and in SRNS 4.03 ± 3.42. This shows overall levels of FT4 and TSH normal, so it can be concluded that in children with relapsing and resistant nephrotic syndrome in Ulin General Hospital Banjarmasin don’t have hypothyroidism. Keywords: FT4 level, TSH level, relaps nephrotic syndrome, steroid resistant nephrotic syndrome (SRNS) Abstrak: Salah satu komplikasi dari sindrom nefrotik adalah hipotiroid. Hipotiroid pada sindrom nefrotik disebabkan karena adanya kerusakan filtrasi glomerulus dan disfungsi tubulus proksimal yang menyebabkan FT4 terbuang lewat urin. Hipotiroid pada anak dapat menyebabkan keterlambatan tumbuh kembang dan gangguan metabolisme tubuh. Tujuan dari penelitian ini untuk mengetahui gambaran kadar hormon FT4 dan TSH pada anak sindrom nefrotik relap dan sindrom nefrotik resisten steroid di RSUD Ulin Banjarmasin periode Januari 2017 – Agustus 2018. Sampel penelitian terdiri dari 12 orang pasien anak sindrom nefrotik yang telah memenuhi kriteria inklusi. Penelitian yang dilakukan bersifat deskriptif dengan pendekatan cross sectional  retrospektif. Hasil penelitian menunjukan dari 12 orang pasien SN, terdiri dari 6 orang SN relaps dan 6 orang SNRS secara keseluruhan rerata kadar FT4 20,31 ± 7,72, dan TSH 4,5 ± 4,3. Rerata kadar FT4 pada SN Relaps 17,34±3 dan pada SNRS 17,34, sedangkan kadar TSH pada SN Relaps 4,9± 5,3 dan pada SNRS 4,03± 3,42.  Hal ini menunjukan secara keseluruhan kadar FT4 dan TSH normal, sehingga dapat disimpulkan pada anak sindrom nefrotik relaps dan resisten di RSUD Ulin Banjarmasin tidak mengalami hipotiroid Kata-kata kunci: Kadar FT4, kadar TSH, sindrom nefrotik relap, sindrom nefrotik resisten steroid
Perbedaan Jumlah Trombosit Pasien Demam Berdarah Dengue Primer dan Sekunder pada Anak Ikrima Nurul Arifa; FX Hendriyono; Edi Hartoyo
Homeostasis Vol 1, No 1 (2018)
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Abstract: Dengue hemorrhagic fever (DHF) is an endemic disease in tropical and subtropical climates caused by dengue virus infection. Platelet count is assumed to be one of the markers in primary and secondary dengue virus infection. The aim of this research is to know the difference between platelet count of primary and secondary dengue patients in children in RSUD Ulin Banjarmasin. This research use analytic observational method with cross sectional research design. The populations in this study were all pediatric patients diagnosed with DHF at RSUD Ulin Banjarmasin period of February-June 2017 with the number of research subjects meeting the inclusion and exclusion criteria of 21 samples consisting of 5 primary DHF samples and 16 secondary DHF samples. It was used T-independent test as the research method. The average platelet count in the primary DHF group was 116.600/μL and in the secondary DHF group  58.979/μL.  Based  on  the research,  it  can  be concluded that  there are significant differences of platelet count in primary and secondary dengue patients (p=0,001). Keywords: dengue hemorrhagic fever, platelet, IgM and IgG, children Abstrak: Demam Berdarah Dengue (DBD) Merupakan Penyakit Endemik Di Negara Beriklim Tropis Dan Subtropis Yang Disebabkan Oleh Infeksi Virus Dengue. Pemeriksaan jumlah trombosit diperkirakan bisa menjadi salah satu penanda infeksi dengue primer dan sekunder. Penelitian ini