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All Journal Jurnal Ilmiah Farmasi INDONESIAN JOURNAL OF PHARMACY JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Rochmy Istikharah
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Universitas Islam Indonesia, Yogyakarta, Indonesia
Medicine & Pharmacology Public Health

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Journal : JKKI : Jurnal Kedokteran dan Kesehatan Indonesia

 1 
Characterization, formulation and evaluation of glibenclamide with ß-cyclodextrin inclusion complexes tablets Yandi Syukri; Farida Ulfa; Asih Lestari; Lelita Ayu Saputri; Rochmy Istikharah; Aris Perdana Kusuma
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 3, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol9.Iss3.art3

Abstract

Background: Glibenclamide is an oral antidiabetic drug which is practically insoluble in water. Formation of ß-cyclodextrin inclusion complex was able to increase glibenclamide solubility. Objective: Aims of this study are to characterize, formulate and evaluate  inclusion complex tablets of glibenclamide to meet the requirements in Pharmacopeia.Methods: Inclusion complex was prepared in a 1: 1 and 1: 2 molar ratio  by spray drying method. Characterization were performed by using Fourier Transform Infrared (FTIR) spectroscopy and Scanning Electron Microscope (SEM). Further, it was formulated into tablets by direct compression technique using primojel and crospovidone as disintegrants.   Uniformity weight, hardness, friability, disintegration, and tablets were evaluated include dissolution. Dissolution studies of inclusion complex were performed by using United States Pharmacopeia (USP) II apparatus.  Drug concentration dissolution was determined with high pressure liquid chromatography (HPLC).Results: Result of FTIR and SEM provided evidence of  glibenclamide and ß-cyclodextrin complex formation after using spray drying methods. The tablet evaluation with primojel and crospovidone as disintegrant showed that increase concentration of disintegrant would increase disintegration time of the tablets. All of the formulas meet the requirements in the Pharmacopoeia.Conclusion: The inclusion complex of glibenclamide–ß cyclodextrin successfully used for enhancing the solubility of glibenclamide. The tablets meet the requirements in Pharmacopeia.
Co-Authors Arifa Caryn Dea Utami Hasyono Aris Perdana Kusuma, Aris Perdana Asih Lestari Dimas Adhi Pradana Dzihni Meytasari Ediati Ediati Ediati Sasmito Evie Andriyani, Evie Farah Deastasa Nabilah Farida Ulfa Khittah Dea Annisa Annisa Lelita Ayu Saputri Lutfi Chabib, Lutfi Maulana Ardhi Nofran Putra Pratama Rumiyati ., Rumiyati Rumiyati Rumiyati Sri Rahayu W., Sri Rahayu Tamhid, Hady Anshory Yandi Syukri