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All Journal The Indonesian Biomedical Journal Baselang: Jurnal Ilmu Pertanian, Peternakan, Perikanan dan Lingkungan Andalasian International Journal of Social and Entrepreneurial Development Open Access DRIVERset
Bastian Nova
Universitas Andalas
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Environmental Science Public Health Social Sciences Other

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Role of Estrogen Receptor Alpha rs3798577 Polymorphism in Breast Carcinoma Risk Determination Pieri Kumaladewi; Wirsma Arif Harahap; Bastian Nova; Irianiwati Widodo; Ramadhan Karsono; Ferry Sandra; Bethy Suryawathy Hernowo
The Indonesian Biomedical Journal Vol 14, No 4 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i4.2002

Abstract

BACKGROUND: Interaction between estrogen and estrogen receptor (ER) takes part in the regulation and differentiation of breast tumorigenesis. Some ERα polymorphisms, including ERα rs3798577, are reported to be associated with the risk and aggressiveness of breast carcinoma since the site was reported to be targeted by microRNA, which can further modulate the ERα expression. Hence, this study was conducted to disclose the possible role of ERα SNP rs3798577 on breast carcinoma patients.METHODS: Samples were taken from the post-mastectomy breast carcinoma tissues of female patients and screened based on the completeness of medical and histopathological records. DNA isolation was proceeded using real time-polymerase chain reaction (RT-PCR) then analyzed for high resolution melting (HRM). The nucleotide base sequence was then analyzed based on rs3798577 ERα polymorphism. ER immunohistochemistry test was carried out and counted quantitatively based on the staining intensity and the percentage of the stained cells.RESULTS: Out of 65 samples, there were 33 samples as wild type and 32 samples as variant type. Most variant and wild type had >80% ERα percentage. Most variant type had middle ERα intensity, while wild type had strong ERα intensity. Higher percentage of variant type (52.2%) was found with weak ERα histoscore, meanwhile higher percentage of wild type (52.4%) was found with strong ERα histoscore, but not significant (p=0.725).CONCLUSION: ERα rs3798577 variant type had a lower ERα intensity and weaker ERα histoscore compared to the wild type, suggesting that ERα rs3798577 polymorphism might play a role in breast carcinoma risk determination.KEYWORDS: breast cancer, ERα, rs3798577, polymorphism, immunoexpression
Halal Industrial Village Assistance and Signing Cooperation Agreement With Batu Gadang Village Aisman Aisman; Rini Rini; Hasbullah Hasbullah; Diana Sylvi; Purnama Dini Hari; Ismed Ismed; Cesar Welya Refdi; Wellyalina Wellyalina; Felga Zulfia Rasdiana; Reni Koja; Bastian Nova; Linda Wati
Andalasian International Journal of Social and Entrepreneurial Development Vol. 2 No. 02 (2022): Andalasian International Journal of Social and Entrepreneurial Development
Publisher : Institute of Research And Community Service, Andalas University / LPPM Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aijsed.v2.i02.9-12.2023

Abstract

This community service activity carried out by the Faculty of Agricultural Technology, Andalas University, Padang, is in collaboration with the Batu Gadang Village, Lubuk Kilangan District, Padang City. The activity location is in the Batu Gadang (Indarung) Lurah Office which has been prepared in such a good way, in the Batu Gadang Village there are still MSMEs that do not have halal certification and have the potential to be used as a model for a halal food industry village in West Sumatra. The main problem encountered is the lack of information received by MSME actors in the Batu Gadang Village to obtain halal certificates. Therefore, it is necessary to provide assistance to MSME actors in the Batu Gadang sub-district from the beginning until the issuance of the halal certificate
Halal Industrial Village Assistance and Signing Cooperation Agreement With Batu Gadang Village Aisman Aisman; Rini Rini; Hasbullah Hasbullah; Diana Sylvi; Purnama Dini Hari; Ismed Ismed; Cesar Welya Refdi; Wellyalina Wellyalina; Felga Zulfia Rasdiana; Reni Koja; Bastian Nova; Linda Wati
Andalasian International Journal of Social and Entrepreneurial Development Vol. 2 No. 02 (2022): Andalasian International Journal of Social and Entrepreneurial Development
Publisher : Institute of Research And Community Service, Andalas University / LPPM Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aijsed.v2.i02.9-12.2023

Abstract

This community service activity carried out by the Faculty of Agricultural Technology, Andalas University, Padang, is in collaboration with the Batu Gadang Village, Lubuk Kilangan District, Padang City. The activity location is in the Batu Gadang (Indarung) Lurah Office which has been prepared in such a good way, in the Batu Gadang Village there are still MSMEs that do not have halal certification and have the potential to be used as a model for a halal food industry village in West Sumatra. The main problem encountered is the lack of information received by MSME actors in the Batu Gadang Village to obtain halal certificates. Therefore, it is necessary to provide assistance to MSME actors in the Batu Gadang sub-district from the beginning until the issuance of the halal certificate
Desain Primer dan Deteksi Gen CHS (Chalcone Synthase) pada Tanaman Gambir (Uncaria gambir (Hunter) Roxb.) Tipe Riau Mancik Bastian Nova; Epi Supri Wardi; Miftahur Rahmi; Fadillatul Zikri
Baselang Vol 4, No 1: APRIL 2024
Publisher : Fakultas Pertanian Universitas Muara Bungo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36355/bsl.v4i1.124

Abstract

Gambir merupakan salah satu tanaman yang menghasilkan katekin. Kandungan katekin merupakan parameter dalam menentukan mutu gambir. Salah satu gen yang terlibat dalam pembentukkan katekin adalah gen CHS (Chalcone synthase). Penelitian ini bertujuan untuk mendapatkanprimer yang dapat digunakan untuk mendeteksi gen CHS (Chalcone synthase) pada tanaman gambir tipe Riau Mancik serta untuk melihat binding site dengan hasil isolasi DNA tanaman gambir terhadap primer yang telah didesain. Pendesainan primer dilakukan dengan mengalignment 21 data tanaman yang mengandung sekuen gen CHS yang terdapat di NCBI. Hasil desain primer didapatkan 8 pasang primer degeneratif dengan 4 primer forward dan 2 primer reverse. Primer yang memiliki binding site dengan hasil isolasi DNA yaitu pasangan primer A1F dengan C1R menghasilkan produk dengan estimasi 724 bp.
Co-Authors Aisman Aisman Bethy Suryawathy Hernowo Diana Sylvi Fadillatul Zikri Felga Zulfia Rasdiana Ferry Sandra Hasbullah Hasbullah Irianiwati Widodo Ismed Ismed Linda Wati Linda Wati Miftahur Rahmi Pieri Kumaladewi Purnama Dini Hari Ramadhan Karsono Reni Koja Rini Rini Wardi, Epi Supri Wellyalina Wellyalina Welya Refdi, Cesar Wirsma Arif Harahap