bertujuan mengetahui perbedaan jumlah trombosit pasien DBD primer dan sekunder pada anak di RSUD Ulin Banjarmasin. Penelitian ini menggunakan metode observasional analitik dengan rancangan penelitian cross sectional. Populasi dalam penelitian ini adalah semua pasien anak yang didiagnosis DBD di RSUD Ulin Banjarmasin periode Februari-Juni  2017  dengan  jumlah subjek  penelitian  yang memenuhi  kriteria inklusi  dan eksklusi sebanyak 21 sampel terdiri dari 5 sampel DBD primer dan 16 sampel DBD sekunder. Analisis data dilakukan dengan uji T tidak berpasangan. Rata-rata jumlah trombosit pada kelompok  DBD  primer  sebesar  116.600/µL  dan  pada  kelompok  DBD  sekunder  sebesar 58.979/µL. Berdasarkan penelitian yang dilakukan dapat disimpulkan terdapat perbedaan bermakna jumlah trombosit pada pasien DBD primer dan sekunder (p=0,001). Kata-kata kunci: demam berdarah dengue, trombosit, IgM dan IgG, anak
KORELASI ALKALINE PHOSPHATASE DAN KALSIUM SERUM PADA PENDERITA PENYAKIT GINJAL KRONIK YANG MENJALANI HEMODIALISIS RUTIN Marcella Pavita; FX Hendriyono; Mohammad Rudiansyah
Homeostasis Vol 2, No 3 (2019)
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Abstract: Chronic kidney disease is one of the health problems throughout the world with incidence and prevalence that always rincrease, bad outcome, and high costs. In patients with CKD there are an imbalance of fluids and minerals due to kidney inability to excrete fluids which affect calcium levels in blood and enzyme alkaline phosphatase (ALP) levels. Alkaline phosphatase is an enzyme which works on alkaline so calcium can easily deposit in tissue. This study is conduncted to determine the correlation of ALP and serum calcium in CKD patients undergoing routine hemodialysis. Observasional analytic with cross sectional approach on 30 research subject is used for the method. The reasearch subjects were selected by purposive sampling with an alternative tests Sommers d gamma. The results showed no correlation between ALP and serum calcium in CKD patients undergoing routine hemodialysis (p value=0,91) Keywords: chronic kidney disease , alkaline phosphatase, calcium, routine hemodialysis Abstrak: Penyakit ginjal kronik merupakan masalah kesehatan diseluruh dunia dengan insidensi dan prevalensi yang selalu meningkat, hasil yang buruk dan biaya perawatan yang tinggi. Pada penderita PGK keseimbangan cairan dan mineral akan terganggu akibat ketidakmampuan ginjal dalam eksresi cairan sehingga akan mempengaruhi kadar kalsium dan enzim alkaline phosphatase (ALP) dalam darah. Alkaline phosphatase merupakan enzim untuk mempersiapkan suasana basa agar kalsium mudah terdeposit pada jaringan. Penelitian ini dilakukan di instalasi hemodialisis RSUD Ulin Banjarmasin untuk mengetahui korelasi ALP dan kalsium serum pada penderita PGK yang menjalani hemodialisis rutin. Metode yang digunakan adalah observasional analitik dengan pendekatan cross sectional pada 30 subjek penelitian. Subjek penelitian dipilih dengan menggunakan purposive sampling dengan analisis uji alternatif Sommers d gamma. Hasil uji analisis menunjukan tidak adanya korelasi antara ALP dan kalsium serum pada penderita PGK yang menjalani hemodialisis rutin (p value=0,91) Kata-kata kunci: Penyakit ginjal kronik, alkaline phosphatase, kalsium, hemodialisis rutin.
