Article Per Year (5 Year)
p-Index From 2019 - 2024
0.408
P-Index
This Author published in this journals
All Journal International Journal of Advanced Health Science and Technology
Mohd Nazil Salleh
Institute of Biomedical Science, Malaysia Institute Medical Laboratory Science, PICOMS International University College, Malaysia
Electrical & Electronics Engineering Health Professions Nursing Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Anti-Bacterial Activity of Novel Synthesized Chalcone Against S. epidermidis and S. aureus Isolated from Packed Red Cell Blood Product Aulia Rahman; Wiwit Sepvianti; Serafica Btari Christiyani Kusumaningrum; Arum Sari; Mohd Nazil Salleh
International Journal of Advanced Health Science and Technology Vol. 2 No. 6 (2022): December
Publisher : Forum Ilmiah Teknologi dan Ilmu Kesehatan (FORITIKES)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/ijahst.v2i6.174

Abstract

Bacterial contamination in blood product was still a problem in Indonesia. Various studies to improve the safety of blood product by inhibiting the bacterial growth in blood product was developed. Chalcone, is one of the natural compounds that has ability to inhibit the bacterial growth, so it can be possible to use that compound for anti-bacterial use in the future. This study aim is to evaluate the anti-bacterial activity of novel synthesis chalcone (E)-1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one against S. epidermidis and S. aureus isolated from packed red cell blood product. A novel chalcone was synthesized by Claisen-Schmidt Methods while anti-bacterial activity test was done by Agar Diffusion Methods. Chalcone that has been synthesized then characterized by Fourier Transform Infra-Red (FTIR) Methods and Gas Chromatography – Mass Spectrometry (GC-MS). Chalcone was synthesized through a condensation reaction between an aldehyde (benzaldehyde) and ketone (acetophenone) with NaOH as alkaline catalyst. The results from sedimentary analysis using FTIR showed an absorption of the C=C group in the typical medium of chalcone compounds, at the wave number of 1516.96 cm-1. The results of GC-MS characterization resulted a GC chromatogram with one peak with time of retention (tR) 19.68 minutes and relative purity 100%. MS mass spectrum shows that the molecular ion (M+) of this compound was detected at 224 which equivalents to the molecular weight of the chalcone compound. Anti-bacterial test showed that the synthetic chalcone compound with 5% concentration had an inhibitory ability of 56.02% on S. epidermidis and 54.10% on S. aureus, while 2.5% chalcone concentration had an inhibitory ability of 29.17% on S. epidermidis and 50.45% on S. aureus, and 1.25% chalcone concentration had inhibitory ability 0% on S. epidermidis and 37.27% on S. aureus.
Analysis of Images of Neutrophil Lymphocyte Ratio and Bacteria Density Level of Helicobacter Pylori in Tissue in Gastritis Patients Fadia Rakhmalia; Anik Handayati; Evy Diah Woelansari; Mohd Nazil Salleh
International Journal of Advanced Health Science and Technology Vol. 2 No. 6 (2022): December
Publisher : Forum Ilmiah Teknologi dan Ilmu Kesehatan (FORITIKES)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/ijahst.v2i6.181

Abstract

Gastritis is an inflammatory disease that can last for a long time. Helicobacter pylori infection is known as the main cause of peptic ulcer and the most common cause of gastritis. Helicobacter Pylori infection will cause mononuclear (MN) and polymorphonuclear (PMN) cell infiltration and will increase the production of proinflammatory cytokines in the gastric mucosa compared to non-Helicobacter Pylori gastritis. Helicobacter Pylori with histopathological examination diagnosis. This type of research is descriptive observational with purposive sampling data collection technique at the Anatomical Pathology Laboratory Installation, RSPAL dr. Ramelan Surabaya. The data used are the results of a biopsy of 60 samples that were determined as gastritis with histopathological examination of the identification of Helicobacter Pylori bacteria in gastric tissue classified by the level of bacterial density using The Updated Sydney System, as well as haemogram data for complete blood examination to further calculate the neutrophil lymphocyte ratio (NLR). The data were processed using descriptive statistical tests to determine the average neutrophil lymphocyte ratio (NLR). Based on the statistics of the r-Spearman test, the density of Helicobacter Pylori, (Pν = 0.000) below < 0.005 indicates that there is a strong relationship between the neutrophil lymphocyte ratio (NLR) and the density of Helicobacter Pylori bacteria.
Co-Authors Anik Handayati Arum Sari Aulia Rahman Evy Diah Woelansari Fadia Rakhmalia Kusumaningrum, Serafica Btari Christiyani Sepvianti, Wiwit