Gambaran Jumlah Leukosit pada Pasien Kanker Serviks yang Menerima Kemoterapi Jessica Manoralisa; Hariadi Hariadi; FX Hendriyono
Homeostasis Vol 3, No 1 (2020)
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Abstract: Cervical cancer is malignancy disease in cervix. Chemotherapy is cancer’s treatment using systemic drugs. This study determines the description of leukocytes number in cervical cancer patients who receive paclitaxel and carboplatin chemotherapy phases I, II, III and IV at Ulin General Hospital Banjarmasin in August 2018 - March 2019. This is descriptive study with cohort approach. The results showed 46 patients who appropriate the criteria, 1 patient with IB stage and 45 patients with IIIB stage. Patients with early-stage have normal leukocyte number before chemotherapy and after first, second and third chemotherapy then decrease after fourth chemotherapy. At advanced stage, leukocyte number have 12 patients (26.7%) increase before chemotherapy. Four patients (8.9%) increase and 5 patients (11.1%) decrease after first chemotherapy. One patient (2.2%)  increase and 7 patients (15.6%) decrease after second chemotherapy. One patient (2.2 increase after third chemotherapy and 11 patients (24.5%) decrease after third and fourth chemotherapy. Keywords: leukocyte, paclitaxel, carboplatin, cervical cancer. Abstrak: Kanker serviks adalah penyakit keganasan leher rahim. Kemoterapi adalah salah satu pengobatan dengan menggunakan obat sistemik. Penelitian ini dilakukan untuk mengetahui gambaran jumlah leukosit pasien kanker serviks yang menerima kemoterapi paklitaksel dan karboplatin fase I, II, III dan IV di RSUD Ulin Banjarmasin periode Agustus 2018 – Maret 2019. Penelitian bersifat deskriptif dengan desain kohort. Hasil penelitian didapatkan 46 pasien memenuhi kriteria, 1 pasien stadium IB dan 45 pasien stadium IIIB. Pada stadium awal didapatkan jumlah leukosit pasien normal sebelum kemoterapi dan sesudah kemoterapi pertama, kedua, ketiga kemudian menurun sesudah kemoterapi keempat. Pada pasien stadium lanjut didapatkan data jumlah leukosit sebanyak 12 pasien (26,7%) meningkat sebelum kemoterapi. Sebanyak 4 pasien (8,9%) meningkat dan 5 pasien (11,1%) menurun sesudah kemoterapi pertama. Sebanyak 1 pasien (2,2%) meningkat dan 7 pasien (15,6%) menurun sesudah kemoterapi kedua. Sebanyak 1 pasien (2,2%) meningkat sesudah kemoterapi ketiga dan 11 pasien (24,5%) menurun sesudah kemoterapi ketiga dan keempat. Kata-kata kunci: leukosit, paklitaksel, karboplatin, kanker serviks.
Gambaran Jumlah Trombosit pada Pasien Kanker Serviks yang Menerima Kemoterapi Rifdah Amalina Winarno; Hariadi Hariadi; FX Hendriyono
Homeostasis Vol 3, No 3 (2020)
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Abstract: Cervical cancer is a malignancy in the cervix. Chemotherapy is a therapy to kills cancer cells. The side effect of chemotherapy is myelosuppression which results in decreased platelet production. The purpose of study is to determine the description of platelets amount in cervical cancer patients who received paclitaxel and carboplatin chemotherapy phase I, II, III and IV at RSUD Ulin Banjarmasin. This study is descriptive by taking medical records data of cervical cancer patients at RSUD Ulin Banjarmasin period August 2018 - March 2019. The study obtained by 46 patients with cervical cancer included in the criteria. There are 1 patient (2,2%) stage IB and 45 patients (97,8%) stage IIIB. Platelet amount are 100% normal in phase I, II, III and IV stage IB cervical cancer patients. In stage IIIB, 14 patients (31,1%) increased and no decreased before chemotherapy. One patient (2,2%) decreased and nine patients (20%) increased after the first chemotherapy. Three patients (6,7%) decreased and four patients (8.9%) increased after the second chemotherapy. Five patients (11,1%) decreased and three patients (6,7%) increased after the third chemotherapy. Seven patients (15,6%) decreased and five patients (11,1%) increased after the fourth chemotherapy. Keywords: cervical cancer, platelet amount, chemotherapy Abstrak: Kanker serviks yaitu keganasan di leher rahim. Kemoterapi adalah terapi untuk menghancurkan sel kanker. Efek samping kemoterapi yaitu mielosupresi yang mengakibatkan terjadinya penurunan produksi trombosit. Tujuan penelitian ini untuk mengetahui gambaran jumlah trombosit pada pasien kanker serviks yang menerima kemoterapi paklitaksel dan karboplatin fase I, II, III dan IV di RSUD Ulin Banjarmasin. Penelitian ini bersifat deskriptif dengan pengambilan data rekam medik pasien kanker serviks di RSUD Ulin Banjarmasin periode Agustus 2018 – Maret 2019. Hasil penelitian diperoleh 46 pasien kanker serviks yang memenuhi kriteria. Terdapat 1 pasien (2,2%) stadium IB dan 45 pasien (97,8%) stadium IIIB. Jumlah trombosit 100 % normal pada pasien kanker serviks stadium IB fase I, II, III dan IV. Pada stadium IIIB, didapatkan 14 pasien (31,1%) meningkat dan tidak ada yang menurun sebelum kemoterapi. Sebanyak 1 pasien (2,2%) menurun dan 9 pasien (20%) meningkat sesudah kemoterapi pertama. Sebanyak 3 pasien (6,7%) menurun dan 4 pasien (8,9%) meningkat sesudah kemoterapi kedua. Sebanyak 5 pasien (11,1%) menurun dan 3 pasien (6,7%) meningkat sesudah kemoterapi ketiga. Sebanyak 7 pasien (15,6%) menurun dan 5 pasien (11,1%) meningkat sesudah kemoterapi keempat. Kata-kata kunci:  Kanker serviks, jumlah trombosit, kemoterapi
Gambaran Kadar Kreatinin Darah pada Pasien Kanker Serviks yang Menerima Kemoterapi Aghfierna Herza Berliana; Hariadi Hariadi; FX Hendriyono
Homeostasis Vol 3, No 2 (2020)
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Abstract: One of the treatment modality for cervical cancer is chemotherapy. Paclitaxel and carboplatin are chemotherapy regiment that being used in Ulin General Hospital Banjarmasin. The aimed of this study is to know the overview of blood creatinine level in cervical cancer patient receiving paclitaxel and carboplatin chemotherapy phase I, II, III and IV. The study was descriptive study with cohort design study. Results obtained 42 patient that fulfill criteria. In IB stage the blood creatinine level are still at normal range either when before chemotherapy or after chemotherapy phase I, II, III and IV. In IIIB stage was obtained 1 patient (2,44%) experienced a decrease of blood creatinine level before chemotherapy. After first chemotherapy 1 patient (2,44%) experienced an increase. After second chemotherapy 1 patient (2,44%) experienced an increase and 1 patient (2,44%) experienced a decrease. After third and fourth chemotherapy 3 patient (4,88%) experienced an increase. Keywords: creatinine blood level , carboplatin, paclitaxel, cervical cancer Abstrak: Salah satu modalitas pengobatan kanker serviks adalah kemoterapi. Paklitaksel dan karboplatin merupakan salah satu regimen kemoterapi yang digunakan di RSUD Ulin Banjarmasin. Penelitian ini bertujuan untuk mengetahui gambaran kadar kreatinin darah pada pasien kanker serviks yang menerima kemoterapi paklitaksel dan karboplatin pada fase I, II, III dan IV. Penelitian ini bersifat deskritif dengan menggunakan desain studi kohort. Hasil penelitian diperoleh 42 pasien yang memenuhi kriteria. Pada stadium IB kadar kreatinin masih dalam batas normal baik pada pengukuran sebelum kemoterapi yang pertama maupun sesudah kemoterapi fase I, II, III dan IV. Pada stadium IIIB didapatkan sebanyak 1 pasien (2,44%) mengalami penurunan kadar kreatinin sebelum kemoterapi. Sebanyak 1 pasien (2,44%) mengalami peningkatan sesudah kemoterapi yang pertama. Sebanyak 1 pasien (2,44%) mengalami peningkatan dan 1 pasien (2,44%) mengalami penurunan sesudah kemoterapi yang kedua. Sebanyak 2 pasien (4,88%) mengalami peningkatan yang sesudah kemoterapi yang ketiga dan keempat. Kata-kata kunci:  kadar kreatinin darah, karboplatin, paklitaksel, kanker serviks
KORELASI KADAR KOLESTEROL TOTAL DAN MASSA LEMAK PADA PASIEN PENYAKIT GINJAL KRONIK YANG MENJALANI HEMODIALISIS RUTIN Meyta Saskia Regita Putri; FX Hendriyono; Mohammad Rudiansyah
Homeostasis Vol 2, No 3 (2019)
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Abstract: Chronic kidney disease (CKD) is one of the global public health problems with prevalence 13,4% in 2016. In CKD hypoalbuminemia increases the activity of 3-hydroxy-3-methylglutaril CoA reductase that works on cholesterol synthesis, resulting in hypercholesterolemia. The aim of the study was to find a correlation between total cholesterol levels and fat mass in CKD patients undergoing routine hemodialysis. This is an observational analytic studies with cross-sectional approach. Thirty subjects were obtained by purposive sampling. Subjects were male CKD patients aged between 25-59 years old undergoing hemodialysis, twice a week at least for 3 months, in Hemodialysis Installation of Ulin Hospital Banjarmasin. From this study, the median of total cholesterol level was 183 mg / dL (108-371 mg / dL). The median of fat mass was 12,2%, (4,8-31,6%). The correlation test, Spearman somers' gamma, results showed no correlation (p = 0,108). There is no correlation between total cholesterol levels and fat mass in CKD patients undergoing routine hemodialysis. Keywords: Total cholesterol, fat mass, chronic renal failure, routine hemodialysis.Abstrak: Penyakit ginjal kronik (PGK) merupakan salah satu masalah kesehatan masyarakat global dengan prevalensi 13.4% pada tahun 2016. Pada PGK terjadi hipoalbuminemia yang meningkatkan kerja enzim 3-hidroksi-3-metilglutaril KoA reduktase yang bekerja pada sintesis kolesterol, sehingga terjadi hiperkolesterolemia. Tujuan penelitian untuk mencari adanya korelasi kadar kolesterol total dan massa lemak pada pasien PGK yang menjalani hemodialisis rutin. Penelitian ini bersifat observasional analitik dengan pendekatan cross-sectional. Subyek didapat dengan metode purposive sampling sebanyak 30. Subyek adalah pasien PGK laki-laki berusia 25-59 tahun yang menjalani hemodialisis 2 kali seminggu minimal selama 3 bulan di Instalasi Hemodialisis RSUD Ulin Banjarmasin. Hasil penelitian didapatkan nilai median kadar kolesterol total 183 mg/dL (108-371 mg/dL). Nilai median massa lemak pada penelitian ini 12,2% (4,8-31,6%). Hasil uji korelasi Spearman somers’d gamma menunjukan tidak terdapat korelasi pada penelitian ini (p=0,108). Tidak terdapat korelasi antara kadar kolesterol total dan massa lemak pada pasien PGK yang menjalani hemodialisis rutin. Kata-kata kunci: kolesterol total, massa lemak, penyakit ginjal kronik, hemodialisis rutin
GAMBARAN KADAR KALSIUM TOTAL DAN VITAMIN D PADA ANAK SINDROM NEFROTIK DI RSUD ULIN BANJARMASIN Nurul Muth Mainnah; FX Hendriyono; Selli Muljanto
Homeostasis Vol 2, No 3 (2019)
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Abstract: Complications nephrotic syndrome (NS) include hypocalcaemia and vitamin D deficiency. That are due to increased glomerular permeability of protein. This study aimed to describe the total calcium and vitamin D levels in children with relapse NS, steroid-dependent NS and steroid-resistant NS (SRNS) at Ulin General Hospital Banjarmasin on January 2017-August 2018. This research method with a retrospective cross-sectional approach. There were 21 subjects consisted of relapse NS (38.1%), steroid dependent NS (33.3%) and SRNS (28.6%) were selected by purposive sampling according to inclusion criteria. The results of the study on NS children at Ulin General Hospital Banjarmasin were found to have a mean total calcium levels of 9.35±1.55 mg/dL and a mean vitamin D levels of 19.85±8.79 ng/mL. Furthermore, the mean total calcium levels in relapse NS was 9.43±1.72 mg/dL, steroid dependent NS 9.46±1.29 mg/dL and SRNS 9.12±1.83 mg/dL and the mean vitamin D levels in relapsed NS 19.56±6.17 ng/mL, steroid-dependent NS 21.73±10.46 ng/mL, SRNS 18.03±10.79 ng/mL. It can be concluded that in children with relapse NS, steroid-dependent NS and SRNS at Ulin General Hospital Banjarmasin have a normal mean total calcium levels and decreased a mean of vitamin D levels. Keywords: nephrotic syndrome, relapse nephrotic syndrome, steroid-dependent nephrotic syndrome,   steroid-resistant nephrotic syndrome, total calcium, vitamin D. Abstrak: Komplikasi sindrom nefrotik (SN) diantaranya hipokalsemia dan defisiensi vitamin D. Hal tersebut disebabkan meningkatnya permeabilitas glomerulus terhadap protein. Penelitian ini bertujuan untuk mengetahui gambaran kadar kalsium total dan vitamin D pada pasien SN relaps, SN dependen steroid dan SN resisten steroid (SNRS) di RSUD Ulin Banjarmasin periode Januari 2017-Agustus 2018. Metode penelitian dengan pendekatan cross sectional retrospektif. Didapatkan 21 subjek terdiri dari SN relaps (38,1%), SN dependen steroid (33,3%) dan SNRS (28,6%) dipilih melalui purposive sampling yang memenuhi kriteria inklusi. Hasil penelitian pada pasien SN anak didapatkan rerata kadar kalsium total 9,35±1,55 mg/dL dan rerata kadar vitamin D 19,85±8,79 ng/mL. Selanjutnya rerata kadar kalsium total pada SN relaps 9,43±1,72 mg/dL, SN dependen steroid 9,46±1,29 mg/dL dan SNRS 9,12±1,83 mg/dL serta rerata kadar vitamin D pada SN relaps 19,56±6,17 ng/mL, SN dependen steroid 21,73±10,46 ng/mL, SNRS 18,03±10,79 ng/mL. Dapat disimpulkan pada pasien SN relaps, SN dependen steroid dan SNRS di RSUD Ulin Banjarmasin memiliki rerata kadar kalsium total yang normal dan rerata kadar vitamin D yang menurun. Kata-kata kunci: sindrom nefrotik, sindrom nefrotik relaps, sindrom nefrotik dependen steroid, sindrom nefrotik resisten steroid, kalsium total, vitamin D
Perbedaan Kadar Kreatinin Sebelum dan Sesudah Kemoterapi Berbasis Platinum Rusyda Taqiya Rahmi; Sasongko Hadi Priyono; Azma Rosida; M. Darwin Prenggono; FX Hendriyono
Homeostasis Vol 3, No 3 (2020)
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Abstract

Abstract: Platinum analog has a potential cytostatic effect and causing nephrotoxicity or a decrease in kidney function. This study used creatinine level to assess kidney function that are carried out routinely before the patient starts the chemotherapy cycle. This study aimed to determine the differences in creatinine levels before and after platinum-based chemotherapy. This an analytical study used retrospective cohort design with a total sample of 70 people according to inclusion criteria. The result showed a median creatinine level of breast cancer patients before and after platinum-based chemotherapy is 0,63 mg/dL and 0,75 mg/dL. Wilcoxon test results obtained”p=0,000 (p <0.05), considered as a significant difference between creatinine level  before and after platinum-based chemotherapy in breast cancer patients period January 2018-June 2019 in Ulin Hospital Banjarmasin, but the change of creatinine levels remain in the normal range. Keywords: platinum, based” chemotherapy, creatinine” levels, breast cancer” Abstrak: Analog platinum memiliki efek sitostatika poten dan efek samping nefrotoksisitas atau penurunan fungsi ginjal. Penilaian fungsi ginjal menggunakan parameter kadar kreatinin yang dilakukan secara rutin sebelum pasien memulai siklus kemoterapi. Penelitian bertujuan untuk mengetahui perbedaan kadar kreatinin sebelum dan sesudah kemoterapi berbasis platinum. Ini adalah penelitian observasional analitik dengan pendekatan Kohort Retrospektif dengan subjek penelitian 70 orang sesuai kriteria inklusi. Didapatkan median kadar kreatinin sebelum dan sesudah kemoterapi berbasis platinum sebesar 0,63 mg/dL dan 0,75 mg/dL. Uji Wilcoxon menunjukkan nilai p=0,000 (p<0,05), disimpulkan terdapat perbedaan bermakna kadar kreatinin sebelum dan sesudah kemoterapi berbasis platinumpada pasien kanker payudara periode Januari 2018-Juni 2019 di RSUD Ulin Banjarmasin meskipun perubahan kadar kreatinin masih dalam rentang normal. Kata-kata kunci: kemoterapi berbasis platinum, kadar kreatinin, kanker payudara
Co-Authors Aghfierna Herza Berliana Azma Rosida Edi Hartoyo Hariadi Hariadi Ikrima Nurul Arifa Jessica Manoralisa Larissa Faisa Faisa Lathifah Laila Ulfa Marcella Pavita Meyta Saskia Regita Putri Mohammad Rudiansyah Nurul Muth Mainnah Prenggono, Muhamad Darwin Rifdah Amalina Winarno Rusyda Taqiya Rahmi Sasongko Hadi Priyono Sasongko Hadi Priyono Selli Muljanto Siti Annisa Rezki Triska Dianti Wahyuningrum